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Protein

Hepatocyte nuclear factor 4-gamma

Gene

Hnf4g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Has a lower transcription activation potential than HNF4-alpha (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 84Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri12 – 32NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri48 – 72NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-210745. Regulation of gene expression in beta cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 4-gamma
Short name:
HNF-4-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group A member 2
Gene namesi
Name:Hnf4g
Synonyms:Nr2a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1353604. Hnf4g.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535631 – 408Hepatocyte nuclear factor 4-gammaAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei370PhosphothreonineBy similarity1
Modified residuei373PhosphothreonineBy similarity1
Modified residuei377PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WUU6.
PaxDbiQ9WUU6.
PRIDEiQ9WUU6.

PTM databases

iPTMnetiQ9WUU6.
PhosphoSitePlusiQ9WUU6.

Expressioni

Gene expression databases

CleanExiMM_HNF4G.

Interactioni

Protein-protein interaction databases

BioGridi206019. 6 interactors.
STRINGi10090.ENSMUSP00000017832.

Structurei

3D structure databases

ProteinModelPortaliQ9WUU6.
SMRiQ9WUU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 32NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri48 – 72NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
HOGENOMiHOG000260822.
HOVERGENiHBG005606.
InParanoidiQ9WUU6.
KOiK08037.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WUU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF
60 70 80 90 100
SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTYEGSN
110 120 130 140 150
IPSINTLAQA EVRSCQISVP SPSSSTDINI KKIASISDVC ESMKQQLLVL
160 170 180 190 200
VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNH
210 220 230 240 250
YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA
260 270 280 290 300
KGLSDPVKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL LLPTLQSITW
310 320 330 340 350
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGSHLHHPM HPHLSQDPLT
360 370 380 390 400
GQTILLGPMS TLVHTDQIAT PETPLPSPPQ GSGQEPYKIT ANQASVISHQ

SLSKQKQL
Length:408
Mass (Da):45,897
Last modified:December 1, 2000 - v2
Checksum:i5E4AF2E53BCDC7F1
GO

Sequence cautioni

The sequence CAB43724 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242626 mRNA. Translation: CAB43724.1. Different initiation.
RefSeqiNP_038948.1. NM_013920.2.
UniGeneiMm.330897.

Genome annotation databases

GeneIDi30942.
KEGGimmu:30942.

Similar proteinsi

Entry informationi

Entry nameiHNF4G_MOUSE
AccessioniPrimary (citable) accession number: Q9WUU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: August 30, 2017
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families