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Protein

Proline dehydrogenase 1, mitochondrial

Gene

Prodh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts proline to delta-1-pyrroline-5-carboxylate.

Catalytic activityi

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.

Cofactori

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from L-proline.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Proline dehydrogenase 1, mitochondrial (Prodh)
  2. Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Aldh4a1)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processProline metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-70688 Proline catabolism
UniPathwayiUPA00261; UER00373

Names & Taxonomyi

Protein namesi
Recommended name:
Proline dehydrogenase 1, mitochondrial (EC:1.5.5.2)
Alternative name(s):
Proline oxidase
Gene namesi
Name:Prodh
Synonyms:Pro1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:97770 Prodh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Pro/re mice that have a premature termination on Prodh are sluggish in their movement.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000025801? – 599Proline dehydrogenase 1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei356N6-acetyllysineCombined sources1
Modified residuei367N6-acetyllysineCombined sources1
Modified residuei485N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9WU79
MaxQBiQ9WU79
PaxDbiQ9WU79
PeptideAtlasiQ9WU79
PRIDEiQ9WU79

PTM databases

iPTMnetiQ9WU79
PhosphoSitePlusiQ9WU79
SwissPalmiQ9WU79

Expressioni

Tissue specificityi

Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle.

Gene expression databases

BgeeiENSMUSG00000003526
CleanExiMM_PRODH
ExpressionAtlasiQ9WU79 baseline and differential
GenevisibleiQ9WU79 MM

Interactioni

Protein-protein interaction databases

IntActiQ9WU79, 3 interactors
MINTiQ9WU79
STRINGi10090.ENSMUSP00000003620

Structurei

3D structure databases

ProteinModelPortaliQ9WU79
SMRiQ9WU79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proline oxidase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0186 Eukaryota
COG0506 LUCA
GeneTreeiENSGT00390000006265
HOGENOMiHOG000233406
HOVERGENiHBG008262
InParanoidiQ9WU79
KOiK00318
OMAiYLNEASC
OrthoDBiEOG091G05G3
PhylomeDBiQ9WU79
TreeFamiTF313544

Family and domain databases

InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR002872 Proline_DH_dom
IPR015659 Proline_oxidase
PANTHERiPTHR13914 PTHR13914, 1 hit
PfamiView protein in Pfam
PF01619 Pro_dh, 1 hit
SUPFAMiSSF51730 SSF51730, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WU79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKRVFLLR SVAPRVAALS TKPQAQEQPP ASPEALRGCG AAKAVRPPVP
60 70 80 90 100
AVDFTNTQEA YRSRRSWELV RNLLVLRLCA SPVLLAHHEQ LFQVARKLLG
110 120 130 140 150
QRMFERLMKM TFYGHFVAGE DQESIRPLIR HNKAFGVGFI LDYGVEEDLS
160 170 180 190 200
PEEAERKEME SCTSEAERDG SGANKREKQY QVHPAFGDRR DGVISARTYF
210 220 230 240 250
YANEAKCDNY MENLLQCIKA SGGASDGGFS AIKLTALGRP QFLLQFSDVL
260 270 280 290 300
TRWRRFFHQM AAEQGQAGRA AVDTKLEVAV LQDSIAKMGI ASRAEIEGWF
310 320 330 340 350
TPETLGVSGT VDLLDWNSLI DSRTRLSRHL VVPNVQTGQL EPLLSRFTEE
360 370 380 390 400
EEQQMKRMLQ RMDVLAKKAK EAGVRLMIDA EQSYFQPAIS RLTLEMQRRF
410 420 430 440 450
NVDKPFIFNT FQCYLKDAYD NVTLDMELAR REGWCFGAKL VRGAYMAQER
460 470 480 490 500
VRAAEIGYED PINPTYEATN AMYHRCLNYV LEELKHSTKA EVMVASHNED
510 520 530 540 550
TVHFTLCRMK EIGLHPADGQ VCFGQLLGMC DQISFPLGQA GFPVYKYVPY
560 570 580 590
GPVMEVLPYL SRRALENSSI MKGAQRERQL LWQELRRRLR TGSLFHHPA
Length:599
Mass (Da):68,036
Last modified:April 5, 2011 - v2
Checksum:i528AA436920CE5DD
GO

Sequence cautioni

The sequence AAD24776 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI25328 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EDK97501 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 8FL → HE in AAF21467 (Ref. 5) Curated2
Sequence conflicti303E → V in BAE25683 (PubMed:16141072).Curated1
Sequence conflicti379D → G in BAE25683 (PubMed:16141072).Curated1
Sequence conflicti436F → S in AAD24776 (PubMed:10192398).Curated1
Sequence conflicti443G → R in AAD24776 (PubMed:10192398).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144068 mRNA Translation: BAE25683.1
AC087064 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97501.1 Sequence problems.
AF120279 mRNA Translation: AAD24776.1 Different initiation.
U80020 mRNA Translation: AAF21467.1
BC125327 mRNA Translation: AAI25328.1 Different initiation.
CCDSiCCDS37278.1
RefSeqiNP_035302.2, NM_011172.2
UniGeneiMm.28456

Genome annotation databases

EnsembliENSMUST00000003620; ENSMUSP00000003620; ENSMUSG00000003526
ENSMUST00000216391; ENSMUSP00000149861; ENSMUSG00000111321
GeneIDi19125
KEGGimmu:19125
UCSCiuc007ymu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPROD_MOUSE
AccessioniPrimary (citable) accession number: Q9WU79
Secondary accession number(s): A0JLW6, Q3UNR4, Q9QX61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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