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Q9WUM4

- COR1C_MOUSE

UniProt

Q9WUM4 - COR1C_MOUSE

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Protein
Coronin-1C
Gene
Coro1c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in cytokinesis, motility, and signal transduction By similarity.

GO - Molecular functioni

  1. actin filament binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. actin cortical patch assembly Source: MGI
  2. actin cytoskeleton organization Source: RefGenome
  3. phagocytosis Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1C
Alternative name(s):
Coronin-3
Gene namesi
Name:Coro1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1345964. Coro1c.

Subcellular locationi

Cell membrane By similarity. Cell projectionlamellipodium. Cytoplasmcytoskeleton By similarity
Note: Localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas By similarity.

GO - Cellular componenti

  1. actin cytoskeleton Source: RefGenome
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: MGI
  4. lamellipodium Source: UniProtKB-SubCell
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Coronin-1C
PRO_0000050927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei446 – 4461N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9WUM4.
PaxDbiQ9WUM4.
PRIDEiQ9WUM4.

PTM databases

PhosphoSiteiQ9WUM4.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ9WUM4.
BgeeiQ9WUM4.
CleanExiMM_CORO1C.
GenevestigatoriQ9WUM4.

Interactioni

Subunit structurei

Homotrimer. Binds F-actin By similarity.

Protein-protein interaction databases

BioGridi204714. 3 interactions.
IntActiQ9WUM4. 3 interactions.
MINTiMINT-4091604.

Structurei

3D structure databases

ProteinModelPortaliQ9WUM4.
SMRiQ9WUM4. Positions 8-391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati78 – 11841WD 1
Add
BLAST
Repeati128 – 16841WD 2
Add
BLAST
Repeati172 – 20231WD 3
Add
BLAST
Repeati215 – 24935WD 4
Add
BLAST
Repeati263 – 30341WD 5
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili435 – 47440 By similarity
Add
BLAST

Domaini

The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization By similarity.

Sequence similaritiesi

Belongs to the WD repeat coronin family.
Contains 5 WD repeats.

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00730000110618.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ9WUM4.
KOiK13887.
OMAiPKISMAS.
PhylomeDBiQ9WUM4.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027333. CORO1C.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF10. PTHR10856:SF10. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUM4-1 [UniParc]FASTAAdd to Basket

« Hide

MRRVVRQSKF RHVFGQAVKN DQCYDDIRVS RVTWDSSFCA VNPRFVAIII    50
EASGGGAFLV LPLHKTGRID KSYPTVCGHT GPVLDIDWCP HNDQVIASGS 100
EDCTVMVWQI PENGLTLSLT EPVVILEGHS KRVGIVAWHP TARNVLLSAG 150
CDNAIIIWNV GTGEALINLD DMHSDMIYNV SWSRNGSLIC TASKDKKVRV 200
IDPRKQEIVA EKEKAHEGAR PMRAIFLADG NVFTTGFSRM SERQLALWNP 250
KNMQEPIALH EMDTSNGVLL PFYDPDTSII YLCGKGDSSI RYFEITDESP 300
YVHYLNTFSS KEPQRGMGYM PKRGLDVNKC EIARFFKLHE RKCEPIIMTV 350
PRKSDLFQDD LYPDTAGPEA ALEAEEWFEG KNADPILISL KHGYIPGKNR 400
DLKVVKKNIL DSKPAANKKS ELSCAPKKPT DTASVQNEAK LDEILKEIKS 450
IKETICSQDE RISKLEQQLA KMAA 474
Length:474
Mass (Da):53,121
Last modified:October 11, 2004 - v2
Checksum:i4B1C41E1BB59AFCF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661T → S in AAD32705. 1 Publication
Sequence conflicti422 – 4221L → F in AAD32705. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143957 mRNA. Translation: AAD32705.1.
AK079327 mRNA. Translation: BAC37609.1.
AK082986 mRNA. Translation: BAC38722.1.
AK088101 mRNA. Translation: BAC40144.1.
BC019444 mRNA. Translation: AAH19444.1.
BC085498 mRNA. Translation: AAH85498.1.
CCDSiCCDS19555.1.
RefSeqiNP_035909.2. NM_011779.3.
UniGeneiMm.260158.

Genome annotation databases

EnsembliENSMUST00000004646; ENSMUSP00000004646; ENSMUSG00000004530.
GeneIDi23790.
KEGGimmu:23790.
UCSCiuc008yyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143957 mRNA. Translation: AAD32705.1 .
AK079327 mRNA. Translation: BAC37609.1 .
AK082986 mRNA. Translation: BAC38722.1 .
AK088101 mRNA. Translation: BAC40144.1 .
BC019444 mRNA. Translation: AAH19444.1 .
BC085498 mRNA. Translation: AAH85498.1 .
CCDSi CCDS19555.1.
RefSeqi NP_035909.2. NM_011779.3.
UniGenei Mm.260158.

3D structure databases

ProteinModelPortali Q9WUM4.
SMRi Q9WUM4. Positions 8-391.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204714. 3 interactions.
IntActi Q9WUM4. 3 interactions.
MINTi MINT-4091604.

PTM databases

PhosphoSitei Q9WUM4.

Proteomic databases

MaxQBi Q9WUM4.
PaxDbi Q9WUM4.
PRIDEi Q9WUM4.

Protocols and materials databases

DNASUi 23790.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004646 ; ENSMUSP00000004646 ; ENSMUSG00000004530 .
GeneIDi 23790.
KEGGi mmu:23790.
UCSCi uc008yyu.1. mouse.

Organism-specific databases

CTDi 23603.
MGIi MGI:1345964. Coro1c.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00730000110618.
HOGENOMi HOG000166356.
HOVERGENi HBG059978.
InParanoidi Q9WUM4.
KOi K13887.
OMAi PKISMAS.
PhylomeDBi Q9WUM4.
TreeFami TF314280.

Miscellaneous databases

ChiTaRSi CORO1C. mouse.
NextBioi 303391.
PROi Q9WUM4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WUM4.
Bgeei Q9WUM4.
CleanExi MM_CORO1C.
Genevestigatori Q9WUM4.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR027333. CORO1C.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR10856. PTHR10856. 1 hit.
PTHR10856:SF10. PTHR10856:SF10. 1 hit.
Pfami PF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein."
    Okumura M., Kung C., Wong S., Rodgers M., Thomas M.L.
    DNA Cell Biol. 17:779-787(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Spinal cord and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Salivary gland.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCOR1C_MOUSE
AccessioniPrimary (citable) accession number: Q9WUM4
Secondary accession number(s): Q8VCQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi