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Protein

Programmed cell death 1 ligand 2

Gene

Pdcd1lg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death 1 ligand 2
Short name:
PD-1 ligand 2
Short name:
PD-L2
Short name:
PDCD1 ligand 2
Short name:
Programmed death ligand 2
Alternative name(s):
Butyrophilin B7-DC
Short name:
B7-DC
CD_antigen: CD273
Gene namesi
Name:Pdcd1lg2
Synonyms:B7dc, Btdc, Cd273, Pdl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1930125. Pdcd1lg2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 221ExtracellularSequence analysisAdd BLAST202
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 247CytoplasmicSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33D → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi39S → Y: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi41E → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi56R → S: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi58S → Y: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi65D → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi67S → Y: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi71E → S: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi72R → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi84K → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi88H → A: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi101R → S: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi103L → A: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi105I → A: Abolishes the binding to PDCD1. 1 Publication1
Mutagenesisi111D → S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells. 1 Publication1
Mutagenesisi113K → S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells. 1 Publication1
Mutagenesisi116T → Y: No effect on PDCD1 binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001455620 – 247Programmed cell death 1 ligand 2Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 102PROSITE-ProRule annotation
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi143 ↔ 192PROSITE-ProRule annotation1 Publication
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUL5.
PRIDEiQ9WUL5.

PTM databases

PhosphoSitePlusiQ9WUL5.

Expressioni

Tissue specificityi

Expressed in immature and mature bone marrow-derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin.2 Publications

Gene expression databases

BgeeiENSMUSG00000016498.
CleanExiMM_PDCD1LG2.
ExpressionAtlasiQ9WUL5. baseline and differential.
GenevisibleiQ9WUL5. MM.

Interactioni

Subunit structurei

Interacts with PDCD1.2 Publications

Protein-protein interaction databases

BioGridi208388. 1 interactor.
DIPiDIP-46166N.
STRINGi10090.ENSMUSP00000108195.

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 33Combined sources6
Beta strandi38 – 44Combined sources7
Turni46 – 48Combined sources3
Helixi52 – 54Combined sources3
Beta strandi55 – 61Combined sources7
Beta strandi63 – 69Combined sources7
Beta strandi73 – 75Combined sources3
Helixi77 – 82Combined sources6
Beta strandi84 – 89Combined sources6
Helixi94 – 96Combined sources3
Beta strandi98 – 106Combined sources9
Beta strandi109 – 121Combined sources13
Beta strandi126 – 132Combined sources7
Turni134 – 136Combined sources3
Beta strandi139 – 149Combined sources11
Beta strandi152 – 155Combined sources4
Beta strandi163 – 168Combined sources6
Beta strandi174 – 182Combined sources9
Beta strandi190 – 196Combined sources7
Turni197 – 200Combined sources4
Beta strandi201 – 207Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BOVX-ray1.77A20-123[»]
3BP5X-ray1.80B20-220[»]
3BP6X-ray1.60B20-220[»]
3RNKX-ray1.74B20-123[»]
3RNQX-ray1.60B20-220[»]
ProteinModelPortaliQ9WUL5.
SMRiQ9WUL5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WUL5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 118Ig-like V-typeAdd BLAST98
Domaini122 – 203Ig-like C2-typeAdd BLAST82

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCK. Eukaryota.
ENOG4111V14. LUCA.
GeneTreeiENSGT00650000093373.
HOGENOMiHOG000059625.
HOVERGENiHBG082112.
InParanoidiQ9WUL5.
KOiK06708.
OMAiVAWDYKY.
OrthoDBiEOG091G0F5W.
PhylomeDBiQ9WUL5.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLPILNL SLQLHPVAAL FTVTAPKEVY TVDVGSSVSL ECDFDRRECT
60 70 80 90 100
ELEGIRASLQ KVENDTSLQS ERATLLEEQL PLGKALFHIP SVQVRDSGQY
110 120 130 140 150
RCLVICGAAW DYKYLTVKVK ASYMRIDTRI LEVPGTGEVQ LTCQARGYPL
160 170 180 190 200
AEVSWQNVSV PANTSHIRTP EGLYQVTSVL RLKPQPSRNF SCMFWNAHMK
210 220 230 240
ELTSAIIDPL SRMEPKVPRT WPLHVFIPAC TIALIFLAIV IIQRKRI
Length:247
Mass (Da):27,820
Last modified:November 1, 1999 - v1
Checksum:i9BFDDE14F3EC138F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142780 mRNA. Translation: AAD33892.1.
AK089369 mRNA. Translation: BAC40858.1.
CCDSiCCDS29736.1.
RefSeqiNP_067371.1. NM_021396.2.
UniGeneiMm.116737.

Genome annotation databases

EnsembliENSMUST00000112576; ENSMUSP00000108195; ENSMUSG00000016498.
GeneIDi58205.
KEGGimmu:58205.
UCSCiuc008hdk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142780 mRNA. Translation: AAD33892.1.
AK089369 mRNA. Translation: BAC40858.1.
CCDSiCCDS29736.1.
RefSeqiNP_067371.1. NM_021396.2.
UniGeneiMm.116737.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BOVX-ray1.77A20-123[»]
3BP5X-ray1.80B20-220[»]
3BP6X-ray1.60B20-220[»]
3RNKX-ray1.74B20-123[»]
3RNQX-ray1.60B20-220[»]
ProteinModelPortaliQ9WUL5.
SMRiQ9WUL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208388. 1 interactor.
DIPiDIP-46166N.
STRINGi10090.ENSMUSP00000108195.

PTM databases

PhosphoSitePlusiQ9WUL5.

Proteomic databases

PaxDbiQ9WUL5.
PRIDEiQ9WUL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112576; ENSMUSP00000108195; ENSMUSG00000016498.
GeneIDi58205.
KEGGimmu:58205.
UCSCiuc008hdk.2. mouse.

Organism-specific databases

CTDi80380.
MGIiMGI:1930125. Pdcd1lg2.

Phylogenomic databases

eggNOGiENOG410IVCK. Eukaryota.
ENOG4111V14. LUCA.
GeneTreeiENSGT00650000093373.
HOGENOMiHOG000059625.
HOVERGENiHBG082112.
InParanoidiQ9WUL5.
KOiK06708.
OMAiVAWDYKY.
OrthoDBiEOG091G0F5W.
PhylomeDBiQ9WUL5.
TreeFamiTF331083.

Enzyme and pathway databases

ReactomeiR-MMU-389948. PD-1 signaling.

Miscellaneous databases

EvolutionaryTraceiQ9WUL5.
PROiQ9WUL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016498.
CleanExiMM_PDCD1LG2.
ExpressionAtlasiQ9WUL5. baseline and differential.
GenevisibleiQ9WUL5. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPD1L2_MOUSE
AccessioniPrimary (citable) accession number: Q9WUL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.