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Protein

Receptor activity-modifying protein 2

Gene

Ramp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.1 Publication

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • adherens junction assembly Source: UniProtKB
  • adrenomedullin receptor signaling pathway Source: MGI
  • amylin receptor signaling pathway Source: MGI
  • angiogenesis Source: UniProtKB
  • basement membrane assembly Source: UniProtKB
  • bicellular tight junction assembly Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: MGI
  • heart development Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • negative regulation of endothelial cell apoptotic process Source: UniProtKB
  • negative regulation of vascular permeability Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cAMP metabolic process Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of vasculogenesis Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein transport Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of G-protein coupled receptor protein signaling pathway Source: InterPro
  • sprouting angiogenesis Source: UniProtKB
  • vascular smooth muscle cell development Source: UniProtKB
  • vasculogenesis Source: MGI

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 2
Gene namesi
Name:Ramp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1859650 Ramp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 159ExtracellularSequence analysisAdd BLAST115
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 189CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi52

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000003017345 – 189Receptor activity-modifying protein 2Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 113By similarity
Disulfide bondi98 ↔ 145By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WUP0
PaxDbiQ9WUP0
PeptideAtlasiQ9WUP0
PRIDEiQ9WUP0

PTM databases

PhosphoSitePlusiQ9WUP0

Expressioni

Tissue specificityi

Ubiquitous. Expressed predominantly in embryonic brain, lung and gut and in adult heart, lung, skeletal muscle and brain.2 Publications

Gene expression databases

BgeeiENSMUSG00000001240
ExpressionAtlasiQ9WUP0 baseline and differential
GenevisibleiQ9WUP0 MM

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP2.

Protein-protein interaction databases

IntActiQ9WUP0, 1 interactor
MINTiQ9WUP0
STRINGi10090.ENSMUSP00000122072

Structurei

3D structure databases

ProteinModelPortaliQ9WUP0
SMRiQ9WUP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYPR Eukaryota
ENOG4112A9G LUCA
GeneTreeiENSGT00390000016200
HOVERGENiHBG067366
InParanoidiQ9WUP0
KOiK08448
OMAiVEENYEM
OrthoDBiEOG091G0RMZ
PhylomeDBiQ9WUP0
TreeFamiTF333286

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRVERAP GGSRLGVTRA QRPTALCLPP LLLLLLLLLG AVSASPESLN
60 70 80 90 100
QSLPESQNQS HPTEDSLVSK GKMEDYETHV LPCWYEYKSC MDSVKDWCNW
110 120 130 140 150
TLISRHYSDL QNCLEYNADK FGLGFPNPLA ENIILEAHLI HFANCSLVQP
160 170 180
TFSDPPEDVL LAMIIAPICL IPFLVTLVVW RSKDSDAQA
Length:189
Mass (Da):21,017
Last modified:November 1, 1999 - v1
Checksum:iCEE51D9FE9751F10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10P → T in AAH69992 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146523 mRNA Translation: AAD35019.1
AJ250490 mRNA Translation: CAB59512.1
AF209906 mRNA Translation: AAF21038.1
AK003810 mRNA Translation: BAB23009.1
BC069992 mRNA Translation: AAH69992.1
CCDSiCCDS25457.1
PIRiJC7262
RefSeqiNP_062317.1, NM_019444.2
UniGeneiMm.260698

Genome annotation databases

EnsembliENSMUST00000129680; ENSMUSP00000122072; ENSMUSG00000001240
GeneIDi54409
KEGGimmu:54409
UCSCiuc007lny.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAMP2_MOUSE
AccessioniPrimary (citable) accession number: Q9WUP0
Secondary accession number(s): Q6IS25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health