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Reviewed, UniProtKB/Swiss-Prot Q9WU79 (PROD_MOUSE)

Last modified June 16, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Proline dehydrogenase, mitochondrial
    EC=1.5.99.8
Alternative name(s):
    Proline oxidase
Gene names
Name: Prodh
Synonyms: Pro1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Converts proline to delta-1-pyrroline-5-carboxylate.

Catalytic activity

L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.

Cofactor

FAD.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.

Subcellular location

Mitochondrion matrix.

Tissue specificity

Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle.

Involvement in disease

Pro/re mice that have a premature termination on Prodh are sluggish in their movement.

Sequence similarities

Belongs to the proline oxidase family.

Ontologies

Keywords
   Biological processProline metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processglutamate biosynthetic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

proline catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial inner membrane

Inferred from direct assay. Source: MGI

mitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionproline dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 497Proline dehydrogenase, mitochondrialPRO_0000025801

Sequences

Sequence LengthMass (Da)Tools
Q9WU79-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 9B5C80FBBE8C3589

FASTA49756,774
        10         20         30         40         50         60 
MFERLMKMTF YGHFVAGEDQ ESIRPLIRHN KAFGVGFILD YGVEEDLSPE EAERKEMESC 

        70         80         90        100        110        120 
TSEAERDGSG ANKREKQYQV HPAFGDRRDG VISARTYFYA NEAKCDNYME NLLQCIKASG 

       130        140        150        160        170        180 
GASDGGFSAI KLTALGRPQF LLQFSDVLTR WRRFFHQMAA EQGQAGRAAV DTKLEVAVLQ 

       190        200        210        220        230        240 
DSIAKMGIAS RAEIEGWFTP ETLGVSGTVD LLDWNSLIDS RTRLSRHLVV PNVQTGQLEP 

       250        260        270        280        290        300 
LLSRFTEEEE QQMKRMLQRM DVLAKKAKEA GVRLMIDAEQ SYFQPAISRL TLEMQRRFNV 

       310        320        330        340        350        360 
DKPFIFNTFQ CYLKDAYDNV TLDMELARRE GWCSGAKLVR RAYMAQERVR AAEIGYEDPI 

       370        380        390        400        410        420 
NPTYEATNAM YHRCLNYVLE ELKHSTKAEV MVASHNEDTV HFTLCRMKEI GLHPADGQVC 

       430        440        450        460        470        480 
FGQLLGMCDQ ISFPLGQAGF PVYKYVPYGP VMEVLPYLSR RALENSSIMK GAQRERQLLW 

       490 
QELRRRLRTG SLFHHPA 

« Hide

References

[1]"The gene encoding proline dehydrogenase modulates sensorimotor gating in mice."
Gogos J.A., Santha M., Takacs Z., Beck K.D., Luine V., Lucas L.R., Nadler J.V., Karayiorgou M.
Nat. Genet. 21:434-439(1999) [PubMed: 10192398] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 and PRO/RE.
Tissue: Cerebellum.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF120279 mRNA. Translation: AAD24776.1.
IPIIPI00322760.
UniGeneMm.28456

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000003526. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:97770. Prodh.

Phylogenomic databases

HOVERGENQ9WU79.

Enzyme and pathway databases

BRENDA1.5.99.8. 244.

Gene expression databases

BgeeQ9WU79.
CleanExMM_PRODH.
GermOnlineENSMUSG00000003526. Mus musculus.

Family and domain databases

InterProIPR002872. Proline_DH.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERPTHR13914. Proline_oxidase. 1 hit.
PfamPF01619. Pro_dh. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry namePROD_MOUSE
AccessionPrimary (citable) accession number: Q9WU79
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents