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Protein

Early growth response protein 4

Gene

Egr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. cellular response to cAMP Source: GO_Central
  2. cellular response to gonadotropin stimulus Source: GO_Central
  3. negative regulation of apoptotic process Source: GO_Central
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 4
Short name:
EGR-4
Gene namesi
Name:Egr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:99252. Egr4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Early growth response protein 4PRO_0000047129Add
BLAST

Proteomic databases

PRIDEiQ9WUF2.

Expressioni

Gene expression databases

BgeeiQ9WUF2.
CleanExiMM_EGR4.
ExpressionAtlasiQ9WUF2. baseline and differential.
GenevestigatoriQ9WUF2.

Structurei

3D structure databases

ProteinModelPortaliQ9WUF2.
SMRiQ9WUF2. Positions 370-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000112347.
HOVERGENiHBG005574.
InParanoidiQ9WUF2.
KOiK12498.
OMAiKCSARCF.
OrthoDBiEOG7Z69C7.
PhylomeDBiQ9WUF2.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHLSDFSGS DALLSKPTEG CAHASPELPR LPARDAPSAA AYPGGDFLSW
60 70 80 90 100
ALSSCGAGGD LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF
110 120 130 140 150
NLMSGILGLA PFPGPEAAAS RSPLDVPFPA GPDALLPDLY SPDLSSAAFP
160 170 180 190 200
EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG LRAPPASPAL DAAASAFKGP
210 220 230 240 250
YAPWELLSAG VPGNCGSQGS FQTTPEARFS AVGTKVEDLL SISCPAELPG
260 270 280 290 300
PAARLYQAGA YDTFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA
310 320 330 340 350
APPAQLSPLG LRGAATADFS KPLVADLPGG SGVAAPSSPA ASFPAAKARR
360 370 380 390 400
KGRRGGKCSA RCFCPRPHVK AFACPVESCV RSFARSDELN RHLRIHTGHK
410 420 430 440 450
PFQCRICLRN FSRSDHLTTH VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK
460 470
VHLKQKARAE ERLKGLGFYS LGLSFAAL
Length:478
Mass (Da):49,554
Last modified:November 1, 1999 - v1
Checksum:i495926882CE4E371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132613 Genomic DNA. Translation: AAD28267.1.
CCDSiCCDS20297.1.
RefSeqiNP_065621.1. NM_020596.2.
UniGeneiMm.44137.

Genome annotation databases

EnsembliENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341.
GeneIDi13656.
KEGGimmu:13656.
UCSCiuc009cpy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132613 Genomic DNA. Translation: AAD28267.1.
CCDSiCCDS20297.1.
RefSeqiNP_065621.1. NM_020596.2.
UniGeneiMm.44137.

3D structure databases

ProteinModelPortaliQ9WUF2.
SMRiQ9WUF2. Positions 370-453.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9WUF2.

Protocols and materials databases

DNASUi13656.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341.
GeneIDi13656.
KEGGimmu:13656.
UCSCiuc009cpy.1. mouse.

Organism-specific databases

CTDi1961.
MGIiMGI:99252. Egr4.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000112347.
HOVERGENiHBG005574.
InParanoidiQ9WUF2.
KOiK12498.
OMAiKCSARCF.
OrthoDBiEOG7Z69C7.
PhylomeDBiQ9WUF2.
TreeFamiTF318980.

Miscellaneous databases

NextBioi284396.
PROiQ9WUF2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUF2.
CleanExiMM_EGR4.
ExpressionAtlasiQ9WUF2. baseline and differential.
GenevestigatoriQ9WUF2.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice."
    Tourtellotte W.G., Nagarajan R., Auyeung A., Mueller C., Milbrandt J.
    Development 126:5061-5071(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiEGR4_MOUSE
AccessioniPrimary (citable) accession number: Q9WUF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.