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Q9WUD6

- WNT8B_MOUSE

UniProt

Q9WUD6 - WNT8B_MOUSE

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Protein

Protein Wnt-8b

Gene

Wnt8b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. receptor binding Source: MGI

GO - Biological processi

  1. cell-cell signaling Source: MGI
  2. cell fate commitment Source: RefGenome
  3. negative regulation of gene expression Source: MGI
  4. neuron differentiation Source: RefGenome
  5. organ morphogenesis Source: MGI
  6. positive regulation of gene expression Source: MGI
  7. signal transduction Source: MGI
  8. Wnt signaling pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
REACT_213918. WNT ligand biogenesis and trafficking.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-8b
Gene namesi
Name:Wnt8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:109485. Wnt8b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RefGenome
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 350329Protein Wnt-8bPRO_0000041451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 64By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi103 ↔ 111By similarity
Disulfide bondi113 ↔ 131By similarity
Disulfide bondi179 ↔ 193By similarity
Disulfide bondi181 ↔ 188By similarity
Disulfide bondi255 ↔ 293By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi271 ↔ 286By similarity
Disulfide bondi290 ↔ 332By similarity
Disulfide bondi308 ↔ 323By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi315 ↔ 316By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9WUD6.

PTM databases

PhosphoSiteiQ9WUD6.

Expressioni

Gene expression databases

BgeeiQ9WUD6.
CleanExiMM_WNT8B.
ExpressionAtlasiQ9WUD6. baseline and differential.
GenevestigatoriQ9WUD6.

Structurei

3D structure databases

ProteinModelPortaliQ9WUD6.
SMRiQ9WUD6. Positions 30-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG277037.
HOVERGENiHBG001595.
InParanoidiQ9WUD6.
PhylomeDBiQ9WUD6.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF94. PTHR12027:SF94. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUD6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLMKPVCVL LVTCVLHRSH AWSVNNFLMT GPKAYLVYSS SVAAGAQSGI
60 70 80 90 100
EECKYQFAWD RWNCPERALQ LSSHGGLRSA NRETAFVHAI SSAGVMYTLT
110 120 130 140 150
RNCSLGDFDN CGCDDSRNGQ LGGQGWLWGG CSDNVGFGEA ISKQFVDALE
160 170 180 190 200
TGQDARAAMN LHNNEAGRKA VKGTMKRTCK CHGVSGSCTT QTCWLQLPEF
210 220 230 240 250
REVGAHLKEK YHAALKVDLL QGAGNSAAGR GAIADTFRSI STRELVHLED
260 270 280 290 300
SPDYCLENKT LGLLGTEGRE CLRRGRALGR WERRSCRRLC GDCGLAVEER
310 320 330 340 350
RAETVSSCNC KFHWCCAVRC EQCRRRVTKY FCSRAERPPR GAAHKPGKNS
Length:350
Mass (Da):38,576
Last modified:November 1, 1999 - v1
Checksum:i69CEE7790461597A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130349 mRNA. Translation: AAD31816.1.
UniGeneiMm.88365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130349 mRNA. Translation: AAD31816.1 .
UniGenei Mm.88365.

3D structure databases

ProteinModelPortali Q9WUD6.
SMRi Q9WUD6. Positions 30-333.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WUD6.

Proteomic databases

PRIDEi Q9WUD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:109485. Wnt8b.

Phylogenomic databases

eggNOGi NOG277037.
HOVERGENi HBG001595.
InParanoidi Q9WUD6.
PhylomeDBi Q9WUD6.

Enzyme and pathway databases

Reactomei REACT_207044. TCF dependent signaling in response to WNT.
REACT_213918. WNT ligand biogenesis and trafficking.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

PROi Q9WUD6.
SOURCEi Search...

Gene expression databases

Bgeei Q9WUD6.
CleanExi MM_WNT8B.
ExpressionAtlasi Q9WUD6. baseline and differential.
Genevestigatori Q9WUD6.

Family and domain databases

InterProi IPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF94. PTHR12027:SF94. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse Wnt8B is expressed in the developing forebrain and maps to chromosome 19."
    Richardson M., Redmond D., Watson C.J., Mason J.O.
    Mamm. Genome 10:923-925(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiWNT8B_MOUSE
AccessioniPrimary (citable) accession number: Q9WUD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3