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Protein

Voltage-dependent T-type calcium channel subunit alpha

Gene

Cacna1g

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.UniRule annotation

GO - Molecular functioni

  • low voltage-gated calcium channel activity Source: MGI
  • scaffold protein binding Source: MGI
  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  • action potential Source: MGI
  • calcium ion import Source: MGI
  • calcium ion transmembrane transport Source: MGI
  • chemical synaptic transmission Source: MGI
  • regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
  • regulation of heart rate Source: MGI
  • regulation of membrane potential Source: MGI
  • response to nickel cation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi1.A.1.11.12. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1gImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201678. Cacna1g.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 142HelicalSequence analysisAdd BLAST20
Transmembranei214 – 237HelicalSequence analysisAdd BLAST24
Transmembranei342 – 363HelicalSequence analysisAdd BLAST22
Transmembranei369 – 394HelicalSequence analysisAdd BLAST26
Transmembranei744 – 762HelicalSequence analysisAdd BLAST19
Transmembranei774 – 795HelicalSequence analysisAdd BLAST22
Transmembranei865 – 884HelicalSequence analysisAdd BLAST20
Transmembranei941 – 964HelicalSequence analysisAdd BLAST24
Transmembranei1278 – 1296HelicalSequence analysisAdd BLAST19
Transmembranei1316 – 1337HelicalSequence analysisAdd BLAST22
Transmembranei1349 – 1368HelicalSequence analysisAdd BLAST20
Transmembranei1413 – 1435HelicalSequence analysisAdd BLAST23
Transmembranei1515 – 1538HelicalSequence analysisAdd BLAST24
Transmembranei1620 – 1641HelicalSequence analysisAdd BLAST22
Transmembranei1653 – 1676HelicalSequence analysisAdd BLAST24
Transmembranei1754 – 1773HelicalSequence analysisAdd BLAST20
Transmembranei1837 – 1859HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • cytoplasm Source: MGI
  • plasma membrane Source: MGI
  • voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9WUT2.

Expressioni

Gene expression databases

GenevisibleiQ9WUT2. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098127.

Structurei

3D structure databases

ProteinModelPortaliQ9WUT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 405Ion_transInterPro annotationAdd BLAST326
Domaini743 – 969Ion_transInterPro annotationAdd BLAST227
Domaini1276 – 1548Ion_transInterPro annotationAdd BLAST273
Domaini1619 – 1869Ion_transInterPro annotationAdd BLAST251

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1547 – 1581Sequence analysisAdd BLAST35
Coiled coili1858 – 1882Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
HOVERGENiHBG050764.
KOiK04854.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 6 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

Q9WUT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG
60 70 80 90 100
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM
110 120 130 140 150
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
160 170 180 190 200
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
210 220 230 240 250
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
260 270 280 290 300
LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCGL
310 320 330 340 350
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
360 370 380 390 400
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
410 420 430 440 450
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
460 470 480 490 500
LAQVSRAVGV RAGLLSSPVA RGGQEPQPSG SCSRSHRRLS VHHLVHHHHH
510 520 530 540 550
HHHHYHLGNG TLRVPRASPE IQDRDANGSR WLMLPPPSTP TPSGGPPRGA
560 570 580 590 600
ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE
610 620 630 640 650
MLKDKALVEV APSPGPPTLT TFNIPPGPFS SMHKLLETQS TGACHSSCKI
660 670 680 690 700
SSPCSKADSG ACGPDSCPYC ARTGAGEPES ADHEMPDSDS EAVYEFTQDA
710 720 730 740 750
QHSDLRDPHR RRRPSLGPDA EPSSVLAFWR LICDTFRKIV DSKYFGRGIM
760 770 780 790 800
IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM LLKLLVYGPF
810 820 830 840 850
GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA
860 870 880 890 900
LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
910 920 930 940 950
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF
960 970 980 990 1000
GNYVLFNLLV AILVEGFQAE EIGKREDTSG QLSCIQLPVN SQGGDATKSE
1010 1020 1030 1040 1050
SEPDFFSPSV DGDGDRKKRL ALVALGEHSE LRKSLLPPLI IHTAATPMSL
1060 1070 1080 1090 1100
PKSSSTGVGE ALGSGSRRTS SSGSAEPGTA HHEMKSPPSA RSSPHSPWSA
1110 1120 1130 1140 1150
ASSWTSRRSS RNSLGRAPSL KRRSPSGERR SLLSGEGQES QDEEESSEED
1160 1170 1180 1190 1200
RASPAGSDHR HRGSLEREAK SSFDLPDTLQ VPGLHRTASG RSSASEHQDC
1210 1220 1230 1240 1250
NGKSASGRLA RTLRADDPPL DGDDGDDEGN LSKGERLRAW VRARLPACCR
1260 1270 1280 1290 1300
ERDSWSAYIF PPQSRFRLLC HRIITHKMFD HVVLVIIFLN CITIAMERPK
1310 1320 1330 1340 1350
IDPHSAERIF LTLSNYIFTA VFLAEMTVKV VALGWCFGEQ AYLRSSWNVL
1360 1370 1380 1390 1400
DGLLVLISVI DILVSMVSDS GTKILGMLRV LRLLRTLRPL RVISRAQGLK
1410 1420 1430 1440 1450
LVVETLMSSL KPIGNIVVIC CAFFIIFGIL GVQLFKGKFF VCQGEDTRNI
1460 1470 1480 1490 1500
TNKSDCAEAS YRWVRHKYNF DNLGQALMSL FVLASKDGWV DIMYDGLDAV
1510 1520 1530 1540 1550
GVDQQPIMNH NPWMLLYFIS FLLIVAFFVL NMFVGVVVEN FHKCRQHQEE
1560 1570 1580 1590 1600
EEARRREEKR LKRLEKKRRS KEKQMADLML DDVIASGSSA SAASEAQCKP
1610 1620 1630 1640 1650
YYSDYSRFRL LVHHLCTSHY LDLFITGVIG LNVVTMAMEH YQQPQILDEA
1660 1670 1680 1690 1700
LKICNYIFTV IFVLESVFKL VAFGFRRFFQ DRWNQLDLAI VLLSIMGITL
1710 1720 1730 1740 1750
EEIEVNASLP INPTIIRIMR VLRIARVLKL LKMAVGMRAL LDTVMQALPQ
1760 1770 1780 1790 1800
VGNLGLLFML LFFIFAALGV ELFGDLECDE THPCEGLGRH ATFRNFGMAF
1810 1820 1830 1840 1850
LTLFRVSTGD NWNGIMKDTL RDCDQESTCY NTVISPIYFV SFVLTAQFVL
1860 1870 1880 1890 1900
VNVVIAVLMK HLEESNKEAK EEAELEAELE LEMKTLSPQP HSPLGSPFLW
1910 1920 1930 1940 1950
PGVEGVNSPD SPKPGAPHTT AHIGAASSGF SLEHPTMVPH TEEGPVPLGP
1960 1970 1980 1990 2000
DLLTVRKSGV SRTHSLPNDS YMCRNGSTAE RSLGHRGWGL PKAQSGSILS
2010 2020 2030 2040 2050
VHSQPADTSC ILQLPKDAHY LLQPHGAPTW GAIPKLPPPG RSPLAQRPLR
2060 2070 2080 2090 2100
RQAAIRTDSL DVQGLGSRED LLSEVSGPSC PLTRSSSFWG GSSIQVQQRS
2110 2120 2130 2140 2150
GSQSKVSKHI RLPAPCPGLE PSWAKDPQET RSSLELDTEL SWISGDLLPS
2160 2170 2180 2190 2200
SQEEPLSPRD LKKCYSVEAQ SCRRRPGSWL DEQRRHSIAV SCLDSGSQPR
2210 2220 2230 2240 2250
LCPSPSSLGG QPLGGPGSRP KKKLSPPSIS IDPPESQGPR PPCSPGVCLR
2260 2270 2280 2290
RRAPASDSKD PSASSPLDST AASPSPKKDA LSLSGLSSDP TDLDP
Length:2,295
Mass (Da):253,960
Last modified:November 1, 1999 - v1
Checksum:iFE817D054ED26984
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012569 mRNA. Translation: CAB40793.1.
RefSeqiNP_001106284.1. NM_001112813.2.
NP_001171359.1. NM_001177888.1.
NP_001171361.1. NM_001177890.1.
NP_033913.2. NM_009783.3.
UniGeneiMm.29585.

Genome annotation databases

GeneIDi12291.
KEGGimmu:12291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012569 mRNA. Translation: CAB40793.1.
RefSeqiNP_001106284.1. NM_001112813.2.
NP_001171359.1. NM_001177888.1.
NP_001171361.1. NM_001177890.1.
NP_033913.2. NM_009783.3.
UniGeneiMm.29585.

3D structure databases

ProteinModelPortaliQ9WUT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098127.

Protein family/group databases

TCDBi1.A.1.11.12. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbiQ9WUT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12291.
KEGGimmu:12291.

Organism-specific databases

CTDi8913.
MGIiMGI:1201678. Cacna1g.

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
HOVERGENiHBG050764.
KOiK04854.

Miscellaneous databases

ChiTaRSiCacna1g. mouse.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ9WUT2. MM.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 6 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9WUT2_MOUSE
AccessioniPrimary (citable) accession number: Q9WUT2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.