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Protein

Origin recognition complex subunit 6

Gene

Orc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA-dependent DNA replication Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 6
Gene namesi
Name:Orc6
Synonyms:Orc6l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929285. Orc6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Origin recognition complex subunit 6PRO_0000127098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WUJ8.
MaxQBiQ9WUJ8.
PaxDbiQ9WUJ8.
PRIDEiQ9WUJ8.

PTM databases

iPTMnetiQ9WUJ8.
PhosphoSiteiQ9WUJ8.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034132.

Structurei

3D structure databases

ProteinModelPortaliQ9WUJ8.
SMRiQ9WUJ8. Positions 94-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC6 family.Curated

Phylogenomic databases

eggNOGiKOG4557. Eukaryota.
ENOG4111GUY. LUCA.
HOGENOMiHOG000065679.
HOVERGENiHBG007876.
InParanoidiQ9WUJ8.
PhylomeDBiQ9WUJ8.

Family and domain databases

InterProiIPR008721. ORC6.
IPR020529. ORC6_met/pln.
[Graphical view]
PfamiPF05460. ORC6. 1 hit.
[Graphical view]
ProDomiPD315657. Origin_recog_cplx_su6-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9WUJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESELVRRLA PRLGLAEPSV LRKAEEFLRL SKVKCVSLSA RSSETSNAVI
60 70 80 90 100
CLDLAASCRK CPLDRAYLIR LSGLNKMMYQ SCLKSFECLL GLNSNVGIRD
110 120 130 140 150
LAVQFSCTEA VNLAAEILQS YKSGLPETQR ADLDLSRPLF TTAALLSACK
160 170 180 190 200
ILKIKVDKTK MITTSGVKKA ILDRLCKQLE KIGQQINRDS ADLARPALKR
210 220 230 240 250
KKPEFSPTLK KKEPGLEPPA KEIEVIETLH KLPKDEDLTQ DYEEWKRKIL
260
ENAAKAQTAT AE
Length:262
Mass (Da):29,188
Last modified:November 1, 1999 - v1
Checksum:iF8D27EF9C87DE16C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139659 mRNA. Translation: AAD32667.1.
CCDSiCCDS22497.1.
UniGeneiMm.29709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139659 mRNA. Translation: AAD32667.1.
CCDSiCCDS22497.1.
UniGeneiMm.29709.

3D structure databases

ProteinModelPortaliQ9WUJ8.
SMRiQ9WUJ8. Positions 94-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034132.

PTM databases

iPTMnetiQ9WUJ8.
PhosphoSiteiQ9WUJ8.

Proteomic databases

EPDiQ9WUJ8.
MaxQBiQ9WUJ8.
PaxDbiQ9WUJ8.
PRIDEiQ9WUJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1929285. Orc6.

Phylogenomic databases

eggNOGiKOG4557. Eukaryota.
ENOG4111GUY. LUCA.
HOGENOMiHOG000065679.
HOVERGENiHBG007876.
InParanoidiQ9WUJ8.
PhylomeDBiQ9WUJ8.

Miscellaneous databases

ChiTaRSiOrc6. mouse.
PROiQ9WUJ8.
SOURCEiSearch...

Family and domain databases

InterProiIPR008721. ORC6.
IPR020529. ORC6_met/pln.
[Graphical view]
PfamiPF05460. ORC6. 1 hit.
[Graphical view]
ProDomiPD315657. Origin_recog_cplx_su6-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "cDNA Cloning of a homolog for Saccharomyces cerevisiae ORC6 from Mus musculus."
    Dean F.B., O'Donnell M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells."
    Kneissl M., Puetter V., Szalay A.A., Grummt F.
    J. Mol. Biol. 327:111-128(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DBF4.

Entry informationi

Entry nameiORC6_MOUSE
AccessioniPrimary (citable) accession number: Q9WUJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: March 16, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.