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Protein

Eukaryotic translation initiation factor 4H

Gene

Eif4h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • developmental growth Source: MGI
  • eukaryotic translation initiation factor 4F complex assembly Source: GO_Central
  • formation of translation preinitiation complex Source: GO_Central
  • sexual reproduction Source: MGI

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-72649 Translation initiation complex formation
R-MMU-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4H
Short name:
eIF-4H
Alternative name(s):
Williams-Beuren syndrome chromosomal region 1 protein homolog
Gene namesi
Name:Eif4h
Synonyms:Wbscr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1341822 Eif4h

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000816202 – 248Eukaryotic translation initiation factor 4HAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei19Omega-N-methylarginineCombined sources1
Modified residuei21PhosphoserineBy similarity1
Modified residuei22Omega-N-methylarginineCombined sources1
Modified residuei24PhosphoserineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei136Omega-N-methylarginineCombined sources1
Modified residuei166Omega-N-methylarginineCombined sources1
Modified residuei175Omega-N-methylarginineCombined sources1
Modified residuei230PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9WUK2
PaxDbiQ9WUK2
PRIDEiQ9WUK2

PTM databases

iPTMnetiQ9WUK2
PhosphoSitePlusiQ9WUK2
SwissPalmiQ9WUK2

Miscellaneous databases

PMAP-CutDBiQ9WUK2

Expressioni

Tissue specificityi

Expressed at high levels in heart, liver and testis and at lower levels in brain, spleen, lung, skeletal muscle, kidney and embryonic tissues. Both isoforms are expressed at similar levels.1 Publication

Gene expression databases

BgeeiENSMUSG00000040731
CleanExiMM_EIF4H
ExpressionAtlasiQ9WUK2 baseline and differential
GenevisibleiQ9WUK2 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204551, 1 interactor
STRINGi10090.ENSMUSP00000048833

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 40Combined sources3
Beta strandi42 – 48Combined sources7
Helixi55 – 61Combined sources7
Turni62 – 64Combined sources3
Beta strandi67 – 74Combined sources8
Beta strandi76 – 78Combined sources3
Beta strandi80 – 91Combined sources12
Helixi92 – 98Combined sources7
Helixi99 – 101Combined sources3
Beta strandi112 – 115Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNGNMR-A34-123[»]
ProteinModelPortaliQ9WUK2
SMRiQ9WUK2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WUK2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 118RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00530000063406
HOGENOMiHOG000013063
HOVERGENiHBG018193
InParanoidiQ9WUK2
OMAiKVNRAQQ
OrthoDBiEOG091G0PIF
PhylomeDBiQ9WUK2
TreeFamiTF313897

Family and domain databases

CDDicd12401 RRM_eIF4H, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034229 eIF4H_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q9WUK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP
60 70 80 90 100
FNTVQGDIDA IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT
110 120 130 140 150
YDGALLGDRS LRVDIAEGRK QDKGGFGFRK GGPDDRGMGG SRESRGGWDS
160 170 180 190 200
RDDFNSGYRD DFLGGRGGSR PGDRRAGPPM GSRFRDGPPL RGSNMDFREP
210 220 230 240
TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE EVVQKEQE
Length:248
Mass (Da):27,341
Last modified:January 23, 2007 - v3
Checksum:i23E5393BAF183477
GO
Isoform Short (identifier: Q9WUK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-156: Missing.

Show »
Length:228
Mass (Da):25,186
Checksum:iA8F5B0957AA856E9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005800137 – 156Missing in isoform Short. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139987 Genomic DNA Translation: AAD34859.1
AF139987 Genomic DNA Translation: AAD34860.1
AF289664 Genomic DNA Translation: AAF99330.1
BC014796 mRNA Translation: AAH14796.1
CCDSiCCDS19723.1 [Q9WUK2-1]
CCDS84968.1 [Q9WUK2-2]
RefSeqiNP_001299796.1, NM_001312867.1 [Q9WUK2-2]
NP_291039.1, NM_033561.2 [Q9WUK2-1]
UniGeneiMm.27955
Mm.351377

Genome annotation databases

EnsembliENSMUST00000036125; ENSMUSP00000048833; ENSMUSG00000040731 [Q9WUK2-2]
ENSMUST00000202622; ENSMUSP00000143910; ENSMUSG00000040731 [Q9WUK2-1]
GeneIDi22384
KEGGimmu:22384
UCSCiuc008zwp.1 mouse [Q9WUK2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIF4H_MOUSE
AccessioniPrimary (citable) accession number: Q9WUK2
Secondary accession number(s): Q9WUK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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