Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor type 9

Gene

Ccr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: MGI

GO - Biological processi

  • CD8-positive, gamma-delta intraepithelial T cell differentiation Source: MGI
  • chemotaxis Source: MGI
  • immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 9
Short name:
C-C CKR-9
Short name:
CC-CKR-9
Short name:
CCR-9
Alternative name(s):
Chemokine C-C receptor 10
CD_antigen: CDw199
Gene namesi
Name:Ccr9
Synonyms:Cmkbr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1341902. Ccr9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949ExtracellularSequence analysisAdd
BLAST
Transmembranei50 – 7627Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini77 – 859CytoplasmicSequence analysis
Transmembranei86 – 10621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini107 – 12014ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 14222Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini143 – 16018CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini182 – 21029ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23828Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini239 – 25416CytoplasmicSequence analysisAdd
BLAST
Transmembranei255 – 28026Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini281 – 30424ExtracellularSequence analysisAdd
BLAST
Transmembranei305 – 32218Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini323 – 36947CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369C-C chemokine receptor type 9PRO_0000069292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi119 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUT7.
PRIDEiQ9WUT7.

PTM databases

iPTMnetiQ9WUT7.
PhosphoSiteiQ9WUT7.

Expressioni

Tissue specificityi

Highly expressed in the thymus and low in lymph nodes and spleen.

Gene expression databases

BgeeiQ9WUT7.
CleanExiMM_CCR9.
ExpressionAtlasiQ9WUT7. baseline and differential.
GenevisibleiQ9WUT7. MM.

Interactioni

Protein-protein interaction databases

BioGridi198769. 1 interaction.
DIPiDIP-5886N.
STRINGi10090.ENSMUSP00000126758.

Structurei

3D structure databases

ProteinModelPortaliQ9WUT7.
SMRiQ9WUT7. Positions 44-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9WUT7.
KOiK04184.
OMAiTWRQKRL.
OrthoDBiEOG77WWD0.
PhylomeDBiQ9WUT7.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPTELTSLI PGMFDDFSYD STASTDDYMN LNFSSFFCKK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGTLGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLAT
110 120 130 140 150
LPFWAIAAAG QWMFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIVQ
160 170 180 190 200
AMKAQVWRQK RLLYSKMVCI TIWVMAAVLC TPEILYSQVS GESGIATCTM
210 220 230 240 250
VYPKDKNAKL KSAVLILKVT LGFFLPFMVM AFCYTIIIHT LVQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFIMSQFPY NSILVVQAVD AYAMFISNCT ISTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Length:369
Mass (Da):41,913
Last modified:November 1, 1999 - v1
Checksum:i6971F76F0A24B4AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132336 mRNA. Translation: CAB43480.1.
AJ131357 mRNA. Translation: CAB66136.2.
AK019478 mRNA. Translation: BAB31747.1.
AK050615 mRNA. Translation: BAC34344.1.
AK153975 mRNA. Translation: BAE32291.1.
BC132166 mRNA. Translation: AAI32167.1.
BC132466 mRNA. Translation: AAI32467.1.
CCDSiCCDS23662.1.
RefSeqiNP_001160097.1. NM_001166625.1.
NP_034043.1. NM_009913.6.
UniGeneiMm.440604.
Mm.442383.

Genome annotation databases

EnsembliENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530.
ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530.
ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530.
ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530.
GeneIDi12769.
KEGGimmu:12769.
UCSCiuc009sgl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132336 mRNA. Translation: CAB43480.1.
AJ131357 mRNA. Translation: CAB66136.2.
AK019478 mRNA. Translation: BAB31747.1.
AK050615 mRNA. Translation: BAC34344.1.
AK153975 mRNA. Translation: BAE32291.1.
BC132166 mRNA. Translation: AAI32167.1.
BC132466 mRNA. Translation: AAI32467.1.
CCDSiCCDS23662.1.
RefSeqiNP_001160097.1. NM_001166625.1.
NP_034043.1. NM_009913.6.
UniGeneiMm.440604.
Mm.442383.

3D structure databases

ProteinModelPortaliQ9WUT7.
SMRiQ9WUT7. Positions 44-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198769. 1 interaction.
DIPiDIP-5886N.
STRINGi10090.ENSMUSP00000126758.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9WUT7.
PhosphoSiteiQ9WUT7.

Proteomic databases

PaxDbiQ9WUT7.
PRIDEiQ9WUT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530.
ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530.
ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530.
ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530.
GeneIDi12769.
KEGGimmu:12769.
UCSCiuc009sgl.2. mouse.

Organism-specific databases

CTDi10803.
MGIiMGI:1341902. Ccr9.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9WUT7.
KOiK04184.
OMAiTWRQKRL.
OrthoDBiEOG77WWD0.
PhylomeDBiQ9WUT7.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiCcr9. mouse.
PROiQ9WUT7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUT7.
CleanExiMM_CCR9.
ExpressionAtlasiQ9WUT7. baseline and differential.
GenevisibleiQ9WUT7. MM.

Family and domain databases

InterProiIPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK."
    Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.
    J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9."
    Wurbel M.A., Philippe J.-M., Nguyen C., Victorero G., Freeman T., Wooding P., Miazek A., Mattei M.-G., Malissen M., Jordan B.R., Malissen B., Carrier A., Naquet P.
    Eur. J. Immunol. 30:262-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Skin and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCR9_MOUSE
AccessioniPrimary (citable) accession number: Q9WUT7
Secondary accession number(s): A2RSM5, Q543I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.