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Protein

Vomeronasal type-1 receptor 49

Gene

Vmn1r49

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor implicated in the regulation of social and reproductive behavior.2 Publications

GO - Molecular functioni

  • pheromone receptor activity Source: InterPro
  • receptor activity Source: MGI

GO - Biological processi

  • response to pheromone Source: UniProtKB-KW
  • sensory perception of chemical stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 49
Alternative name(s):
Vomeronasal receptor VRi2
Vomeronasal type-1 receptor B2
Gene namesi
Name:Vmn1r49
Synonyms:V1rb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1344384. Vmn1r49.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212ExtracellularSequence analysisAdd
BLAST
Transmembranei13 – 3321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini34 – 5017CytoplasmicSequence analysisAdd
BLAST
Transmembranei51 – 7121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini72 – 9322ExtracellularSequence analysisAdd
BLAST
Transmembranei94 – 11421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini115 – 13521CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 19034ExtracellularSequence analysisAdd
BLAST
Transmembranei191 – 21121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini212 – 23827CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 26910ExtracellularSequence analysis
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31020CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show a disrupted pattern of axonal projections to the accessory olfactory bulb. Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Vomeronasal type-1 receptor 49PRO_0000239974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Disulfide bondi85 ↔ 172PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUF1.
PRIDEiQ9WUF1.

PTM databases

iPTMnetiQ9WUF1.
PhosphoSiteiQ9WUF1.

Expressioni

Tissue specificityi

Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ.1 Publication

Gene expression databases

BgeeiENSMUSG00000095932.
CleanExiMM_V1RB2.
GenevisibleiQ9WUF1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071762.

Structurei

3D structure databases

ProteinModelPortaliQ9WUF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KEG8. Eukaryota.
ENOG4111AMP. LUCA.
GeneTreeiENSGT00530000062929.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9WUF1.
KOiK04614.
OrthoDBiEOG090A0AUS.
PhylomeDBiQ9WUF1.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKANLLHTD NNMKIILFSE VSVGISANTI LFFARLCKLL GENKPKPIDL
60 70 80 90 100
YIAFLSLTQL MLLITMGLIA VDMFMPWGRW NSTTCQSLIY LHRLLRGLAL
110 120 130 140 150
SATCLLNVLW TITLSSRSSC LTKFKHKSPH HISGAFLFFY VLYMSFSSHV
160 170 180 190 200
LVSIIVTPNL TSEDFMYVTQ SCSLLPMSYS RESRFSTLMA IRETFLISLM
210 220 230 240 250
ALSSGYMVAL LWRHKKQAQH LRSTSLSSKA SPEQRATRTI MLLTSLFVVL
260 270 280 290 300
YILERVVFQS RLKFKDCSVF YFVHIIMSHS YATVSPFVFI CTEKHIIKFW
310
ESIFGRIVNI
Length:310
Mass (Da):35,523
Last modified:November 1, 1999 - v1
Checksum:i65F9A3F4B44A1011
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132114 mRNA. Translation: AAD28626.1.
AF291490 Genomic DNA. Translation: AAG42084.1.
CCDSiCCDS20351.1.
RefSeqiNP_036041.1. NM_011911.1.
XP_006506128.1. XM_006506065.1.
UniGeneiMm.89985.

Genome annotation databases

EnsembliENSMUST00000071865; ENSMUSP00000071762; ENSMUSG00000095932.
ENSMUST00000203791; ENSMUSP00000145107; ENSMUSG00000095932.
GeneIDi24112.
KEGGimmu:24112.
UCSCiuc009cwt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132114 mRNA. Translation: AAD28626.1.
AF291490 Genomic DNA. Translation: AAG42084.1.
CCDSiCCDS20351.1.
RefSeqiNP_036041.1. NM_011911.1.
XP_006506128.1. XM_006506065.1.
UniGeneiMm.89985.

3D structure databases

ProteinModelPortaliQ9WUF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071762.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9WUF1.
PhosphoSiteiQ9WUF1.

Proteomic databases

PaxDbiQ9WUF1.
PRIDEiQ9WUF1.

Protocols and materials databases

DNASUi24112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071865; ENSMUSP00000071762; ENSMUSG00000095932.
ENSMUST00000203791; ENSMUSP00000145107; ENSMUSG00000095932.
GeneIDi24112.
KEGGimmu:24112.
UCSCiuc009cwt.1. mouse.

Organism-specific databases

CTDi24112.
MGIiMGI:1344384. Vmn1r49.

Phylogenomic databases

eggNOGiENOG410KEG8. Eukaryota.
ENOG4111AMP. LUCA.
GeneTreeiENSGT00530000062929.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9WUF1.
KOiK04614.
OrthoDBiEOG090A0AUS.
PhylomeDBiQ9WUF1.

Miscellaneous databases

PROiQ9WUF1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000095932.
CleanExiMM_V1RB2.
GenevisibleiQ9WUF1. MM.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1R49_MOUSE
AccessioniPrimary (citable) accession number: Q9WUF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.