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Protein

Receptor activity-modifying protein 2

Gene

Ramp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.1 Publication

GO - Molecular functioni

  • coreceptor activity Source: MGI
  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • adherens junction assembly Source: UniProtKB
  • angiogenesis Source: UniProtKB
  • basement membrane assembly Source: UniProtKB
  • bicellular tight junction assembly Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • cAMP biosynthetic process Source: UniProtKB
  • cellular response to hormone stimulus Source: Ensembl
  • cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  • female pregnancy Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: MGI
  • heart development Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • negative regulation of endothelial cell apoptotic process Source: UniProtKB
  • negative regulation of vascular permeability Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of vasculogenesis Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein transport Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of G-protein coupled receptor protein signaling pathway Source: InterPro
  • response to estradiol Source: Ensembl
  • response to hypoxia Source: Ensembl
  • response to progesterone Source: Ensembl
  • sprouting angiogenesis Source: UniProtKB
  • vascular smooth muscle cell development Source: UniProtKB
  • vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 2
Gene namesi
Name:Ramp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1859650. Ramp2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 159ExtracellularSequence analysisAdd BLAST115
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 189CytoplasmicSequence analysis9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000003017345 – 189Receptor activity-modifying protein 2Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi83 ↔ 113By similarity
Disulfide bondi98 ↔ 145By similarity
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WUP0.
PaxDbiQ9WUP0.
PeptideAtlasiQ9WUP0.
PRIDEiQ9WUP0.

PTM databases

PhosphoSitePlusiQ9WUP0.

Expressioni

Tissue specificityi

Ubiquitous. Expressed predominantly in embryonic brain, lung and gut and in adult heart, lung, skeletal muscle and brain.2 Publications

Gene expression databases

BgeeiENSMUSG00000001240.
ExpressionAtlasiQ9WUP0. baseline and differential.
GenevisibleiQ9WUP0. MM.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP2.

Protein-protein interaction databases

IntActiQ9WUP0. 1 interactor.
MINTiMINT-4131787.
STRINGi10090.ENSMUSP00000122072.

Structurei

3D structure databases

ProteinModelPortaliQ9WUP0.
SMRiQ9WUP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYPR. Eukaryota.
ENOG4112A9G. LUCA.
GeneTreeiENSGT00390000016200.
HOVERGENiHBG067366.
InParanoidiQ9WUP0.
KOiK08448.
OMAiMESYERT.
OrthoDBiEOG091G0RMZ.
PhylomeDBiQ9WUP0.
TreeFamiTF333286.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRVERAP GGSRLGVTRA QRPTALCLPP LLLLLLLLLG AVSASPESLN
60 70 80 90 100
QSLPESQNQS HPTEDSLVSK GKMEDYETHV LPCWYEYKSC MDSVKDWCNW
110 120 130 140 150
TLISRHYSDL QNCLEYNADK FGLGFPNPLA ENIILEAHLI HFANCSLVQP
160 170 180
TFSDPPEDVL LAMIIAPICL IPFLVTLVVW RSKDSDAQA
Length:189
Mass (Da):21,017
Last modified:November 1, 1999 - v1
Checksum:iCEE51D9FE9751F10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10P → T in AAH69992 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146523 mRNA. Translation: AAD35019.1.
AJ250490 mRNA. Translation: CAB59512.1.
AF209906 mRNA. Translation: AAF21038.1.
AK003810 mRNA. Translation: BAB23009.1.
BC069992 mRNA. Translation: AAH69992.1.
CCDSiCCDS25457.1.
PIRiJC7262.
RefSeqiNP_062317.1. NM_019444.2.
UniGeneiMm.260698.
Mm.298256.

Genome annotation databases

EnsembliENSMUST00000129680; ENSMUSP00000122072; ENSMUSG00000001240.
GeneIDi54409.
KEGGimmu:54409.
UCSCiuc007lny.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146523 mRNA. Translation: AAD35019.1.
AJ250490 mRNA. Translation: CAB59512.1.
AF209906 mRNA. Translation: AAF21038.1.
AK003810 mRNA. Translation: BAB23009.1.
BC069992 mRNA. Translation: AAH69992.1.
CCDSiCCDS25457.1.
PIRiJC7262.
RefSeqiNP_062317.1. NM_019444.2.
UniGeneiMm.260698.
Mm.298256.

3D structure databases

ProteinModelPortaliQ9WUP0.
SMRiQ9WUP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WUP0. 1 interactor.
MINTiMINT-4131787.
STRINGi10090.ENSMUSP00000122072.

PTM databases

PhosphoSitePlusiQ9WUP0.

Proteomic databases

MaxQBiQ9WUP0.
PaxDbiQ9WUP0.
PeptideAtlasiQ9WUP0.
PRIDEiQ9WUP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000129680; ENSMUSP00000122072; ENSMUSG00000001240.
GeneIDi54409.
KEGGimmu:54409.
UCSCiuc007lny.1. mouse.

Organism-specific databases

CTDi10266.
MGIiMGI:1859650. Ramp2.

Phylogenomic databases

eggNOGiENOG410IYPR. Eukaryota.
ENOG4112A9G. LUCA.
GeneTreeiENSGT00390000016200.
HOVERGENiHBG067366.
InParanoidiQ9WUP0.
KOiK08448.
OMAiMESYERT.
OrthoDBiEOG091G0RMZ.
PhylomeDBiQ9WUP0.
TreeFamiTF333286.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

ChiTaRSiRamp2. mouse.
PROiQ9WUP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001240.
ExpressionAtlasiQ9WUP0. baseline and differential.
GenevisibleiQ9WUP0. MM.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP2_MOUSE
AccessioniPrimary (citable) accession number: Q9WUP0
Secondary accession number(s): Q6IS25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.