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Q9WUG6 (INSL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like peptide INSL5

Short name=Insulin-like peptide 5
Alternative name(s):
Relaxin/insulin-like factor 2
Relaxin/insulin-like protein
Gene names
Name:Insl5
Synonyms:Rif, Rif2, Zins3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length135 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor By similarity.

Subunit structure

Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Highest expression in colon with lower levels in thymus. Minimal levels in testis. Ref.1

Sequence similarities

Belongs to the insulin family.

Sequence caution

The sequence AAF09093.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 4624Insulin-like peptide INSL5 B chain
PRO_0000016166
Propeptide49 – 11466Connecting peptide Potential
PRO_0000016167
Peptide115 – 13521Insulin-like peptide INSL5 A chain
PRO_0000016168

Amino acid modifications

Disulfide bond29 ↔ 122Interchain (between B and A chains) By similarity
Disulfide bond41 ↔ 135Interchain (between B and A chains) By similarity
Disulfide bond121 ↔ 126 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WUG6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 05FF9A0F613DBF92

FASTA13515,524
        10         20         30         40         50         60 
MKGPTLALFL LLVLLAVVEV RSRQTVKLCG LDYVRTVIYI CASSRWRRHL EGHFHSQQAE 

        70         80         90        100        110        120 
TRNYLQLLDR HEPSKKTLEH SLPKTDLSGQ ELVRDPQAPK EGLWELKKHS VVSRRDLQAL 

       130 
CCREGCSMKE LSTLC 

« Hide

References

« Hide 'large scale' references
[1]"Identification of INSL5, a new member of the insulin superfamily."
Conklin D., Lofton-Day C.E., Haldeman B.A., Ching A., Whitmore T.E., Lok S., Jaspers S.
Genomics 60:50-56(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Colon.
[2]"Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney."
Hsu S.Y.
Mol. Endocrinol. 13:2163-2174(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB.
Tissue: Ovary.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF133817 mRNA. Translation: AAD29687.1.
AF076971 mRNA. Translation: AAD48089.1.
AF054842 mRNA. Translation: AAF09093.1. Different initiation.
AF054843 mRNA. Translation: AAF09094.1.
BC010968 mRNA. Translation: AAH10968.1.
CCDSCCDS18406.1.
RefSeqNP_001277577.1. NM_001290648.1.
NP_035961.1. NM_011831.2.
UniGeneMm.100163.

3D structure databases

ProteinModelPortalQ9WUG6.
SMRQ9WUG6. Positions 23-51, 110-135.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9WUG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084382; ENSMUSP00000081416; ENSMUSG00000066090.
GeneID23919.
KEGGmmu:23919.
UCSCuc008txa.1. mouse.

Organism-specific databases

CTD10022.
MGIMGI:1346085. Insl5.

Phylogenomic databases

eggNOGNOG38979.
GeneTreeENSGT00510000049372.
HOGENOMHOG000111888.
HOVERGENHBG052135.
InParanoidQ9WUG6.
OrthoDBEOG73V6N0.
TreeFamTF333404.

Gene expression databases

BgeeQ9WUG6.
CleanExMM_INSL5.
GenevestigatorQ9WUG6.

Family and domain databases

Gene3D1.10.100.10. 2 hits.
InterProIPR016179. Insulin-like.
IPR022353. Insulin_CS.
[Graphical view]
PfamPF00049. Insulin. 1 hit.
[Graphical view]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 2 hits.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio303693.
PROQ9WUG6.
SOURCESearch...

Entry information

Entry nameINSL5_MOUSE
AccessionPrimary (citable) accession number: Q9WUG6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot