Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9WUK6

- ZBT18_MOUSE

UniProt

Q9WUK6 - ZBT18_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger and BTB domain-containing protein 18

Gene

Zbtb18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri370 – 39223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48924C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. cerebellum development Source: MGI
  2. cerebral cortex development Source: MGI
  3. hippocampus development Source: MGI
  4. homeostasis of number of cells Source: MGI
  5. in utero embryonic development Source: MGI
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. neuron development Source: MGI
  9. regulation of cell division Source: MGI
  10. skeletal muscle tissue development Source: UniProtKB
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 18
Alternative name(s):
58 kDa repressor protein
Transcriptional repressor RP58
Zinc finger protein 238
Short name:
Zfp-238
Gene namesi
Name:Zbtb18
Synonyms:Rp58, Zfp238, Znf238
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1353609. Zbtb18.

Subcellular locationi

Nucleus
Note: Associates with condensed chromatin.

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death shortly after birth. Brain of mutant mice display dysplasia of the neocortex and of the hippocampus, reduction of the number of mature cortical neurons and defects of laminar organization. In the cortex, an impaired cell-division patterning during the late embryonic stage and an enhancement of apoptosis of the postmitotic neurons are observed.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Zinc finger and BTB domain-containing protein 18PRO_0000047478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei516 – 5161PhosphoserineBy similarity
Modified residuei517 – 5171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WUK6.
PaxDbiQ9WUK6.
PRIDEiQ9WUK6.

PTM databases

PhosphoSiteiQ9WUK6.

Expressioni

Developmental stagei

In the developing brain, expression is detected at embryonic day (E) 10 in the neuroepithelium, and subsequently in the ventricular zones of the cerebral cortex in the E12 embryo. Strong expression is observed in the preplate in the cerebral cortex from this stage onward. High levels of expression continue to be detected in the cortical plate and subventricular zone of the neocortex, hippocampus, and parts of the amygdala, but not in the thalamus or striatum. In the developing cerebral cortex, it is expressed both in postmitotic glutamatergic projection neurons and in their progenitor cells, but not in GABAergic interneurons. Also expressed in the adult neocortex, hippocampus, parts of the amygdala and granule cells in the cerebellum.1 Publication

Gene expression databases

BgeeiQ9WUK6.
CleanExiMM_ZFP238.
ExpressionAtlasiQ9WUK6. baseline and differential.
GenevestigatoriQ9WUK6.

Interactioni

Subunit structurei

Interacts with DNMT3A.By similarity

Protein-protein interaction databases

BioGridi206006. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9WUK6.
SMRiQ9WUK6. Positions 2-113, 370-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9168BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni310 – 427118Interaction with DNMT3ABy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri370 – 39223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48924C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118922.
HOGENOMiHOG000234147.
HOVERGENiHBG059113.
InParanoidiQ9WUK6.
PhylomeDBiQ9WUK6.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFPDHSRHL LQCLSEQRHQ GFLCDCTVLV GDAQFRAHRA VLASCSMYFH
60 70 80 90 100
LFYKDQLDKR DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA
110 120 130 140 150
ASYLHMYDIV KVCKKKLKEK ATTEADSTKK EEDASSCSDK VESLSDGSSH
160 170 180 190 200
MAGDLPSDED EGEDDKLNIL PSKRDLAAEP GNMWMRLPSD SAGIPQAGGE
210 220 230 240 250
AEPHATAAGK TVASPCSSTE SLSQRSVTSV RDSADVDCVL DLSVKSSLSG
260 270 280 290 300
VENLNSSYFS SQDVLRSNLV QVKVEKEASC DESDVGTNDY DMEHSTVKES
310 320 330 340 350
VSTNNRVQYE PAHLAPLRED SVLRELDRED KASDDEMMTP ESERVQVEGG
360 370 380 390 400
MENSLLPYVS NILSPAGQIF MCPLCNKVFP SPHILQIHLS THFREQDGIR
410 420 430 440 450
SKPAADVNVP TCSLCGKTFS CMYTLKRHER THSGEKPYTC TQCGKSFQYS
460 470 480 490 500
HNLSRHAVVH TREKPHACKW CERRFTQSGD LYRHIRKFHC ELVNSLSVKS
510 520
EALSLPTVRD WTLEDSSQEL WK
Length:522
Mass (Da):58,385
Last modified:November 1, 1999 - v1
Checksum:i41E169E690D8B849
GO

Sequence cautioni

The sequence AAH50909.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421L → V in AAH54742. (PubMed:15489334)Curated
Sequence conflicti42 – 421L → V in AAH54529. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140224 mRNA. Translation: AAD34547.1.
AK147200 mRNA. Translation: BAE27758.1.
BC050909 mRNA. Translation: AAH50909.1. Different initiation.
BC054529 mRNA. Translation: AAH54529.1.
BC054742 mRNA. Translation: AAH54742.1.
CCDSiCCDS15553.1.
RefSeqiNP_001012330.1. NM_001012330.1.
NP_038943.3. NM_013915.3.
XP_006496956.1. XM_006496893.1.
XP_006496957.1. XM_006496894.1.
XP_006496958.1. XM_006496895.1.
XP_006496959.1. XM_006496896.1.
UniGeneiMm.330700.

Genome annotation databases

EnsembliENSMUST00000077225; ENSMUSP00000076463; ENSMUSG00000063659.
GeneIDi30928.
KEGGimmu:30928.
UCSCiuc007dul.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140224 mRNA. Translation: AAD34547.1 .
AK147200 mRNA. Translation: BAE27758.1 .
BC050909 mRNA. Translation: AAH50909.1 . Different initiation.
BC054529 mRNA. Translation: AAH54529.1 .
BC054742 mRNA. Translation: AAH54742.1 .
CCDSi CCDS15553.1.
RefSeqi NP_001012330.1. NM_001012330.1.
NP_038943.3. NM_013915.3.
XP_006496956.1. XM_006496893.1.
XP_006496957.1. XM_006496894.1.
XP_006496958.1. XM_006496895.1.
XP_006496959.1. XM_006496896.1.
UniGenei Mm.330700.

3D structure databases

ProteinModelPortali Q9WUK6.
SMRi Q9WUK6. Positions 2-113, 370-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206006. 1 interaction.

PTM databases

PhosphoSitei Q9WUK6.

Proteomic databases

MaxQBi Q9WUK6.
PaxDbi Q9WUK6.
PRIDEi Q9WUK6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077225 ; ENSMUSP00000076463 ; ENSMUSG00000063659 .
GeneIDi 30928.
KEGGi mmu:30928.
UCSCi uc007dul.2. mouse.

Organism-specific databases

CTDi 10472.
MGIi MGI:1353609. Zbtb18.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118922.
HOGENOMi HOG000234147.
HOVERGENi HBG059113.
InParanoidi Q9WUK6.
PhylomeDBi Q9WUK6.

Miscellaneous databases

NextBioi 307332.
PROi Q9WUK6.
SOURCEi Search...

Gene expression databases

Bgeei Q9WUK6.
CleanExi MM_ZFP238.
ExpressionAtlasi Q9WUK6. baseline and differential.
Genevestigatori Q9WUK6.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin."
    Meng G., Inazawa J., Ishida R., Tokura K., Nakahara K., Aoki K., Kasai M.
    Gene 242:59-64(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver and Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Spatial and temporal expression of RP58, a novel zinc finger transcriptional repressor, in mouse brain."
    Ohtaka-Maruyama C., Miwa A., Kawano H., Kasai M., Okado H.
    J. Comp. Neurol. 502:1098-1108(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex."
    Okado H., Ohtaka-Maruyama C., Sugitani Y., Fukuda Y., Ishida R., Hirai S., Miwa A., Takahashi A., Aoki K., Mochida K., Suzuki O., Honda T., Nakajima K., Ogawa M., Terashima T., Matsuda J., Kawano H., Kasai M.
    Dev. Biol. 331:140-151(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  6. Cited for: FUNCTION.

Entry informationi

Entry nameiZBT18_MOUSE
AccessioniPrimary (citable) accession number: Q9WUK6
Secondary accession number(s): Q3UHU9, Q7TMA6, Q80YQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3