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Protein

Protein Wnt-8b

Gene

Wnt8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

GO - Molecular functioni

  1. frizzled binding Source: GO_Central
  2. receptor binding Source: MGI

GO - Biological processi

  1. cell-cell signaling Source: MGI
  2. cell fate commitment Source: GO_Central
  3. negative regulation of gene expression Source: MGI
  4. neuron differentiation Source: GO_Central
  5. organ morphogenesis Source: MGI
  6. positive regulation of gene expression Source: MGI
  7. signal transduction Source: MGI
  8. Wnt signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.
REACT_317277. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_335672. TCF dependent signaling in response to WNT.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-8b
Gene namesi
Name:Wnt8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109485. Wnt8b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: GO_Central
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 350329Protein Wnt-8bPRO_0000041451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 64By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi103 ↔ 111By similarity
Disulfide bondi113 ↔ 131By similarity
Disulfide bondi179 ↔ 193By similarity
Disulfide bondi181 ↔ 188By similarity
Lipidationi185 – 1851O-palmitoleyl serineBy similarity
Disulfide bondi255 ↔ 293By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi271 ↔ 286By similarity
Disulfide bondi290 ↔ 332By similarity
Disulfide bondi308 ↔ 323By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi315 ↔ 316By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleylation leads to Wnt signaling pathway inhibition (By similarity).By similarity
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PRIDEiQ9WUD6.

PTM databases

PhosphoSiteiQ9WUD6.

Expressioni

Gene expression databases

BgeeiQ9WUD6.
CleanExiMM_WNT8B.
ExpressionAtlasiQ9WUD6. baseline and differential.
GenevestigatoriQ9WUD6.

Structurei

3D structure databases

ProteinModelPortaliQ9WUD6.
SMRiQ9WUD6. Positions 30-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG277037.
HOVERGENiHBG001595.
InParanoidiQ9WUD6.
PhylomeDBiQ9WUD6.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF94. PTHR12027:SF94. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLMKPVCVL LVTCVLHRSH AWSVNNFLMT GPKAYLVYSS SVAAGAQSGI
60 70 80 90 100
EECKYQFAWD RWNCPERALQ LSSHGGLRSA NRETAFVHAI SSAGVMYTLT
110 120 130 140 150
RNCSLGDFDN CGCDDSRNGQ LGGQGWLWGG CSDNVGFGEA ISKQFVDALE
160 170 180 190 200
TGQDARAAMN LHNNEAGRKA VKGTMKRTCK CHGVSGSCTT QTCWLQLPEF
210 220 230 240 250
REVGAHLKEK YHAALKVDLL QGAGNSAAGR GAIADTFRSI STRELVHLED
260 270 280 290 300
SPDYCLENKT LGLLGTEGRE CLRRGRALGR WERRSCRRLC GDCGLAVEER
310 320 330 340 350
RAETVSSCNC KFHWCCAVRC EQCRRRVTKY FCSRAERPPR GAAHKPGKNS
Length:350
Mass (Da):38,576
Last modified:November 1, 1999 - v1
Checksum:i69CEE7790461597A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130349 mRNA. Translation: AAD31816.1.
UniGeneiMm.88365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130349 mRNA. Translation: AAD31816.1.
UniGeneiMm.88365.

3D structure databases

ProteinModelPortaliQ9WUD6.
SMRiQ9WUD6. Positions 30-333.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9WUD6.

Proteomic databases

PRIDEiQ9WUD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109485. Wnt8b.

Phylogenomic databases

eggNOGiNOG277037.
HOVERGENiHBG001595.
InParanoidiQ9WUD6.
PhylomeDBiQ9WUD6.

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.
REACT_317277. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_335672. TCF dependent signaling in response to WNT.

Miscellaneous databases

PROiQ9WUD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WUD6.
CleanExiMM_WNT8B.
ExpressionAtlasiQ9WUD6. baseline and differential.
GenevestigatoriQ9WUD6.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF94. PTHR12027:SF94. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse Wnt8B is expressed in the developing forebrain and maps to chromosome 19."
    Richardson M., Redmond D., Watson C.J., Mason J.O.
    Mamm. Genome 10:923-925(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiWNT8B_MOUSE
AccessioniPrimary (citable) accession number: Q9WUD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 29, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.