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Protein

Insulin-like peptide INSL5

Gene

Insl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of feeding behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like peptide INSL5
Short name:
Insulin-like peptide 5
Alternative name(s):
Relaxin/insulin-like factor 2
Relaxin/insulin-like protein
Cleaved into the following 2 chains:
Gene namesi
Name:Insl5
Synonyms:Rif, Rif2, Zins3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346085. Insl5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001616623 – 46Insulin-like peptide INSL5 B chainAdd BLAST24
PropeptideiPRO_000001616749 – 114Connecting peptideSequence analysisAdd BLAST66
PeptideiPRO_0000016168115 – 135Insulin-like peptide INSL5 A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 122Interchain (between B and A chains)By similarity
Disulfide bondi41 ↔ 135Interchain (between B and A chains)By similarity
Disulfide bondi121 ↔ 126By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9WUG6.
PRIDEiQ9WUG6.

Expressioni

Tissue specificityi

Highest expression in colon with lower levels in thymus. Minimal levels in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000066090.
CleanExiMM_INSL5.
ExpressionAtlasiQ9WUG6. baseline and differential.
GenevisibleiQ9WUG6. MM.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081416.

Structurei

3D structure databases

ProteinModelPortaliQ9WUG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4WA. Eukaryota.
ENOG410YMTH. LUCA.
GeneTreeiENSGT00510000049372.
HOGENOMiHOG000111888.
HOVERGENiHBG052135.
InParanoidiQ9WUG6.
KOiK05255.
TreeFamiTF333404.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGPTLALFL LLVLLAVVEV RSRQTVKLCG LDYVRTVIYI CASSRWRRHL
60 70 80 90 100
EGHFHSQQAE TRNYLQLLDR HEPSKKTLEH SLPKTDLSGQ ELVRDPQAPK
110 120 130
EGLWELKKHS VVSRRDLQAL CCREGCSMKE LSTLC
Length:135
Mass (Da):15,524
Last modified:November 1, 1999 - v1
Checksum:i05FF9A0F613DBF92
GO

Sequence cautioni

The sequence AAF09093 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133817 mRNA. Translation: AAD29687.1.
AF076971 mRNA. Translation: AAD48089.1.
AF054842 mRNA. Translation: AAF09093.1. Different initiation.
AF054843 mRNA. Translation: AAF09094.1.
BC010968 mRNA. Translation: AAH10968.1.
CCDSiCCDS18406.1.
RefSeqiNP_001277577.1. NM_001290648.1.
NP_035961.1. NM_011831.2.
UniGeneiMm.100163.

Genome annotation databases

EnsembliENSMUST00000084382; ENSMUSP00000081416; ENSMUSG00000066090.
GeneIDi23919.
KEGGimmu:23919.
UCSCiuc008txa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133817 mRNA. Translation: AAD29687.1.
AF076971 mRNA. Translation: AAD48089.1.
AF054842 mRNA. Translation: AAF09093.1. Different initiation.
AF054843 mRNA. Translation: AAF09094.1.
BC010968 mRNA. Translation: AAH10968.1.
CCDSiCCDS18406.1.
RefSeqiNP_001277577.1. NM_001290648.1.
NP_035961.1. NM_011831.2.
UniGeneiMm.100163.

3D structure databases

ProteinModelPortaliQ9WUG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081416.

Proteomic databases

PaxDbiQ9WUG6.
PRIDEiQ9WUG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084382; ENSMUSP00000081416; ENSMUSG00000066090.
GeneIDi23919.
KEGGimmu:23919.
UCSCiuc008txa.1. mouse.

Organism-specific databases

CTDi10022.
MGIiMGI:1346085. Insl5.

Phylogenomic databases

eggNOGiENOG410J4WA. Eukaryota.
ENOG410YMTH. LUCA.
GeneTreeiENSGT00510000049372.
HOGENOMiHOG000111888.
HOVERGENiHBG052135.
InParanoidiQ9WUG6.
KOiK05255.
TreeFamiTF333404.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-444821. Relaxin receptors.

Miscellaneous databases

PROiQ9WUG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066090.
CleanExiMM_INSL5.
ExpressionAtlasiQ9WUG6. baseline and differential.
GenevisibleiQ9WUG6. MM.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINSL5_MOUSE
AccessioniPrimary (citable) accession number: Q9WUG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.