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Q9WUU6 (HNF4G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatocyte nuclear factor 4-gamma

Short name=HNF-4-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group A member 2
Gene names
Name:Hnf4g
Synonyms:Nr2a2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor. Has a lower transcription activation potential than HNF4-alpha By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence caution

The sequence CAB43724.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Hepatocyte nuclear factor 4-gamma
PRO_0000053563

Regions

DNA binding9 – 8476Nuclear receptor
Zinc finger12 – 3221NR C4-type
Zinc finger48 – 7225NR C4-type

Sequences

Sequence LengthMass (Da)Tools
Q9WUU6 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 5E4AF2E53BCDC7F1

FASTA40845,897
        10         20         30         40         50         60 
MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF SRQCVVDKDK 

        70         80         90        100        110        120 
RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTYEGSN IPSINTLAQA EVRSCQISVP 

       130        140        150        160        170        180 
SPSSSTDINI KKIASISDVC ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL 

       190        200        210        220        230        240 
LLGATKRSMM YKDILLLGNH YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL 

       250        260        270        280        290        300 
KAIVFFDPDA KGLSDPVKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL LLPTLQSITW 

       310        320        330        340        350        360 
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGSHLHHPM HPHLSQDPLT GQTILLGPMS 

       370        380        390        400 
TLVHTDQIAT PETPLPSPPQ GSGQEPYKIT ANQASVISHQ SLSKQKQL 

« Hide

References

[1]"Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma."
Taraviras S., Mantamadiotis T., Dong-Si T., Mincheva A., Lichter P., Drewes T., Ryffel G.U., Monaghan A.P., Schutz G.
Biochim. Biophys. Acta 1490:21-32(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ242626 mRNA. Translation: CAB43724.1. Different initiation.
RefSeqNP_038948.1. NM_013920.2.
UniGeneMm.330897.

3D structure databases

ProteinModelPortalQ9WUU6.
SMRQ9WUU6. Positions 11-328.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206019. 6 interactions.

PTM databases

PhosphoSiteQ9WUU6.

Proteomic databases

MaxQBQ9WUU6.
PRIDEQ9WUU6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108393; ENSMUSP00000104030; ENSMUSG00000017688.
GeneID30942.
KEGGmmu:30942.

Organism-specific databases

CTD3174.
MGIMGI:1353604. Hnf4g.

Phylogenomic databases

eggNOGNOG241134.
GeneTreeENSGT00740000115493.
HOGENOMHOG000260822.
HOVERGENHBG005606.
InParanoidQ9WUU6.
KOK08037.
OrthoDBEOG7K3TKX.

Enzyme and pathway databases

ReactomeREACT_13641. Regulation of Beta-Cell Development.
REACT_188576. Developmental Biology.

Gene expression databases

BgeeQ9WUU6.
CleanExMM_HNF4G.
GenevestigatorQ9WUU6.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307386.
PROQ9WUU6.
SOURCESearch...

Entry information

Entry nameHNF4G_MOUSE
AccessionPrimary (citable) accession number: Q9WUU6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot