Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9WU66

- SFRP5_MOUSE

UniProt

Q9WU66 - SFRP5_MOUSE

Protein

Secreted frizzled-related protein 5

Gene

Sfrp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

    GO - Molecular functioni

    1. PDZ domain binding Source: RefGenome
    2. Wnt-activated receptor activity Source: RefGenome
    3. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. brain development Source: RefGenome
    2. canonical Wnt signaling pathway Source: RefGenome
    3. cell differentiation Source: UniProtKB-KW
    4. convergent extension involved in axis elongation Source: MGI
    5. digestive tract morphogenesis Source: MGI
    6. gonad development Source: RefGenome
    7. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    8. negative regulation of catenin import into nucleus Source: Ensembl
    9. negative regulation of cell proliferation Source: Ensembl
    10. negative regulation of JUN kinase activity Source: MGI
    11. negative regulation of planar cell polarity pathway involved in axis elongation Source: MGI
    12. negative regulation of protein kinase B signaling Source: Ensembl
    13. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    14. negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Source: Ensembl
    15. planar cell polarity pathway involved in neural tube closure Source: MGI
    16. post-anal tail morphogenesis Source: MGI
    17. regulation of establishment of planar polarity Source: MGI
    18. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    19. vasculature development Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted frizzled-related protein 5
    Short name:
    sFRP-5
    Gene namesi
    Name:Sfrp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1860298. Sfrp5.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular region Source: UniProtKB-SubCell
    3. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 314293Secreted frizzled-related protein 5PRO_0000032556Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 113By similarity
    Disulfide bondi60 ↔ 106By similarity
    Disulfide bondi97 ↔ 132By similarity
    Disulfide bondi121 ↔ 159By similarity
    Disulfide bondi125 ↔ 149By similarity
    Disulfide bondi178 ↔ 250By similarity
    Disulfide bondi181 ↔ 252By similarity
    Disulfide bondi195 ↔ 300By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9WU66.

    PTM databases

    PhosphoSiteiQ9WU66.

    Expressioni

    Gene expression databases

    BgeeiQ9WU66.
    CleanExiMM_SFRP5.
    GenevestigatoriQ9WU66.

    Interactioni

    Protein-protein interaction databases

    BioGridi207687. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WU66.
    SMRiQ9WU66. Positions 57-153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 162118FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 300123NTRPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240950.
    GeneTreeiENSGT00750000117588.
    HOGENOMiHOG000231058.
    HOVERGENiHBG052928.
    InParanoidiQ9WU66.
    KOiK02222.
    OrthoDBiEOG789CBZ.
    PhylomeDBiQ9WU66.
    TreeFamiTF350133.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WU66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVAWSARTA ALALLLGALH GAPTRGQEYD YYGWQAEPLH GRSYSKPPQC    50
    LDIPADLPLC HTVGYKRMRL PNLLEHESLA EVKQQASSWL PLLAKRCHSD 100
    TQVFLCSLFA PVCLDRPIYP CRSLCEAARA GCAPLMEAYG FPWPEMLHCH 150
    KFPLDNDLCI AVQFGHLPAT APPVTKICAQ CEMEHSADGL MEQMCSSDFV 200
    VKMRIKEIKI DNGDRKLIGA QKKKKLLKAG PLKRKDTKKL VLHMKNGASC 250
    PCPQLDNLTG SFLVMGRKVE GQLLLTAVYR WDKKNKEMKF AVKFMFSYPC 300
    SLYYPFFYGA AEPH 314
    Length:314
    Mass (Da):35,382
    Last modified:November 1, 1999 - v1
    Checksum:i296847F56D1CAFDD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281A → V in AAH32921. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117759 mRNA. Translation: AAD25053.1.
    BC032921 mRNA. Translation: AAH32921.1.
    CCDSiCCDS29826.1.
    RefSeqiNP_061250.2. NM_018780.3.
    UniGeneiMm.470071.

    Genome annotation databases

    EnsembliENSMUST00000018966; ENSMUSP00000018966; ENSMUSG00000018822.
    GeneIDi54612.
    KEGGimmu:54612.
    UCSCiuc008hnl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117759 mRNA. Translation: AAD25053.1 .
    BC032921 mRNA. Translation: AAH32921.1 .
    CCDSi CCDS29826.1.
    RefSeqi NP_061250.2. NM_018780.3.
    UniGenei Mm.470071.

    3D structure databases

    ProteinModelPortali Q9WU66.
    SMRi Q9WU66. Positions 57-153.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207687. 2 interactions.

    PTM databases

    PhosphoSitei Q9WU66.

    Proteomic databases

    PRIDEi Q9WU66.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018966 ; ENSMUSP00000018966 ; ENSMUSG00000018822 .
    GeneIDi 54612.
    KEGGi mmu:54612.
    UCSCi uc008hnl.2. mouse.

    Organism-specific databases

    CTDi 6425.
    MGIi MGI:1860298. Sfrp5.

    Phylogenomic databases

    eggNOGi NOG240950.
    GeneTreei ENSGT00750000117588.
    HOGENOMi HOG000231058.
    HOVERGENi HBG052928.
    InParanoidi Q9WU66.
    KOi K02222.
    OrthoDBi EOG789CBZ.
    PhylomeDBi Q9WU66.
    TreeFami TF350133.

    Miscellaneous databases

    NextBioi 311420.
    PROi Q9WU66.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WU66.
    CleanExi MM_SFRP5.
    Genevestigatori Q9WU66.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium."
      Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B., Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.
      Hum. Mol. Genet. 8:575-583(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiSFRP5_MOUSE
    AccessioniPrimary (citable) accession number: Q9WU66
    Secondary accession number(s): Q8K269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3