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Q9WU66 (SFRP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secreted frizzled-related protein 5

Short name=sFRP-5
Gene names
Name:Sfrp5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Subcellular location

Secreted By similarity.

Domain

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the secreted frizzled-related protein (sFRP) family.

Contains 1 FZ (frizzled) domain.

Contains 1 NTR domain.

Ontologies

Keywords
   Biological processDifferentiation
Wnt signaling pathway
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

convergent extension involved in axis elongation

Inferred from genetic interaction PubMed 18257070. Source: MGI

digestive tract morphogenesis

Inferred from genetic interaction PubMed 19300477. Source: MGI

gonad development

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of JUN kinase activity

Inferred from genetic interaction PubMed 19300477. Source: MGI

negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of catenin import into nucleus

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of planar cell polarity pathway involved in axis elongation

Inferred from genetic interaction PubMed 18257070. Source: MGI

negative regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

planar cell polarity pathway involved in neural tube closure

Inferred from genetic interaction PubMed 18257070. Source: MGI

post-anal tail morphogenesis

Inferred from genetic interaction PubMed 16700072. Source: MGI

regulation of establishment of planar polarity

Inferred from genetic interaction PubMed 19300477. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

vasculature development

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionPDZ domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 314293Secreted frizzled-related protein 5
PRO_0000032556

Regions

Domain45 – 162118FZ
Domain178 – 300123NTR

Amino acid modifications

Disulfide bond50 ↔ 113 By similarity
Disulfide bond60 ↔ 106 By similarity
Disulfide bond97 ↔ 132 By similarity
Disulfide bond121 ↔ 159 By similarity
Disulfide bond125 ↔ 149 By similarity
Disulfide bond178 ↔ 250 By similarity
Disulfide bond181 ↔ 252 By similarity
Disulfide bond195 ↔ 300 By similarity

Experimental info

Sequence conflict1281A → V in AAH32921. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9WU66 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 296847F56D1CAFDD

FASTA31435,382
        10         20         30         40         50         60 
MWVAWSARTA ALALLLGALH GAPTRGQEYD YYGWQAEPLH GRSYSKPPQC LDIPADLPLC 

        70         80         90        100        110        120 
HTVGYKRMRL PNLLEHESLA EVKQQASSWL PLLAKRCHSD TQVFLCSLFA PVCLDRPIYP 

       130        140        150        160        170        180 
CRSLCEAARA GCAPLMEAYG FPWPEMLHCH KFPLDNDLCI AVQFGHLPAT APPVTKICAQ 

       190        200        210        220        230        240 
CEMEHSADGL MEQMCSSDFV VKMRIKEIKI DNGDRKLIGA QKKKKLLKAG PLKRKDTKKL 

       250        260        270        280        290        300 
VLHMKNGASC PCPQLDNLTG SFLVMGRKVE GQLLLTAVYR WDKKNKEMKF AVKFMFSYPC 

       310 
SLYYPFFYGA AEPH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium."
Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B., Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.
Hum. Mol. Genet. 8:575-583(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Retina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117759 mRNA. Translation: AAD25053.1.
BC032921 mRNA. Translation: AAH32921.1.
CCDSCCDS29826.1.
RefSeqNP_061250.2. NM_018780.3.
UniGeneMm.470071.

3D structure databases

ProteinModelPortalQ9WU66.
SMRQ9WU66. Positions 57-153.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207687. 2 interactions.

PTM databases

PhosphoSiteQ9WU66.

Proteomic databases

PRIDEQ9WU66.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000018966; ENSMUSP00000018966; ENSMUSG00000018822.
GeneID54612.
KEGGmmu:54612.
UCSCuc008hnl.2. mouse.

Organism-specific databases

CTD6425.
MGIMGI:1860298. Sfrp5.

Phylogenomic databases

eggNOGNOG240950.
GeneTreeENSGT00750000117588.
HOGENOMHOG000231058.
HOVERGENHBG052928.
InParanoidQ9WU66.
KOK02222.
OrthoDBEOG789CBZ.
PhylomeDBQ9WU66.
TreeFamTF350133.

Gene expression databases

BgeeQ9WU66.
CleanExMM_SFRP5.
GenevestigatorQ9WU66.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PfamPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311420.
PROQ9WU66.
SOURCESearch...

Entry information

Entry nameSFRP5_MOUSE
AccessionPrimary (citable) accession number: Q9WU66
Secondary accession number(s): Q8K269
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot