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Protein

Transmembrane protein 115

Gene

Tmem115

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115Curated
Alternative name(s):
Protein PL6 homologCurated
Gene namesi
Name:Tmem115Imported
Synonyms:Pl6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930765. Tmem115.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicCuratedAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini41 – 9757LumenalCuratedAdd
BLAST
Transmembranei98 – 11821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini119 – 1268CytoplasmicCurated
Transmembranei127 – 14721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 16518LumenalCuratedAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini187 – 350164CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Transmembrane protein 115PRO_0000058452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WUH1.
MaxQBiQ9WUH1.
PaxDbiQ9WUH1.
PRIDEiQ9WUH1.

PTM databases

iPTMnetiQ9WUH1.
PhosphoSiteiQ9WUH1.
SwissPalmiQ9WUH1.

Expressioni

Gene expression databases

BgeeiQ9WUH1.
CleanExiMM_TMEM115.
ExpressionAtlasiQ9WUH1. baseline and differential.
GenevisibleiQ9WUH1. MM.

Interactioni

Subunit structurei

Homooligomer. Interacts with COPB1. May interact with LMAN1. Interacts with the COG complex; probably through COG3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207950. 3 interactions.
STRINGi10090.ENSMUSP00000010189.

Structurei

3D structure databases

ProteinModelPortaliQ9WUH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 205205Mediates homooligomerizationBy similarityAdd
BLAST
Regioni206 – 22924Mediates localization to the GolgiBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2890. Eukaryota.
ENOG410XQM0. LUCA.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ9WUH1.
OMAiVCGRSER.
OrthoDBiEOG7XH6QP.
PhylomeDBiQ9WUH1.
TreeFamiTF315100.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRALPGARQ HLGAILASAS VVVKALCAVV LFLYLLSFAV DTGCLAVTPG
60 70 80 90 100
YLFPPNFWIW TLATHGLMEQ HVWDVAISLA TVVVAGRLLE PLWGALELLI
110 120 130 140 150
FFSVVNVSVG LLGALAYLLT YMASFNLVYL FTIRIHGALG FLGGVLVALK
160 170 180 190 200
QTMGDCVVLR VPQVRVSVVP MLLLALLLLL RLATLLQSPA LASYGFGLLS
210 220 230 240 250
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHGLLVKV
260 270 280 290 300
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
310 320 330 340 350
QSAWPSMDDD EEEAGAKTDS PLPLEEASTP PGKVTVPESS LITLETAPLL
Length:350
Mass (Da):38,099
Last modified:November 1, 1999 - v1
Checksum:i9D8B9B164CA2842D
GO

Sequence cautioni

The sequence AAH09099.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134238 mRNA. Translation: AAD24193.1.
BC009099 mRNA. Translation: AAH09099.1. Different initiation.
BC019473 mRNA. Translation: AAH19473.1.
CCDSiCCDS23490.1.
RefSeqiNP_062678.1. NM_019704.2.
UniGeneiMm.260153.

Genome annotation databases

EnsembliENSMUST00000010189; ENSMUSP00000010189; ENSMUSG00000010045.
GeneIDi56395.
KEGGimmu:56395.
UCSCiuc009rlk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134238 mRNA. Translation: AAD24193.1.
BC009099 mRNA. Translation: AAH09099.1. Different initiation.
BC019473 mRNA. Translation: AAH19473.1.
CCDSiCCDS23490.1.
RefSeqiNP_062678.1. NM_019704.2.
UniGeneiMm.260153.

3D structure databases

ProteinModelPortaliQ9WUH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207950. 3 interactions.
STRINGi10090.ENSMUSP00000010189.

PTM databases

iPTMnetiQ9WUH1.
PhosphoSiteiQ9WUH1.
SwissPalmiQ9WUH1.

Proteomic databases

EPDiQ9WUH1.
MaxQBiQ9WUH1.
PaxDbiQ9WUH1.
PRIDEiQ9WUH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010189; ENSMUSP00000010189; ENSMUSG00000010045.
GeneIDi56395.
KEGGimmu:56395.
UCSCiuc009rlk.1. mouse.

Organism-specific databases

CTDi11070.
MGIiMGI:1930765. Tmem115.

Phylogenomic databases

eggNOGiKOG2890. Eukaryota.
ENOG410XQM0. LUCA.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ9WUH1.
OMAiVCGRSER.
OrthoDBiEOG7XH6QP.
PhylomeDBiQ9WUH1.
TreeFamiTF315100.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

NextBioi312496.
PROiQ9WUH1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUH1.
CleanExiMM_TMEM115.
ExpressionAtlasiQ9WUH1. baseline and differential.
GenevisibleiQ9WUH1. MM.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse ortholog of the human gene PL6."
    Ivanov S., Minna J., Lerman M.I.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTM115_MOUSE
AccessioniPrimary (citable) accession number: Q9WUH1
Secondary accession number(s): Q91VT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1999
Last modified: March 16, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.