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Protein

Wnt inhibitory factor 1

Gene

Wif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Names & Taxonomyi

Protein namesi
Recommended name:
Wnt inhibitory factor 1
Short name:
WIF-1
Gene namesi
Name:Wif1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1344332. Wif1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000777629 – 379Wnt inhibitory factor 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi140 ↔ 177By similarity
Disulfide bondi182 ↔ 192By similarity
Disulfide bondi186 ↔ 198By similarity
Disulfide bondi200 ↔ 209By similarity
Disulfide bondi214 ↔ 224By similarity
Disulfide bondi218 ↔ 230By similarity
Disulfide bondi232 ↔ 241By similarity
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi246 ↔ 256By similarity
Disulfide bondi250 ↔ 262By similarity
Disulfide bondi278 ↔ 288By similarity
Disulfide bondi282 ↔ 294By similarity
Disulfide bondi296 ↔ 305By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi314 ↔ 326By similarity
Disulfide bondi328 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUA1.
PRIDEiQ9WUA1.

PTM databases

PhosphoSitePlusiQ9WUA1.

Expressioni

Tissue specificityi

Expression highest in heart and lung. Lower in brain and eye.

Gene expression databases

BgeeiENSMUSG00000020218.
CleanExiMM_WIF1.
ExpressionAtlasiQ9WUA1. baseline and differential.
GenevisibleiQ9WUA1. MM.

Interactioni

Subunit structurei

Interacts with MYOC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020439.

Structurei

3D structure databases

ProteinModelPortaliQ9WUA1.
SMRiQ9WUA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 177WIFPROSITE-ProRule annotationAdd BLAST140
Domaini178 – 210EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini211 – 242EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini243 – 271EGF-like 3PROSITE-ProRule annotationAdd BLAST29
Domaini274 – 306EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini307 – 338EGF-like 5PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 WIF domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQQ0. Eukaryota.
ENOG41104IN. LUCA.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000015769.
HOVERGENiHBG017335.
InParanoidiQ9WUA1.
KOiK01691.
OMAiRCIGNNM.
OrthoDBiEOG091G08T8.
PhylomeDBiQ9WUA1.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003306. WIF.
IPR013309. Wnt-inh.
[Graphical view]
PfamiPF12661. hEGF. 3 hits.
PF02019. WIF. 1 hit.
[Graphical view]
PRINTSiPR01901. WIFPROTEIN.
ProDomiPD013948. WIF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00181. EGF. 5 hits.
SM00469. WIF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 5 hits.
PS50814. WIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRRAFPAF ALRLWSILPC LLLLRADAGQ PPEESLYLWI DAHQARVLIG
60 70 80 90 100
FEEDILIVSE GKMAPFTHDF RKAQQRMPAI PVNIHSMNFT WQAAGQAEYF
110 120 130 140 150
YEFLSLRSLD KGIMADPTVN VPLLGTVPHK ASVVQVGFPC LGKQDGVAAF
160 170 180 190 200
EVNVIVMNSE GNTILRTPQN AIFFKTCQQA ECPGGCRNGG FCNERRVCEC
210 220 230 240 250
PDGFYGPHCE KALCIPRCMN GGLCVTPGFC ICPPGFYGVN CDKANCSTTC
260 270 280 290 300
FNGGTCFYPG KCICPPGLEG EQCELSKCPQ PCRNGGKCIG KSKCKCPKGY
310 320 330 340 350
QGDLCSKPVC EPGCGAHGTC HEPNKCQCRE GWHGRHCNKR YGASLMHAPR
360 370
PAGAGLERHT PSLKKAEDRR DPPESNYIW
Length:379
Mass (Da):41,590
Last modified:November 1, 1999 - v1
Checksum:iE3765F2642B2BC9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122923 mRNA. Translation: AAD25403.1.
BC013268 mRNA. Translation: AAH13268.1.
CCDSiCCDS24209.1.
RefSeqiNP_036045.1. NM_011915.2.
UniGeneiMm.32831.

Genome annotation databases

EnsembliENSMUST00000020439; ENSMUSP00000020439; ENSMUSG00000020218.
GeneIDi24117.
KEGGimmu:24117.
UCSCiuc007hfj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122923 mRNA. Translation: AAD25403.1.
BC013268 mRNA. Translation: AAH13268.1.
CCDSiCCDS24209.1.
RefSeqiNP_036045.1. NM_011915.2.
UniGeneiMm.32831.

3D structure databases

ProteinModelPortaliQ9WUA1.
SMRiQ9WUA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020439.

PTM databases

PhosphoSitePlusiQ9WUA1.

Proteomic databases

PaxDbiQ9WUA1.
PRIDEiQ9WUA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020439; ENSMUSP00000020439; ENSMUSG00000020218.
GeneIDi24117.
KEGGimmu:24117.
UCSCiuc007hfj.2. mouse.

Organism-specific databases

CTDi11197.
MGIiMGI:1344332. Wif1.

Phylogenomic databases

eggNOGiENOG410IQQ0. Eukaryota.
ENOG41104IN. LUCA.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000015769.
HOVERGENiHBG017335.
InParanoidiQ9WUA1.
KOiK01691.
OMAiRCIGNNM.
OrthoDBiEOG091G08T8.
PhylomeDBiQ9WUA1.

Enzyme and pathway databases

ReactomeiR-MMU-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Miscellaneous databases

ChiTaRSiWif1. mouse.
PROiQ9WUA1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020218.
CleanExiMM_WIF1.
ExpressionAtlasiQ9WUA1. baseline and differential.
GenevisibleiQ9WUA1. MM.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003306. WIF.
IPR013309. Wnt-inh.
[Graphical view]
PfamiPF12661. hEGF. 3 hits.
PF02019. WIF. 1 hit.
[Graphical view]
PRINTSiPR01901. WIFPROTEIN.
ProDomiPD013948. WIF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00181. EGF. 5 hits.
SM00469. WIF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 5 hits.
PS50814. WIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWIF1_MOUSE
AccessioniPrimary (citable) accession number: Q9WUA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.