Reviewed,
UniProtKB/Swiss-Prot Q9WUP4 (S5A3_MOUSE)
Last modified
November 4, 2008.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 3-oxo-5-alpha-steroid 4-dehydrogenase 3 EC=1.3.99.5 Alternative name(s): Steroid 5-alpha-reductase 3 SR type 3 Steroid 5-alpha-reductase 2-like | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 330 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) By similarity. |
| Catalytic activity | A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor. |
| Subcellular location | Microsome membrane; Multi-pass membrane proteinBy similarity. Endoplasmic reticulum membrane; Multi-pass membrane proteinPotential. |
| Sequence similarities | Belongs to the steroid 5-alpha reductase family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Domain | Transmembrane |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsomeInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-oxo-5-alpha-steroid 4-dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 330 | 330 | 3-oxo-5-alpha-steroid 4-dehydrogenase 3 | PRO_0000317704 | |||||
Regions | |||||||||
| Transmembrane | 17 – 37 | 21 | Potential | ||||||
| Transmembrane | 81 – 101 | 21 | Potential | ||||||
| Transmembrane | 133 – 153 | 21 | Potential | ||||||
| Transmembrane | 170 – 190 | 21 | Potential | ||||||
| Transmembrane | 207 – 227 | 21 | Potential | ||||||
| Transmembrane | 278 – 298 | 21 | Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 109 | 1 | G → S in BAE36955, BAE23944, BAC35871 and BAC30537. Ref.2 | ||||||
| Sequence conflict | 298 | 1 | F → S in BAE36955, BAE23944, BAC35871 and BAC30537. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5." Wilsbacher L.D., Sangoram A.M., Antoch M.P., Takahashi J.S. Genome Res. 10:1928-1940(2000) [PubMed: 11116088] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum, Thymus and Urinary bladder. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AF146793 Genomic DNA. Translation: AAD30567.1. AK040198 mRNA. Translation: BAC30537.1. AK075635 mRNA. Translation: BAC35871.1. AK139290 mRNA. Translation: BAE23944.1. AK162527 mRNA. Translation: BAE36955.1. BC145647 mRNA. Translation: AAI45648.1. | |
| RefSeq | NP_065636.2. XP_001471752.1. |
| UniGene | Mm.289446 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000029233. Mus musculus. [Contig view] |
| GeneID | 100044230. 57357. |
| KEGG | mmu:100044230. mmu:57357. |
Organism-specific databases | |
| MGI | MGI:1930252. Srd5a3. |
Phylogenomic databases | |
| HOVERGEN | Q9WUP4. |
Gene expression databases | |
| ArrayExpress | Q9WUP4. |
| CleanEx | MM_SRD5A3. |
Family and domain databases | |
| InterPro | IPR001104. 3-oxo-5_a-steroid_4-DHase_C. [Graphical view] |
| Pfam | PF02544. Steroid_dh. 1 hit. [Graphical view] |
| PROSITE | PS50244. S5A_REDUCTASE. 1 hit. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 457733. |
| SOURCE | Search... |
Entry information
| Entry name | S5A3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9WUP4 Secondary accession number(s): Q8BGE3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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