Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 115

Gene

Tmem115

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115Curated
Alternative name(s):
Protein PL6 homologCurated
Gene namesi
Name:Tmem115Imported
Synonyms:Pl6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930765. Tmem115.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicCuratedAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 97LumenalCuratedAdd BLAST57
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 126CytoplasmicCurated8
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 165LumenalCuratedAdd BLAST18
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 350CytoplasmicCuratedAdd BLAST164

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584521 – 350Transmembrane protein 115Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WUH1.
MaxQBiQ9WUH1.
PaxDbiQ9WUH1.
PRIDEiQ9WUH1.

PTM databases

iPTMnetiQ9WUH1.
PhosphoSitePlusiQ9WUH1.
SwissPalmiQ9WUH1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000010045.
CleanExiMM_TMEM115.
ExpressionAtlasiQ9WUH1. baseline and differential.
GenevisibleiQ9WUH1. MM.

Interactioni

Subunit structurei

Homooligomer. Interacts with COPB1. May interact with LMAN1. Interacts with the COG complex; probably through COG3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207950. 3 interactors.
STRINGi10090.ENSMUSP00000010189.

Structurei

3D structure databases

ProteinModelPortaliQ9WUH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 205Mediates homooligomerizationBy similarityAdd BLAST205
Regioni206 – 229Mediates localization to the GolgiBy similarityAdd BLAST24

Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2890. Eukaryota.
ENOG410XQM0. LUCA.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ9WUH1.
OMAiLEIHLWE.
OrthoDBiEOG091G0B9B.
PhylomeDBiQ9WUH1.
TreeFamiTF315100.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRALPGARQ HLGAILASAS VVVKALCAVV LFLYLLSFAV DTGCLAVTPG
60 70 80 90 100
YLFPPNFWIW TLATHGLMEQ HVWDVAISLA TVVVAGRLLE PLWGALELLI
110 120 130 140 150
FFSVVNVSVG LLGALAYLLT YMASFNLVYL FTIRIHGALG FLGGVLVALK
160 170 180 190 200
QTMGDCVVLR VPQVRVSVVP MLLLALLLLL RLATLLQSPA LASYGFGLLS
210 220 230 240 250
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHGLLVKV
260 270 280 290 300
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
310 320 330 340 350
QSAWPSMDDD EEEAGAKTDS PLPLEEASTP PGKVTVPESS LITLETAPLL
Length:350
Mass (Da):38,099
Last modified:November 1, 1999 - v1
Checksum:i9D8B9B164CA2842D
GO

Sequence cautioni

The sequence AAH09099 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134238 mRNA. Translation: AAD24193.1.
BC009099 mRNA. Translation: AAH09099.1. Different initiation.
BC019473 mRNA. Translation: AAH19473.1.
CCDSiCCDS23490.1.
RefSeqiNP_062678.1. NM_019704.2.
UniGeneiMm.260153.

Genome annotation databases

EnsembliENSMUST00000010189; ENSMUSP00000010189; ENSMUSG00000010045.
GeneIDi56395.
KEGGimmu:56395.
UCSCiuc009rlk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134238 mRNA. Translation: AAD24193.1.
BC009099 mRNA. Translation: AAH09099.1. Different initiation.
BC019473 mRNA. Translation: AAH19473.1.
CCDSiCCDS23490.1.
RefSeqiNP_062678.1. NM_019704.2.
UniGeneiMm.260153.

3D structure databases

ProteinModelPortaliQ9WUH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207950. 3 interactors.
STRINGi10090.ENSMUSP00000010189.

PTM databases

iPTMnetiQ9WUH1.
PhosphoSitePlusiQ9WUH1.
SwissPalmiQ9WUH1.

Proteomic databases

EPDiQ9WUH1.
MaxQBiQ9WUH1.
PaxDbiQ9WUH1.
PRIDEiQ9WUH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010189; ENSMUSP00000010189; ENSMUSG00000010045.
GeneIDi56395.
KEGGimmu:56395.
UCSCiuc009rlk.1. mouse.

Organism-specific databases

CTDi11070.
MGIiMGI:1930765. Tmem115.

Phylogenomic databases

eggNOGiKOG2890. Eukaryota.
ENOG410XQM0. LUCA.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ9WUH1.
OMAiLEIHLWE.
OrthoDBiEOG091G0B9B.
PhylomeDBiQ9WUH1.
TreeFamiTF315100.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

PROiQ9WUH1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010045.
CleanExiMM_TMEM115.
ExpressionAtlasiQ9WUH1. baseline and differential.
GenevisibleiQ9WUH1. MM.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM115_MOUSE
AccessioniPrimary (citable) accession number: Q9WUH1
Secondary accession number(s): Q91VT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.