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Protein

Opsin-3

Gene

Opn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in encephalic photoreception.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-3
Alternative name(s):
Encephalopsin
Panopsin
Gene namesi
Name:Opn3
Synonyms:Ecpn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1338022. Opn3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 75CytoplasmicSequence analysisAdd BLAST12
Transmembranei76 – 100Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini101 – 115ExtracellularSequence analysisAdd BLAST15
Transmembranei116 – 135Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini136 – 151CytoplasmicSequence analysisAdd BLAST16
Transmembranei152 – 175Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini176 – 199ExtracellularSequence analysisAdd BLAST24
Transmembranei200 – 227Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini228 – 253CytoplasmicSequence analysisAdd BLAST26
Transmembranei254 – 277Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini278 – 285ExtracellularSequence analysis8
Transmembranei286 – 310Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini311 – 400CytoplasmicSequence analysisAdd BLAST90

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978141 – 400Opsin-3Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 186PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Modified residuei297N6-(retinylidene)lysine1
Lipidationi323S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9WUK7.
PRIDEiQ9WUK7.

PTM databases

PhosphoSitePlusiQ9WUK7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026525.
CleanExiMM_OPN3.
GenevisibleiQ9WUK7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027809.

Structurei

3D structure databases

ProteinModelPortaliQ9WUK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000029042.
HOVERGENiHBG100337.
InParanoidiQ9WUK7.
KOiK04256.
OMAiVNGYGHL.
OrthoDBiEOG091G0ALC.
PhylomeDBiQ9WUK7.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSGNRSGDQ GYWEDGAGAE GAAPAGTRSP APLFSPTAYE RLALLLGCLA
60 70 80 90 100
LLGVGGNLLV LLLYSKFPRL RTPTHLFLVN LSLGDLLVSL FGVTFTFASC
110 120 130 140 150
LRNGWVWDAV GCAWDGFSGS LFGFVSITTL TVLAYERYIR VVHARVINFS
160 170 180 190 200
WAWRAITYIW LYSLAWAGAP LLGWNRYILD IHGLGCTVDW RSKDANDSSF
210 220 230 240 250
VLFLFLGCLV VPVGIIAHCY GHILYSVRML RCVEDLQTIQ VIKMLRYEKK
260 270 280 290 300
VAKMCFLMAF VFLTCWMPYI VTRFLVVNGY GHLVTPTVSI VSYLFAKSST
310 320 330 340 350
VYNPVIYIFM NRKFRRSLLQ LLCFRLLRCQ RPAKNLPAAE SEMHIRPIVM
360 370 380 390 400
SQKDGDRPKK KVTFNSSSII FIITSDESLS VEDSDRSSAS KVDVIQVRPL
Length:400
Mass (Da):44,947
Last modified:November 1, 1999 - v1
Checksum:iAAFA81386C48BDB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140241 mRNA. Translation: AAD32670.1.
AF482427 Genomic DNA. Translation: AAO15719.1.
AK043135 mRNA. Translation: BAC31471.1.
AK132822 mRNA. Translation: BAE21380.1.
CCDSiCCDS15549.1.
RefSeqiNP_034228.1. NM_010098.3.
UniGeneiMm.32744.

Genome annotation databases

EnsembliENSMUST00000027809; ENSMUSP00000027809; ENSMUSG00000026525.
GeneIDi13603.
KEGGimmu:13603.
UCSCiuc007dtq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140241 mRNA. Translation: AAD32670.1.
AF482427 Genomic DNA. Translation: AAO15719.1.
AK043135 mRNA. Translation: BAC31471.1.
AK132822 mRNA. Translation: BAE21380.1.
CCDSiCCDS15549.1.
RefSeqiNP_034228.1. NM_010098.3.
UniGeneiMm.32744.

3D structure databases

ProteinModelPortaliQ9WUK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027809.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9WUK7.

Proteomic databases

PaxDbiQ9WUK7.
PRIDEiQ9WUK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027809; ENSMUSP00000027809; ENSMUSG00000026525.
GeneIDi13603.
KEGGimmu:13603.
UCSCiuc007dtq.2. mouse.

Organism-specific databases

CTDi23596.
MGIiMGI:1338022. Opn3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000029042.
HOVERGENiHBG100337.
InParanoidiQ9WUK7.
KOiK04256.
OMAiVNGYGHL.
OrthoDBiEOG091G0ALC.
PhylomeDBiQ9WUK7.
TreeFamiTF324998.

Miscellaneous databases

PROiQ9WUK7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026525.
CleanExiMM_OPN3.
GenevisibleiQ9WUK7. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPN3_MOUSE
AccessioniPrimary (citable) accession number: Q9WUK7
Secondary accession number(s): Q3V0X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.