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Protein

Hepatocyte nuclear factor 4-gamma

Gene

Hnf4g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Has a lower transcription activation potential than HNF4-alpha (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi9 – 8476Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri12 – 3221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri48 – 7225NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. endocrine pancreas development Source: Reactome
  2. positive regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.
REACT_322034. Regulation of gene expression in beta cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 4-gamma
Short name:
HNF-4-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group A member 2
Gene namesi
Name:Hnf4g
Synonyms:Nr2a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1353604. Hnf4g.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: UniProtKB-SubCell
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Hepatocyte nuclear factor 4-gammaPRO_0000053563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei370 – 3701PhosphothreonineBy similarity
Modified residuei373 – 3731PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WUU6.
PRIDEiQ9WUU6.

PTM databases

PhosphoSiteiQ9WUU6.

Expressioni

Gene expression databases

BgeeiQ9WUU6.
CleanExiMM_HNF4G.
ExpressionAtlasiQ9WUU6. baseline and differential.
GenevestigatoriQ9WUU6.

Interactioni

Protein-protein interaction databases

BioGridi206019. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9WUU6.
SMRiQ9WUU6. Positions 11-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri48 – 7225NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG241134.
HOGENOMiHOG000260822.
HOVERGENiHBG005606.
InParanoidiQ9WUU6.
KOiK08037.
OrthoDBiEOG7K3TKX.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF
60 70 80 90 100
SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTYEGSN
110 120 130 140 150
IPSINTLAQA EVRSCQISVP SPSSSTDINI KKIASISDVC ESMKQQLLVL
160 170 180 190 200
VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNH
210 220 230 240 250
YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA
260 270 280 290 300
KGLSDPVKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL LLPTLQSITW
310 320 330 340 350
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGSHLHHPM HPHLSQDPLT
360 370 380 390 400
GQTILLGPMS TLVHTDQIAT PETPLPSPPQ GSGQEPYKIT ANQASVISHQ

SLSKQKQL
Length:408
Mass (Da):45,897
Last modified:November 30, 2000 - v2
Checksum:i5E4AF2E53BCDC7F1
GO

Sequence cautioni

The sequence CAB43724.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242626 mRNA. Translation: CAB43724.1. Different initiation.
RefSeqiNP_038948.1. NM_013920.2.
UniGeneiMm.330897.

Genome annotation databases

GeneIDi30942.
KEGGimmu:30942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242626 mRNA. Translation: CAB43724.1. Different initiation.
RefSeqiNP_038948.1. NM_013920.2.
UniGeneiMm.330897.

3D structure databases

ProteinModelPortaliQ9WUU6.
SMRiQ9WUU6. Positions 11-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206019. 6 interactions.

PTM databases

PhosphoSiteiQ9WUU6.

Proteomic databases

MaxQBiQ9WUU6.
PRIDEiQ9WUU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30942.
KEGGimmu:30942.

Organism-specific databases

CTDi3174.
MGIiMGI:1353604. Hnf4g.

Phylogenomic databases

eggNOGiNOG241134.
HOGENOMiHOG000260822.
HOVERGENiHBG005606.
InParanoidiQ9WUU6.
KOiK08037.
OrthoDBiEOG7K3TKX.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.
REACT_322034. Regulation of gene expression in beta cells.

Miscellaneous databases

NextBioi307386.
PROiQ9WUU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUU6.
CleanExiMM_HNF4G.
ExpressionAtlasiQ9WUU6. baseline and differential.
GenevestigatoriQ9WUU6.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma."
    Taraviras S., Mantamadiotis T., Dong-Si T., Mincheva A., Lichter P., Drewes T., Ryffel G.U., Monaghan A.P., Schutz G.
    Biochim. Biophys. Acta 1490:21-32(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHNF4G_MOUSE
AccessioniPrimary (citable) accession number: Q9WUU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2000
Last sequence update: November 30, 2000
Last modified: March 31, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.