ID TN13B_MOUSE Reviewed; 309 AA. AC Q9WU72; Q7TQ58; DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 25-JAN-2012, entry version 92. DE RecName: Full=Tumor necrosis factor ligand superfamily member 13B; DE AltName: Full=B-cell-activating factor; DE AltName: Full=BAFF; DE AltName: CD_antigen=CD257; DE Contains: DE RecName: Full=Tumor necrosis factor ligand superfamily member 13b, membrane form; DE Contains: DE RecName: Full=Tumor necrosis factor ligand superfamily member 13b, soluble form; GN Name=Tnfsf13b; Synonyms=Baff; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX MEDLINE=99288033; PubMed=10359578; DOI=10.1084/jem.189.11.1747; RA Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.-L., RA Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., RA Valmori D., Romero P., Werner-Favre C., Zubler R.H., Browning J.L., RA Tschopp J.; RT "BAFF, a novel ligand of the tumor necrosis factor family, stimulates RT B cell growth."; RL J. Exp. Med. 189:1747-1756(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT SER-79. RC STRAIN=NZB; RX MEDLINE=21850530; PubMed=11862414; DOI=10.1007/s00251-001-0396-6; RA Jiang Y., Ohtsuji M., Abe M., Li N., Xiu Y., Wen X.S., Shirai T., RA Hirose S.; RT "Polymorphism and chromosomal mapping of the mouse gene for B-cell RT activating factor belonging to the tumor necrosis factor family (Baff) RT and association with the autoimmune phenotype."; RL Immunogenetics 53:810-813(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION, RP POST-TRANSLATIONAL MODIFICATION, AND SUBUNIT. RC STRAIN=BALB/c; RX MEDLINE=22877063; PubMed=12867412; DOI=10.1074/jbc.M306852200; RA Gavin A.L., Ait-Azzouzene D., Ware C.F., Nemazee D.; RT "DeltaBAFF, an alternate splice isoform that regulates receptor RT binding and biopresentation of the B cell survival cytokine, BAFF."; RL J. Biol. Chem. 278:38220-38228(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. CC TNFSF13/APRIL binds to the same 2 receptors. Together, they form a CC 2 ligands -2 receptors pathway involved in the stimulation of B- CC and T-cell function and the regulation of humoral immunity. A CC third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the CC survival of mature B-cells and the B-cell response. CC -!- FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and CC bioactivity. CC -!- SUBUNIT: Homotrimer. Isoform 2 heteromultimerizes with isoform 1, CC probably limiting the amount of functional isoform 1 on the cell CC surface. CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane CC protein. CC -!- SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily CC member 13b, soluble form: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9WU72-1; Sequence=Displayed; CC Name=2; Synonyms=DeltaBAFF; CC IsoId=Q9WU72-2; Sequence=VSP_041184; CC -!- TISSUE SPECIFICITY: Isoform 2 is expressed in many myeloid cell CC lines. CC -!- PTM: The soluble form derives from the membrane form by CC proteolytic processing. CC -!- PTM: Isoform 2 is not efficiently shed from the membrane unlike CC isoform 1. CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF119383; AAD22475.1; -; mRNA. DR EMBL; AF352245; AAL83939.1; -; mRNA. DR EMBL; AY290823; AAP82036.1; -; mRNA. DR EMBL; CH466566; EDL22044.1; -; Genomic_DNA. DR EMBL; BC106840; AAI06841.1; -; mRNA. DR IPI; IPI00124038; -. DR IPI; IPI00987994; -. DR RefSeq; NP_296371.1; NM_033622.1. DR UniGene; Mm.28835; -. DR ProteinModelPortal; Q9WU72; -. DR SMR; Q9WU72; 166-309. DR STRING; Q9WU72; -. DR PRIDE; Q9WU72; -. DR Ensembl; ENSMUST00000033892; ENSMUSP00000033892; ENSMUSG00000031497. DR Ensembl; ENSMUST00000164814; ENSMUSP00000129091; ENSMUSG00000031497. DR GeneID; 24099; -. DR KEGG; mmu:24099; -. DR CTD; 10673; -. DR MGI; MGI:1344376; Tnfsf13b. DR GeneTree; ENSGT00530000063837; -. DR HOGENOM; HBG715020; -. DR HOVERGEN; HBG061472; -. DR InParanoid; Q9WU72; -. DR OMA; ILPQKES; -. DR OrthoDB; EOG47M206; -. DR PhylomeDB; Q9WU72; -. DR NextBio; 304105; -. DR ArrayExpress; Q9WU72; -. DR Bgee; Q9WU72; -. DR Genevestigator; Q9WU72; -. DR GermOnline; ENSMUSG00000031497; Mus musculus. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro. DR GO; GO:0031296; P:B cell costimulation; IDA:MGI. DR GO; GO:0001782; P:B cell homeostasis; IMP:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0048305; P:immunoglobulin secretion; IGI:MGI. DR GO; GO:0030890; P:positive regulation of B cell proliferation; IDA:MGI. DR GO; GO:0002636; P:positive regulation of germinal center formation; IMP:MGI. DR GO; GO:0045885; P:positive regulation of survival gene product expression; IDA:MGI. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI. DR GO; GO:0031295; P:T cell costimulation; IDA:MGI. DR InterPro; IPR006052; TNF. DR InterPro; IPR008983; Tumour_necrosis_fac-like. DR Gene3D; G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1. DR KO; K05476; -. DR Pfam; PF00229; TNF; 1. DR SMART; SM00207; TNF; 1. DR SUPFAM; SSF49842; TNF_like; 1. DR PROSITE; PS00251; TNF_1; FALSE_NEG. DR PROSITE; PS50049; TNF_2; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; KW Cleavage on pair of basic residues; Complete proteome; Cytokine; KW Disulfide bond; Glycoprotein; Membrane; Polymorphism; KW Reference proteome; Secreted; Signal-anchor; Transmembrane; KW Transmembrane helix. FT CHAIN 1 309 Tumor necrosis factor ligand superfamily FT member 13b, membrane form. FT /FTId=PRO_0000034530. FT CHAIN 127 309 Tumor necrosis factor ligand superfamily FT member 13b, soluble form. FT /FTId=PRO_0000034531. FT TOPO_DOM 1 47 Cytoplasmic (Potential). FT TRANSMEM 48 68 Helical; Signal-anchor for type II FT membrane protein; (Potential). FT TOPO_DOM 69 309 Extracellular (Potential). FT SITE 126 127 Cleavage (By similarity). FT CARBOHYD 117 117 N-linked (GlcNAc...) (Potential). FT CARBOHYD 266 266 N-linked (GlcNAc...) (Potential). FT DISULFID 256 269 By similarity. FT VAR_SEQ 166 185 IIQDCLQLIADSDTPTIRKG -> R (in isoform 2). FT /FTId=VSP_041184. FT VARIANT 79 79 N -> S (in strain: NZB). SQ SEQUENCE 309 AA; 34192 MW; F3DE6056E66034B4 CRC64; MDESAKTLPP PCLCFCSEKG EDMKVGYDPI TPQKEEGAWF GICRDGRLLA ATLLLALLSS SFTAMSLYQL AALQADLMNL RMELQSYRGS ATPAAAGAPE LTAGVKLLTP AAPRPHNSSR GHRNRRAFQG PEETEQDVDL SAPPAPCLPG CRHSQHDDNG MNLRNIIQDC LQLIADSDTP TIRKGTYTFV PWLLSFKRGN ALEEKENKIV VRQTGYFFIY SQVLYTDPIF AMGHVIQRKK VHVFGDELSL VTLFRCIQNM PKTLPNNSCY SAGIARLEEG DEIQLAIPRE NAQISRNGDD TFFGALKLL //