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Protein

Wnt inhibitory factor 1

Gene

Wif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Wnt inhibitory factor 1
Short name:
WIF-1
Gene namesi
Name:Wif1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1344332 Wif1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000777629 – 379Wnt inhibitory factor 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 177By similarity
Disulfide bondi182 ↔ 192By similarity
Disulfide bondi186 ↔ 198By similarity
Disulfide bondi200 ↔ 209By similarity
Disulfide bondi214 ↔ 224By similarity
Disulfide bondi218 ↔ 230By similarity
Disulfide bondi232 ↔ 241By similarity
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi246 ↔ 256By similarity
Disulfide bondi250 ↔ 262By similarity
Disulfide bondi278 ↔ 288By similarity
Disulfide bondi282 ↔ 294By similarity
Disulfide bondi296 ↔ 305By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi314 ↔ 326By similarity
Disulfide bondi328 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUA1
PRIDEiQ9WUA1

PTM databases

PhosphoSitePlusiQ9WUA1

Expressioni

Tissue specificityi

Expression highest in heart and lung. Lower in brain and eye.

Gene expression databases

BgeeiENSMUSG00000020218
CleanExiMM_WIF1
ExpressionAtlasiQ9WUA1 baseline and differential
GenevisibleiQ9WUA1 MM

Interactioni

Subunit structurei

Interacts with MYOC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020439

Structurei

3D structure databases

ProteinModelPortaliQ9WUA1
SMRiQ9WUA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 177WIFPROSITE-ProRule annotationAdd BLAST140
Domaini178 – 210EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini211 – 242EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini243 – 271EGF-like 3PROSITE-ProRule annotationAdd BLAST29
Domaini274 – 306EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini307 – 338EGF-like 5PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQQ0 Eukaryota
ENOG41104IN LUCA
GeneTreeiENSGT00760000119131
HOGENOMiHOG000015769
HOVERGENiHBG017335
InParanoidiQ9WUA1
KOiK01691
OMAiDKGIMAD
OrthoDBiEOG091G08T8
PhylomeDBiQ9WUA1

Family and domain databases

Gene3Di2.60.40.2170, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003306 WIF
IPR038677 WIF_sf
IPR013309 Wnt-inh
PfamiView protein in Pfam
PF12661 hEGF, 3 hits
PF02019 WIF, 1 hit
PRINTSiPR01901 WIFPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948 WIF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00469 WIF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS50814 WIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRRAFPAF ALRLWSILPC LLLLRADAGQ PPEESLYLWI DAHQARVLIG
60 70 80 90 100
FEEDILIVSE GKMAPFTHDF RKAQQRMPAI PVNIHSMNFT WQAAGQAEYF
110 120 130 140 150
YEFLSLRSLD KGIMADPTVN VPLLGTVPHK ASVVQVGFPC LGKQDGVAAF
160 170 180 190 200
EVNVIVMNSE GNTILRTPQN AIFFKTCQQA ECPGGCRNGG FCNERRVCEC
210 220 230 240 250
PDGFYGPHCE KALCIPRCMN GGLCVTPGFC ICPPGFYGVN CDKANCSTTC
260 270 280 290 300
FNGGTCFYPG KCICPPGLEG EQCELSKCPQ PCRNGGKCIG KSKCKCPKGY
310 320 330 340 350
QGDLCSKPVC EPGCGAHGTC HEPNKCQCRE GWHGRHCNKR YGASLMHAPR
360 370
PAGAGLERHT PSLKKAEDRR DPPESNYIW
Length:379
Mass (Da):41,590
Last modified:November 1, 1999 - v1
Checksum:iE3765F2642B2BC9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122923 mRNA Translation: AAD25403.1
BC013268 mRNA Translation: AAH13268.1
CCDSiCCDS24209.1
RefSeqiNP_036045.1, NM_011915.2
UniGeneiMm.32831

Genome annotation databases

EnsembliENSMUST00000020439; ENSMUSP00000020439; ENSMUSG00000020218
GeneIDi24117
KEGGimmu:24117
UCSCiuc007hfj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiWIF1_MOUSE
AccessioniPrimary (citable) accession number: Q9WUA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health