Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor activity-modifying protein 3

Gene

Ramp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.2 Publications

GO - Molecular functioni

  • coreceptor activity Source: MGI
  • protein transporter activity Source: MGI
  • receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 3
Gene namesi
Name:Ramp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1860292. Ramp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11795ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13720HelicalSequence analysisAdd
BLAST
Topological domaini138 – 14710CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 147125Receptor activity-modifying protein 3PRO_0000030177Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi39 ↔ 71By similarity
Disulfide bondi56 ↔ 103By similarity
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUP1.
PRIDEiQ9WUP1.

Expressioni

Tissue specificityi

Expressed predominantly in the testis, embryonic and adult brain and in kidney.2 Publications

Gene expression databases

BgeeiQ9WUP1.
GenevisibleiQ9WUP1. MM.

Interactioni

Subunit structurei

Interacts with GPER1 (By similarity). Heterodimer of CALCRL and RAMP3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047518.

Structurei

3D structure databases

ProteinModelPortaliQ9WUP1.
SMRiQ9WUP1. Positions 39-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXGF. Eukaryota.
ENOG4111U8C. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9WUP1.
KOiK08449.
OMAiVDVWKWC.
OrthoDBiEOG7ZKSD3.
PhylomeDBiQ9WUP1.
TreeFamiTF333286.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPAQRLHL LPLLLLLCGE CAQVCGCNET GMLERLPRCG KAFADMMQKV
60 70 80 90 100
AVWKWCNLSE FIVYYESFTN CTEMETNIMG CYWPNPLAQS FITGIHRQFF
110 120 130 140
SNCTVDRTHW EDPPDEVLIP LIAVPVVLTV AMAGLVVWRS KHTDRLL
Length:147
Mass (Da):16,779
Last modified:November 1, 1999 - v1
Checksum:i359EE741034C34E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146524 mRNA. Translation: AAD35020.1.
AJ250491 mRNA. Translation: CAB59513.1.
AF209907 mRNA. Translation: AAF21039.1.
AL603787 Genomic DNA. Translation: CAI24221.1.
BC024765 mRNA. Translation: AAH24765.1.
CCDSiCCDS24425.1.
PIRiJC7263.
RefSeqiNP_062384.1. NM_019511.3.
UniGeneiMm.39884.

Genome annotation databases

EnsembliENSMUST00000045374; ENSMUSP00000047518; ENSMUSG00000041046.
GeneIDi56089.
KEGGimmu:56089.
UCSCiuc007hzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146524 mRNA. Translation: AAD35020.1.
AJ250491 mRNA. Translation: CAB59513.1.
AF209907 mRNA. Translation: AAF21039.1.
AL603787 Genomic DNA. Translation: CAI24221.1.
BC024765 mRNA. Translation: AAH24765.1.
CCDSiCCDS24425.1.
PIRiJC7263.
RefSeqiNP_062384.1. NM_019511.3.
UniGeneiMm.39884.

3D structure databases

ProteinModelPortaliQ9WUP1.
SMRiQ9WUP1. Positions 39-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047518.

Proteomic databases

PaxDbiQ9WUP1.
PRIDEiQ9WUP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045374; ENSMUSP00000047518; ENSMUSG00000041046.
GeneIDi56089.
KEGGimmu:56089.
UCSCiuc007hzd.1. mouse.

Organism-specific databases

CTDi10268.
MGIiMGI:1860292. Ramp3.

Phylogenomic databases

eggNOGiENOG410IXGF. Eukaryota.
ENOG4111U8C. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9WUP1.
KOiK08449.
OMAiVDVWKWC.
OrthoDBiEOG7ZKSD3.
PhylomeDBiQ9WUP1.
TreeFamiTF333286.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ9WUP1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUP1.
GenevisibleiQ9WUP1. MM.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of mouse CGRP/adrenomedullin receptor subunits."
    Derst C., Preisig-Mueller R., Gerhardus J., Daut J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function."
    Husmann K., Sexton P.M., Fischer J.A., Born W.
    Mol. Cell. Endocrinol. 162:35-43(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. "Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis."
    Ono Y., Okano I., Kojima M., Okada K., Kangawa K.
    Biochem. Biophys. Res. Commun. 271:197-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Lung.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection."
    Lenhart P.M., Broselid S., Barrick C.J., Leeb-Lundberg L.M., Caron K.M.
    J. Mol. Endocrinol. 51:191-202(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAMP3_MOUSE
AccessioniPrimary (citable) accession number: Q9WUP1
Secondary accession number(s): Q5SWP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.