ID TN13B_MOUSE Reviewed; 309 AA. AC Q9WU72; DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 03-NOV-2009, entry version 74. DE RecName: Full=Tumor necrosis factor ligand superfamily member 13B; DE AltName: Full=B cell-activating factor; DE AltName: Full=BAFF; DE AltName: CD_antigen=CD257; DE Contains: DE RecName: Full=Tumor necrosis factor ligand superfamily member 13b, membrane form; DE Contains: DE RecName: Full=Tumor necrosis factor ligand superfamily member 13b, soluble form; GN Name=Tnfsf13b; Synonyms=Baff; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=99288033; PubMed=10359578; DOI=10.1084/jem.189.11.1747; RA Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.-L., RA Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., RA Valmori D., Romero P., Werner-Favre C., Zubler R.H., Browning J.L., RA Tschopp J.; RT "BAFF, a novel ligand of the tumor necrosis factor family, stimulates RT B cell growth."; RL J. Exp. Med. 189:1747-1756(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-79. RC STRAIN=NZB; RX MEDLINE=21850530; PubMed=11862414; DOI=10.1007/s00251-001-0396-6; RA Jiang Y., Ohtsuji M., Abe M., Li N., Xiu Y., Wen X.S., Shirai T., RA Hirose S.; RT "Polymorphism and chromosomal mapping of the mouse gene for B-cell RT activating factor belonging to the tumor necrosis factor family (Baff) RT and association with the autoimmune phenotype."; RL Immunogenetics 53:810-813(2001). CC -!- FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. CC TNFSF13/APRIL binds to the same 2 receptors. Together, they form a CC 2 ligands -2 receptors pathway involved in the stimulation of B- CC and T-cell function and the regulation of humoral immunity. A CC third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the CC survival of mature B-cells and the B-cell response. CC -!- SUBUNIT: Homotrimer. CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane CC protein. CC -!- SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily CC member 13b, soluble form: Secreted. CC -!- PTM: The soluble form derives from the membrane form by CC proteolytic processing. CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF119383; AAD22475.1; -; mRNA. DR EMBL; AF352245; AAL83939.1; -; mRNA. DR IPI; IPI00124038; -. DR RefSeq; NP_296371.1; -. DR UniGene; Mm.28835; -. DR HSSP; Q9Y275; 1KXG. DR SMR; Q9WU72; 166-309. DR STRING; Q9WU72; -. DR PRIDE; Q9WU72; -. DR Ensembl; ENSMUST00000033892; ENSMUSP00000033892; ENSMUSG00000031497; Mus musculus. DR GeneID; 24099; -. DR KEGG; mmu:24099; -. DR UCSC; uc009kup.1; mouse. DR CTD; 24099; -. DR MGI; MGI:1344376; Tnfsf13b. DR HOGENOM; Q9WU72; -. DR HOVERGEN; Q9WU72; -. DR OMA; LALLSCC; -. DR NextBio; 304105; -. DR ArrayExpress; Q9WU72; -. DR Bgee; Q9WU72; -. DR Genevestigator; Q9WU72; -. DR GermOnline; ENSMUSG00000031497; Mus musculus. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro. DR GO; GO:0031296; P:B cell costimulation; IDA:MGI. DR GO; GO:0001782; P:B cell homeostasis; IMP:MGI. DR GO; GO:0048305; P:immunoglobulin secretion; IGI:MGI. DR GO; GO:0030890; P:positive regulation of B cell proliferation; IDA:MGI. DR GO; GO:0002636; P:positive regulation of germinal center form...; IMP:MGI. DR GO; GO:0045885; P:positive regulation of survival gene produc...; IDA:MGI. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI. DR GO; GO:0031295; P:T cell costimulation; IDA:MGI. DR InterPro; IPR006052; TNF_family. DR InterPro; IPR008983; Tumour_necrosis_fac-like. DR Gene3D; G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1. DR Pfam; PF00229; TNF; 1. DR SMART; SM00207; TNF; 1. DR PROSITE; PS00251; TNF_1; FALSE_NEG. DR PROSITE; PS50049; TNF_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Cleavage on pair of basic residues; Cytokine; KW Disulfide bond; Glycoprotein; Membrane; Polymorphism; Secreted; KW Signal-anchor; Transmembrane. FT CHAIN 1 309 Tumor necrosis factor ligand superfamily FT member 13b, membrane form. FT /FTId=PRO_0000034530. FT CHAIN 127 309 Tumor necrosis factor ligand superfamily FT member 13b, soluble form. FT /FTId=PRO_0000034531. FT TOPO_DOM 1 47 Cytoplasmic (Potential). FT TRANSMEM 48 68 Signal-anchor for type II membrane FT protein (Potential). FT TOPO_DOM 69 309 Extracellular (Potential). FT SITE 126 127 Cleavage (By similarity). FT CARBOHYD 117 117 N-linked (GlcNAc...) (Potential). FT CARBOHYD 266 266 N-linked (GlcNAc...) (Potential). FT DISULFID 256 269 By similarity. FT VARIANT 79 79 N -> S (in strain: NZB). SQ SEQUENCE 309 AA; 34192 MW; F3DE6056E66034B4 CRC64; MDESAKTLPP PCLCFCSEKG EDMKVGYDPI TPQKEEGAWF GICRDGRLLA ATLLLALLSS SFTAMSLYQL AALQADLMNL RMELQSYRGS ATPAAAGAPE LTAGVKLLTP AAPRPHNSSR GHRNRRAFQG PEETEQDVDL SAPPAPCLPG CRHSQHDDNG MNLRNIIQDC LQLIADSDTP TIRKGTYTFV PWLLSFKRGN ALEEKENKIV VRQTGYFFIY SQVLYTDPIF AMGHVIQRKK VHVFGDELSL VTLFRCIQNM PKTLPNNSCY SAGIARLEEG DEIQLAIPRE NAQISRNGDD TFFGALKLL //