Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Copper transport protein ATOX1

Gene

Atox1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121CopperPROSITE-ProRule annotation
Metal bindingi15 – 151CopperPROSITE-ProRule annotation

GO - Molecular functioni

  • copper chaperone activity Source: Ensembl
  • copper ion binding Source: RGD
  • copper ion transmembrane transporter activity Source: RGD

GO - Biological processi

  • cellular copper ion homeostasis Source: RGD
  • copper ion transmembrane transport Source: GOC
  • intracellular copper ion transport Source: RGD
  • response to oxidative stress Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein ATOX1
Alternative name(s):
ATX1 homolog protein Rah1
Metal transport protein ATX1
Gene namesi
Name:Atox1
Synonyms:Rah1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621684. Atox1.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • intracellular Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Copper transport protein ATOX1PRO_0000212539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9WUC4.
PRIDEiQ9WUC4.

PTM databases

iPTMnetiQ9WUC4.

Expressioni

Gene expression databases

GenevisibleiQ9WUC4. RN.

Interactioni

Subunit structurei

Interacts with ATP7B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017588.

Structurei

3D structure databases

ProteinModelPortaliQ9WUC4.
SMRiQ9WUC4. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 6867HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATX1 family.Curated
Contains 1 HMA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1603. Eukaryota.
COG2608. LUCA.
GeneTreeiENSGT00390000005805.
HOGENOMiHOG000038877.
HOVERGENiHBG050610.
InParanoidiQ9WUC4.
KOiK07213.
OMAiHEFFVDM.
OrthoDBiEOG786H6B.
PhylomeDBiQ9WUC4.
TreeFamiTF352589.

Family and domain databases

InterProiIPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WUC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKHEFSVDM TCGGCAEAVS RVLNKLGGVE FNIDLPNKKV CIESEHSSDI
60
LLATLNKTGK AVSYLGPK
Length:68
Mass (Da):7,292
Last modified:November 1, 1999 - v1
Checksum:i57D01EC1FCDC6371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177671 mRNA. Translation: AAD53914.1.
AF127137 mRNA. Translation: AAD27844.1.
BC058458 mRNA. Translation: AAH58458.1.
PIRiJC7133.
RefSeqiNP_445811.1. NM_053359.2.
UniGeneiRn.11992.

Genome annotation databases

EnsembliENSRNOT00000017588; ENSRNOP00000017588; ENSRNOG00000013118.
GeneIDi84355.
KEGGirno:84355.
UCSCiRGD:621684. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177671 mRNA. Translation: AAD53914.1.
AF127137 mRNA. Translation: AAD27844.1.
BC058458 mRNA. Translation: AAH58458.1.
PIRiJC7133.
RefSeqiNP_445811.1. NM_053359.2.
UniGeneiRn.11992.

3D structure databases

ProteinModelPortaliQ9WUC4.
SMRiQ9WUC4. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017588.

PTM databases

iPTMnetiQ9WUC4.

Proteomic databases

PaxDbiQ9WUC4.
PRIDEiQ9WUC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017588; ENSRNOP00000017588; ENSRNOG00000013118.
GeneIDi84355.
KEGGirno:84355.
UCSCiRGD:621684. rat.

Organism-specific databases

CTDi475.
RGDi621684. Atox1.

Phylogenomic databases

eggNOGiKOG1603. Eukaryota.
COG2608. LUCA.
GeneTreeiENSGT00390000005805.
HOGENOMiHOG000038877.
HOVERGENiHBG050610.
InParanoidiQ9WUC4.
KOiK07213.
OMAiHEFFVDM.
OrthoDBiEOG786H6B.
PhylomeDBiQ9WUC4.
TreeFamiTF352589.

Miscellaneous databases

PROiQ9WUC4.

Gene expression databases

GenevisibleiQ9WUC4. RN.

Family and domain databases

InterProiIPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Expression profile of the copper homeostasis gene, rAtox1, in the rat brain."
    Naeve G.S., Vana A.M., Eggold J.R., Kelner G.S., Maki R., Desouza E.B., Foster A.C.
    Neuroscience 93:1179-1187(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  4. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 26-57, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiATOX1_RAT
AccessioniPrimary (citable) accession number: Q9WUC4
Secondary accession number(s): Q549B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.