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Protein

Voltage-dependent T-type calcium channel subunit alpha

Gene

Cacna1g

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1gImported
ORF Names:rCG_32907Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68942. Cacna1g.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 142HelicalSequence analysisAdd BLAST20
Transmembranei214 – 237HelicalSequence analysisAdd BLAST24
Transmembranei342 – 363HelicalSequence analysisAdd BLAST22
Transmembranei369 – 394HelicalSequence analysisAdd BLAST26
Transmembranei745 – 763HelicalSequence analysisAdd BLAST19
Transmembranei775 – 796HelicalSequence analysisAdd BLAST22
Transmembranei866 – 885HelicalSequence analysisAdd BLAST20
Transmembranei942 – 965HelicalSequence analysisAdd BLAST24
Transmembranei1279 – 1297HelicalSequence analysisAdd BLAST19
Transmembranei1317 – 1338HelicalSequence analysisAdd BLAST22
Transmembranei1350 – 1369HelicalSequence analysisAdd BLAST20
Transmembranei1414 – 1436HelicalSequence analysisAdd BLAST23
Transmembranei1516 – 1539HelicalSequence analysisAdd BLAST24
Transmembranei1614 – 1635HelicalSequence analysisAdd BLAST22
Transmembranei1647 – 1670HelicalSequence analysisAdd BLAST24
Transmembranei1748 – 1767HelicalSequence analysisAdd BLAST20
Transmembranei1831 – 1853HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiQ9WUB8. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061436.

Structurei

3D structure databases

ProteinModelPortaliQ9WUB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 405Ion_transInterPro annotationAdd BLAST326
Domaini744 – 970Ion_transInterPro annotationAdd BLAST227
Domaini1277 – 1549Ion_transInterPro annotationAdd BLAST273
Domaini1613 – 1863Ion_transInterPro annotationAdd BLAST251

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1548 – 1575Sequence analysisAdd BLAST28
Coiled coili1852 – 1876Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000007742.
HOVERGENiHBG050764.
OMAiESNMEPH.
OrthoDBiEOG091G02L1.
PhylomeDBiQ9WUB8.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 7 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

Q9WUB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG
60 70 80 90 100
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM
110 120 130 140 150
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
160 170 180 190 200
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
210 220 230 240 250
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
260 270 280 290 300
LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCSL
310 320 330 340 350
DYETYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
360 370 380 390 400
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
410 420 430 440 450
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
460 470 480 490 500
LAQVSRAIGV RAGLLSSPVA RSGQEPQPSG SCTRSHRRLS VHHLVHHHHH
510 520 530 540 550
HHHHYHLGNG TLRVPRASPE IQDRDANGSR RLMLPPPSTP TPSGGPPRGA
560 570 580 590 600
ESVHSFYHAD CHLEPVRCQA PPPRCPSEAS GRTVGSGKVY PTVHTSPPPE
610 620 630 640 650
ILKDKALVEV APSPGPPTLT SFNIPPGPFS SMHKLLETQS TGACHSSCKI
660 670 680 690 700
SSPCSKADSG ACGPDSCPYC ARTGAGEPES ADHVMPDSDS EAVYEFTQDA
710 720 730 740 750
QHSDLRDPHS RRRQRSLGPD AEPSSVLAFW RLICDTFRKI VDSKYFGRGI
760 770 780 790 800
MIAILVNTLS MGIEYHEQPE ELTNALEISN IVFTSLFALE MLLKLLVYGP
810 820 830 840 850
FGYIKNPYNI FDGVIVVISV WEIVGQQGGG LSVLRTFRLM RVLKLVRFLP
860 870 880 890 900
ALQRQLVVLM KTMDNVATFC MLLMLFIFIF SILGMHLFGC KFASERDGDT
910 920 930 940 950
LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL YNGMASTSSW AALYFIALMT
960 970 980 990 1000
FGNYVLFNLL VAILVEGFQA EEIGKREDAS GQLSCIQLPV NSQGGDATKS
1010 1020 1030 1040 1050
ESEPDFFSPS VDGDGDRKKR LALVALGEHA ELRKSLLPPL IIHTAATPMS
1060 1070 1080 1090 1100
LPKSSSTGVG EALGSGSRRT SSSGSAEPGA AHHEMKSPPS ARSSPHSPWS
1110 1120 1130 1140 1150
AASSWTSRRS SRNSLGRAPS LKRRSPSGER RSLLSGEGQE SQDEEESSEE
1160 1170 1180 1190 1200
DRASPAGSDH RHRGSLEREA KSSFDLPDTL QVPGLHRTAS GRSSASEHQD
1210 1220 1230 1240 1250
CNGKSASGRL ARTLRTDDPQ LDGDDDNDEG NLSKGERIQA WVRSRLPACC
1260 1270 1280 1290 1300
RERDSWSAYI FPPQSRFRLL CHRIITHKMF DHVVLVIIFL NCITIAMERP
1310 1320 1330 1340 1350
KIDPHSAERI FLTLSNYIFT AVFLAEMTVK VVALGWCFGE QAYLRSSWNV
1360 1370 1380 1390 1400
LDGLLVLISV IDILVSMVSD SGTKILGMLR VLRLLRTLRP LRVISRAQGL
1410 1420 1430 1440 1450
KLVVETLMSS LKPIGNIVVI CCAFFIIFGI LGVQLFKGKF FVCQGEDTRN
1460 1470 1480 1490 1500
ITNKSDCAEA SYRWVRHKYN FDNLGQALMS LFVLASKDGW VDIMYDGLDA
1510 1520 1530 1540 1550
VGVDQQPIMN HNPWMLLYFI SFLLIVAFFV LNMFVGVVVE NFHKCRQHQE
1560 1570 1580 1590 1600
EEEARRREEK RLRRLEKKRR NLMLDDVIAS GSSASAASEA QCKPYYSDYS
1610 1620 1630 1640 1650
RFRLLVHHLC TSHYLDLFIT GVIGLNVVTM AMEHYQQPQI LDEALKICNY
1660 1670 1680 1690 1700
IFTVIFVFES VFKLVAFGFR RFFQDRWNQL DLAIVLLSIM GITLEEIEVN
1710 1720 1730 1740 1750
ASLPINPTII RIMRVLRIAR VLKLLKMAVG MRALLDTVMQ ALPQVGNLGL
1760 1770 1780 1790 1800
LFMLLFFIFA ALGVELFGDL ECDETHPCEG LGRHATFRNF GMAFLTLFRV
1810 1820 1830 1840 1850
STGDNWNGIM KDTLRDCDQE STCYNTVISP IYFVSFVLTA QFVLVNVVIA
1860 1870 1880 1890 1900
VLMKHLEESN KEAKEEAELE AELELEMKTL SPQPHSPLGS PFLWPGVEGV
1910 1920 1930 1940 1950
NSPDSPKPGA PHTTAHIGAA SGFSLEHPTM VPHPEEVPVP LGPDLLTVRK
1960 1970 1980 1990 2000
SGVSRTHSLP NDSYMCRNGS TAERSLGHRG WGLPKAQSGS ILSVHSQPAD
2010 2020 2030 2040 2050
TSCILQLPKD VHYLLQPHGA PTWGAIPKLP PPGRSPLAQR PLRRQAAIRT
2060 2070 2080 2090 2100
DSLDVQGLGS REDLLSEVSG PSCPLTRSSS FWGGSSIQVQ QRSGIQSKVS
2110 2120 2130 2140 2150
KHIRLPAPCP GLEPSWAKDP PETRSSLELD TELSWISGDL LPSSQEEPLS
2160 2170 2180 2190 2200
PRDLKKCYSV ETQSCRRRPG SWLDEQRRHS IAVSCLDSGS QPRLCPSPSS
2210 2220 2230 2240 2250
LGGQPLGGPG SRPKKKLSPP SISIDPPESQ GSRPPCSPGV CLRRRAPASD
2260 2270 2280
SKDPSVSSPL DSTAASPSPK KDTLSLSGLS SDPTDMDP
Length:2,288
Mass (Da):253,478
Last modified:November 1, 1999 - v1
Checksum:iB89DBB5A1D81757F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030343 Genomic DNA. No translation available.
AABR07030344 Genomic DNA. No translation available.
AABR07030345 Genomic DNA. No translation available.
AF125161 mRNA. Translation: AAD26858.1.
CH473948 Genomic DNA. Translation: EDM05704.1.
UniGeneiRn.86960.

Genome annotation databases

EnsembliENSRNOT00000092024; ENSRNOP00000072061; ENSRNOG00000060528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030343 Genomic DNA. No translation available.
AABR07030344 Genomic DNA. No translation available.
AABR07030345 Genomic DNA. No translation available.
AF125161 mRNA. Translation: AAD26858.1.
CH473948 Genomic DNA. Translation: EDM05704.1.
UniGeneiRn.86960.

3D structure databases

ProteinModelPortaliQ9WUB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000092024; ENSRNOP00000072061; ENSRNOG00000060528.

Organism-specific databases

RGDi68942. Cacna1g.

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000007742.
HOVERGENiHBG050764.
OMAiESNMEPH.
OrthoDBiEOG091G02L1.
PhylomeDBiQ9WUB8.

Gene expression databases

ExpressionAtlasiQ9WUB8. baseline.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 7 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9WUB8_RAT
AccessioniPrimary (citable) accession number: Q9WUB8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.