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Q9WUM4

- COR1C_MOUSE

UniProt

Q9WUM4 - COR1C_MOUSE

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Protein

Coronin-1C

Gene

Coro1c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in cytokinesis, motility, and signal transduction.By similarity

GO - Molecular functioni

  1. actin filament binding Source: RefGenome

GO - Biological processi

  1. actin cortical patch assembly Source: MGI
  2. actin cytoskeleton organization Source: RefGenome
  3. phagocytosis Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1C
Alternative name(s):
Coronin-3
Gene namesi
Name:Coro1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1345964. Coro1c.

Subcellular locationi

Cell membrane By similarity. Cell projectionlamellipodium. Cytoplasmcytoskeleton By similarity
Note: Localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas.By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: RefGenome
  2. cell projection Source: UniProtKB-KW
  3. cytoplasm Source: UniProtKB-KW
  4. cytoskeleton Source: MGI
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Coronin-1CPRO_0000050927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei446 – 4461N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9WUM4.
PaxDbiQ9WUM4.
PRIDEiQ9WUM4.

PTM databases

PhosphoSiteiQ9WUM4.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9WUM4.
CleanExiMM_CORO1C.
ExpressionAtlasiQ9WUM4. baseline and differential.
GenevestigatoriQ9WUM4.

Interactioni

Subunit structurei

Homotrimer. Binds F-actin (By similarity).By similarity

Protein-protein interaction databases

BioGridi204714. 3 interactions.
IntActiQ9WUM4. 3 interactions.
MINTiMINT-4091604.

Structurei

3D structure databases

ProteinModelPortaliQ9WUM4.
SMRiQ9WUM4. Positions 8-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati78 – 11841WD 1Add
BLAST
Repeati128 – 16841WD 2Add
BLAST
Repeati172 – 20231WD 3Add
BLAST
Repeati215 – 24935WD 4Add
BLAST
Repeati263 – 30341WD 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili435 – 47440By similarityAdd
BLAST

Domaini

The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.By similarity

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ9WUM4.
KOiK13886.
OMAiPKISMAS.
PhylomeDBiQ9WUM4.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027333. CORO1C.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF10. PTHR10856:SF10. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRVVRQSKF RHVFGQAVKN DQCYDDIRVS RVTWDSSFCA VNPRFVAIII
60 70 80 90 100
EASGGGAFLV LPLHKTGRID KSYPTVCGHT GPVLDIDWCP HNDQVIASGS
110 120 130 140 150
EDCTVMVWQI PENGLTLSLT EPVVILEGHS KRVGIVAWHP TARNVLLSAG
160 170 180 190 200
CDNAIIIWNV GTGEALINLD DMHSDMIYNV SWSRNGSLIC TASKDKKVRV
210 220 230 240 250
IDPRKQEIVA EKEKAHEGAR PMRAIFLADG NVFTTGFSRM SERQLALWNP
260 270 280 290 300
KNMQEPIALH EMDTSNGVLL PFYDPDTSII YLCGKGDSSI RYFEITDESP
310 320 330 340 350
YVHYLNTFSS KEPQRGMGYM PKRGLDVNKC EIARFFKLHE RKCEPIIMTV
360 370 380 390 400
PRKSDLFQDD LYPDTAGPEA ALEAEEWFEG KNADPILISL KHGYIPGKNR
410 420 430 440 450
DLKVVKKNIL DSKPAANKKS ELSCAPKKPT DTASVQNEAK LDEILKEIKS
460 470
IKETICSQDE RISKLEQQLA KMAA
Length:474
Mass (Da):53,121
Last modified:October 11, 2004 - v2
Checksum:i4B1C41E1BB59AFCF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661T → S in AAD32705. (PubMed:9778037)Curated
Sequence conflicti422 – 4221L → F in AAD32705. (PubMed:9778037)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143957 mRNA. Translation: AAD32705.1.
AK079327 mRNA. Translation: BAC37609.1.
AK082986 mRNA. Translation: BAC38722.1.
AK088101 mRNA. Translation: BAC40144.1.
BC019444 mRNA. Translation: AAH19444.1.
BC085498 mRNA. Translation: AAH85498.1.
CCDSiCCDS19555.1.
RefSeqiNP_035909.2. NM_011779.3.
UniGeneiMm.260158.

Genome annotation databases

EnsembliENSMUST00000004646; ENSMUSP00000004646; ENSMUSG00000004530.
GeneIDi23790.
KEGGimmu:23790.
UCSCiuc008yyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143957 mRNA. Translation: AAD32705.1 .
AK079327 mRNA. Translation: BAC37609.1 .
AK082986 mRNA. Translation: BAC38722.1 .
AK088101 mRNA. Translation: BAC40144.1 .
BC019444 mRNA. Translation: AAH19444.1 .
BC085498 mRNA. Translation: AAH85498.1 .
CCDSi CCDS19555.1.
RefSeqi NP_035909.2. NM_011779.3.
UniGenei Mm.260158.

3D structure databases

ProteinModelPortali Q9WUM4.
SMRi Q9WUM4. Positions 8-391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204714. 3 interactions.
IntActi Q9WUM4. 3 interactions.
MINTi MINT-4091604.

PTM databases

PhosphoSitei Q9WUM4.

Proteomic databases

MaxQBi Q9WUM4.
PaxDbi Q9WUM4.
PRIDEi Q9WUM4.

Protocols and materials databases

DNASUi 23790.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004646 ; ENSMUSP00000004646 ; ENSMUSG00000004530 .
GeneIDi 23790.
KEGGi mmu:23790.
UCSCi uc008yyu.1. mouse.

Organism-specific databases

CTDi 23603.
MGIi MGI:1345964. Coro1c.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119195.
HOGENOMi HOG000166356.
HOVERGENi HBG059978.
InParanoidi Q9WUM4.
KOi K13886.
OMAi PKISMAS.
PhylomeDBi Q9WUM4.
TreeFami TF314280.

Miscellaneous databases

ChiTaRSi Coro1c. mouse.
NextBioi 303391.
PROi Q9WUM4.
SOURCEi Search...

Gene expression databases

Bgeei Q9WUM4.
CleanExi MM_CORO1C.
ExpressionAtlasi Q9WUM4. baseline and differential.
Genevestigatori Q9WUM4.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR027333. CORO1C.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR10856. PTHR10856. 1 hit.
PTHR10856:SF10. PTHR10856:SF10. 1 hit.
Pfami PF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein."
    Okumura M., Kung C., Wong S., Rodgers M., Thomas M.L.
    DNA Cell Biol. 17:779-787(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Spinal cord and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Salivary gland.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCOR1C_MOUSE
AccessioniPrimary (citable) accession number: Q9WUM4
Secondary accession number(s): Q8VCQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3