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Q9WUM4

- COR1C_MOUSE

UniProt

Q9WUM4 - COR1C_MOUSE

Protein

Coronin-1C

Gene

Coro1c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    May be involved in cytokinesis, motility, and signal transduction.By similarity

    GO - Molecular functioni

    1. actin filament binding Source: RefGenome

    GO - Biological processi

    1. actin cortical patch assembly Source: MGI
    2. actin cytoskeleton organization Source: RefGenome
    3. phagocytosis Source: MGI

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coronin-1C
    Alternative name(s):
    Coronin-3
    Gene namesi
    Name:Coro1c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1345964. Coro1c.

    Subcellular locationi

    Cell membrane By similarity. Cell projectionlamellipodium. Cytoplasmcytoskeleton By similarity
    Note: Localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas.By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: RefGenome
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: MGI
    4. lamellipodium Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Coronin-1CPRO_0000050927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei446 – 4461N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9WUM4.
    PaxDbiQ9WUM4.
    PRIDEiQ9WUM4.

    PTM databases

    PhosphoSiteiQ9WUM4.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9WUM4.
    BgeeiQ9WUM4.
    CleanExiMM_CORO1C.
    GenevestigatoriQ9WUM4.

    Interactioni

    Subunit structurei

    Homotrimer. Binds F-actin By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204714. 3 interactions.
    IntActiQ9WUM4. 3 interactions.
    MINTiMINT-4091604.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUM4.
    SMRiQ9WUM4. Positions 8-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati78 – 11841WD 1Add
    BLAST
    Repeati128 – 16841WD 2Add
    BLAST
    Repeati172 – 20231WD 3Add
    BLAST
    Repeati215 – 24935WD 4Add
    BLAST
    Repeati263 – 30341WD 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili435 – 47440By similarityAdd
    BLAST

    Domaini

    The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.By similarity

    Sequence similaritiesi

    Belongs to the WD repeat coronin family.Curated
    Contains 5 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00730000110618.
    HOGENOMiHOG000166356.
    HOVERGENiHBG059978.
    InParanoidiQ9WUM4.
    KOiK13887.
    OMAiPKISMAS.
    PhylomeDBiQ9WUM4.
    TreeFamiTF314280.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR027333. CORO1C.
    IPR015505. Coronin.
    IPR015048. DUF1899.
    IPR015049. DUF1900.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR10856. PTHR10856. 1 hit.
    PTHR10856:SF10. PTHR10856:SF10. 1 hit.
    PfamiPF08953. DUF1899. 1 hit.
    PF08954. DUF1900. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WUM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRVVRQSKF RHVFGQAVKN DQCYDDIRVS RVTWDSSFCA VNPRFVAIII    50
    EASGGGAFLV LPLHKTGRID KSYPTVCGHT GPVLDIDWCP HNDQVIASGS 100
    EDCTVMVWQI PENGLTLSLT EPVVILEGHS KRVGIVAWHP TARNVLLSAG 150
    CDNAIIIWNV GTGEALINLD DMHSDMIYNV SWSRNGSLIC TASKDKKVRV 200
    IDPRKQEIVA EKEKAHEGAR PMRAIFLADG NVFTTGFSRM SERQLALWNP 250
    KNMQEPIALH EMDTSNGVLL PFYDPDTSII YLCGKGDSSI RYFEITDESP 300
    YVHYLNTFSS KEPQRGMGYM PKRGLDVNKC EIARFFKLHE RKCEPIIMTV 350
    PRKSDLFQDD LYPDTAGPEA ALEAEEWFEG KNADPILISL KHGYIPGKNR 400
    DLKVVKKNIL DSKPAANKKS ELSCAPKKPT DTASVQNEAK LDEILKEIKS 450
    IKETICSQDE RISKLEQQLA KMAA 474
    Length:474
    Mass (Da):53,121
    Last modified:October 11, 2004 - v2
    Checksum:i4B1C41E1BB59AFCF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661T → S in AAD32705. (PubMed:9778037)Curated
    Sequence conflicti422 – 4221L → F in AAD32705. (PubMed:9778037)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF143957 mRNA. Translation: AAD32705.1.
    AK079327 mRNA. Translation: BAC37609.1.
    AK082986 mRNA. Translation: BAC38722.1.
    AK088101 mRNA. Translation: BAC40144.1.
    BC019444 mRNA. Translation: AAH19444.1.
    BC085498 mRNA. Translation: AAH85498.1.
    CCDSiCCDS19555.1.
    RefSeqiNP_035909.2. NM_011779.3.
    UniGeneiMm.260158.

    Genome annotation databases

    EnsembliENSMUST00000004646; ENSMUSP00000004646; ENSMUSG00000004530.
    GeneIDi23790.
    KEGGimmu:23790.
    UCSCiuc008yyu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF143957 mRNA. Translation: AAD32705.1 .
    AK079327 mRNA. Translation: BAC37609.1 .
    AK082986 mRNA. Translation: BAC38722.1 .
    AK088101 mRNA. Translation: BAC40144.1 .
    BC019444 mRNA. Translation: AAH19444.1 .
    BC085498 mRNA. Translation: AAH85498.1 .
    CCDSi CCDS19555.1.
    RefSeqi NP_035909.2. NM_011779.3.
    UniGenei Mm.260158.

    3D structure databases

    ProteinModelPortali Q9WUM4.
    SMRi Q9WUM4. Positions 8-391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204714. 3 interactions.
    IntActi Q9WUM4. 3 interactions.
    MINTi MINT-4091604.

    PTM databases

    PhosphoSitei Q9WUM4.

    Proteomic databases

    MaxQBi Q9WUM4.
    PaxDbi Q9WUM4.
    PRIDEi Q9WUM4.

    Protocols and materials databases

    DNASUi 23790.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004646 ; ENSMUSP00000004646 ; ENSMUSG00000004530 .
    GeneIDi 23790.
    KEGGi mmu:23790.
    UCSCi uc008yyu.1. mouse.

    Organism-specific databases

    CTDi 23603.
    MGIi MGI:1345964. Coro1c.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00730000110618.
    HOGENOMi HOG000166356.
    HOVERGENi HBG059978.
    InParanoidi Q9WUM4.
    KOi K13887.
    OMAi PKISMAS.
    PhylomeDBi Q9WUM4.
    TreeFami TF314280.

    Miscellaneous databases

    ChiTaRSi CORO1C. mouse.
    NextBioi 303391.
    PROi Q9WUM4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WUM4.
    Bgeei Q9WUM4.
    CleanExi MM_CORO1C.
    Genevestigatori Q9WUM4.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR027333. CORO1C.
    IPR015505. Coronin.
    IPR015048. DUF1899.
    IPR015049. DUF1900.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR10856. PTHR10856. 1 hit.
    PTHR10856:SF10. PTHR10856:SF10. 1 hit.
    Pfami PF08953. DUF1899. 1 hit.
    PF08954. DUF1900. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein."
      Okumura M., Kung C., Wong S., Rodgers M., Thomas M.L.
      DNA Cell Biol. 17:779-787(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Cerebellum, Spinal cord and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Salivary gland.
    4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiCOR1C_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUM4
    Secondary accession number(s): Q8VCQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3