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Q9WUM4 (COR1C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coronin-1C
Alternative name(s):
Coronin-3
Gene names
Name:Coro1c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in cytokinesis, motility, and signal transduction By similarity.

Subunit structure

Homotrimer. Binds F-actin By similarity.

Subcellular location

Cell membrane By similarity. Cell projectionlamellipodium. Cytoplasmcytoskeleton By similarity. Note: Localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas By similarity.

Tissue specificity

Ubiquitous.

Domain

The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization By similarity.

Sequence similarities

Belongs to the WD repeat coronin family.

Contains 5 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Coronin-1C
PRO_0000050927

Regions

Repeat78 – 11841WD 1
Repeat128 – 16841WD 2
Repeat172 – 20231WD 3
Repeat215 – 24935WD 4
Repeat263 – 30341WD 5
Coiled coil435 – 47440 By similarity

Amino acid modifications

Modified residue4461N6-acetyllysine By similarity

Experimental info

Sequence conflict661T → S in AAD32705. Ref.1
Sequence conflict4221L → F in AAD32705. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9WUM4 [UniParc].

Last modified October 11, 2004. Version 2.
Checksum: 4B1C41E1BB59AFCF

FASTA47453,121
        10         20         30         40         50         60 
MRRVVRQSKF RHVFGQAVKN DQCYDDIRVS RVTWDSSFCA VNPRFVAIII EASGGGAFLV 

        70         80         90        100        110        120 
LPLHKTGRID KSYPTVCGHT GPVLDIDWCP HNDQVIASGS EDCTVMVWQI PENGLTLSLT 

       130        140        150        160        170        180 
EPVVILEGHS KRVGIVAWHP TARNVLLSAG CDNAIIIWNV GTGEALINLD DMHSDMIYNV 

       190        200        210        220        230        240 
SWSRNGSLIC TASKDKKVRV IDPRKQEIVA EKEKAHEGAR PMRAIFLADG NVFTTGFSRM 

       250        260        270        280        290        300 
SERQLALWNP KNMQEPIALH EMDTSNGVLL PFYDPDTSII YLCGKGDSSI RYFEITDESP 

       310        320        330        340        350        360 
YVHYLNTFSS KEPQRGMGYM PKRGLDVNKC EIARFFKLHE RKCEPIIMTV PRKSDLFQDD 

       370        380        390        400        410        420 
LYPDTAGPEA ALEAEEWFEG KNADPILISL KHGYIPGKNR DLKVVKKNIL DSKPAANKKS 

       430        440        450        460        470 
ELSCAPKKPT DTASVQNEAK LDEILKEIKS IKETICSQDE RISKLEQQLA KMAA 

« Hide

References

« Hide 'large scale' references
[1]"Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein."
Okumura M., Kung C., Wong S., Rodgers M., Thomas M.L.
DNA Cell Biol. 17:779-787(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Cerebellum, Spinal cord and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Salivary gland.
[4]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[5]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF143957 mRNA. Translation: AAD32705.1.
AK079327 mRNA. Translation: BAC37609.1.
AK082986 mRNA. Translation: BAC38722.1.
AK088101 mRNA. Translation: BAC40144.1.
BC019444 mRNA. Translation: AAH19444.1.
BC085498 mRNA. Translation: AAH85498.1.
RefSeqNP_035909.2. NM_011779.3.
UniGeneMm.260158.

3D structure databases

ProteinModelPortalQ9WUM4.
SMRQ9WUM4. Positions 8-391.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204714. 1 interaction.
IntActQ9WUM4. 3 interactions.
MINTMINT-4091604.

PTM databases

PhosphoSiteQ9WUM4.

Proteomic databases

PaxDbQ9WUM4.
PRIDEQ9WUM4.

Protocols and materials databases

DNASU23790.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000004646; ENSMUSP00000004646; ENSMUSG00000004530.
GeneID23790.
KEGGmmu:23790.
UCSCuc008yyu.1. mouse.

Organism-specific databases

CTD23603.
MGIMGI:1345964. Coro1c.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00730000110618.
HOGENOMHOG000166356.
HOVERGENHBG059978.
InParanoidQ9WUM4.
KOK13887.
OMAPKISMAS.
PhylomeDBQ9WUM4.
TreeFamTF314280.

Gene expression databases

ArrayExpressQ9WUM4.
BgeeQ9WUM4.
CleanExMM_CORO1C.
GenevestigatorQ9WUM4.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR027333. CORO1A/1C.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF10. PTHR10856:SF10. 1 hit.
PfamPF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCORO1C. mouse.
NextBio303391.
PROQ9WUM4.
SOURCESearch...

Entry information

Entry nameCOR1C_MOUSE
AccessionPrimary (citable) accession number: Q9WUM4
Secondary accession number(s): Q8VCQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot