Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynactin subunit 6

Gene

Dctn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • catalytic activity Source: UniProtKB
  • dynein complex binding Source: UniProtKB

GO - Biological processi

  • lipid biosynthetic process Source: UniProtKB
  • mitochondrion organization Source: UniProtKB
  • mitotic spindle organization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 6
Alternative name(s):
Dynactin subunit p27
Protein WS-3
Gene namesi
Name:Dctn6
Synonyms:Ws3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1343154 Dctn6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798311 – 190Dynactin subunit 6Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186Phosphothreonine; by CDK1By similarity1

Post-translational modificationi

Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WUB4
MaxQBiQ9WUB4
PaxDbiQ9WUB4
PRIDEiQ9WUB4

PTM databases

iPTMnetiQ9WUB4
PhosphoSitePlusiQ9WUB4

Expressioni

Inductioni

Up-regulated in Ant1-deficient mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000031516
CleanExiMM_DCTN6
ExpressionAtlasiQ9WUB4 baseline and differential
GenevisibleiQ9WUB4 MM

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with PLK1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9WUB4, 1 interactor
STRINGi10090.ENSMUSP00000033913

Structurei

3D structure databases

ProteinModelPortaliQ9WUB4
SMRiQ9WUB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4042 Eukaryota
ENOG410YETF LUCA
GeneTreeiENSGT00390000017890
HOGENOMiHOG000046876
HOVERGENiHBG051326
InParanoidiQ9WUB4
KOiK10428
OMAiHPKATIF
PhylomeDBiQ9WUB4
TreeFamiTF352888

Family and domain databases

InterProiView protein in InterPro
IPR027777 DCTN6
IPR001451 Hexapep
IPR011004 Trimer_LpxA-like_sf
PANTHERiPTHR13072 PTHR13072, 1 hit
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WUB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIII
60 70 80 90 100
GEGNLIEEQA LIINAHPDNI IPDTEDTEPK PMIIGTNNVF EVGCHSQAMK
110 120 130 140 150
MGDNNVIESK AYVGRNVILT SGCIIGACCS LNTFEAIPEN TVIYGADCLR
160 170 180 190
RVQTERPQPQ TLQLDFLMKI LPNYHHLKKT MKGSSTPVKN
Length:190
Mass (Da):20,670
Last modified:November 1, 1999 - v1
Checksum:iF18919A1089EB69A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100K → T in AAF05616 (PubMed:10525537).Curated1
Sequence conflicti168M → I in BAC40276 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124788 mRNA Translation: AAD30477.1
AF190796 mRNA Translation: AAF05616.1
AK003618 mRNA Translation: BAB22892.1
AK088312 mRNA Translation: BAC40276.1
BC029249 mRNA Translation: AAH29249.1
CCDSiCCDS22238.1
RefSeqiNP_001280686.1, NM_001293757.1
NP_001280687.1, NM_001293758.1
NP_001280688.1, NM_001293759.1
NP_035852.1, NM_011722.4
UniGeneiMm.150373

Genome annotation databases

EnsembliENSMUST00000033913; ENSMUSP00000033913; ENSMUSG00000031516
GeneIDi22428
KEGGimmu:22428
UCSCiuc009lko.3 mouse

Similar proteinsi

Entry informationi

Entry nameiDCTN6_MOUSE
AccessioniPrimary (citable) accession number: Q9WUB4
Secondary accession number(s): Q8C2M9, Q9QZB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health