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Protein
Submitted name:

RCG32907, isoform CRA_b

Gene

Cacna1g

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
RCG32907, isoform CRA_bImported
Submitted name:
T-type calcium channel isoformImported
Submitted name:
Voltage-dependent T-type calcium channel subunit alpha-1GImported
Gene namesi
Name:Cacna1gImported
ORF Names:rCG_32907Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68942. Cacna1g.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei123 – 14220HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23724HelicalSequence analysisAdd
BLAST
Transmembranei342 – 36322HelicalSequence analysisAdd
BLAST
Transmembranei369 – 39426HelicalSequence analysisAdd
BLAST
Transmembranei745 – 76319HelicalSequence analysisAdd
BLAST
Transmembranei775 – 79622HelicalSequence analysisAdd
BLAST
Transmembranei866 – 88520HelicalSequence analysisAdd
BLAST
Transmembranei942 – 96524HelicalSequence analysisAdd
BLAST
Transmembranei1279 – 129719HelicalSequence analysisAdd
BLAST
Transmembranei1317 – 133822HelicalSequence analysisAdd
BLAST
Transmembranei1350 – 136920HelicalSequence analysisAdd
BLAST
Transmembranei1414 – 143623HelicalSequence analysisAdd
BLAST
Transmembranei1516 – 153924HelicalSequence analysisAdd
BLAST
Transmembranei1614 – 163522HelicalSequence analysisAdd
BLAST
Transmembranei1647 – 167024HelicalSequence analysisAdd
BLAST
Transmembranei1748 – 176720HelicalSequence analysisAdd
BLAST
Transmembranei1831 – 185323HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061436.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 405326Ion_transInterPro annotationAdd
BLAST
Domaini744 – 970227Ion_transInterPro annotationAdd
BLAST
Domaini1277 – 1549273Ion_transInterPro annotationAdd
BLAST
Domaini1613 – 1863251Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1548 – 157528Sequence analysisAdd
BLAST
Coiled coili1852 – 187625Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000007742.
HOVERGENiHBG050764.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 7 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

Q9WUB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG
60 70 80 90 100
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM
110 120 130 140 150
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
160 170 180 190 200
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
210 220 230 240 250
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
260 270 280 290 300
LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCSL
310 320 330 340 350
DYETYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
360 370 380 390 400
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
410 420 430 440 450
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
460 470 480 490 500
LAQVSRAIGV RAGLLSSPVA RSGQEPQPSG SCTRSHRRLS VHHLVHHHHH
510 520 530 540 550
HHHHYHLGNG TLRVPRASPE IQDRDANGSR RLMLPPPSTP TPSGGPPRGA
560 570 580 590 600
ESVHSFYHAD CHLEPVRCQA PPPRCPSEAS GRTVGSGKVY PTVHTSPPPE
610 620 630 640 650
ILKDKALVEV APSPGPPTLT SFNIPPGPFS SMHKLLETQS TGACHSSCKI
660 670 680 690 700
SSPCSKADSG ACGPDSCPYC ARTGAGEPES ADHVMPDSDS EAVYEFTQDA
710 720 730 740 750
QHSDLRDPHS RRRQRSLGPD AEPSSVLAFW RLICDTFRKI VDSKYFGRGI
760 770 780 790 800
MIAILVNTLS MGIEYHEQPE ELTNALEISN IVFTSLFALE MLLKLLVYGP
810 820 830 840 850
FGYIKNPYNI FDGVIVVISV WEIVGQQGGG LSVLRTFRLM RVLKLVRFLP
860 870 880 890 900
ALQRQLVVLM KTMDNVATFC MLLMLFIFIF SILGMHLFGC KFASERDGDT
910 920 930 940 950
LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL YNGMASTSSW AALYFIALMT
960 970 980 990 1000
FGNYVLFNLL VAILVEGFQA EEIGKREDAS GQLSCIQLPV NSQGGDATKS
1010 1020 1030 1040 1050
ESEPDFFSPS VDGDGDRKKR LALVALGEHA ELRKSLLPPL IIHTAATPMS
1060 1070 1080 1090 1100
LPKSSSTGVG EALGSGSRRT SSSGSAEPGA AHHEMKSPPS ARSSPHSPWS
1110 1120 1130 1140 1150
AASSWTSRRS SRNSLGRAPS LKRRSPSGER RSLLSGEGQE SQDEEESSEE
1160 1170 1180 1190 1200
DRASPAGSDH RHRGSLEREA KSSFDLPDTL QVPGLHRTAS GRSSASEHQD
1210 1220 1230 1240 1250
CNGKSASGRL ARTLRTDDPQ LDGDDDNDEG NLSKGERIQA WVRSRLPACC
1260 1270 1280 1290 1300
RERDSWSAYI FPPQSRFRLL CHRIITHKMF DHVVLVIIFL NCITIAMERP
1310 1320 1330 1340 1350
KIDPHSAERI FLTLSNYIFT AVFLAEMTVK VVALGWCFGE QAYLRSSWNV
1360 1370 1380 1390 1400
LDGLLVLISV IDILVSMVSD SGTKILGMLR VLRLLRTLRP LRVISRAQGL
1410 1420 1430 1440 1450
KLVVETLMSS LKPIGNIVVI CCAFFIIFGI LGVQLFKGKF FVCQGEDTRN
1460 1470 1480 1490 1500
ITNKSDCAEA SYRWVRHKYN FDNLGQALMS LFVLASKDGW VDIMYDGLDA
1510 1520 1530 1540 1550
VGVDQQPIMN HNPWMLLYFI SFLLIVAFFV LNMFVGVVVE NFHKCRQHQE
1560 1570 1580 1590 1600
EEEARRREEK RLRRLEKKRR NLMLDDVIAS GSSASAASEA QCKPYYSDYS
1610 1620 1630 1640 1650
RFRLLVHHLC TSHYLDLFIT GVIGLNVVTM AMEHYQQPQI LDEALKICNY
1660 1670 1680 1690 1700
IFTVIFVFES VFKLVAFGFR RFFQDRWNQL DLAIVLLSIM GITLEEIEVN
1710 1720 1730 1740 1750
ASLPINPTII RIMRVLRIAR VLKLLKMAVG MRALLDTVMQ ALPQVGNLGL
1760 1770 1780 1790 1800
LFMLLFFIFA ALGVELFGDL ECDETHPCEG LGRHATFRNF GMAFLTLFRV
1810 1820 1830 1840 1850
STGDNWNGIM KDTLRDCDQE STCYNTVISP IYFVSFVLTA QFVLVNVVIA
1860 1870 1880 1890 1900
VLMKHLEESN KEAKEEAELE AELELEMKTL SPQPHSPLGS PFLWPGVEGV
1910 1920 1930 1940 1950
NSPDSPKPGA PHTTAHIGAA SGFSLEHPTM VPHPEEVPVP LGPDLLTVRK
1960 1970 1980 1990 2000
SGVSRTHSLP NDSYMCRNGS TAERSLGHRG WGLPKAQSGS ILSVHSQPAD
2010 2020 2030 2040 2050
TSCILQLPKD VHYLLQPHGA PTWGAIPKLP PPGRSPLAQR PLRRQAAIRT
2060 2070 2080 2090 2100
DSLDVQGLGS REDLLSEVSG PSCPLTRSSS FWGGSSIQVQ QRSGIQSKVS
2110 2120 2130 2140 2150
KHIRLPAPCP GLEPSWAKDP PETRSSLELD TELSWISGDL LPSSQEEPLS
2160 2170 2180 2190 2200
PRDLKKCYSV ETQSCRRRPG SWLDEQRRHS IAVSCLDSGS QPRLCPSPSS
2210 2220 2230 2240 2250
LGGQPLGGPG SRPKKKLSPP SISIDPPESQ GSRPPCSPGV CLRRRAPASD
2260 2270 2280
SKDPSVSSPL DSTAASPSPK KDTLSLSGLS SDPTDMDP
Length:2,288
Mass (Da):253,478
Last modified:November 1, 1999 - v1
Checksum:iB89DBB5A1D81757F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030343 Genomic DNA. No translation available.
AABR07030344 Genomic DNA. No translation available.
AABR07030345 Genomic DNA. No translation available.
AF125161 mRNA. Translation: AAD26858.1.
CH473948 Genomic DNA. Translation: EDM05704.1.
UniGeneiRn.86960.

Genome annotation databases

EnsembliENSRNOT00000092024; ENSRNOP00000072061; ENSRNOG00000060528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030343 Genomic DNA. No translation available.
AABR07030344 Genomic DNA. No translation available.
AABR07030345 Genomic DNA. No translation available.
AF125161 mRNA. Translation: AAD26858.1.
CH473948 Genomic DNA. Translation: EDM05704.1.
UniGeneiRn.86960.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000092024; ENSRNOP00000072061; ENSRNOG00000060528.

Organism-specific databases

RGDi68942. Cacna1g.

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000007742.
HOVERGENiHBG050764.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 7 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells."
    Zhuang H., Bhattacharjee A., Hu F., Zhang M., Goswami T., Wang L., Wu S., Berggren P.O., Li M.
    Diabetes 49:59-64(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PancreasImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (JUN-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9WUB8_RAT
AccessioniPrimary (citable) accession number: Q9WUB8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.