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Q9WU79 (PROD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proline dehydrogenase 1, mitochondrial
EC=1.5.99.8
Alternative name(s):
Proline oxidase
Gene names
Name:Prodh
Synonyms:Pro1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts proline to delta-1-pyrroline-5-carboxylate.

Catalytic activity

L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.

Cofactor

FAD.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.

Subcellular location

Mitochondrion matrix.

Tissue specificity

Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle.

Involvement in disease

Pro/re mice that have a premature termination on Prodh are sluggish in their movement.

Sequence similarities

Belongs to the proline oxidase family.

Sequence caution

The sequence AAD24776.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI25328.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence EDK97501.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 599Proline dehydrogenase 1, mitochondrialPRO_0000025801

Experimental info

Sequence conflict7 – 82FL → HE in AAF21467. Ref.5
Sequence conflict3031E → V in BAE25683. Ref.1
Sequence conflict3791D → G in BAE25683. Ref.1
Sequence conflict4361F → S in AAD24776. Ref.4
Sequence conflict4431G → R in AAD24776. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9WU79 [UniParc].

Last modified April 5, 2011. Version 2.
Checksum: 528AA436920CE5DD

FASTA59968,036
        10         20         30         40         50         60 
MALKRVFLLR SVAPRVAALS TKPQAQEQPP ASPEALRGCG AAKAVRPPVP AVDFTNTQEA 

        70         80         90        100        110        120 
YRSRRSWELV RNLLVLRLCA SPVLLAHHEQ LFQVARKLLG QRMFERLMKM TFYGHFVAGE 

       130        140        150        160        170        180 
DQESIRPLIR HNKAFGVGFI LDYGVEEDLS PEEAERKEME SCTSEAERDG SGANKREKQY 

       190        200        210        220        230        240 
QVHPAFGDRR DGVISARTYF YANEAKCDNY MENLLQCIKA SGGASDGGFS AIKLTALGRP 

       250        260        270        280        290        300 
QFLLQFSDVL TRWRRFFHQM AAEQGQAGRA AVDTKLEVAV LQDSIAKMGI ASRAEIEGWF 

       310        320        330        340        350        360 
TPETLGVSGT VDLLDWNSLI DSRTRLSRHL VVPNVQTGQL EPLLSRFTEE EEQQMKRMLQ 

       370        380        390        400        410        420 
RMDVLAKKAK EAGVRLMIDA EQSYFQPAIS RLTLEMQRRF NVDKPFIFNT FQCYLKDAYD 

       430        440        450        460        470        480 
NVTLDMELAR REGWCFGAKL VRGAYMAQER VRAAEIGYED PINPTYEATN AMYHRCLNYV 

       490        500        510        520        530        540 
LEELKHSTKA EVMVASHNED TVHFTLCRMK EIGLHPADGQ VCFGQLLGMC DQISFPLGQA 

       550        560        570        580        590 
GFPVYKYVPY GPVMEVLPYL SRRALENSSI MKGAQRERQL LWQELRRRLR TGSLFHHPA

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The gene encoding proline dehydrogenase modulates sensorimotor gating in mice."
Gogos J.A., Santha M., Takacs Z., Beck K.D., Luine V., Lucas L.R., Nadler J.V., Karayiorgou M.
Nat. Genet. 21:434-439(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-599.
Strain: C57BL/6 and PRO/Re.
Tissue: Cerebellum.
[5]Lin W.-W., Hu C.A., Valle D.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-599.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-599.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK144068 mRNA. Translation: BAE25683.1.
AC087064 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97501.1. Sequence problems.
AF120279 mRNA. Translation: AAD24776.1. Different initiation.
U80020 mRNA. Translation: AAF21467.1.
BC125327 mRNA. Translation: AAI25328.1. Different initiation.
IPIIPI00322760.
RefSeqNP_035302.2. NM_011172.2.
UniGeneMm.28456.

3D structure databases

ProteinModelPortalQ9WU79.
SMRQ9WU79. Positions 349-580.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000003620.

PTM databases

PhosphoSiteQ9WU79.

Proteomic databases

PaxDbQ9WU79.
PRIDEQ9WU79.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003620; ENSMUSP00000003620; ENSMUSG00000003526.
ENSMUST00000136776; ENSMUSP00000117597; ENSMUSG00000003526.
GeneID19125.
KEGGmmu:19125.

Organism-specific databases

CTD5625.
MGIMGI:97770. Prodh.

Phylogenomic databases

eggNOGCOG0506.
GeneTreeENSGT00390000006265.
HOGENOMHOG000233406.
HOVERGENHBG008262.
InParanoidA0JLW6.
KOK00318.
OMAASEAKCD.
OrthoDBEOG41G35C.

Enzyme and pathway databases

UniPathwayUPA00261; UER00373.

Gene expression databases

ArrayExpressQ9WU79.
BgeeQ9WU79.
CleanExMM_PRODH.
GenevestigatorQ9WU79.
GermOnlineENSMUSG00000003526. Mus musculus.

Family and domain databases

InterProIPR002872. Proline_DH.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERPTHR13914. PTHR13914. 1 hit.
PfamPF01619. Pro_dh. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295730.
SOURCESearch...

Entry information

Entry namePROD_MOUSE
AccessionPrimary (citable) accession number: Q9WU79
Secondary accession number(s): A0JLW6, Q3UNR4, Q9QX61
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 5, 2011
Last modified: May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents