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Q9WUU6

- HNF4G_MOUSE

UniProt

Q9WUU6 - HNF4G_MOUSE

Protein

Hepatocyte nuclear factor 4-gamma

Gene

Hnf4g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Transcription factor. Has a lower transcription activation potential than HNF4-alpha By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi9 – 8476Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri12 – 3221NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri48 – 7225NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    2. sequence-specific DNA binding Source: InterPro
    3. steroid hormone receptor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. endocrine pancreas development Source: Reactome
    2. positive regulation of transcription, DNA-templated Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_214529. Regulation of gene expression in beta cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte nuclear factor 4-gamma
    Short name:
    HNF-4-gamma
    Alternative name(s):
    Nuclear receptor subfamily 2 group A member 2
    Gene namesi
    Name:Hnf4g
    Synonyms:Nr2a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1353604. Hnf4g.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProtKB-SubCell
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Hepatocyte nuclear factor 4-gammaPRO_0000053563Add
    BLAST

    Proteomic databases

    MaxQBiQ9WUU6.
    PRIDEiQ9WUU6.

    PTM databases

    PhosphoSiteiQ9WUU6.

    Expressioni

    Gene expression databases

    BgeeiQ9WUU6.
    CleanExiMM_HNF4G.
    GenevestigatoriQ9WUU6.

    Interactioni

    Protein-protein interaction databases

    BioGridi206019. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUU6.
    SMRiQ9WUU6. Positions 11-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3221NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri48 – 7225NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG241134.
    GeneTreeiENSGT00740000115493.
    HOGENOMiHOG000260822.
    HOVERGENiHBG005606.
    InParanoidiQ9WUU6.
    KOiK08037.
    OrthoDBiEOG7K3TKX.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WUU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF    50
    SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTYEGSN 100
    IPSINTLAQA EVRSCQISVP SPSSSTDINI KKIASISDVC ESMKQQLLVL 150
    VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNH 200
    YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA 250
    KGLSDPVKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL LLPTLQSITW 300
    QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGSHLHHPM HPHLSQDPLT 350
    GQTILLGPMS TLVHTDQIAT PETPLPSPPQ GSGQEPYKIT ANQASVISHQ 400
    SLSKQKQL 408
    Length:408
    Mass (Da):45,897
    Last modified:December 1, 2000 - v2
    Checksum:i5E4AF2E53BCDC7F1
    GO

    Sequence cautioni

    The sequence CAB43724.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242626 mRNA. Translation: CAB43724.1. Different initiation.
    RefSeqiNP_038948.1. NM_013920.2.
    UniGeneiMm.330897.

    Genome annotation databases

    EnsembliENSMUST00000108393; ENSMUSP00000104030; ENSMUSG00000017688.
    GeneIDi30942.
    KEGGimmu:30942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ242626 mRNA. Translation: CAB43724.1 . Different initiation.
    RefSeqi NP_038948.1. NM_013920.2.
    UniGenei Mm.330897.

    3D structure databases

    ProteinModelPortali Q9WUU6.
    SMRi Q9WUU6. Positions 11-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206019. 6 interactions.

    PTM databases

    PhosphoSitei Q9WUU6.

    Proteomic databases

    MaxQBi Q9WUU6.
    PRIDEi Q9WUU6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108393 ; ENSMUSP00000104030 ; ENSMUSG00000017688 .
    GeneIDi 30942.
    KEGGi mmu:30942.

    Organism-specific databases

    CTDi 3174.
    MGIi MGI:1353604. Hnf4g.

    Phylogenomic databases

    eggNOGi NOG241134.
    GeneTreei ENSGT00740000115493.
    HOGENOMi HOG000260822.
    HOVERGENi HBG005606.
    InParanoidi Q9WUU6.
    KOi K08037.
    OrthoDBi EOG7K3TKX.

    Enzyme and pathway databases

    Reactomei REACT_214529. Regulation of gene expression in beta cells.

    Miscellaneous databases

    NextBioi 307386.
    PROi Q9WUU6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WUU6.
    CleanExi MM_HNF4G.
    Genevestigatori Q9WUU6.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma."
      Taraviras S., Mantamadiotis T., Dong-Si T., Mincheva A., Lichter P., Drewes T., Ryffel G.U., Monaghan A.P., Schutz G.
      Biochim. Biophys. Acta 1490:21-32(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHNF4G_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3