Reviewed, UniProtKB/Swiss-Prot Q9WU79 (PROD_MOUSE)

Names and origin

Protein names

Recommended name:
    Proline dehydrogenase, mitochondrial
    EC=1.5.99.8
Alternative name(s):
    Proline oxidase

Gene names

Name:	Prodh
Synonyms:	Pro1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Subcellular location	Mitochondrion matrix.
Tissue specificity	Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle.
Involvement in disease	Pro/re mice that have a premature termination on Prodh are sluggish in their movement.
Sequence similarities	Belongs to the proline oxidase family.

Ontologies

Keywords
Biological process	Proline metabolism
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial inner membrane Inferred from direct assay. Source: MGI mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	proline dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 497		Proline dehydrogenase, mitochondrial		PRO_0000025801

Sequences

	Sequence		Length	Mass (Da)
	Q9WU79-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 9B5C80FBBE8C3589	FASTA	497	56,774
	10 20 30 40 50 60 MFERLMKMTF YGHFVAGEDQ ESIRPLIRHN KAFGVGFILD YGVEEDLSPE EAERKEMESC 70 80 90 100 110 120 TSEAERDGSG ANKREKQYQV HPAFGDRRDG VISARTYFYA NEAKCDNYME NLLQCIKASG 130 140 150 160 170 180 GASDGGFSAI KLTALGRPQF LLQFSDVLTR WRRFFHQMAA EQGQAGRAAV DTKLEVAVLQ 190 200 210 220 230 240 DSIAKMGIAS RAEIEGWFTP ETLGVSGTVD LLDWNSLIDS RTRLSRHLVV PNVQTGQLEP 250 260 270 280 290 300 LLSRFTEEEE QQMKRMLQRM DVLAKKAKEA GVRLMIDAEQ SYFQPAISRL TLEMQRRFNV 310 320 330 340 350 360 DKPFIFNTFQ CYLKDAYDNV TLDMELARRE GWCSGAKLVR RAYMAQERVR AAEIGYEDPI 370 380 390 400 410 420 NPTYEATNAM YHRCLNYVLE ELKHSTKAEV MVASHNEDTV HFTLCRMKEI GLHPADGQVC 430 440 450 460 470 480 FGQLLGMCDQ ISFPLGQAGF PVYKYVPYGP VMEVLPYLSR RALENSSIMK GAQRERQLLW 490 QELRRRLRTG SLFHHPA

References

[1]	"The gene encoding proline dehydrogenase modulates sensorimotor gating in mice." Gogos J.A., Santha M., Takacs Z., Beck K.D., Luine V., Lucas L.R., Nadler J.V., Karayiorgou M. Nat. Genet. 21:434-439(1999) [PubMed: 10192398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 and PRO/RE. Tissue: Cerebellum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF120279 mRNA. Translation: AAD24776.1.
IPI	IPI00322760.
UniGene	Mm.28456
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000003526. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:97770. Prodh.
Phylogenomic databases
HOVERGEN	Q9WU79.
Enzyme and pathway databases
BRENDA	1.5.99.8. 244.
Gene expression databases
Bgee	Q9WU79.
CleanEx	MM_PRODH.
GermOnline	ENSMUSG00000003526. Mus musculus.
Family and domain databases
InterPro	IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view]
PANTHER	PTHR13914. Proline_oxidase. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

PROD_MOUSE

Accession

Primary (citable) accession number: Q9WU79

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)