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Protein

Secreted frizzled-related protein 5

Gene

Sfrp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

GO - Molecular functioni

  1. Wnt-protein binding Source: GO_Central

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. convergent extension involved in axis elongation Source: MGI
  3. digestive tract morphogenesis Source: MGI
  4. negative regulation of canonical Wnt signaling pathway Source: MGI
  5. negative regulation of catenin import into nucleus Source: MGI
  6. negative regulation of cell proliferation Source: MGI
  7. negative regulation of JUN kinase activity Source: MGI
  8. negative regulation of planar cell polarity pathway involved in axis elongation Source: MGI
  9. negative regulation of protein kinase B signaling Source: MGI
  10. negative regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  11. negative regulation of Wnt signaling pathway Source: MGI
  12. negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Source: MGI
  13. planar cell polarity pathway involved in neural tube closure Source: MGI
  14. post-anal tail morphogenesis Source: MGI
  15. regulation of establishment of planar polarity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 5
Short name:
sFRP-5
Gene namesi
Name:Sfrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1860298. Sfrp5.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 314293Secreted frizzled-related protein 5PRO_0000032556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 113By similarity
Disulfide bondi60 ↔ 106By similarity
Disulfide bondi97 ↔ 132By similarity
Disulfide bondi121 ↔ 159By similarity
Disulfide bondi125 ↔ 149By similarity
Disulfide bondi178 ↔ 250By similarity
Disulfide bondi181 ↔ 252By similarity
Disulfide bondi195 ↔ 300By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9WU66.

PTM databases

PhosphoSiteiQ9WU66.

Expressioni

Gene expression databases

BgeeiQ9WU66.
CleanExiMM_SFRP5.
GenevestigatoriQ9WU66.

Interactioni

Protein-protein interaction databases

BioGridi207687. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9WU66.
SMRiQ9WU66. Positions 57-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 162118FZPROSITE-ProRule annotationAdd
BLAST
Domaini178 – 300123NTRPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ9WU66.
KOiK02222.
OrthoDBiEOG789CBZ.
PhylomeDBiQ9WU66.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WU66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVAWSARTA ALALLLGALH GAPTRGQEYD YYGWQAEPLH GRSYSKPPQC
60 70 80 90 100
LDIPADLPLC HTVGYKRMRL PNLLEHESLA EVKQQASSWL PLLAKRCHSD
110 120 130 140 150
TQVFLCSLFA PVCLDRPIYP CRSLCEAARA GCAPLMEAYG FPWPEMLHCH
160 170 180 190 200
KFPLDNDLCI AVQFGHLPAT APPVTKICAQ CEMEHSADGL MEQMCSSDFV
210 220 230 240 250
VKMRIKEIKI DNGDRKLIGA QKKKKLLKAG PLKRKDTKKL VLHMKNGASC
260 270 280 290 300
PCPQLDNLTG SFLVMGRKVE GQLLLTAVYR WDKKNKEMKF AVKFMFSYPC
310
SLYYPFFYGA AEPH
Length:314
Mass (Da):35,382
Last modified:November 1, 1999 - v1
Checksum:i296847F56D1CAFDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281A → V in AAH32921 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117759 mRNA. Translation: AAD25053.1.
BC032921 mRNA. Translation: AAH32921.1.
CCDSiCCDS29826.1.
RefSeqiNP_061250.2. NM_018780.3.
UniGeneiMm.470071.

Genome annotation databases

GeneIDi54612.
KEGGimmu:54612.
UCSCiuc008hnl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117759 mRNA. Translation: AAD25053.1.
BC032921 mRNA. Translation: AAH32921.1.
CCDSiCCDS29826.1.
RefSeqiNP_061250.2. NM_018780.3.
UniGeneiMm.470071.

3D structure databases

ProteinModelPortaliQ9WU66.
SMRiQ9WU66. Positions 57-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207687. 2 interactions.

PTM databases

PhosphoSiteiQ9WU66.

Proteomic databases

PRIDEiQ9WU66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54612.
KEGGimmu:54612.
UCSCiuc008hnl.2. mouse.

Organism-specific databases

CTDi6425.
MGIiMGI:1860298. Sfrp5.

Phylogenomic databases

eggNOGiNOG240950.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ9WU66.
KOiK02222.
OrthoDBiEOG789CBZ.
PhylomeDBiQ9WU66.
TreeFamiTF350133.

Miscellaneous databases

NextBioi311420.
PROiQ9WU66.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WU66.
CleanExiMM_SFRP5.
GenevestigatoriQ9WU66.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium."
    Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B., Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.
    Hum. Mol. Genet. 8:575-583(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiSFRP5_MOUSE
AccessioniPrimary (citable) accession number: Q9WU66
Secondary accession number(s): Q8K269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1999
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.