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Q9WUD6

- WNT8B_MOUSE

UniProt

Q9WUD6 - WNT8B_MOUSE

Protein

Protein Wnt-8b

Gene

Wnt8b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor binding Source: MGI

    GO - Biological processi

    1. cell-cell signaling Source: MGI
    2. cell fate commitment Source: RefGenome
    3. negative regulation of gene expression Source: MGI
    4. neuron differentiation Source: RefGenome
    5. organ morphogenesis Source: MGI
    6. positive regulation of gene expression Source: MGI
    7. signal transduction Source: MGI
    8. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
    REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-8b
    Gene namesi
    Name:Wnt8b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:109485. Wnt8b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RefGenome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 350329Protein Wnt-8bPRO_0000041451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 64By similarity
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 111By similarity
    Disulfide bondi113 ↔ 131By similarity
    Disulfide bondi179 ↔ 193By similarity
    Disulfide bondi181 ↔ 188By similarity
    Disulfide bondi255 ↔ 293By similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi271 ↔ 286By similarity
    Disulfide bondi290 ↔ 332By similarity
    Disulfide bondi308 ↔ 323By similarity
    Disulfide bondi310 ↔ 320By similarity
    Disulfide bondi315 ↔ 316By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9WUD6.

    PTM databases

    PhosphoSiteiQ9WUD6.

    Expressioni

    Gene expression databases

    BgeeiQ9WUD6.
    CleanExiMM_WNT8B.
    GenevestigatoriQ9WUD6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WUD6.
    SMRiQ9WUD6. Positions 30-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG277037.
    HOVERGENiHBG001595.
    InParanoidiQ9WUD6.
    PhylomeDBiQ9WUD6.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF94. PTHR12027:SF94. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WUD6-1 [UniParc]FASTAAdd to Basket

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    MFLMKPVCVL LVTCVLHRSH AWSVNNFLMT GPKAYLVYSS SVAAGAQSGI    50
    EECKYQFAWD RWNCPERALQ LSSHGGLRSA NRETAFVHAI SSAGVMYTLT 100
    RNCSLGDFDN CGCDDSRNGQ LGGQGWLWGG CSDNVGFGEA ISKQFVDALE 150
    TGQDARAAMN LHNNEAGRKA VKGTMKRTCK CHGVSGSCTT QTCWLQLPEF 200
    REVGAHLKEK YHAALKVDLL QGAGNSAAGR GAIADTFRSI STRELVHLED 250
    SPDYCLENKT LGLLGTEGRE CLRRGRALGR WERRSCRRLC GDCGLAVEER 300
    RAETVSSCNC KFHWCCAVRC EQCRRRVTKY FCSRAERPPR GAAHKPGKNS 350
    Length:350
    Mass (Da):38,576
    Last modified:November 1, 1999 - v1
    Checksum:i69CEE7790461597A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130349 mRNA. Translation: AAD31816.1.
    UniGeneiMm.88365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130349 mRNA. Translation: AAD31816.1 .
    UniGenei Mm.88365.

    3D structure databases

    ProteinModelPortali Q9WUD6.
    SMRi Q9WUD6. Positions 30-333.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WUD6.

    Proteomic databases

    PRIDEi Q9WUD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:109485. Wnt8b.

    Phylogenomic databases

    eggNOGi NOG277037.
    HOVERGENi HBG001595.
    InParanoidi Q9WUD6.
    PhylomeDBi Q9WUD6.

    Enzyme and pathway databases

    Reactomei REACT_207044. TCF dependent signaling in response to WNT.
    REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Miscellaneous databases

    PROi Q9WUD6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WUD6.
    CleanExi MM_WNT8B.
    Genevestigatori Q9WUD6.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF94. PTHR12027:SF94. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Wnt8B is expressed in the developing forebrain and maps to chromosome 19."
      Richardson M., Redmond D., Watson C.J., Mason J.O.
      Mamm. Genome 10:923-925(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiWNT8B_MOUSE
    AccessioniPrimary (citable) accession number: Q9WUD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3