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Q9WUG6

- INSL5_MOUSE

UniProt

Q9WUG6 - INSL5_MOUSE

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Protein

Insulin-like peptide INSL5

Gene
Insl5, Rif, Rif2, Zins3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor By similarity.

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_198713. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like peptide INSL5
Short name:
Insulin-like peptide 5
Alternative name(s):
Relaxin/insulin-like factor 2
Relaxin/insulin-like protein
Cleaved into the following 2 chains:
Gene namesi
Name:Insl5
Synonyms:Rif, Rif2, Zins3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1346085. Insl5.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 4624Insulin-like peptide INSL5 B chainPRO_0000016166Add
BLAST
Propeptidei49 – 11466Connecting peptide Reviewed predictionPRO_0000016167Add
BLAST
Peptidei115 – 13521Insulin-like peptide INSL5 A chainPRO_0000016168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 122Interchain (between B and A chains) By similarity
Disulfide bondi41 ↔ 135Interchain (between B and A chains) By similarity
Disulfide bondi121 ↔ 126 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ9WUG6.

Expressioni

Tissue specificityi

Highest expression in colon with lower levels in thymus. Minimal levels in testis.1 Publication

Gene expression databases

BgeeiQ9WUG6.
CleanExiMM_INSL5.
GenevestigatoriQ9WUG6.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9WUG6.
SMRiQ9WUG6. Positions 23-51, 110-135.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38979.
GeneTreeiENSGT00510000049372.
HOGENOMiHOG000111888.
HOVERGENiHBG052135.
InParanoidiQ9WUG6.
OrthoDBiEOG73V6N0.
TreeFamiTF333404.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUG6-1 [UniParc]FASTAAdd to Basket

« Hide

MKGPTLALFL LLVLLAVVEV RSRQTVKLCG LDYVRTVIYI CASSRWRRHL    50
EGHFHSQQAE TRNYLQLLDR HEPSKKTLEH SLPKTDLSGQ ELVRDPQAPK 100
EGLWELKKHS VVSRRDLQAL CCREGCSMKE LSTLC 135
Length:135
Mass (Da):15,524
Last modified:November 1, 1999 - v1
Checksum:i05FF9A0F613DBF92
GO

Sequence cautioni

The sequence AAF09093.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133817 mRNA. Translation: AAD29687.1.
AF076971 mRNA. Translation: AAD48089.1.
AF054842 mRNA. Translation: AAF09093.1. Different initiation.
AF054843 mRNA. Translation: AAF09094.1.
BC010968 mRNA. Translation: AAH10968.1.
CCDSiCCDS18406.1.
RefSeqiNP_001277577.1. NM_001290648.1.
NP_035961.1. NM_011831.2.
UniGeneiMm.100163.

Genome annotation databases

EnsembliENSMUST00000084382; ENSMUSP00000081416; ENSMUSG00000066090.
GeneIDi23919.
KEGGimmu:23919.
UCSCiuc008txa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133817 mRNA. Translation: AAD29687.1 .
AF076971 mRNA. Translation: AAD48089.1 .
AF054842 mRNA. Translation: AAF09093.1 . Different initiation.
AF054843 mRNA. Translation: AAF09094.1 .
BC010968 mRNA. Translation: AAH10968.1 .
CCDSi CCDS18406.1.
RefSeqi NP_001277577.1. NM_001290648.1.
NP_035961.1. NM_011831.2.
UniGenei Mm.100163.

3D structure databases

ProteinModelPortali Q9WUG6.
SMRi Q9WUG6. Positions 23-51, 110-135.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9WUG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084382 ; ENSMUSP00000081416 ; ENSMUSG00000066090 .
GeneIDi 23919.
KEGGi mmu:23919.
UCSCi uc008txa.1. mouse.

Organism-specific databases

CTDi 10022.
MGIi MGI:1346085. Insl5.

Phylogenomic databases

eggNOGi NOG38979.
GeneTreei ENSGT00510000049372.
HOGENOMi HOG000111888.
HOVERGENi HBG052135.
InParanoidi Q9WUG6.
OrthoDBi EOG73V6N0.
TreeFami TF333404.

Enzyme and pathway databases

Reactomei REACT_198713. Relaxin receptors.

Miscellaneous databases

NextBioi 303693.
PROi Q9WUG6.
SOURCEi Search...

Gene expression databases

Bgeei Q9WUG6.
CleanExi MM_INSL5.
Genevestigatori Q9WUG6.

Family and domain databases

Gene3Di 1.10.100.10. 2 hits.
InterProi IPR016179. Insulin-like.
IPR022353. Insulin_CS.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 2 hits.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of INSL5, a new member of the insulin superfamily."
    Conklin D., Lofton-Day C.E., Haldeman B.A., Ching A., Whitmore T.E., Lok S., Jaspers S.
    Genomics 60:50-56(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Colon.
  2. "Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney."
    Hsu S.Y.
    Mol. Endocrinol. 13:2163-2174(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB.
    Tissue: Ovary.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiINSL5_MOUSE
AccessioniPrimary (citable) accession number: Q9WUG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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