Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9WUF2

- EGR4_MOUSE

UniProt

Q9WUF2 - EGR4_MOUSE

Protein

Early growth response protein 4

Gene

Egr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cellular response to cAMP Source: RefGenome
    2. cellular response to gonadotropin stimulus Source: RefGenome
    3. negative regulation of apoptotic process Source: RefGenome
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Early growth response protein 4
    Short name:
    EGR-4
    Gene namesi
    Name:Egr4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:99252. Egr4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Early growth response protein 4PRO_0000047129Add
    BLAST

    Proteomic databases

    PRIDEiQ9WUF2.

    Expressioni

    Gene expression databases

    BgeeiQ9WUF2.
    CleanExiMM_EGR4.
    GenevestigatoriQ9WUF2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUF2.
    SMRiQ9WUF2. Positions 370-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00550000074455.
    HOGENOMiHOG000112347.
    HOVERGENiHBG005574.
    InParanoidiQ9WUF2.
    KOiK12498.
    OMAiCFLEGPA.
    OrthoDBiEOG7Z69C7.
    PhylomeDBiQ9WUF2.
    TreeFamiTF318980.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WUF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHLSDFSGS DALLSKPTEG CAHASPELPR LPARDAPSAA AYPGGDFLSW    50
    ALSSCGAGGD LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF 100
    NLMSGILGLA PFPGPEAAAS RSPLDVPFPA GPDALLPDLY SPDLSSAAFP 150
    EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG LRAPPASPAL DAAASAFKGP 200
    YAPWELLSAG VPGNCGSQGS FQTTPEARFS AVGTKVEDLL SISCPAELPG 250
    PAARLYQAGA YDTFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA 300
    APPAQLSPLG LRGAATADFS KPLVADLPGG SGVAAPSSPA ASFPAAKARR 350
    KGRRGGKCSA RCFCPRPHVK AFACPVESCV RSFARSDELN RHLRIHTGHK 400
    PFQCRICLRN FSRSDHLTTH VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK 450
    VHLKQKARAE ERLKGLGFYS LGLSFAAL 478
    Length:478
    Mass (Da):49,554
    Last modified:November 1, 1999 - v1
    Checksum:i495926882CE4E371
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132613 Genomic DNA. Translation: AAD28267.1.
    CCDSiCCDS20297.1.
    RefSeqiNP_065621.1. NM_020596.2.
    UniGeneiMm.44137.

    Genome annotation databases

    EnsembliENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341.
    GeneIDi13656.
    KEGGimmu:13656.
    UCSCiuc009cpy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132613 Genomic DNA. Translation: AAD28267.1 .
    CCDSi CCDS20297.1.
    RefSeqi NP_065621.1. NM_020596.2.
    UniGenei Mm.44137.

    3D structure databases

    ProteinModelPortali Q9WUF2.
    SMRi Q9WUF2. Positions 370-453.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9WUF2.

    Protocols and materials databases

    DNASUi 13656.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095759 ; ENSMUSP00000093433 ; ENSMUSG00000071341 .
    GeneIDi 13656.
    KEGGi mmu:13656.
    UCSCi uc009cpy.1. mouse.

    Organism-specific databases

    CTDi 1961.
    MGIi MGI:99252. Egr4.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00550000074455.
    HOGENOMi HOG000112347.
    HOVERGENi HBG005574.
    InParanoidi Q9WUF2.
    KOi K12498.
    OMAi CFLEGPA.
    OrthoDBi EOG7Z69C7.
    PhylomeDBi Q9WUF2.
    TreeFami TF318980.

    Miscellaneous databases

    NextBioi 284396.
    PROi Q9WUF2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WUF2.
    CleanExi MM_EGR4.
    Genevestigatori Q9WUF2.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice."
      Tourtellotte W.G., Nagarajan R., Auyeung A., Mueller C., Milbrandt J.
      Development 126:5061-5071(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiEGR4_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3