ID   Q9WUP6_RAT              Unreviewed;       129 AA.
AC   Q9WUP6;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1999, sequence version 1.
DT   08-NOV-2023, entry version 114.
DE   SubName: Full=Desert hedgehog protein {ECO:0000313|EMBL:AAD31927.1};
DE   Flags: Fragment;
GN   Name=Dhh {ECO:0000313|RGD:620711};
GN   Synonyms=dhh {ECO:0000313|EMBL:AAD31927.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAD31927.1};
RN   [1] {ECO:0000313|EMBL:AAD31927.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAD31927.1};
RA   Garges P.L., Meyer R.A.Jr., Brown C.A., Price D.K.;
RT   "Desert hedgehog in the rat.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the hedgehog family.
CC       {ECO:0000256|ARBA:ARBA00010649}.
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DR   EMBL; AF148226; AAD31927.1; -; mRNA.
DR   AlphaFoldDB; Q9WUP6; -.
DR   UCSC; RGD:620711; rat.
DR   AGR; RGD:620711; -.
DR   RGD; 620711; Dhh.
DR   PhylomeDB; Q9WUP6; -.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; ISO:RGD.
DR   GO; GO:0005113; F:patched binding; ISO:RGD.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; ISO:RGD.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0033327; P:Leydig cell differentiation; ISO:RGD.
DR   GO; GO:0008584; P:male gonad development; ISO:RGD.
DR   GO; GO:0030238; P:male sex determination; ISO:RGD.
DR   GO; GO:0042552; P:myelination; IEP:RGD.
DR   GO; GO:0001649; P:osteoblast differentiation; ISO:RGD.
DR   GO; GO:0038001; P:paracrine signaling; ISO:RGD.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISO:RGD.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0050810; P:regulation of steroid biosynthetic process; ISO:RGD.
DR   GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR   GO; GO:0043627; P:response to estrogen; IEP:RGD.
DR   GO; GO:0014044; P:Schwann cell development; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR   GO; GO:0007286; P:spermatid development; IEP:RGD.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   Gene3D; 3.30.1380.10; -; 1.
DR   InterPro; IPR001657; Hedgehog.
DR   InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf.
DR   InterPro; IPR000320; Hedgehog_signalling_dom.
DR   PANTHER; PTHR11889:SF56; DESERT HEDGEHOG PROTEIN; 1.
DR   PANTHER; PTHR11889; HEDGEHOG; 1.
DR   Pfam; PF01085; HH_signal; 1.
DR   PRINTS; PR00632; SONICHHOG.
DR   SUPFAM; SSF55166; Hedgehog/DD-peptidase; 1.
PE   2: Evidence at transcript level;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          5..129
FT                   /note="Hedgehog N-terminal signalling"
FT                   /evidence="ECO:0000259|Pfam:PF01085"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAD31927.1"
FT   NON_TER         129
FT                   /evidence="ECO:0000313|EMBL:AAD31927.1"
SQ   SEQUENCE   129 AA;  14579 MW;  AB33509B3E751319 CRC64;
     SVQSCGPGRG PVGRRRYVRK QLVPLLYKQF VPSMPERTLG ASGPAEGRVT RGSERFRDLV
     PNYNPDIIFK DEENSGADRL MTERCKERVN ALAIAVMNMW PGVRLRVTEG WDEDGHHAQD
     SLHYEGRAL
//