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Protein

Cbp/p300-interacting transactivator 4

Gene

Cited4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 4
Alternative name(s):
MSG1-related protein 2
Short name:
MRG-2
Gene namesi
Name:Cited4Imported
Synonyms:Mrg2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1861694. Cited4.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Cbp/p300-interacting transactivator 4PRO_0000233310Add
BLAST

Proteomic databases

PaxDbiQ9WUL8.
PRIDEiQ9WUL8.

Expressioni

Tissue specificityi

Strongly expressed in heart, spleen and testis, and weakly in liver and kidney.1 Publication

Developmental stagei

Undetectable in nulliparous mammary glands but strongly expressed in 11.5 dpc pregnant mammary glands. Strong expression continued until the end of the lactacting stage and then rapidly diminished during the weaning stage.1 Publication

Gene expression databases

BgeeiQ9WUL8.
ExpressionAtlasiQ9WUL8. baseline and differential.
GenevisibleiQ9WUL8. MM.

Interactioni

Subunit structurei

Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.By similarity1 Publication

Protein-protein interaction databases

BioGridi207856. 15 interactions.
STRINGi10090.ENSMUSP00000092408.

Structurei

3D structure databases

ProteinModelPortaliQ9WUL8.
SMRiQ9WUL8. Positions 132-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 125109Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CITED family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IZSZ. Eukaryota.
ENOG4111C3F. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000231079.
HOVERGENiHBG075182.
InParanoidiQ9WUL8.
OMAiSFQPFPA.
OrthoDBiEOG72NRRB.
PhylomeDBiQ9WUL8.
TreeFamiTF331915.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9WUL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADHLMLAEG YCLLQVPPHT HGPHAPRTLQ PYAGPGMDSG LRPRGAPLGP
60 70 80 90 100
PPPPGTLAYG SFGSPVSFQP FPVSQSPGAG STHLQSAATP SPGRIPAPPA
110 120 130 140 150
AAGGPSPLQP APGAAASLPP PPPPPALGCM DTELIDEEAL TSLELELGLH
160 170 180
RVRELPELFL GQSEFDCFSD LGSAPAAGSV SC
Length:182
Mass (Da):18,398
Last modified:November 1, 1999 - v1
Checksum:iC819C70AFD82043C
GO
Isoform 21 Publication (identifier: Q9WUL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-120: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:78
Mass (Da):8,362
Checksum:i9C88DBD539CFBDAB
GO
Isoform 31 Publication (identifier: Q9WUL8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:53
Mass (Da):5,742
Checksum:i90DBD60F5788A9BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171S → W in BAB28054 (PubMed:16141072).Curated
Sequence conflicti120 – 1201P → R in BAB28054 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 129129Missing in isoform 3. 1 PublicationVSP_052036Add
BLAST
Alternative sequencei17 – 120104Missing in isoform 2. 1 PublicationVSP_052035Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143369 mRNA. Translation: AAD37357.1.
AK012136 mRNA. Translation: BAB28054.1.
AK154030 mRNA. Translation: BAE32327.1.
BC025116 mRNA. Translation: AAH25116.1.
BC080723 mRNA. Translation: AAH80723.1.
CCDSiCCDS18592.1. [Q9WUL8-1]
RefSeqiNP_062509.1. NM_019563.2. [Q9WUL8-1]
UniGeneiMm.272646.

Genome annotation databases

EnsembliENSMUST00000094814; ENSMUSP00000092408; ENSMUSG00000070803. [Q9WUL8-1]
GeneIDi56222.
KEGGimmu:56222.
UCSCiuc008unl.1. mouse. [Q9WUL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143369 mRNA. Translation: AAD37357.1.
AK012136 mRNA. Translation: BAB28054.1.
AK154030 mRNA. Translation: BAE32327.1.
BC025116 mRNA. Translation: AAH25116.1.
BC080723 mRNA. Translation: AAH80723.1.
CCDSiCCDS18592.1. [Q9WUL8-1]
RefSeqiNP_062509.1. NM_019563.2. [Q9WUL8-1]
UniGeneiMm.272646.

3D structure databases

ProteinModelPortaliQ9WUL8.
SMRiQ9WUL8. Positions 132-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207856. 15 interactions.
STRINGi10090.ENSMUSP00000092408.

Proteomic databases

PaxDbiQ9WUL8.
PRIDEiQ9WUL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094814; ENSMUSP00000092408; ENSMUSG00000070803. [Q9WUL8-1]
GeneIDi56222.
KEGGimmu:56222.
UCSCiuc008unl.1. mouse. [Q9WUL8-1]

Organism-specific databases

CTDi163732.
MGIiMGI:1861694. Cited4.

Phylogenomic databases

eggNOGiENOG410IZSZ. Eukaryota.
ENOG4111C3F. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000231079.
HOVERGENiHBG075182.
InParanoidiQ9WUL8.
OMAiSFQPFPA.
OrthoDBiEOG72NRRB.
PhylomeDBiQ9WUL8.
TreeFamiTF331915.

Miscellaneous databases

ChiTaRSiCited4. mouse.
PROiQ9WUL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUL8.
ExpressionAtlasiQ9WUL8. baseline and differential.
GenevisibleiQ9WUL8. MM.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells."
    Yahata T., Takedatsu H., Dunwoodie S.L., Braganca J., Swingler T., Withington S.L., Hur J., Coser K.R., Isselbacher K.J., Bhattacharya S., Shioda T.
    Genomics 80:601-613(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CREBBP; EP300 AND TFAP2, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Mammary glandImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6JImported and NODImported.
    Tissue: EmbryoImported and ThymusImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: NMRIImported.
    Tissue: Mammary glandImported.
  4. "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein."
    Yahata T., Shao W., Endoh H., Hur J., Coser K.R., Sun H., Ueda Y., Kato S., Isselbacher K.J., Brown M., Shioda T.
    Genes Dev. 15:2598-2612(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCITE4_MOUSE
AccessioniPrimary (citable) accession number: Q9WUL8
Secondary accession number(s): Q66JX0, Q8R176, Q9CZV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.