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Protein

Inhibin beta C chain

Gene

Inhbc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta C chain
Alternative name(s):
Activin beta-C chain
Gene namesi
Name:Inhbc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621194. Inhbc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 236218Sequence analysisPRO_0000033734Add
BLAST
Chaini237 – 351115Inhibin beta C chainPRO_0000033735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi239 ↔ 247By similarity
Disulfide bondi246 ↔ 316By similarity
Disulfide bondi275 ↔ 348By similarity
Disulfide bondi279 ↔ 350By similarity
Disulfide bondi315 – 315InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUK5.
PRIDEiQ9WUK5.

Expressioni

Gene expression databases

GenevisibleiQ9WUK5. RN.

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010240.

Structurei

3D structure databases

ProteinModelPortaliQ9WUK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiQ9WUK5.
KOiK04667.
OMAiEGYAMNF.
OrthoDBiEOG74R1Q4.
PhylomeDBiQ9WUK5.
TreeFamiTF351791.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSLLLALL FLTLATVVNL KTDGPCPACW GATFDLESHR ELLLDLAKKS
60 70 80 90 100
ILDKLHLSQR PILSRPVSRE ALKTALRRLR GTRAETLLEH DQRQEYEIIS
110 120 130 140 150
FADTGLSNIN QTRLEFHFSD RTTGGVEVLQ TRFMFFMQLP PNTTQTMNIR
160 170 180 190 200
VLVLRPYDTN LTLTSQYMLQ VDASGWYQLL LGPEAQAACS QGHLTLELVP
210 220 230 240 250
ESQLAHSSLI LDGVSHRPFV AAQVRVEGKH RVRRRGINCQ GLSRMCCRQE
260 270 280 290 300
FFVDFREIGW HDWIIQPEGY AMNFCTGQCP LHVAGMPGIS ASFHTAVLNL
310 320 330 340 350
LKANTDAGTA RRGSCCVPTS RRPLSLLYYD RDSNIVKTDI PDMVVEACGC

S
Length:351
Mass (Da):39,335
Last modified:November 1, 1999 - v1
Checksum:i6B219BF6C3E180A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140031 mRNA. Translation: AAD30132.1.
BC089799 mRNA. Translation: AAH89799.1.
RefSeqiNP_072136.1. NM_022614.2.
UniGeneiRn.48697.

Genome annotation databases

EnsembliENSRNOT00000010240; ENSRNOP00000010240; ENSRNOG00000007700.
GeneIDi64549.
KEGGirno:64549.
UCSCiRGD:621194. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140031 mRNA. Translation: AAD30132.1.
BC089799 mRNA. Translation: AAH89799.1.
RefSeqiNP_072136.1. NM_022614.2.
UniGeneiRn.48697.

3D structure databases

ProteinModelPortaliQ9WUK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010240.

Proteomic databases

PaxDbiQ9WUK5.
PRIDEiQ9WUK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010240; ENSRNOP00000010240; ENSRNOG00000007700.
GeneIDi64549.
KEGGirno:64549.
UCSCiRGD:621194. rat.

Organism-specific databases

CTDi3626.
RGDi621194. Inhbc.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiQ9WUK5.
KOiK04667.
OMAiEGYAMNF.
OrthoDBiEOG74R1Q4.
PhylomeDBiQ9WUK5.
TreeFamiTF351791.

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.

Miscellaneous databases

PROiQ9WUK5.

Gene expression databases

GenevisibleiQ9WUK5. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rat activin beta C and beta E: sequence and expression."
    Rossmanith W., Peter B., Schulte-Hermann R.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiINHBC_RAT
AccessioniPrimary (citable) accession number: Q9WUK5
Secondary accession number(s): Q5FVS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.