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Protein

Coronin-1B

Gene

Coro1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1B
Alternative name(s):
Coronin-2
Gene namesi
Name:Coro1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1345963. Coro1b.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Coronin-1BPRO_0000050923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WUM3.
MaxQBiQ9WUM3.
PaxDbiQ9WUM3.
PRIDEiQ9WUM3.

PTM databases

iPTMnetiQ9WUM3.
PhosphoSiteiQ9WUM3.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9WUM3.
CleanExiMM_CORO1B.
ExpressionAtlasiQ9WUM3. baseline and differential.
GenevisibleiQ9WUM3. MM.

Interactioni

Subunit structurei

Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204713. 1 interaction.
IntActiQ9WUM3. 2 interactions.
MINTiMINT-4091591.
STRINGi10090.ENSMUSP00000008893.

Structurei

3D structure databases

ProteinModelPortaliQ9WUM3.
SMRiQ9WUM3. Positions 10-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati80 – 12041WD 1Add
BLAST
Repeati130 – 17041WD 2Add
BLAST
Repeati174 – 21340WD 3Add
BLAST
Repeati217 – 26044WD 4Add
BLAST
Repeati265 – 30541WD 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili444 – 48239Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ9WUM3.
KOiK13886.
OMAiNSCEITR.
PhylomeDBiQ9WUM3.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV
60 70 80 90 100
IVEASGGGAF MVLPLNKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS
110 120 130 140 150
GSEDCTVMVW QIPENGLTSP LTEPVVVLEG HTKRVGIITW HPTARNVLLS
160 170 180 190 200
AGCDNVVLIW NVGTAEELYR LDSLHPDLIY NVSWNHNGSL FCSACKDKSV
210 220 230 240 250
RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTTGFS RMSERQLALW
260 270 280 290 300
DPENLEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITDE
310 320 330 340 350
PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM
360 370 380 390 400
TVPRKSDLFQ DDLYPDTAGP EAALEAEDWV SGQDANPILI SLREAYVPSK
410 420 430 440 450
QRDLKVSRRN VLSDSRPASY SRSGASTATA VTDVPSGNLA GAGEAGKLEE
460 470 480
VMQELRALRM LVKEQGERIS RLEEQLGRME NGDT
Length:484
Mass (Da):53,912
Last modified:November 1, 1999 - v1
Checksum:i9631CC02E7EAC72F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti393 – 3931R → G in BAB25985 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143956 mRNA. Translation: AAD32704.1.
AK008947 mRNA. Translation: BAB25985.1.
AK149639 mRNA. Translation: BAE29000.1.
CCDSiCCDS29418.1.
RefSeqiNP_035908.1. NM_011778.2.
XP_006531804.1. XM_006531741.2.
XP_006531805.1. XM_006531742.1.
XP_006544959.1. XM_006544896.2.
XP_006544960.1. XM_006544897.1.
UniGeneiMm.276859.

Genome annotation databases

EnsembliENSMUST00000008893; ENSMUSP00000008893; ENSMUSG00000024835.
ENSMUST00000181494; ENSMUSP00000137780; ENSMUSG00000097771.
GeneIDi23789.
KEGGimmu:23789.
UCSCiuc008fyy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143956 mRNA. Translation: AAD32704.1.
AK008947 mRNA. Translation: BAB25985.1.
AK149639 mRNA. Translation: BAE29000.1.
CCDSiCCDS29418.1.
RefSeqiNP_035908.1. NM_011778.2.
XP_006531804.1. XM_006531741.2.
XP_006531805.1. XM_006531742.1.
XP_006544959.1. XM_006544896.2.
XP_006544960.1. XM_006544897.1.
UniGeneiMm.276859.

3D structure databases

ProteinModelPortaliQ9WUM3.
SMRiQ9WUM3. Positions 10-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204713. 1 interaction.
IntActiQ9WUM3. 2 interactions.
MINTiMINT-4091591.
STRINGi10090.ENSMUSP00000008893.

PTM databases

iPTMnetiQ9WUM3.
PhosphoSiteiQ9WUM3.

Proteomic databases

EPDiQ9WUM3.
MaxQBiQ9WUM3.
PaxDbiQ9WUM3.
PRIDEiQ9WUM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008893; ENSMUSP00000008893; ENSMUSG00000024835.
ENSMUST00000181494; ENSMUSP00000137780; ENSMUSG00000097771.
GeneIDi23789.
KEGGimmu:23789.
UCSCiuc008fyy.1. mouse.

Organism-specific databases

CTDi57175.
MGIiMGI:1345963. Coro1b.

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ9WUM3.
KOiK13886.
OMAiNSCEITR.
PhylomeDBiQ9WUM3.
TreeFamiTF314280.

Miscellaneous databases

ChiTaRSiCoro1b. mouse.
NextBioi303387.
PROiQ9WUM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUM3.
CleanExiMM_CORO1B.
ExpressionAtlasiQ9WUM3. baseline and differential.
GenevisibleiQ9WUM3. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein."
    Okumura M., Kung C., Wong S., Rodgers M., Thomas M.L.
    DNA Cell Biol. 17:779-787(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Stomach.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 34-46; 135-145 AND 423-456, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. "Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility."
    Cai L., Holoweckyj N., Schaller M.D., Bear J.E.
    J. Biol. Chem. 280:31913-31923(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH ACTR2; ARPC1B AND ARPC2.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCOR1B_MOUSE
AccessioniPrimary (citable) accession number: Q9WUM3
Secondary accession number(s): Q3UEB1, Q9CVA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.