Q9WUD6 (WNT8B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-8b

Gene names

Name:

Wnt8b

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway involved in forebrain neuron fate commitment Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cell-cell signaling Traceable author statement PubMed 9889131. Source: MGI endoderm development Inferred from Biological aspect of Ancestor. Source: RefGenome eye development Inferred from Biological aspect of Ancestor. Source: RefGenome hypothalamus development Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome otic placode formation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of gene expression Inferred from mutant phenotype PubMed 19890917. Source: MGI
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 350	329	Protein Wnt-8b		PRO_0000041451
Amino acid modifications
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9WUD6 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 69CEE7790461597A	FASTA	350	38,576
	10 20 30 40 50 60 MFLMKPVCVL LVTCVLHRSH AWSVNNFLMT GPKAYLVYSS SVAAGAQSGI EECKYQFAWD 70 80 90 100 110 120 RWNCPERALQ LSSHGGLRSA NRETAFVHAI SSAGVMYTLT RNCSLGDFDN CGCDDSRNGQ 130 140 150 160 170 180 LGGQGWLWGG CSDNVGFGEA ISKQFVDALE TGQDARAAMN LHNNEAGRKA VKGTMKRTCK 190 200 210 220 230 240 CHGVSGSCTT QTCWLQLPEF REVGAHLKEK YHAALKVDLL QGAGNSAAGR GAIADTFRSI 250 260 270 280 290 300 STRELVHLED SPDYCLENKT LGLLGTEGRE CLRRGRALGR WERRSCRRLC GDCGLAVEER 310 320 330 340 350 RAETVSSCNC KFHWCCAVRC EQCRRRVTKY FCSRAERPPR GAAHKPGKNS

References

[1]	"Mouse Wnt8B is expressed in the developing forebrain and maps to chromosome 19." Richardson M., Redmond D., Watson C.J., Mason J.O. Mamm. Genome 10:923-925(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF130349 mRNA. Translation: AAD31816.1.
IPI	IPI00124527.
UniGene	Mm.88365.
3D structure databases
ProteinModelPortal	Q9WUD6.
SMR	Q9WUD6. Positions 30-333.
ModBase	Search...
PTM databases
PhosphoSite	Q9WUD6.
Proteomic databases
PRIDE	Q9WUD6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:109485. Wnt8b.
Phylogenomic databases
eggNOG	NOG277037.
HOVERGEN	HBG001595.
InParanoid	Q9WUD6.
OrthoDB	EOG4CNQRC.
Gene expression databases
ArrayExpress	Q9WUD6.
Bgee	Q9WUD6.
CleanEx	MM_WNT8B.
Genevestigator	Q9WUD6.
GermOnline	ENSMUSG00000036961. Mus musculus.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013301. Wnt8. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF6. PTHR12027:SF6. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01892. WNT8PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

WNT8B_MOUSE

Accession

Primary (citable) accession number: Q9WUD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program