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Q9WUG6

- INSL5_MOUSE

UniProt

Q9WUG6 - INSL5_MOUSE

Protein

Insulin-like peptide INSL5

Gene

Insl5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor By similarity.By similarity

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_198713. Relaxin receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like peptide INSL5
    Short name:
    Insulin-like peptide 5
    Alternative name(s):
    Relaxin/insulin-like factor 2
    Relaxin/insulin-like protein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Insl5
    Synonyms:Rif, Rif2, Zins3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1346085. Insl5.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 4624Insulin-like peptide INSL5 B chainPRO_0000016166Add
    BLAST
    Propeptidei49 – 11466Connecting peptideSequence AnalysisPRO_0000016167Add
    BLAST
    Peptidei115 – 13521Insulin-like peptide INSL5 A chainPRO_0000016168Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 122Interchain (between B and A chains)By similarity
    Disulfide bondi41 ↔ 135Interchain (between B and A chains)By similarity
    Disulfide bondi121 ↔ 126By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ9WUG6.

    Expressioni

    Tissue specificityi

    Highest expression in colon with lower levels in thymus. Minimal levels in testis.1 Publication

    Gene expression databases

    BgeeiQ9WUG6.
    CleanExiMM_INSL5.
    GenevestigatoriQ9WUG6.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUG6.
    SMRiQ9WUG6. Positions 23-51, 110-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38979.
    GeneTreeiENSGT00510000049372.
    HOGENOMiHOG000111888.
    HOVERGENiHBG052135.
    InParanoidiQ9WUG6.
    OrthoDBiEOG73V6N0.
    TreeFamiTF333404.

    Family and domain databases

    Gene3Di1.10.100.10. 2 hits.
    InterProiIPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 2 hits.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WUG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGPTLALFL LLVLLAVVEV RSRQTVKLCG LDYVRTVIYI CASSRWRRHL    50
    EGHFHSQQAE TRNYLQLLDR HEPSKKTLEH SLPKTDLSGQ ELVRDPQAPK 100
    EGLWELKKHS VVSRRDLQAL CCREGCSMKE LSTLC 135
    Length:135
    Mass (Da):15,524
    Last modified:November 1, 1999 - v1
    Checksum:i05FF9A0F613DBF92
    GO

    Sequence cautioni

    The sequence AAF09093.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133817 mRNA. Translation: AAD29687.1.
    AF076971 mRNA. Translation: AAD48089.1.
    AF054842 mRNA. Translation: AAF09093.1. Different initiation.
    AF054843 mRNA. Translation: AAF09094.1.
    BC010968 mRNA. Translation: AAH10968.1.
    CCDSiCCDS18406.1.
    RefSeqiNP_001277577.1. NM_001290648.1.
    NP_035961.1. NM_011831.2.
    UniGeneiMm.100163.

    Genome annotation databases

    EnsembliENSMUST00000084382; ENSMUSP00000081416; ENSMUSG00000066090.
    GeneIDi23919.
    KEGGimmu:23919.
    UCSCiuc008txa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133817 mRNA. Translation: AAD29687.1 .
    AF076971 mRNA. Translation: AAD48089.1 .
    AF054842 mRNA. Translation: AAF09093.1 . Different initiation.
    AF054843 mRNA. Translation: AAF09094.1 .
    BC010968 mRNA. Translation: AAH10968.1 .
    CCDSi CCDS18406.1.
    RefSeqi NP_001277577.1. NM_001290648.1.
    NP_035961.1. NM_011831.2.
    UniGenei Mm.100163.

    3D structure databases

    ProteinModelPortali Q9WUG6.
    SMRi Q9WUG6. Positions 23-51, 110-135.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9WUG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084382 ; ENSMUSP00000081416 ; ENSMUSG00000066090 .
    GeneIDi 23919.
    KEGGi mmu:23919.
    UCSCi uc008txa.1. mouse.

    Organism-specific databases

    CTDi 10022.
    MGIi MGI:1346085. Insl5.

    Phylogenomic databases

    eggNOGi NOG38979.
    GeneTreei ENSGT00510000049372.
    HOGENOMi HOG000111888.
    HOVERGENi HBG052135.
    InParanoidi Q9WUG6.
    OrthoDBi EOG73V6N0.
    TreeFami TF333404.

    Enzyme and pathway databases

    Reactomei REACT_198713. Relaxin receptors.

    Miscellaneous databases

    NextBioi 303693.
    PROi Q9WUG6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WUG6.
    CleanExi MM_INSL5.
    Genevestigatori Q9WUG6.

    Family and domain databases

    Gene3Di 1.10.100.10. 2 hits.
    InterProi IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 2 hits.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of INSL5, a new member of the insulin superfamily."
      Conklin D., Lofton-Day C.E., Haldeman B.A., Ching A., Whitmore T.E., Lok S., Jaspers S.
      Genomics 60:50-56(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Colon.
    2. "Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney."
      Hsu S.Y.
      Mol. Endocrinol. 13:2163-2174(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB.
      Tissue: Ovary.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiINSL5_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3