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Protein

Heme-binding protein 2

Gene

Hebp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions (By similarity). May have low affinity for heme (PubMed:15518569).By similarity

Caution

Has been described as heme-binding protein (PubMed:15518569) in mouse, but the human protein does not bind hemin. His-42, a residue essential for heme binding in mouse, is not conserved in all orthologs, or in the heme-binding family member HEBP1.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein 2
Alternative name(s):
Protein SOUL
Gene namesi
Name:Hebp2
Synonyms:Soul
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1860084 Hebp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42H → A: Loss of heme binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001169012 – 205Heme-binding protein 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei181PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9WU63
PaxDbiQ9WU63
PRIDEiQ9WU63

PTM databases

PhosphoSitePlusiQ9WU63

Expressioni

Gene expression databases

BgeeiENSMUSG00000019853
CleanExiMM_HEBP2
ExpressionAtlasiQ9WU63 baseline and differential
GenevisibleiQ9WU63 MM

Interactioni

Subunit structurei

Monomer. Interacts with LRPPRC. May interact with BCL2L1; an interaction with BCL2L1 was observed using a peptide, but not with the full-length protein. The full-length protein would have to undergo a major conformation change for the interaction to occur. Interacts with PDCD6.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020000

Structurei

3D structure databases

ProteinModelPortaliQ9WU63
SMRiQ9WU63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.By similarity

Sequence similaritiesi

Belongs to the HEBP family.Curated

Phylogenomic databases

eggNOGiENOG410IZTQ Eukaryota
ENOG410ZWW6 LUCA
GeneTreeiENSGT00530000063312
HOGENOMiHOG000237638
HOVERGENiHBG097982
InParanoidiQ9WU63
OMAiECPAYEV
OrthoDBiEOG091G0ZIG
PhylomeDBiQ9WU63
TreeFamiTF328887

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR011256 Reg_factor_effector_dom_sf
IPR006917 SOUL_haem-bd
PANTHERiPTHR11220 PTHR11220, 1 hit
PfamiView protein in Pfam
PF04832 SOUL, 1 hit
SUPFAMiSSF55136 SSF55136, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WU63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEPEPDLG VAEGSEDQAL EMPSWKAPED IDPQPGSYEI RHYGPAKWVS
60 70 80 90 100
TCVESLDWDS AIQTGFTKLN GYIQGKNEKE MKIKLTAPVT SYVEPGSSPF
110 120 130 140 150
SESTITISLY IPSEQQPDPP RPSESDVFIE DRAEMTVFVR SFDGFSSGQK
160 170 180 190 200
NQEQLLTLAN ILREEGKVFN EKVFYTAGYS SPFQLLDRNN EVWLIQKNEP

SVENK
Length:205
Mass (Da):23,063
Last modified:November 1, 1999 - v1
Checksum:i821B33F3E77DB05D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117614 mRNA Translation: AAD32097.1
AK078130 mRNA Translation: BAC37141.1
CCDSiCCDS23711.1
RefSeqiNP_062360.1, NM_019487.3
UniGeneiMm.35551

Genome annotation databases

EnsembliENSMUST00000020000; ENSMUSP00000020000; ENSMUSG00000019853
GeneIDi56016
KEGGimmu:56016
UCSCiuc007emk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHEBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9WU63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health