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Q9WU82

- CTNB1_RAT

UniProt

Q9WU82 - CTNB1_RAT

Protein

Catenin beta-1

Gene

Ctnnb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 By similarity. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML By similarity.By similarity

    GO - Molecular functioni

    1. alpha-catenin binding Source: RefGenome
    2. cadherin binding Source: RGD
    3. chromatin binding Source: Ensembl
    4. double-stranded DNA binding Source: Ensembl
    5. ionotropic glutamate receptor binding Source: RGD
    6. nitric-oxide synthase binding Source: RGD
    7. protein binding Source: UniProtKB
    8. protein complex binding Source: RGD
    9. protein kinase binding Source: RefGenome
    10. sequence-specific DNA binding transcription factor activity Source: Ensembl
    11. structural molecule activity Source: RefGenome
    12. transcription coactivator activity Source: UniProtKB
    13. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. adherens junction assembly Source: UniProtKB
    2. anterior/posterior axis specification Source: Ensembl
    3. bone resorption Source: Ensembl
    4. branching involved in ureteric bud morphogenesis Source: RefGenome
    5. canonical Wnt signaling pathway Source: UniProtKB
    6. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: Ensembl
    7. canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: Ensembl
    8. canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Source: UniProtKB
    9. cell adhesion Source: UniProtKB
    10. cell fate specification Source: Ensembl
    11. cell-matrix adhesion Source: RefGenome
    12. cell maturation Source: Ensembl
    13. cellular response to growth factor stimulus Source: UniProtKB
    14. cellular response to indole-3-methanol Source: UniProtKB
    15. cellular response to insulin-like growth factor stimulus Source: RGD
    16. cellular response to mechanical stimulus Source: RGD
    17. central nervous system vasculogenesis Source: RefGenome
    18. cytoskeletal anchoring at plasma membrane Source: RefGenome
    19. determination of dorsal/ventral asymmetry Source: RefGenome
    20. dorsal/ventral axis specification Source: RefGenome
    21. ectoderm development Source: RefGenome
    22. embryonic axis specification Source: RefGenome
    23. embryonic digit morphogenesis Source: Ensembl
    24. embryonic foregut morphogenesis Source: RefGenome
    25. embryonic forelimb morphogenesis Source: Ensembl
    26. embryonic heart tube development Source: Ensembl
    27. embryonic hindlimb morphogenesis Source: Ensembl
    28. embryonic limb morphogenesis Source: RefGenome
    29. embryonic skeletal limb joint morphogenesis Source: Ensembl
    30. endodermal cell fate commitment Source: RefGenome
    31. endothelial tube morphogenesis Source: UniProtKB
    32. epithelial cell differentiation involved in prostate gland development Source: Ensembl
    33. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    34. fungiform papilla formation Source: Ensembl
    35. gastrulation with mouth forming second Source: RefGenome
    36. genitalia morphogenesis Source: Ensembl
    37. glial cell fate determination Source: RefGenome
    38. hair follicle morphogenesis Source: RefGenome
    39. hair follicle placode formation Source: RefGenome
    40. hindbrain development Source: RefGenome
    41. in utero embryonic development Source: Ensembl
    42. layer formation in cerebral cortex Source: Ensembl
    43. lens morphogenesis in camera-type eye Source: Ensembl
    44. liver development Source: RGD
    45. lung-associated mesenchyme development Source: RefGenome
    46. lung cell differentiation Source: RefGenome
    47. lung induction Source: RefGenome
    48. male genitalia development Source: RefGenome
    49. mesenchymal cell proliferation involved in lung development Source: RefGenome
    50. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: RefGenome
    51. midgut development Source: RGD
    52. myoblast differentiation Source: RGD
    53. negative regulation of apoptotic process Source: RefGenome
    54. negative regulation of apoptotic signaling pathway Source: Ensembl
    55. negative regulation of cell proliferation Source: UniProtKB
    56. negative regulation of chondrocyte differentiation Source: RefGenome
    57. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
    58. negative regulation of oligodendrocyte differentiation Source: Ensembl
    59. negative regulation of osteoclast differentiation Source: RefGenome
    60. negative regulation of protein sumoylation Source: UniProtKB
    61. negative regulation of transcription, DNA-templated Source: UniProtKB
    62. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
    63. nephron tubule formation Source: RefGenome
    64. neural plate development Source: Ensembl
    65. neuron migration Source: Ensembl
    66. odontogenesis of dentin-containing tooth Source: RGD
    67. oocyte development Source: RefGenome
    68. osteoclast differentiation Source: Ensembl
    69. oviduct development Source: Ensembl
    70. pancreas development Source: RefGenome
    71. patterning of blood vessels Source: RefGenome
    72. positive regulation of apoptotic process Source: UniProtKB
    73. positive regulation of branching involved in lung morphogenesis Source: RefGenome
    74. positive regulation of determination of dorsal identity Source: Ensembl
    75. positive regulation of endothelial cell differentiation Source: Ensembl
    76. positive regulation of epithelial cell proliferation involved in prostate gland development Source: RefGenome
    77. positive regulation of fibroblast growth factor receptor signaling pathway Source: RefGenome
    78. positive regulation of heparan sulfate proteoglycan biosynthetic process Source: UniProtKB
    79. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RefGenome
    80. positive regulation of MAPK cascade Source: RefGenome
    81. positive regulation of mesenchymal cell proliferation Source: Ensembl
    82. positive regulation of neuroblast proliferation Source: Ensembl
    83. positive regulation of osteoblast differentiation Source: RefGenome
    84. positive regulation of transcription, DNA-templated Source: UniProtKB
    85. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    86. protein heterooligomerization Source: RGD
    87. protein localization to cell surface Source: UniProtKB
    88. proximal/distal pattern formation Source: RefGenome
    89. regulation of calcium ion import Source: UniProtKB
    90. regulation of centriole-centriole cohesion Source: UniProtKB
    91. regulation of centromeric sister chromatid cohesion Source: UniProtKB
    92. regulation of myelination Source: Ensembl
    93. regulation of nephron tubule epithelial cell differentiation Source: Ensembl
    94. regulation of protein localization to cell surface Source: UniProtKB
    95. regulation of secondary heart field cardioblast proliferation Source: Ensembl
    96. regulation of smooth muscle cell proliferation Source: UniProtKB
    97. regulation of T cell proliferation Source: RefGenome
    98. renal inner medulla development Source: RefGenome
    99. renal outer medulla development Source: RefGenome
    100. renal vesicle formation Source: RefGenome
    101. response to cadmium ion Source: RGD
    102. response to cytokine Source: RGD
    103. response to drug Source: Ensembl
    104. response to estradiol Source: UniProtKB
    105. response to estrogen Source: RGD
    106. response to hormone Source: RGD
    107. response to organic cyclic compound Source: RGD
    108. Schwann cell proliferation Source: RGD
    109. single organismal cell-cell adhesion Source: UniProtKB
    110. smooth muscle cell differentiation Source: RefGenome
    111. synapse organization Source: RefGenome
    112. synaptic vesicle transport Source: RefGenome
    113. T cell differentiation in thymus Source: RefGenome
    114. thymus development Source: RefGenome
    115. tongue morphogenesis Source: RefGenome
    116. trachea formation Source: RefGenome
    117. transcription, DNA-templated Source: UniProtKB-KW
    118. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cell adhesion, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_194690. Ca2+ pathway.
    REACT_198375. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_212065. TCF dependent signaling in response to WNT.
    REACT_214025. deactivation of the beta-catenin transactivating complex.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catenin beta-1
    Alternative name(s):
    Beta-catenin
    Gene namesi
    Name:Ctnnb1
    Synonyms:Catnb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi70487. Ctnnb1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication. Nucleus 1 Publication. Cell junctionadherens junction By similarity. Cell junction By similarity. Cell membrane 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity
    Note: Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta- catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Colocalized with RAPGEF2 and TJP1 at cell-cell contacts By similarity.By similarity

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. basolateral plasma membrane Source: RefGenome
    3. beta-catenin destruction complex Source: UniProtKB
    4. beta-catenin-TCF7L2 complex Source: UniProtKB
    5. catenin complex Source: UniProtKB
    6. cell-cell adherens junction Source: RGD
    7. cell-cell junction Source: UniProtKB
    8. cell cortex Source: UniProtKB
    9. cell junction Source: UniProtKB
    10. cell periphery Source: BHF-UCL
    11. centrosome Source: UniProtKB
    12. cytoplasm Source: UniProtKB
    13. cytoplasmic side of plasma membrane Source: RefGenome
    14. cytosol Source: RGD
    15. dendritic shaft Source: RGD
    16. desmosome Source: RefGenome
    17. fascia adherens Source: RefGenome
    18. lamellipodium Source: RefGenome
    19. lateral plasma membrane Source: Ensembl
    20. membrane Source: UniProtKB
    21. microvillus membrane Source: RefGenome
    22. nucleus Source: RGD
    23. perinuclear region of cytoplasm Source: UniProtKB
    24. plasma membrane Source: UniProtKB
    25. protein complex Source: RGD
    26. protein-DNA complex Source: UniProtKB
    27. Scrib-APC-beta-catenin complex Source: Ensembl
    28. spindle pole Source: UniProtKB-SubCell
    29. synapse Source: RGD
    30. transcription factor complex Source: UniProtKB
    31. Z disc Source: RefGenome
    32. zonula adherens Source: RefGenome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 781780Catenin beta-1PRO_0000064273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei23 – 231Phosphoserine; by GSK3-betaBy similarity
    Modified residuei29 – 291Phosphoserine; by GSK3-betaBy similarity
    Modified residuei33 – 331Phosphoserine; by GSK3-beta and HIPK2By similarity
    Modified residuei37 – 371Phosphoserine; by GSK3-beta and HIPK2By similarity
    Modified residuei41 – 411Phosphothreonine; by GSK3-betaBy similarity
    Modified residuei45 – 451PhosphoserineBy similarity
    Modified residuei64 – 641Phosphotyrosine; by PTK6By similarity
    Modified residuei86 – 861Phosphotyrosine; by CSKBy similarity
    Modified residuei142 – 1421Phosphotyrosine; by FYN and PTK6By similarity
    Modified residuei191 – 1911Phosphoserine; by CDK5By similarity
    Modified residuei246 – 2461Phosphoserine; by CDK5By similarity
    Modified residuei331 – 3311PhosphotyrosineBy similarity
    Modified residuei551 – 5511PhosphothreonineBy similarity
    Modified residuei552 – 5521Phosphoserine; by AMPKBy similarity
    Modified residuei556 – 5561PhosphothreonineBy similarity
    Modified residuei619 – 6191S-nitrosocysteineBy similarity
    Modified residuei654 – 6541Phosphotyrosine; by CSKBy similarity
    Modified residuei675 – 6751Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr-41 to Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. Phosphorylated on Ser-33 and Ser-37 by HIPK2; this phosphorylation triggers proteasomal degradation. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization By similarity. Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity By similarity.By similarity
    Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation By similarity.By similarity
    S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, S-nitrosylation, Ubl conjugation

    Proteomic databases

    PaxDbiQ9WU82.
    PRIDEiQ9WU82.

    PTM databases

    PhosphoSiteiQ9WU82.

    Expressioni

    Tissue specificityi

    Expressed in the testis.

    Developmental stagei

    Highly expressed at E30-60 day DPC in the testis. Reduced expression at E90 day DPC.

    Gene expression databases

    GenevestigatoriQ9WU82.

    Interactioni

    Subunit structurei

    Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 Interacts directly with AXIN1; the interaction is regulated by CK2 via BTRC and its subsequent degradation by the proteasome. Interacts directly with AXIN1;the interaction is regulated by CDK2 phosphorylation. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9, BCL9L and possibly also RUVBL1 and CHD8. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding. Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1. Interacts with GLIS2. Interacts with XIRP1. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain) and with SLC30A9. Interacts with EMD. Interacts with SCRIB. Interacts with TNIK and TCF7L2. Interacts with SESTD1 and TRPC4. Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1. Interacts with CAV1. Interacts with TRPV4. The TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. Interacts with PTPRJ. Interacts with PKT7. Interacts with NANOS1. Interacts with CDK2, NDRG2, NEK2 and CDK5. Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B. Interacts with PTK6. Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Identified in a complex with HINT1 and MITF. Interacts with FHIT. The CTNNB1 and TCF4 complex interacts with PML. Interacts with FERMT2. Identified in a complex with TCF4 and FERMT2. Interacts with RAPGEF2. Interacts with FAT1 (via the cytoplasmic domain). Interacts with RORA. May interact with P-cadherin/CDH3.3 Publications

    Protein-protein interaction databases

    BioGridi249913. 11 interactions.
    DIPiDIP-37053N.
    IntActiQ9WU82. 4 interactions.
    MINTiMINT-87458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WU82.
    SMRiQ9WU82. Positions 19-44, 118-682.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati151 – 19141ARM 1Add
    BLAST
    Repeati193 – 23442ARM 2Add
    BLAST
    Repeati235 – 27642ARM 3Add
    BLAST
    Repeati277 – 31842ARM 4Add
    BLAST
    Repeati319 – 36042ARM 5Add
    BLAST
    Repeati361 – 38929ARM 6Add
    BLAST
    Repeati400 – 44142ARM 7Add
    BLAST
    Repeati442 – 48443ARM 8Add
    BLAST
    Repeati489 – 53042ARM 9Add
    BLAST
    Repeati531 – 57141ARM 10Add
    BLAST
    Repeati594 – 63643ARM 11Add
    BLAST
    Repeati637 – 66630ARM 12Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2322Interaction with VCLBy similarityAdd
    BLAST
    Regioni156 – 17823Interaction with BCL9By similarityAdd
    BLAST
    Regioni772 – 78110Interaction with SCRIBBy similarity

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 12 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG297695.
    GeneTreeiENSGT00730000110821.
    HOGENOMiHOG000230958.
    HOVERGENiHBG000919.
    InParanoidiQ9WU82.
    KOiK02105.
    OrthoDBiEOG7X9G6B.
    PhylomeDBiQ9WU82.
    TreeFamiTF317997.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view]
    PfamiPF00514. Arm. 4 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 12 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WU82-1 [UniParc]FASTAAdd to Basket

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    MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG    50
    NPEEEDVDTS QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP 100
    ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT 150
    RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR 200
    TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS 250
    VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300
    LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC 350
    SSNKPAIVEA GGMQALGPHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG 400
    LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT 450
    VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP 500
    PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR 550
    TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 600
    QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG 650
    VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI 700
    GAQGEALGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV 750
    DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L 781
    Length:781
    Mass (Da):85,455
    Last modified:November 1, 1999 - v1
    Checksum:i9C29186B6DD54B87
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti368 – 3681P → L in AAK85253. (PubMed:11867232)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121265 mRNA. Translation: AAD28504.1.
    AF397179 Genomic DNA. Translation: AAK85253.1.
    RefSeqiNP_445809.2. NM_053357.2.
    XP_006244196.1. XM_006244134.1.
    XP_006244197.1. XM_006244135.1.
    XP_006244198.1. XM_006244136.1.
    XP_006244199.1. XM_006244137.1.
    XP_006244200.1. XM_006244138.1.
    UniGeneiRn.112601.

    Genome annotation databases

    EnsembliENSRNOT00000026016; ENSRNOP00000026016; ENSRNOG00000019139.
    GeneIDi84353.
    KEGGirno:84353.
    UCSCiRGD:70487. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121265 mRNA. Translation: AAD28504.1 .
    AF397179 Genomic DNA. Translation: AAK85253.1 .
    RefSeqi NP_445809.2. NM_053357.2.
    XP_006244196.1. XM_006244134.1.
    XP_006244197.1. XM_006244135.1.
    XP_006244198.1. XM_006244136.1.
    XP_006244199.1. XM_006244137.1.
    XP_006244200.1. XM_006244138.1.
    UniGenei Rn.112601.

    3D structure databases

    ProteinModelPortali Q9WU82.
    SMRi Q9WU82. Positions 19-44, 118-682.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249913. 11 interactions.
    DIPi DIP-37053N.
    IntActi Q9WU82. 4 interactions.
    MINTi MINT-87458.

    PTM databases

    PhosphoSitei Q9WU82.

    Proteomic databases

    PaxDbi Q9WU82.
    PRIDEi Q9WU82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026016 ; ENSRNOP00000026016 ; ENSRNOG00000019139 .
    GeneIDi 84353.
    KEGGi rno:84353.
    UCSCi RGD:70487. rat.

    Organism-specific databases

    CTDi 1499.
    RGDi 70487. Ctnnb1.

    Phylogenomic databases

    eggNOGi NOG297695.
    GeneTreei ENSGT00730000110821.
    HOGENOMi HOG000230958.
    HOVERGENi HBG000919.
    InParanoidi Q9WU82.
    KOi K02105.
    OrthoDBi EOG7X9G6B.
    PhylomeDBi Q9WU82.
    TreeFami TF317997.

    Enzyme and pathway databases

    Reactomei REACT_194690. Ca2+ pathway.
    REACT_198375. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_212065. TCF dependent signaling in response to WNT.
    REACT_214025. deactivation of the beta-catenin transactivating complex.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Miscellaneous databases

    NextBioi 616667.
    PROi Q9WU82.

    Gene expression databases

    Genevestigatori Q9WU82.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view ]
    Pfami PF00514. Arm. 4 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 12 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Study on the formation of specialized inter-Sertoli cell junctions in vitro."
      Chung S.S.W., Lee W.M., Cheng C.Y.
      J. Cell. Physiol. 181:258-272(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Testis.
    2. "Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline."
      Li Q., Dixon B.M., Al-Fageeh M., Blum C.A., Dashwood R.H.
      Gene 283:255-262(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Fischer 344.
    3. "The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway."
      Chen H.J., Lin C.M., Lin C.S., Perez-Olle R., Leung C.L., Liem R.K.
      Genes Dev. 20:1933-1945(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH MACF1; APC; AXIN1 AND GSK3B.
    4. "The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals."
      Hou R., Liu L., Anees S., Hiroyasu S., Sibinga N.E.
      J. Cell Biol. 173:417-429(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FAT1.
    5. "A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation."
      Sakamoto I., Kishida S., Fukui A., Kishida M., Yamamoto H., Hino S., Michiue T., Takada S., Asashima M., Kikuchi A.
      J. Biol. Chem. 275:32871-32878(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CHD8.
    6. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCTNB1_RAT
    AccessioniPrimary (citable) accession number: Q9WU82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3