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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

Farsb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20By similarity)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
Gene namesi
Name:Farsb
Synonyms:Farsl, Farslb, Frsb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1346035 Farsb

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270171 – 589Phenylalanine--tRNA ligase beta subunitAdd BLAST589

Proteomic databases

EPDiQ9WUA2
MaxQBiQ9WUA2
PaxDbiQ9WUA2
PRIDEiQ9WUA2

PTM databases

iPTMnetiQ9WUA2
PhosphoSitePlusiQ9WUA2
SwissPalmiQ9WUA2

Expressioni

Gene expression databases

BgeeiENSMUSG00000026245
CleanExiMM_FARSB
ExpressionAtlasiQ9WUA2 baseline and differential
GenevisibleiQ9WUA2 MM

Interactioni

Subunit structurei

Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.By similarity

Protein-protein interaction databases

BioGridi204768, 2 interactors
IntActiQ9WUA2, 2 interactors
STRINGi10090.ENSMUSP00000069508

Structurei

3D structure databases

ProteinModelPortaliQ9WUA2
SMRiQ9WUA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 379B5PROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2472 Eukaryota
COG0072 LUCA
GeneTreeiENSGT00530000063489
HOGENOMiHOG000105095
HOVERGENiHBG009523
InParanoidiQ9WUA2
KOiK01890
OMAiTFTLCSR
OrthoDBiEOG091G04GW
TreeFamiTF105681

Family and domain databases

Gene3Di3.50.40.10, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR004531 Phe-tRNA-synth_IIc_bsu_arc
IPR020825 Phe-tRNA_synthase_B3/B4
IPR005147 tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SUPFAMiSSF46955 SSF46955, 2 hits
TIGRFAMsiTIGR00471 pheT_arch, 1 hit
PROSITEiView protein in PROSITE
PS51483 B5, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WUA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVSVKRDL LFQALGRTYT DEEFDELCFE FGLELDEITS EKQIISKEQG
60 70 80 90 100
HGKAQGASDV VLYKIDVPAN RYDLLCLEGL ARGLQVFKER IKAPVYKRVM
110 120 130 140 150
PKGDIQKLVI TEETAKVRPF AVAAVLRNIK FTKDRYDSFI ELQEKLHQNI
160 170 180 190 200
CRKRALVAIG THDLDTLSGP FTYTAKRPSD IKFKPLNKTK EYTACELMNI
210 220 230 240 250
YKTDNHLKHY LHIIESKPLY PVIYDSNGVV LSMPPIINGN HSKITVNTRN
260 270 280 290 300
IFIECTGTDF TKAKIVLDII VTMFSEHCEN QFTVEAVEVV SPNGKSSTFP
310 320 330 340 350
ELPYRKEMVR ADLINKKVGI RETPANLAKL LTRMCLKSEV IGDGNQIEVE
360 370 380 390 400
IPPTRADVIH ACDIVEDAAI AYGYNNIQMT LPKTYTIANQ FPLNKLTELL
410 420 430 440 450
RLDMAAAGFT EALTFALCSQ EDIADKLGLD ISATKAVHIS NPKTAEFQVA
460 470 480 490 500
RTTLLPGLLK TIAANRKMPL PLKLFEISDV VVKDSGKDVG AKNYRHLCAV
510 520 530 540 550
YYNKTPGFEI IHGLLDRIMQ LLDVPPGEES GGYMIKASAG SAFFPGRCAE
560 570 580
IFVGGQSIGK LGVLHPDVIT KFELTMPCSS LEINIEPFL
Length:589
Mass (Da):65,697
Last modified:July 27, 2011 - v2
Checksum:i5EEE8FF0DF48E751
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti503N → S in AAD26855 (PubMed:10375616).Curated1
Sequence conflicti503N → S in AAH16428 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123263 mRNA Translation: AAD26855.1
AK010271 mRNA Translation: BAB26810.1
AK045432 mRNA Translation: BAC32363.1
BC016428 mRNA Translation: AAH16428.1
CCDSiCCDS15084.1
RefSeqiNP_001265004.1, NM_001278075.1
NP_035941.2, NM_011811.4
UniGeneiMm.17898
Mm.28922
Mm.447792

Genome annotation databases

EnsembliENSMUST00000068333; ENSMUSP00000069508; ENSMUSG00000026245
ENSMUST00000170217; ENSMUSP00000129828; ENSMUSG00000026245
GeneIDi23874
KEGGimmu:23874
UCSCiuc007bqf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSYFB_MOUSE
AccessioniPrimary (citable) accession number: Q9WUA2
Secondary accession number(s): Q9CWZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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