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Protein

Dynactin subunit 6

Gene

Dctn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • catalytic activity Source: UniProtKB
  • dynein complex binding Source: UniProtKB

GO - Biological processi

  • lipid biosynthetic process Source: UniProtKB
  • mitochondrion organization Source: UniProtKB
  • mitotic spindle organization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 6
Alternative name(s):
Dynactin subunit p27
Protein WS-3
Gene namesi
Name:Dctn6
Synonyms:Ws3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1343154. Dctn6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798311 – 190Dynactin subunit 6Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186Phosphothreonine; by CDK1By similarity1

Post-translational modificationi

Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WUB4.
MaxQBiQ9WUB4.
PaxDbiQ9WUB4.
PRIDEiQ9WUB4.

PTM databases

PhosphoSitePlusiQ9WUB4.

Expressioni

Inductioni

Up-regulated in Ant1-deficient mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000031516.
CleanExiMM_DCTN6.
ExpressionAtlasiQ9WUB4. baseline and differential.
GenevisibleiQ9WUB4. MM.

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with PLK1 (By similarity).By similarity

GO - Molecular functioni

  • dynein complex binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ9WUB4. 1 interactor.
STRINGi10090.ENSMUSP00000033913.

Structurei

3D structure databases

ProteinModelPortaliQ9WUB4.
SMRiQ9WUB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4042. Eukaryota.
ENOG410YETF. LUCA.
GeneTreeiENSGT00390000017890.
HOGENOMiHOG000046876.
HOVERGENiHBG051326.
InParanoidiQ9WUB4.
KOiK10428.
OMAiHPKATIF.
PhylomeDBiQ9WUB4.
TreeFamiTF352888.

Family and domain databases

InterProiView protein in InterPro
IPR027777. DCTN6.
IPR001451. Hexapep.
IPR011004. Trimer_LpxA-like.
PANTHERiPTHR13072. PTHR13072. 1 hit.
PfamiView protein in Pfam
PF00132. Hexapep. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WUB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIII
60 70 80 90 100
GEGNLIEEQA LIINAHPDNI IPDTEDTEPK PMIIGTNNVF EVGCHSQAMK
110 120 130 140 150
MGDNNVIESK AYVGRNVILT SGCIIGACCS LNTFEAIPEN TVIYGADCLR
160 170 180 190
RVQTERPQPQ TLQLDFLMKI LPNYHHLKKT MKGSSTPVKN
Length:190
Mass (Da):20,670
Last modified:November 1, 1999 - v1
Checksum:iF18919A1089EB69A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100K → T in AAF05616 (PubMed:10525537).Curated1
Sequence conflicti168M → I in BAC40276 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124788 mRNA. Translation: AAD30477.1.
AF190796 mRNA. Translation: AAF05616.1.
AK003618 mRNA. Translation: BAB22892.1.
AK088312 mRNA. Translation: BAC40276.1.
BC029249 mRNA. Translation: AAH29249.1.
CCDSiCCDS22238.1.
RefSeqiNP_001280686.1. NM_001293757.1.
NP_001280687.1. NM_001293758.1.
NP_001280688.1. NM_001293759.1.
NP_035852.1. NM_011722.4.
UniGeneiMm.150373.

Genome annotation databases

EnsembliENSMUST00000033913; ENSMUSP00000033913; ENSMUSG00000031516.
GeneIDi22428.
KEGGimmu:22428.
UCSCiuc009lko.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiDCTN6_MOUSE
AccessioniPrimary (citable) accession number: Q9WUB4
Secondary accession number(s): Q8C2M9, Q9QZB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families