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Protein

Oligodendrocyte transcription factor 1

Gene

Olig1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 1
Short name:
Oligo1
Alternative name(s):
Olg-1 bHLH protein
Gene namesi
Name:Olig1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621129. Olig1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Oligodendrocyte transcription factor 1PRO_0000127413Add
BLAST

Proteomic databases

PaxDbiQ9WUQ3.
PRIDEiQ9WUQ3.

Expressioni

Tissue specificityi

Expressed specifically in the brain, including the corpus callosum, hippocampal and cerebral white matter. Also detected in cells scattered in gray matter, most probably in oligodendrocytes.1 Publication

Developmental stagei

Expressed in oligodendrocytes of the postnatal optical nerve up to day 30, then the number of expressing cells decreases.1 Publication

Inductioni

By SHH.1 Publication

Gene expression databases

GenevisibleiQ9WUQ3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002827.

Structurei

3D structure databases

ProteinModelPortaliQ9WUQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 15460bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
HOGENOMiHOG000015810.
HOVERGENiHBG053369.
InParanoidiQ9WUQ3.
KOiK09085.
OMAiGTMLRPQ.
OrthoDBiEOG7HF1KN.
PhylomeDBiQ9WUQ3.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032657. Olig1.
[Graphical view]
PANTHERiPTHR19290:SF7. PTHR19290:SF7. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYAVSQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSTS
60 70 80 90 100
SSSTASLLPK PAREKPEAPL AEPRGPAPES GGARADAKEE QQQQQLRRKI
110 120 130 140 150
NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY
160 170 180 190 200
ILLLGSSLQE LRRALGDGAG PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP
210 220 230 240 250
PETLRPTKYL SLALDEPPCG QFALPAGGAG SPGLCSCAVC KFPHLVPAGL
260
GLAAVQAQFS K
Length:261
Mass (Da):27,239
Last modified:August 30, 2002 - v2
Checksum:iC0CE520275550322
GO

Sequence cautioni

The sequence AAD34029.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151367 mRNA. Translation: AAD34029.1. Different initiation.
RefSeqiNP_068538.2. NM_021770.3.
UniGeneiRn.45339.

Genome annotation databases

GeneIDi60394.
KEGGirno:60394.
UCSCiRGD:621129. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151367 mRNA. Translation: AAD34029.1. Different initiation.
RefSeqiNP_068538.2. NM_021770.3.
UniGeneiRn.45339.

3D structure databases

ProteinModelPortaliQ9WUQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002827.

Proteomic databases

PaxDbiQ9WUQ3.
PRIDEiQ9WUQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60394.
KEGGirno:60394.
UCSCiRGD:621129. rat.

Organism-specific databases

CTDi116448.
RGDi621129. Olig1.

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
HOGENOMiHOG000015810.
HOVERGENiHBG053369.
InParanoidiQ9WUQ3.
KOiK09085.
OMAiGTMLRPQ.
OrthoDBiEOG7HF1KN.
PhylomeDBiQ9WUQ3.
TreeFamiTF322733.

Miscellaneous databases

PROiQ9WUQ3.

Gene expression databases

GenevisibleiQ9WUQ3. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032657. Olig1.
[Graphical view]
PANTHERiPTHR19290:SF7. PTHR19290:SF7. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system."
    Lu Q.R., Yuk D.-I., Alberta J.A., Zhu Z., Pawlitzky I., Chan J.A., McMahon A.P., Stiles C.D., Rowitch D.H.
    Neuron 25:317-329(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION BY SHH.
    Strain: Sprague-Dawley.
    Tissue: Brain cortex.

Entry informationi

Entry nameiOLIG1_RAT
AccessioniPrimary (citable) accession number: Q9WUQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: June 8, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.