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Q9WU66

- SFRP5_MOUSE

UniProt

Q9WU66 - SFRP5_MOUSE

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Protein

Secreted frizzled-related protein 5

Gene

Sfrp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

GO - Molecular functioni

  1. PDZ domain binding Source: RefGenome
  2. Wnt-activated receptor activity Source: RefGenome
  3. Wnt-protein binding Source: RefGenome

GO - Biological processi

  1. brain development Source: RefGenome
  2. canonical Wnt signaling pathway Source: RefGenome
  3. cell differentiation Source: UniProtKB-KW
  4. convergent extension involved in axis elongation Source: MGI
  5. digestive tract morphogenesis Source: MGI
  6. gonad development Source: RefGenome
  7. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  8. negative regulation of catenin import into nucleus Source: Ensembl
  9. negative regulation of cell proliferation Source: Ensembl
  10. negative regulation of JUN kinase activity Source: MGI
  11. negative regulation of planar cell polarity pathway involved in axis elongation Source: MGI
  12. negative regulation of protein kinase B signaling Source: Ensembl
  13. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  14. negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Source: Ensembl
  15. planar cell polarity pathway involved in neural tube closure Source: MGI
  16. post-anal tail morphogenesis Source: MGI
  17. regulation of establishment of planar polarity Source: MGI
  18. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  19. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 5
Short name:
sFRP-5
Gene namesi
Name:Sfrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1860298. Sfrp5.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular region Source: UniProtKB-KW
  3. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 314293Secreted frizzled-related protein 5PRO_0000032556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 113By similarity
Disulfide bondi60 ↔ 106By similarity
Disulfide bondi97 ↔ 132By similarity
Disulfide bondi121 ↔ 159By similarity
Disulfide bondi125 ↔ 149By similarity
Disulfide bondi178 ↔ 250By similarity
Disulfide bondi181 ↔ 252By similarity
Disulfide bondi195 ↔ 300By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9WU66.

PTM databases

PhosphoSiteiQ9WU66.

Expressioni

Gene expression databases

BgeeiQ9WU66.
CleanExiMM_SFRP5.
GenevestigatoriQ9WU66.

Interactioni

Protein-protein interaction databases

BioGridi207687. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9WU66.
SMRiQ9WU66. Positions 57-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 162118FZPROSITE-ProRule annotationAdd
BLAST
Domaini178 – 300123NTRPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ9WU66.
KOiK02222.
OrthoDBiEOG789CBZ.
PhylomeDBiQ9WU66.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WU66-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWVAWSARTA ALALLLGALH GAPTRGQEYD YYGWQAEPLH GRSYSKPPQC
60 70 80 90 100
LDIPADLPLC HTVGYKRMRL PNLLEHESLA EVKQQASSWL PLLAKRCHSD
110 120 130 140 150
TQVFLCSLFA PVCLDRPIYP CRSLCEAARA GCAPLMEAYG FPWPEMLHCH
160 170 180 190 200
KFPLDNDLCI AVQFGHLPAT APPVTKICAQ CEMEHSADGL MEQMCSSDFV
210 220 230 240 250
VKMRIKEIKI DNGDRKLIGA QKKKKLLKAG PLKRKDTKKL VLHMKNGASC
260 270 280 290 300
PCPQLDNLTG SFLVMGRKVE GQLLLTAVYR WDKKNKEMKF AVKFMFSYPC
310
SLYYPFFYGA AEPH
Length:314
Mass (Da):35,382
Last modified:November 1, 1999 - v1
Checksum:i296847F56D1CAFDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281A → V in AAH32921. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117759 mRNA. Translation: AAD25053.1.
BC032921 mRNA. Translation: AAH32921.1.
CCDSiCCDS29826.1.
RefSeqiNP_061250.2. NM_018780.3.
UniGeneiMm.470071.

Genome annotation databases

EnsembliENSMUST00000018966; ENSMUSP00000018966; ENSMUSG00000018822.
GeneIDi54612.
KEGGimmu:54612.
UCSCiuc008hnl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117759 mRNA. Translation: AAD25053.1 .
BC032921 mRNA. Translation: AAH32921.1 .
CCDSi CCDS29826.1.
RefSeqi NP_061250.2. NM_018780.3.
UniGenei Mm.470071.

3D structure databases

ProteinModelPortali Q9WU66.
SMRi Q9WU66. Positions 57-153.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207687. 2 interactions.

PTM databases

PhosphoSitei Q9WU66.

Proteomic databases

PRIDEi Q9WU66.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018966 ; ENSMUSP00000018966 ; ENSMUSG00000018822 .
GeneIDi 54612.
KEGGi mmu:54612.
UCSCi uc008hnl.2. mouse.

Organism-specific databases

CTDi 6425.
MGIi MGI:1860298. Sfrp5.

Phylogenomic databases

eggNOGi NOG240950.
GeneTreei ENSGT00760000118864.
HOGENOMi HOG000231058.
HOVERGENi HBG052928.
InParanoidi Q9WU66.
KOi K02222.
OrthoDBi EOG789CBZ.
PhylomeDBi Q9WU66.
TreeFami TF350133.

Miscellaneous databases

NextBioi 311420.
PROi Q9WU66.
SOURCEi Search...

Gene expression databases

Bgeei Q9WU66.
CleanExi MM_SFRP5.
Genevestigatori Q9WU66.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
Pfami PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium."
    Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B., Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.
    Hum. Mol. Genet. 8:575-583(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiSFRP5_MOUSE
AccessioniPrimary (citable) accession number: Q9WU66
Secondary accession number(s): Q8K269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3