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Protein

Receptor activity-modifying protein 3

Gene

Ramp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 3
Gene namesi
Name:Ramp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1860292. Ramp3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 117ExtracellularSequence analysisAdd BLAST95
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 147CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi53.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003017723 – 147Receptor activity-modifying protein 3Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi39 ↔ 71By similarity
Disulfide bondi56 ↔ 103By similarity
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUP1.
PRIDEiQ9WUP1.

Expressioni

Tissue specificityi

Expressed predominantly in the testis, embryonic and adult brain and in kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000041046.
GenevisibleiQ9WUP1. MM.

Interactioni

Subunit structurei

Interacts with GPER1 (By similarity). Heterodimer of CALCRL and RAMP3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047518.

Structurei

3D structure databases

ProteinModelPortaliQ9WUP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXGF. Eukaryota.
ENOG4111U8C. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9WUP1.
KOiK08449.
OMAiVDVWKWC.
OrthoDBiEOG091G0W6Z.
PhylomeDBiQ9WUP1.
TreeFamiTF333286.

Family and domain databases

InterProiView protein in InterPro
IPR006985. RAMP.
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiView protein in Pfam
PF04901. RAMP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPAQRLHL LPLLLLLCGE CAQVCGCNET GMLERLPRCG KAFADMMQKV
60 70 80 90 100
AVWKWCNLSE FIVYYESFTN CTEMETNIMG CYWPNPLAQS FITGIHRQFF
110 120 130 140
SNCTVDRTHW EDPPDEVLIP LIAVPVVLTV AMAGLVVWRS KHTDRLL
Length:147
Mass (Da):16,779
Last modified:November 1, 1999 - v1
Checksum:i359EE741034C34E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146524 mRNA. Translation: AAD35020.1.
AJ250491 mRNA. Translation: CAB59513.1.
AF209907 mRNA. Translation: AAF21039.1.
AL603787 Genomic DNA. Translation: CAI24221.1.
BC024765 mRNA. Translation: AAH24765.1.
CCDSiCCDS24425.1.
PIRiJC7263.
RefSeqiNP_062384.1. NM_019511.3.
UniGeneiMm.39884.

Genome annotation databases

EnsembliENSMUST00000045374; ENSMUSP00000047518; ENSMUSG00000041046.
GeneIDi56089.
KEGGimmu:56089.
UCSCiuc007hzd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRAMP3_MOUSE
AccessioniPrimary (citable) accession number: Q9WUP1
Secondary accession number(s): Q5SWP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families