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Protein

Chloride channel CLIC-like protein 1

Gene

Clcc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a chloride ion channel.1 Publication

GO - Molecular functioni

  • chloride channel activity Source: HGNC

GO - Biological processi

  • chloride transport Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Alternative name(s):
Mid-1-related chloride channel protein 1
Gene namesi
Name:Clcc1
Synonyms:Mclc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708359. Clcc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • cytoplasm Source: HGNC
  • endoplasmic reticulum Source: HGNC
  • Golgi apparatus Source: HGNC
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029768419 – 541Chloride channel CLIC-like protein 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei434PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei482PhosphothreonineBy similarity1
Modified residuei504PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WU61.
PeptideAtlasiQ9WU61.
PRIDEiQ9WU61.

PTM databases

iPTMnetiQ9WU61.
PhosphoSitePlusiQ9WU61.

Expressioni

Tissue specificityi

Expressed in testis (spermatocytes), liver and lung (at protein level). Expressed in spleen, liver, testis, kidney, heart, brain and lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000020360.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042185.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi525 – 530Poly-Ala6

Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJAP. Eukaryota.
ENOG41108E0. LUCA.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ9WU61.
PhylomeDBiQ9WU61.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9WU61-1) [UniParc]FASTAAdd to basket
Also known as: rMCLC-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCSLLLCGC LLLITGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGTSE
60 70 80 90 100
KKEVNPGLSD AQELSDCLQR LDSLTHKVDD CEKKKMKDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDEDRVD VRYDAEILLT RQTLLEIQKF LSGEEWKPGA
160 170 180 190 200
LDDALSDILT NFKSHDAEAW KWQFEDYFGV DPYNVFMVLL CLLCIVALVA
210 220 230 240 250
TELWTYVRWH TQLKRVCIIS FLVSLGWNWI YLYKVAFAQH QANVAKMAPL
260 270 280 290 300
NDVCAKKMDW TENLWEWFRI SWTYKDDPCQ KYYELLIVNP IWLVPPTKAL
310 320 330 340 350
AVTFTNFVTE PLKYIGKGTG EFIKALMKEI PVLLQIPVLV ILALAVLGFC
360 370 380 390 400
YGAGQSVPML RHFRGPEREP PRALEPDDRR RQKELDYRFH GGAGDADFSY
410 420 430 440 450
RGPAGSIEQG PYDKMHVCER DVLRQRQVNM RFPSGNKSPE VLRAFDLPDT
460 470 480 490 500
EAQEHPEVVP SHKPSIVNTS LKETSELPRE STLAECSQCA KDGSGQVPST
510 520 530 540
AESSPIVEKA QLKTDSECRP HSTEAAAAAA RGTDPVSSPC G
Length:541
Mass (Da):61,174
Last modified:November 1, 1999 - v1
Checksum:i07954FC608C8FF40
GO
Isoform 2 (identifier: Q9WU61-2) [UniParc]FASTAAdd to basket
Also known as: rMCLC-2

The sequence of this isoform differs from the canonical sequence as follows:
     44-77: Missing.

Show »
Length:507
Mass (Da):57,430
Checksum:i9D0ED4926970BBF5
GO
Isoform 3 (identifier: Q9WU61-3) [UniParc]FASTAAdd to basket
Also known as: rMCLC-3

The sequence of this isoform differs from the canonical sequence as follows:
     394-394: G → A
     395-541: Missing.

Show »
Length:394
Mass (Da):45,398
Checksum:i05900C221B89611E
GO
Isoform 4 (identifier: Q9WU61-4) [UniParc]FASTAAdd to basket
Also known as: rMCLC-4

The sequence of this isoform differs from the canonical sequence as follows:
     44-77: Missing.
     394-394: G → A
     395-541: Missing.

Show »
Length:360
Mass (Da):41,653
Checksum:i59DAD3D160226EEB
GO
Isoform 5 (identifier: Q9WU61-5) [UniParc]FASTAAdd to basket
Also known as: rMCLC-5

The sequence of this isoform differs from the canonical sequence as follows:
     394-395: GD → EP
     396-541: Missing.

Show »
Length:395
Mass (Da):45,553
Checksum:i6423500C221B8961
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57G → D in AAH81736 (PubMed:15489334).Curated1
Sequence conflicti167A → S in AAH81736 (PubMed:15489334).Curated1
Sequence conflicti417V → A in AAH81736 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02735044 – 77Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_027351394 – 395GD → EP in isoform 5. 1 Publication2
Alternative sequenceiVSP_027352394G → A in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_027353395 – 541Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_027354396 – 541Missing in isoform 5. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052919 mRNA. Translation: BAB79264.1.
AB052920 mRNA. Translation: BAB79265.1.
AB052921 mRNA. Translation: BAB79266.1.
AB052922 mRNA. Translation: BAB59019.1.
AB052923 mRNA. Translation: BAB79267.1.
AF117330 mRNA. Translation: AAD26207.1.
BC081736 mRNA. Translation: AAH81736.1.
RefSeqiNP_596905.1. NM_133414.1. [Q9WU61-1]
XP_006233189.1. XM_006233127.2.
XP_006233190.1. XM_006233128.3.
UniGeneiRn.26586.

Genome annotation databases

GeneIDi170927.
KEGGirno:170927.
UCSCiRGD:708359. rat. [Q9WU61-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052919 mRNA. Translation: BAB79264.1.
AB052920 mRNA. Translation: BAB79265.1.
AB052921 mRNA. Translation: BAB79266.1.
AB052922 mRNA. Translation: BAB59019.1.
AB052923 mRNA. Translation: BAB79267.1.
AF117330 mRNA. Translation: AAD26207.1.
BC081736 mRNA. Translation: AAH81736.1.
RefSeqiNP_596905.1. NM_133414.1. [Q9WU61-1]
XP_006233189.1. XM_006233127.2.
XP_006233190.1. XM_006233128.3.
UniGeneiRn.26586.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042185.

PTM databases

iPTMnetiQ9WU61.
PhosphoSitePlusiQ9WU61.

Proteomic databases

PaxDbiQ9WU61.
PeptideAtlasiQ9WU61.
PRIDEiQ9WU61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170927.
KEGGirno:170927.
UCSCiRGD:708359. rat. [Q9WU61-1]

Organism-specific databases

CTDi23155.
RGDi708359. Clcc1.

Phylogenomic databases

eggNOGiENOG410IJAP. Eukaryota.
ENOG41108E0. LUCA.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ9WU61.
PhylomeDBiQ9WU61.

Miscellaneous databases

PROiQ9WU61.

Gene expression databases

BgeeiENSRNOG00000020360.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCC1_RAT
AccessioniPrimary (citable) accession number: Q9WU61
Secondary accession number(s): Q66HQ5
, Q8VIE8, Q8VIE9, Q8VIF0, Q8VIF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.