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Protein

Four and a half LIM domains protein 1

Gene

Fhl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3125C4-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 1
Short name:
FHL-1
Gene namesi
Name:Fhl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2615. Fhl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 280279Four and a half LIM domains protein 1PRO_0000234933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity
Cross-linki86 – 86Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9WUH4.
PRIDEiQ9WUH4.

PTM databases

iPTMnetiQ9WUH4.

Expressioni

Gene expression databases

ExpressionAtlasiQ9WUH4. baseline and differential.
GenevisibleiQ9WUH4. RN.

Interactioni

Protein-protein interaction databases

BioGridi247233. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9WUH4.
SMRiQ9WUH4. Positions 37-159, 162-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9253LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini101 – 15353LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini162 – 21251LIM zinc-binding 3PROSITE-ProRule annotationAdd
BLAST
Domaini221 – 27656LIM zinc-binding 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3125C4-typeSequence analysisAdd
BLAST

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410INGE. Eukaryota.
ENOG410XSPV. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ9WUH4.
KOiK14365.
PhylomeDBiQ9WUH4.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKFDCHYC RDPLQGKKYV QKDGRHCCLK CFDKFCANTC VECRKPISAD
60 70 80 90 100
AKEVHYKNRY WHDTCFRCAK CLHPLASETF VSKDGKILCN KCATREDSPR
110 120 130 140 150
CKGCFKAIVA GDQNVEYKGT IWHKDCFTCS NCKQVIGTGS FFPKGEDFYC
160 170 180 190 200
VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHAECFVCVT CSKKLAGQRF
210 220 230 240 250
TAVEDQYYCV DCYKNFVAKK CAGCKNPITG FGKGSSVVAY EGQSWHDYCF
260 270 280
HCKKCSVNLA NKRFVFHNEQ VYCPDCAKKL
Length:280
Mass (Da):31,904
Last modified:November 1, 1999 - v1
Checksum:iD9738C08B4707027
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134773 mRNA. Translation: AAD32624.1.
RefSeqiNP_001258128.1. NM_001271199.1.
NP_001258129.1. NM_001271200.1.
UniGeneiRn.54261.

Genome annotation databases

EnsembliENSRNOT00000084594; ENSRNOP00000074052; ENSRNOG00000000875.
ENSRNOT00000087274; ENSRNOP00000074817; ENSRNOG00000000875.
GeneIDi25177.
KEGGirno:25177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134773 mRNA. Translation: AAD32624.1.
RefSeqiNP_001258128.1. NM_001271199.1.
NP_001258129.1. NM_001271200.1.
UniGeneiRn.54261.

3D structure databases

ProteinModelPortaliQ9WUH4.
SMRiQ9WUH4. Positions 37-159, 162-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247233. 1 interaction.

PTM databases

iPTMnetiQ9WUH4.

Proteomic databases

PaxDbiQ9WUH4.
PRIDEiQ9WUH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084594; ENSRNOP00000074052; ENSRNOG00000000875.
ENSRNOT00000087274; ENSRNOP00000074817; ENSRNOG00000000875.
GeneIDi25177.
KEGGirno:25177.

Organism-specific databases

CTDi2273.
RGDi2615. Fhl1.

Phylogenomic databases

eggNOGiENOG410INGE. Eukaryota.
ENOG410XSPV. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ9WUH4.
KOiK14365.
PhylomeDBiQ9WUH4.

Miscellaneous databases

PROiQ9WUH4.

Gene expression databases

ExpressionAtlasiQ9WUH4. baseline and differential.
GenevisibleiQ9WUH4. RN.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat FHL1 protein sequence is very similar to its mouse and human counterparts."
    Morgan M.J.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFHL1_RAT
AccessioniPrimary (citable) accession number: Q9WUH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.