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Protein

C-C chemokine receptor type 9

Gene

Ccr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: MGI

GO - Biological processi

  • CD8-positive, gamma-delta intraepithelial T cell differentiation Source: MGI
  • chemotaxis Source: MGI
  • immune response Source: InterPro

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 9
Short name:
C-C CKR-9
Short name:
CC-CKR-9
Short name:
CCR-9
Alternative name(s):
Chemokine C-C receptor 10
CD_antigen: CDw199
Gene namesi
Name:Ccr9
Synonyms:Cmkbr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1341902. Ccr9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 76Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini107 – 120ExtracellularSequence analysisAdd BLAST14
Transmembranei121 – 142Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini143 – 160CytoplasmicSequence analysisAdd BLAST18
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 210ExtracellularSequence analysisAdd BLAST29
Transmembranei211 – 238Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini239 – 254CytoplasmicSequence analysisAdd BLAST16
Transmembranei255 – 280Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini281 – 304ExtracellularSequence analysisAdd BLAST24
Transmembranei305 – 322Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini323 – 369CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692921 – 369C-C chemokine receptor type 9Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUT7.
PRIDEiQ9WUT7.

PTM databases

iPTMnetiQ9WUT7.
PhosphoSitePlusiQ9WUT7.

Expressioni

Tissue specificityi

Highly expressed in the thymus and low in lymph nodes and spleen.

Gene expression databases

BgeeiENSMUSG00000029530.
CleanExiMM_CCR9.
ExpressionAtlasiQ9WUT7. baseline and differential.
GenevisibleiQ9WUT7. MM.

Interactioni

Protein-protein interaction databases

BioGridi198769. 1 interactor.
DIPiDIP-5886N.
STRINGi10090.ENSMUSP00000126758.

Structurei

3D structure databases

ProteinModelPortaliQ9WUT7.
SMRiQ9WUT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9WUT7.
KOiK04184.
OMAiTWRQKRL.
OrthoDBiEOG091G093O.
PhylomeDBiQ9WUT7.
TreeFamiTF330966.

Family and domain databases

InterProiView protein in InterPro
IPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WUT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPTELTSLI PGMFDDFSYD STASTDDYMN LNFSSFFCKK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGTLGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLAT
110 120 130 140 150
LPFWAIAAAG QWMFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIVQ
160 170 180 190 200
AMKAQVWRQK RLLYSKMVCI TIWVMAAVLC TPEILYSQVS GESGIATCTM
210 220 230 240 250
VYPKDKNAKL KSAVLILKVT LGFFLPFMVM AFCYTIIIHT LVQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFIMSQFPY NSILVVQAVD AYAMFISNCT ISTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Length:369
Mass (Da):41,913
Last modified:November 1, 1999 - v1
Checksum:i6971F76F0A24B4AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132336 mRNA. Translation: CAB43480.1.
AJ131357 mRNA. Translation: CAB66136.2.
AK019478 mRNA. Translation: BAB31747.1.
AK050615 mRNA. Translation: BAC34344.1.
AK153975 mRNA. Translation: BAE32291.1.
BC132166 mRNA. Translation: AAI32167.1.
BC132466 mRNA. Translation: AAI32467.1.
CCDSiCCDS23662.1.
RefSeqiNP_001160097.1. NM_001166625.1.
NP_034043.1. NM_009913.6.
UniGeneiMm.440604.
Mm.442383.

Genome annotation databases

EnsembliENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530.
ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530.
ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530.
ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530.
GeneIDi12769.
KEGGimmu:12769.
UCSCiuc009sgl.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCCR9_MOUSE
AccessioniPrimary (citable) accession number: Q9WUT7
Secondary accession number(s): A2RSM5, Q543I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 10, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families