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Q9WUF2 (EGR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Early growth response protein 4

Short name=EGR-4
Gene names
Name:Egr4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the EGR C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Early growth response protein 4
PRO_0000047129

Regions

Zinc finger372 – 39625C2H2-type 1
Zinc finger402 – 42423C2H2-type 2
Zinc finger430 – 45223C2H2-type 3

Sequences

Sequence LengthMass (Da)Tools
Q9WUF2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 495926882CE4E371

FASTA47849,554
        10         20         30         40         50         60 
MLHLSDFSGS DALLSKPTEG CAHASPELPR LPARDAPSAA AYPGGDFLSW ALSSCGAGGD 

        70         80         90        100        110        120 
LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF NLMSGILGLA PFPGPEAAAS 

       130        140        150        160        170        180 
RSPLDVPFPA GPDALLPDLY SPDLSSAAFP EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG 

       190        200        210        220        230        240 
LRAPPASPAL DAAASAFKGP YAPWELLSAG VPGNCGSQGS FQTTPEARFS AVGTKVEDLL 

       250        260        270        280        290        300 
SISCPAELPG PAARLYQAGA YDTFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA 

       310        320        330        340        350        360 
APPAQLSPLG LRGAATADFS KPLVADLPGG SGVAAPSSPA ASFPAAKARR KGRRGGKCSA 

       370        380        390        400        410        420 
RCFCPRPHVK AFACPVESCV RSFARSDELN RHLRIHTGHK PFQCRICLRN FSRSDHLTTH 

       430        440        450        460        470 
VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK VHLKQKARAE ERLKGLGFYS LGLSFAAL 

« Hide

References

[1]"Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice."
Tourtellotte W.G., Nagarajan R., Auyeung A., Mueller C., Milbrandt J.
Development 126:5061-5071(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132613 Genomic DNA. Translation: AAD28267.1.
CCDSCCDS20297.1.
RefSeqNP_065621.1. NM_020596.2.
UniGeneMm.44137.

3D structure databases

ProteinModelPortalQ9WUF2.
SMRQ9WUF2. Positions 370-453.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9WUF2.

Protocols and materials databases

DNASU13656.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341.
GeneID13656.
KEGGmmu:13656.
UCSCuc009cpy.1. mouse.

Organism-specific databases

CTD1961.
MGIMGI:99252. Egr4.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00550000074455.
HOGENOMHOG000112347.
HOVERGENHBG005574.
InParanoidQ9WUF2.
KOK12498.
OMACFLEGPA.
OrthoDBEOG7Z69C7.
PhylomeDBQ9WUF2.
TreeFamTF318980.

Gene expression databases

BgeeQ9WUF2.
CleanExMM_EGR4.
GenevestigatorQ9WUF2.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio284396.
PROQ9WUF2.
SOURCESearch...

Entry information

Entry nameEGR4_MOUSE
AccessionPrimary (citable) accession number: Q9WUF2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot