T-type calcium channel isoform - Rattus norvegicus (Rat)

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Unreviewed, UniProtKB/TrEMBL Q9WUB8 (Q9WUB8_RAT)

Last modified January 19, 2010. Version 58. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
T-type calcium channel isoform EMBL AAD26858.1
Submitted name:
RCG32907, isoform CRA_b EMBL EDM05704.1

Gene names

Name:	Cacna1g RGD 68942
ORF Names:	rCG_32907 EMBL EDM05704.1

Organism

Rattus norvegicus (Rat) EMBL AAD26858.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	2288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	artery smooth muscle contraction Inferred from mutant phenotype. Source: RGD calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW elevation of cytosolic calcium ion concentration Inferred from mutant phenotype. Source: RGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	cell soma Inferred from direct assay. Source: RGD dendrite Inferred from direct assay. Source: RGD perinuclear region of cytoplasm Inferred from direct assay. Source: RGD voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW low voltage-gated calcium channel activity Inferred from direct assay. Source: RGD
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9WUB8-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B89DBB5A1D81757F
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FASTA

2,288

253,478

        10         20         30         40         50         60 
MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG LPYPALAPVV 

        70         80         90        100        110        120 
FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 

       130        140        150        160        170        180 
DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 

       190        200        210        220        230        240 
TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 

       250        260        270        280        290        300 
CFLPENFSLP LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCSL 

       310        320        330        340        350        360 
DYETYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 

       370        380        390        400        410        420 
YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 

       430        440        450        460        470        480 
STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAIGV RAGLLSSPVA RSGQEPQPSG 

       490        500        510        520        530        540 
SCTRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRVPRASPE IQDRDANGSR RLMLPPPSTP 

       550        560        570        580        590        600 
TPSGGPPRGA ESVHSFYHAD CHLEPVRCQA PPPRCPSEAS GRTVGSGKVY PTVHTSPPPE 

       610        620        630        640        650        660 
ILKDKALVEV APSPGPPTLT SFNIPPGPFS SMHKLLETQS TGACHSSCKI SSPCSKADSG 

       670        680        690        700        710        720 
ACGPDSCPYC ARTGAGEPES ADHVMPDSDS EAVYEFTQDA QHSDLRDPHS RRRQRSLGPD 

       730        740        750        760        770        780 
AEPSSVLAFW RLICDTFRKI VDSKYFGRGI MIAILVNTLS MGIEYHEQPE ELTNALEISN 

       790        800        810        820        830        840 
IVFTSLFALE MLLKLLVYGP FGYIKNPYNI FDGVIVVISV WEIVGQQGGG LSVLRTFRLM 

       850        860        870        880        890        900 
RVLKLVRFLP ALQRQLVVLM KTMDNVATFC MLLMLFIFIF SILGMHLFGC KFASERDGDT 

       910        920        930        940        950        960 
LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL YNGMASTSSW AALYFIALMT FGNYVLFNLL 

       970        980        990       1000       1010       1020 
VAILVEGFQA EEIGKREDAS GQLSCIQLPV NSQGGDATKS ESEPDFFSPS VDGDGDRKKR 

      1030       1040       1050       1060       1070       1080 
LALVALGEHA ELRKSLLPPL IIHTAATPMS LPKSSSTGVG EALGSGSRRT SSSGSAEPGA 

      1090       1100       1110       1120       1130       1140 
AHHEMKSPPS ARSSPHSPWS AASSWTSRRS SRNSLGRAPS LKRRSPSGER RSLLSGEGQE 

      1150       1160       1170       1180       1190       1200 
SQDEEESSEE DRASPAGSDH RHRGSLEREA KSSFDLPDTL QVPGLHRTAS GRSSASEHQD 

      1210       1220       1230       1240       1250       1260 
CNGKSASGRL ARTLRTDDPQ LDGDDDNDEG NLSKGERIQA WVRSRLPACC RERDSWSAYI 

      1270       1280       1290       1300       1310       1320 
FPPQSRFRLL CHRIITHKMF DHVVLVIIFL NCITIAMERP KIDPHSAERI FLTLSNYIFT 

      1330       1340       1350       1360       1370       1380 
AVFLAEMTVK VVALGWCFGE QAYLRSSWNV LDGLLVLISV IDILVSMVSD SGTKILGMLR 

      1390       1400       1410       1420       1430       1440 
VLRLLRTLRP LRVISRAQGL KLVVETLMSS LKPIGNIVVI CCAFFIIFGI LGVQLFKGKF 

      1450       1460       1470       1480       1490       1500 
FVCQGEDTRN ITNKSDCAEA SYRWVRHKYN FDNLGQALMS LFVLASKDGW VDIMYDGLDA 

      1510       1520       1530       1540       1550       1560 
VGVDQQPIMN HNPWMLLYFI SFLLIVAFFV LNMFVGVVVE NFHKCRQHQE EEEARRREEK 

      1570       1580       1590       1600       1610       1620 
RLRRLEKKRR NLMLDDVIAS GSSASAASEA QCKPYYSDYS RFRLLVHHLC TSHYLDLFIT 

      1630       1640       1650       1660       1670       1680 
GVIGLNVVTM AMEHYQQPQI LDEALKICNY IFTVIFVFES VFKLVAFGFR RFFQDRWNQL 

      1690       1700       1710       1720       1730       1740 
DLAIVLLSIM GITLEEIEVN ASLPINPTII RIMRVLRIAR VLKLLKMAVG MRALLDTVMQ 

      1750       1760       1770       1780       1790       1800 
ALPQVGNLGL LFMLLFFIFA ALGVELFGDL ECDETHPCEG LGRHATFRNF GMAFLTLFRV 

      1810       1820       1830       1840       1850       1860 
STGDNWNGIM KDTLRDCDQE STCYNTVISP IYFVSFVLTA QFVLVNVVIA VLMKHLEESN 

      1870       1880       1890       1900       1910       1920 
KEAKEEAELE AELELEMKTL SPQPHSPLGS PFLWPGVEGV NSPDSPKPGA PHTTAHIGAA 

      1930       1940       1950       1960       1970       1980 
SGFSLEHPTM VPHPEEVPVP LGPDLLTVRK SGVSRTHSLP NDSYMCRNGS TAERSLGHRG 

      1990       2000       2010       2020       2030       2040 
WGLPKAQSGS ILSVHSQPAD TSCILQLPKD VHYLLQPHGA PTWGAIPKLP PPGRSPLAQR 

      2050       2060       2070       2080       2090       2100 
PLRRQAAIRT DSLDVQGLGS REDLLSEVSG PSCPLTRSSS FWGGSSIQVQ QRSGIQSKVS 

      2110       2120       2130       2140       2150       2160 
KHIRLPAPCP GLEPSWAKDP PETRSSLELD TELSWISGDL LPSSQEEPLS PRDLKKCYSV 

      2170       2180       2190       2200       2210       2220 
ETQSCRRRPG SWLDEQRRHS IAVSCLDSGS QPRLCPSPSS LGGQPLGGPG SRPKKKLSPP 

      2230       2240       2250       2260       2270       2280 
SISIDPPESQ GSRPPCSPGV CLRRRAPASD SKDPSVSSPL DSTAASPSPK KDTLSLSGLS 


SDPTDMDP

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References

[1]	"Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells." Zhuang H., Bhattacharjee A., Hu F., Zhang M., Goswami T., Wang L., Wu S., Berggren P.O., Li M. Diabetes 49:59-64(2000) [PubMed: 10615950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Pancreas EMBL AAD26858.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM05704.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM05704.1.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AF125161 mRNA. Translation: AAD26858.1. CH473948 Genomic DNA. Translation: EDM05704.1.
IPI	IPI00950405.
UniGene	Rn.86960
3D structure databases
SMR	Q9WUB8. Positions 738-970, 1273-1545.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9WUB8.
Genome annotation databases
Ensembl	ENSRNOT00000067416; ENSRNOP00000061436; ENSRNOG00000002981; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q9WUB8.
Gene expression databases
ArrayExpress	Q9WUB8.
Genevestigator	Q9WUB8.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR005445. VDCC_T_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF44. TVDCCAlpha1. 1 hit.
Pfam	PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01629. TVDCCALPHA1.
ProtoNet	Search...

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Entry information

Entry name

Q9WUB8_RAT

Accession

Primary (citable) accession number: Q9WUB8

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	January 19, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information