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Protein

Lipolysis-stimulated lipoprotein receptor

Gene

Lsr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable role in the clearance of triglyceride-rich lipoprotein from plasma. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.1 Publication

GO - Molecular functioni

  • fatty acid binding Source: HGNC
  • triglyceride binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-171052. LDL-mediated lipid transport.
R-RNO-8855121. VLDL interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipolysis-stimulated lipoprotein receptor
Alternative name(s):
Lipolysis-stimulated remnant receptor
Gene namesi
Name:Lsr
Synonyms:Lisch7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi69236. Lsr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 206ExtracellularSequence analysisAdd BLAST171
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 593CytoplasmicSequence analysisAdd BLAST366

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Chylomicron, LDL, Membrane, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000024531036 – 593Lipolysis-stimulated lipoprotein receptorAdd BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi113 ↔ 165By similarity
Modified residuei283PhosphothreonineCombined sources1
Modified residuei308PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei396PhosphothreonineBy similarity1
Modified residuei407PhosphoserineCombined sources1
Modified residuei410PhosphoserineBy similarity1
Modified residuei436PhosphoserineCombined sources1
Modified residuei471PhosphoserineBy similarity1
Modified residuei473PhosphoserineCombined sources1
Modified residuei478PhosphotyrosineBy similarity1
Modified residuei575PhosphoserineBy similarity1
Modified residuei587PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9WU74.
PRIDEiQ9WU74.

PTM databases

iPTMnetiQ9WU74.
PhosphoSitePlusiQ9WU74.

Expressioni

Tissue specificityi

Specifically expressed in liver. Also detected in kidney and lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000021053.
GenevisibleiQ9WU74. RN.

Interactioni

Subunit structurei

Homotrimer or homotetramer constituted of isoform 1 and/or isoform 2 and isoform 3.1 Publication

Protein-protein interaction databases

IntActiQ9WU74. 1 interactor.
STRINGi10116.ENSRNOP00000041379.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 181Ig-like V-typeAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi227 – 251Cys-richAdd BLAST25

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKMJ. Eukaryota.
ENOG411004A. LUCA.
GeneTreeiENSGT00430000030906.
HOGENOMiHOG000253962.
HOVERGENiHBG061576.
InParanoidiQ9WU74.
OMAiPPAMIPM.
OrthoDBiEOG091G0875.
PhylomeDBiQ9WU74.
TreeFamiTF330877.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR008664. LISCH7.
[Graphical view]
PfamiPF05624. LSR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9WU74-1) [UniParc]FASTAAdd to basket
Also known as: alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAAGACAG APDSHPATVV FVCLFLIIFC PDPASAIQVT VSDPYHVVIL
60 70 80 90 100
FQPVTLPCTY QMSNTLTVPI VIWKYKSFCR DRIADAFSPA SVDNQLNAQL
110 120 130 140 150
AAGNPGYNPY VECQDSVRTV RVVATKQGNA VTLGDYYQGR RITITGNADL
160 170 180 190 200
TFEQTAWGDS GVYYCSVVSA QDLDGNNEAY AELIVLGRTS EAPELLPGFR
210 220 230 240 250
AGPLEDWLFV VVVCLASLLL FLLLGICWCQ CCPHTCCCYV RCPCCPDKCC
260 270 280 290 300
CPEALYAAGK AATSGVPSIY APSIYTHLSP AKTPPPPPAM IPMGPPYGYP
310 320 330 340 350
GDFDRHSSVG GHSSQVPLLR DVDGSVSSEV RSGYRIQANQ QDDSMRVLYY
360 370 380 390 400
MEKELANFDP SRPGPPNGRV ERAMSEVTSL HEDDWRSRPS RAPALTPIRD
410 420 430 440 450
EEWNRHSPQS PRTWEQEPLQ EQPRGGWGSG RPRARSVDAL DDINRPGSTE
460 470 480 490 500
SGRSSPPSSG RRGRAYAPPR SRSRDDLYDP DDPRDLPHSR DPHYYDDIRS
510 520 530 540 550
RDPRADPRSR QRSRDPRDAG FRSRDPQYDG RLLEEALKKK GSGERRRVYR
560 570 580 590
EEEEEEEGQY PPAPPPYSET DSQASRERRL KKNLALSRES LVV
Length:593
Mass (Da):65,777
Last modified:November 1, 1999 - v1
Checksum:i7C0288823492C87F
GO
Isoform 2 (identifier: Q9WU74-2) [UniParc]FASTAAdd to basket
Also known as: alpha'

The sequence of this isoform differs from the canonical sequence as follows:
     187-205: Missing.

Show »
Length:574
Mass (Da):63,797
Checksum:i23850648D4D056DD
GO
Isoform 3 (identifier: Q9WU74-3) [UniParc]FASTAAdd to basket
Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     187-255: GRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLLFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEAL → V

Show »
Length:525
Mass (Da):58,311
Checksum:i8E62038B96B30D15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti481D → E in AAI00627 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019697187 – 255GRTSE…CPEAL → V in isoform 3. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_019698187 – 205Missing in isoform 2. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119667 mRNA. Translation: AAD30028.1.
AF119668 mRNA. Translation: AAD30029.1.
AF119669 mRNA. Translation: AAD30030.1.
BC100626 mRNA. Translation: AAI00627.1.
RefSeqiNP_116005.1. NM_032616.1. [Q9WU74-1]
XP_006228906.1. XM_006228844.3. [Q9WU74-2]
XP_006228907.1. XM_006228845.3. [Q9WU74-3]
UniGeneiRn.48696.

Genome annotation databases

EnsembliENSRNOT00000028585; ENSRNOP00000028585; ENSRNOG00000021053. [Q9WU74-2]
ENSRNOT00000044678; ENSRNOP00000041379; ENSRNOG00000021053. [Q9WU74-1]
GeneIDi64355.
KEGGirno:64355.
UCSCiRGD:69236. rat. [Q9WU74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119667 mRNA. Translation: AAD30028.1.
AF119668 mRNA. Translation: AAD30029.1.
AF119669 mRNA. Translation: AAD30030.1.
BC100626 mRNA. Translation: AAI00627.1.
RefSeqiNP_116005.1. NM_032616.1. [Q9WU74-1]
XP_006228906.1. XM_006228844.3. [Q9WU74-2]
XP_006228907.1. XM_006228845.3. [Q9WU74-3]
UniGeneiRn.48696.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WU74. 1 interactor.
STRINGi10116.ENSRNOP00000041379.

PTM databases

iPTMnetiQ9WU74.
PhosphoSitePlusiQ9WU74.

Proteomic databases

PaxDbiQ9WU74.
PRIDEiQ9WU74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028585; ENSRNOP00000028585; ENSRNOG00000021053. [Q9WU74-2]
ENSRNOT00000044678; ENSRNOP00000041379; ENSRNOG00000021053. [Q9WU74-1]
GeneIDi64355.
KEGGirno:64355.
UCSCiRGD:69236. rat. [Q9WU74-1]

Organism-specific databases

CTDi51599.
RGDi69236. Lsr.

Phylogenomic databases

eggNOGiENOG410IKMJ. Eukaryota.
ENOG411004A. LUCA.
GeneTreeiENSGT00430000030906.
HOGENOMiHOG000253962.
HOVERGENiHBG061576.
InParanoidiQ9WU74.
OMAiPPAMIPM.
OrthoDBiEOG091G0875.
PhylomeDBiQ9WU74.
TreeFamiTF330877.

Enzyme and pathway databases

ReactomeiR-RNO-171052. LDL-mediated lipid transport.
R-RNO-8855121. VLDL interactions.

Miscellaneous databases

PROiQ9WU74.

Gene expression databases

BgeeiENSRNOG00000021053.
GenevisibleiQ9WU74. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR008664. LISCH7.
[Graphical view]
PfamiPF05624. LSR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiLSR_RAT
AccessioniPrimary (citable) accession number: Q9WU74
Secondary accession number(s): Q497B9, Q9WU75, Q9WU76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.