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Protein

C-X-C motif chemokine 14

Gene

Cxcl14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • immune response Source: InterPro
  • inner ear development Source: MGI
  • negative regulation of myoblast differentiation Source: MGI
  • positive regulation of natural killer cell chemotaxis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 14
Alternative name(s):
B-cell and monocyte-activating chemokine
Chemokine BRAK
Kidney-expressed chemokine CXC
MIP-2G
Small-inducible cytokine B14
Gene namesi
Name:Cxcl14
Synonyms:Bmac, Kec, Ks1, Mip2g, Scyb14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1888514. Cxcl14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 9977C-X-C motif chemokine 14PRO_0000005116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 51By similarity
Disulfide bondi27 ↔ 72By similarity

Post-translational modificationi

Ubiquitinated, followed by degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9WUQ5.
PaxDbiQ9WUQ5.
PRIDEiQ9WUQ5.

PTM databases

PhosphoSiteiQ9WUQ5.

Expressioni

Tissue specificityi

Highly expressed in brain, lung, ovary, muscle and in kidney and liver parenchyma, and at lower levels in bone marrow.2 Publications

Gene expression databases

BgeeiQ9WUQ5.
CleanExiMM_CXCL14.
GenevisibleiQ9WUQ5. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021970.

Structurei

3D structure databases

ProteinModelPortaliQ9WUQ5.
SMRiQ9WUQ5. Positions 23-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 6915D-boxAdd
BLAST

Domaini

The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0K5. Eukaryota.
ENOG4111XWS. LUCA.
GeneTreeiENSGT00390000000618.
HOGENOMiHOG000065700.
HOVERGENiHBG054250.
InParanoidiQ9WUQ5.
KOiK10033.
OMAiCQEKMIF.
OrthoDBiEOG7TXKK6.
PhylomeDBiQ9WUQ5.
TreeFamiTF332769.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLAAALLL LLLALCASRV DGSKCKCSRK GPKIRYSDVK KLEMKPKYPH
60 70 80 90
CEEKMVIVTT KSMSRYRGQE HCLHPKLQST KRFIKWYNAW NEKRRVYEE
Length:99
Mass (Da):11,716
Last modified:March 23, 2010 - v2
Checksum:i97352E91FF7F46D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 204ASRV → VRAL in AAD34157 (PubMed:10049774).Curated
Sequence conflicti17 – 204ASRV → VRAL in AAF65570 (PubMed:10946286).Curated
Sequence conflicti17 – 204ASRV → VRAL in AAF03753 (Ref. 4) Curated
Sequence conflicti64 – 641S → F in AAD34157 (PubMed:10049774).Curated
Sequence conflicti64 – 641S → F in AAF65570 (PubMed:10946286).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152377 mRNA. Translation: AAD34157.1.
AF144754 mRNA. Translation: AAF66694.1.
AF252873 mRNA. Translation: AAF65570.1.
AF192557 mRNA. Translation: AAF03753.1.
AB041614 mRNA. Translation: BAA95097.1.
AK004615 mRNA. Translation: BAB23411.1.
AK014351 mRNA. Translation: BAB29292.1.
AK076112 mRNA. Translation: BAC36192.1.
AK155356 mRNA. Translation: BAE33213.1.
CH466546 Genomic DNA. Translation: EDL41235.1.
BC147274 mRNA. Translation: AAI47275.1.
BC147275 mRNA. Translation: AAI47276.1.
AF352784 mRNA. Translation: AAK52902.1.
AF352785 mRNA. Translation: AAK52903.1.
CCDSiCCDS36679.1.
RefSeqiNP_062514.2. NM_019568.2.
XP_006517371.1. XM_006517308.2.
UniGeneiMm.30211.

Genome annotation databases

EnsembliENSMUST00000021970; ENSMUSP00000021970; ENSMUSG00000021508.
GeneIDi57266.
KEGGimmu:57266.
UCSCiuc007qsm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152377 mRNA. Translation: AAD34157.1.
AF144754 mRNA. Translation: AAF66694.1.
AF252873 mRNA. Translation: AAF65570.1.
AF192557 mRNA. Translation: AAF03753.1.
AB041614 mRNA. Translation: BAA95097.1.
AK004615 mRNA. Translation: BAB23411.1.
AK014351 mRNA. Translation: BAB29292.1.
AK076112 mRNA. Translation: BAC36192.1.
AK155356 mRNA. Translation: BAE33213.1.
CH466546 Genomic DNA. Translation: EDL41235.1.
BC147274 mRNA. Translation: AAI47275.1.
BC147275 mRNA. Translation: AAI47276.1.
AF352784 mRNA. Translation: AAK52902.1.
AF352785 mRNA. Translation: AAK52903.1.
CCDSiCCDS36679.1.
RefSeqiNP_062514.2. NM_019568.2.
XP_006517371.1. XM_006517308.2.
UniGeneiMm.30211.

3D structure databases

ProteinModelPortaliQ9WUQ5.
SMRiQ9WUQ5. Positions 23-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021970.

PTM databases

PhosphoSiteiQ9WUQ5.

Proteomic databases

MaxQBiQ9WUQ5.
PaxDbiQ9WUQ5.
PRIDEiQ9WUQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021970; ENSMUSP00000021970; ENSMUSG00000021508.
GeneIDi57266.
KEGGimmu:57266.
UCSCiuc007qsm.2. mouse.

Organism-specific databases

CTDi9547.
MGIiMGI:1888514. Cxcl14.

Phylogenomic databases

eggNOGiENOG410J0K5. Eukaryota.
ENOG4111XWS. LUCA.
GeneTreeiENSGT00390000000618.
HOGENOMiHOG000065700.
HOVERGENiHBG054250.
InParanoidiQ9WUQ5.
KOiK10033.
OMAiCQEKMIF.
OrthoDBiEOG7TXKK6.
PhylomeDBiQ9WUQ5.
TreeFamiTF332769.

Miscellaneous databases

PROiQ9WUQ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUQ5.
CleanExiMM_CXCL14.
GenevisibleiQ9WUQ5. MM.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells."
    Hromas R., Broxmeyer H.E., Kim C., Nakshatri H., Christopherson K. II, Azam M., Hou Y.-H.
    Biochem. Biophys. Res. Commun. 255:703-706(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR alpha-chemokine."
    Sleeman M.A., Fraser J.K., Murison J.G., Kelly S.L., Prestidge R.L., Palmer D.J., Watson J.D., Kumble K.D.
    Int. Immunol. 12:677-689(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/cByJ.
    Tissue: Keratinocyte.
  3. "Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells."
    Cao X., Zhang W., Wan T., He L., Chen T., Yuan Z., Ma S., Yu Y., Chen G.
    J. Immunol. 165:2588-2595(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  4. "Identification of a kidney-expressed chemokine (KEC), a member of the CXC family, that is selectively elevated in aprt knockout mice."
    Wang L., Deng L., Raikwar N., Sahota A., Tischfield J.A.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeJ.
  5. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell, Embryo, Embryonic head and Lung.
  7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  9. Schilderink N., Geerts D.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-99.
    Strain: C57BL/6J.
    Tissue: Fetus and Placenta.

Entry informationi

Entry nameiCXL14_MOUSE
AccessioniPrimary (citable) accession number: Q9WUQ5
Secondary accession number(s): Q548T5, Q91V02, Q9JHH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 23, 2010
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.