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Protein

Glycerol kinase 2

Gene

Gk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism.

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase 2 (Gk2), Glycerol kinase (Gk), Putative glycerol kinase 5 (Gk5)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateBy similarity1
Binding sitei24ATPBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei281ATPBy similarity1
Binding sitei326ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 431ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-75109 Triglyceride biosynthesis
UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase 2 (EC:2.7.1.30)
Short name:
GK 2
Short name:
Glycerokinase 2
Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerol kinase, testis specific 2
Gene namesi
Name:Gk2
Synonyms:Gk-rs2, Gkrs2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1329027 Gk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003436781 – 554Glycerol kinase 2Add BLAST554

Proteomic databases

MaxQBiQ9WU65
PaxDbiQ9WU65
PRIDEiQ9WU65

PTM databases

iPTMnetiQ9WU65
PhosphoSitePlusiQ9WU65

Expressioni

Gene expression databases

BgeeiENSMUSG00000050553
GenevisibleiQ9WU65 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052226

Structurei

3D structure databases

ProteinModelPortaliQ9WU65
SMRiQ9WU65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
GeneTreeiENSGT00530000063143
HOGENOMiHOG000222134
HOVERGENiHBG002451
InParanoidiQ9WU65
KOiK00864
OMAiATRWNPD
OrthoDBiEOG091G04EJ
PhylomeDBiQ9WU65
TreeFamiTF321504

Family and domain databases

InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WU65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKQTSAG PLVGAVVQGT NSTRFLVFNS KTAELVCSHQ VELTQEYPKE
60 70 80 90 100
GWVEQDPKEI LKSVYECIAK ACEKLAEVNI DISNIKAIGV SNQRETTVVW
110 120 130 140 150
DKFTGDPLYN AVVWLDLRTQ STVETLTKKI PGNSNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWMLDN LRPIQKAVEE GRAMFGTIDS WLIWCMTGGV NGGIHCTDVT
210 220 230 240 250
NACRTMLFNI HSLEWDKDLC DFFEIPMSIL PNVCSSSEIY GLMTSGALEG
260 270 280 290 300
VPISGCLGDQ SAALVGQMCF HEGQAKNTYG TGCFLLCNTG QKCVFSEHGL
310 320 330 340 350
LTTLAYKLGK NKPVFYALEG SVAIAGAVIR WLRDNFEIIT TSGEVENLAR
360 370 380 390 400
EVGTSYGCYF VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILDA MNRDCGIPLS HLQVDGGMTN NRILMQLQAD ILHIPVVKSV
460 470 480 490 500
MPETTALGAA MAAGAAEGVN VWSLEPEDLS TILMERYEPQ IQATESEIRF
510 520 530 540 550
STWKRAVMKS MGWVTAKDPE NGDNPVFSCL PLGFFIVSSM TLLIGARCVS

TAEE
Length:554
Mass (Da):60,630
Last modified:November 1, 1999 - v1
Checksum:i8DFD5E85E74F5198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117734 mRNA Translation: AAD24551.1
BC050764 mRNA Translation: AAH50764.1
BC061147 mRNA Translation: AAH61147.1
CCDSiCCDS19454.1
RefSeqiNP_034424.1, NM_010294.1
UniGeneiMm.61206

Genome annotation databases

EnsembliENSMUST00000059657; ENSMUSP00000052226; ENSMUSG00000050553
GeneIDi14626
KEGGimmu:14626
UCSCiuc008yfz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGLPK2_MOUSE
AccessioniPrimary (citable) accession number: Q9WU65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health