Reviewed, UniProtKB/Swiss-Prot Q9WUD6 (WNT8B_MOUSE)

Names and origin

Protein names

Recommended name:
    Protein Wnt-8b

Gene names

Name:

Wnt8b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro cell-cell signaling Traceable author statement. Source: MGI organ morphogenesis Traceable author statement. Source: MGI
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor binding Traceable author statement. Source: MGI signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 350	329	Protein Wnt-8b		PRO_0000041451
Amino acid modifications
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9WUD6-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 69CEE7790461597A	FASTA	350	38,576
	10 20 30 40 50 60 MFLMKPVCVL LVTCVLHRSH AWSVNNFLMT GPKAYLVYSS SVAAGAQSGI EECKYQFAWD 70 80 90 100 110 120 RWNCPERALQ LSSHGGLRSA NRETAFVHAI SSAGVMYTLT RNCSLGDFDN CGCDDSRNGQ 130 140 150 160 170 180 LGGQGWLWGG CSDNVGFGEA ISKQFVDALE TGQDARAAMN LHNNEAGRKA VKGTMKRTCK 190 200 210 220 230 240 CHGVSGSCTT QTCWLQLPEF REVGAHLKEK YHAALKVDLL QGAGNSAAGR GAIADTFRSI 250 260 270 280 290 300 STRELVHLED SPDYCLENKT LGLLGTEGRE CLRRGRALGR WERRSCRRLC GDCGLAVEER 310 320 330 340 350 RAETVSSCNC KFHWCCAVRC EQCRRRVTKY FCSRAERPPR GAAHKPGKNS

References

[1]	"Mouse Wnt8B is expressed in the developing forebrain and maps to chromosome 19." Richardson M., Redmond D., Watson C.J., Mason J.O. Mamm. Genome 10:923-925(1999) [PubMed: 10441746] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF130349 mRNA. Translation: AAD31816.1.
IPI	IPI00124527.
UniGene	Mm.88365
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000036961. Mus musculus. [Contig view]
KEGG	mmu:22423.
Organism-specific databases
MGI	MGI:109485. Wnt8b.
Phylogenomic databases
HOVERGEN	Q9WUD6.
Gene expression databases
ArrayExpress	Q9WUD6.
Bgee	Q9WUD6.
CleanEx	MM_WNT8B.
GermOnline	ENSMUSG00000036961. Mus musculus.
Family and domain databases
InterPro	IPR013301. Wnt8. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view]
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01892. WNT8PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	302861.
SOURCE	Search...

Entry information

Entry name

WNT8B_MOUSE

Accession

Primary (citable) accession number: Q9WUD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)