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Protein

Attractin

Gene

Atrn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system (By similarity).By similarity1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • receptor activity Source: MGI

GO - Biological processi

  • cerebellum development Source: MGI
  • inflammatory response Source: UniProtKB-KW
  • myelination Source: MGI
  • pigmentation Source: MGI
  • regulation of multicellular organism growth Source: MGI
  • response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Attractin
Alternative name(s):
Protein mahogany
Gene namesi
Name:Atrn
Synonyms:Mg, Mgca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1341628. Atrn.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini83 – 1278ExtracellularSequence analysisAdd BLAST1196
Transmembranei1279 – 1299HelicalSequence analysisAdd BLAST21
Topological domaini1300 – 1428CytoplasmicSequence analysisAdd BLAST129

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000039477223 – 82By similarityAdd BLAST60
ChainiPRO_000000748483 – 1428AttractinAdd BLAST1346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi100 ↔ 110By similarity
Disulfide bondi104 ↔ 117By similarity
Disulfide bondi119 ↔ 128By similarity
Disulfide bondi131 ↔ 157By similarity
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi249 ↔ 259By similarity
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi253 ↔ 270By similarity
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi272 ↔ 281By similarity
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi324N-linked (GlcNAc...)Sequence analysis1
Glycosylationi361N-linked (GlcNAc...)Sequence analysis1
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1
Glycosylationi427N-linked (GlcNAc...)Sequence analysis1
Glycosylationi574N-linked (GlcNAc...)Sequence analysis1
Glycosylationi622N-linked (GlcNAc...)Sequence analysis1
Glycosylationi730N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi815 ↔ 917By similarity
Glycosylationi862N-linked (GlcNAc...)Sequence analysis1
Glycosylationi913N-linked (GlcNAc...)Sequence analysis1
Glycosylationi922N-linked (GlcNAc...)Sequence analysis1
Glycosylationi985N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1042N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1053N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1062 ↔ 1070By similarity
Disulfide bondi1064 ↔ 1076By similarity
Glycosylationi1072N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1079 ↔ 1088By similarity
Disulfide bondi1091 ↔ 1105By similarity
Disulfide bondi1108 ↔ 1117By similarity
Disulfide bondi1110 ↔ 1124By similarity
Disulfide bondi1126 ↔ 1136By similarity
Disulfide bondi1139 ↔ 1154By similarity
Glycosylationi1197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1249N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1258N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Heavily glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WU60.
PaxDbiQ9WU60.
PRIDEiQ9WU60.

PTM databases

iPTMnetiQ9WU60.
PhosphoSitePlusiQ9WU60.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027312.
CleanExiMM_ATRN.
GenevisibleiQ9WU60. MM.

Interactioni

Subunit structurei

Monomer and homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028781.

Structurei

3D structure databases

ProteinModelPortaliQ9WU60.
SMRiQ9WU60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 128EGF-likePROSITE-ProRule annotationAdd BLAST29
Domaini131 – 247CUBPROSITE-ProRule annotationAdd BLAST117
Repeati351 – 401Kelch 1Add BLAST51
Repeati402 – 450Kelch 2Add BLAST49
Repeati460 – 507Kelch 3Add BLAST48
Repeati512 – 563Kelch 4Add BLAST52
Repeati565 – 623Kelch 5Add BLAST59
Repeati624 – 670Kelch 6Add BLAST47
Domaini702 – 747PSI 1Add BLAST46
Domaini754 – 793PSI 2Add BLAST40
Domaini794 – 918C-type lectinPROSITE-ProRule annotationAdd BLAST125
Domaini931 – 982PSI 3Add BLAST52
Domaini985 – 1060PSI 4Add BLAST76
Domaini1062 – 1107Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1108 – 1156Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated
Contains 2 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 4 PSI domains.Curated

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOGENOMiHOG000231727.
HOVERGENiHBG004312.
InParanoidiQ9WU60.
OMAiDTGSSQC.
OrthoDBiEOG091G03A0.
TreeFamiTF321873.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF01344. Kelch_1. 2 hits.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 3 hits.
SM00180. EGF_Lam. 2 hits.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50965. SSF50965. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WU60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVAAAAAT EARLRGSTTA TAAPAGRKGR QHRPCTATGA WRPGPRARLC
60 70 80 90 100
LPRVLSRALP PPPLLPLLFS LLLLPLPREA EAAAVAAAVS GSAAAEAKEC
110 120 130 140 150
DRPCVNGGRC NPGTGQCVCP TGWVGEQCQH CGGRFRLTGS SGFVTDGPGN
160 170 180 190 200
YKYKTKCTWL IEGQPNRIMR LRFNHFATEC SWDHLYVYDG DSIYAPLIAA
210 220 230 240 250
FSGLIVPERD GNETAPEVTV TSGYALLHFF SDAAYNLTGF NITYNFDMCP
260 270 280 290 300
NNCSGRGECK SSNSSSAVEC ECSENWKGES CDIPHCTDNC GFPHRGICNA
310 320 330 340 350
SDTRGCSCFP HWQGPGCSIP VPANQSFWTR EEYSDLKLPR ASHKAVVNGN
360 370 380 390 400
IMWVVGGYMF NHSDYSMVLA YDLTSREWLP LNHSVNSVVV RYGHSLALHK
410 420 430 440 450
DKIYMYGGKI DSTGNVTNEL RVFHIHNESW VLLTPKAKDQ YAVVGHSAHI
460 470 480 490 500
VTLASGRVVM LVIFGHCPLY GYISVVQEYD LEKNTWSILH TQGALVQGGY
510 520 530 540 550
GHSSVYDDRT KALYVHGGYK AFSANKYRLA DDLYRYDVDT QMWTILKDSR
560 570 580 590 600
FFRYLHTAVI VSGTMLVFGG NTHNDTSMSH GAKCFSSDFM AYDIACDRWS
610 620 630 640 650
VLPRPELHHD VNRFGHSAVL YNSTMYVFGG FNSLLLSDVL VFTSEQCDAH
660 670 680 690 700
RSEAACVAAG PGIRCLWDTQ SSRCTSWELA TEEQAEKLKS ECFSKRTLDH
710 720 730 740 750
DRCDQHTDCY SCTANTNDCH WCNDHCVPVN HSCTEGQISI AKYESCPKDN
760 770 780 790 800
PMYYCNKKTS CRSCALDQNC QWEPRNQECI ALPENICGNG WHLVGNSCLK
810 820 830 840 850
ITTAKENYDN AKLSCRNHNA FLASLTSQKK VEFVLKQLRL MQSSQSMSKL
860 870 880 890 900
TLTPWVGLRK INVSYWCWED MSPFTNSLLQ WMPSEPSDAG FCGILSEPST
910 920 930 940 950
RGLKAATCIN PLNGSVCERP ANHSAKQCRT PCALRTACGE CTSSSSECMW
960 970 980 990 1000
CSNMKQCVDS NAYVASFPFG QCMEWYTMSS CPPENCSGYC TCSHCLEQPG
1010 1020 1030 1040 1050
CGWCTDPSNT GKGKCIEGSY KGPVKMPSQA SAGNVYPQPL LNSSMCLEDS
1060 1070 1080 1090 1100
RYNWSFIHCP ACQCNGHSKC INQSICEKCE DLTTGKHCET CISGFYGDPT
1110 1120 1130 1140 1150
NGGKCQPCKC NGHASLCNTN TGKCFCTTKG VKGDECQLCE VENRYQGNPL
1160 1170 1180 1190 1200
KGTCYYTLLI DYQFTFSLSQ EDDRYYTAIN FVATPDEQNR DLDMFINASK
1210 1220 1230 1240 1250
NFNLNITWAT SFPAGTQTGE EVPVVSKTNI KEYKDSFSNE KFDFRNHPNI
1260 1270 1280 1290 1300
TFFVYVSNFT WPIKIQIAFS QHSNFMDLVQ FFVTFFSCFL SLLLVAAVVW
1310 1320 1330 1340 1350
KIKQSCWASR RREQLLREMQ QMASRPFASV NVALETDEEP PDLIGGSIKT
1360 1370 1380 1390 1400
VPKPIALEPC FGNKAAVLSV FVRLPRGLGG IPPPGQSGLA VASALVDISQ
1410 1420
QMPIVYKEKS GAVRNRKQQP PAQPGTCI
Length:1,428
Mass (Da):158,058
Last modified:July 27, 2011 - v3
Checksum:iBB54C24E7EF1CE34
GO

Sequence cautioni

The sequence AAD20947 differs from that shown. Reason: Frameshift at position 1388.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → V in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti9A → S in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti20A → T in AAD20947 (PubMed:10086355).Curated1
Sequence conflicti164 – 169QPNRIM → YPNAVL in AAD25372 (PubMed:10086356).Curated6
Sequence conflicti255G → A in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti505V → A in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti833F → L in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti1075I → V in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti1140E → K in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti1171E → G in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti1192L → F in AAD25372 (PubMed:10086356).Curated1
Sequence conflicti1201N → K in AAD25372 (PubMed:10086356).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116897 mRNA. Translation: AAD20947.1. Frameshift.
AF119821 mRNA. Translation: AAD25372.1.
AH007542 Genomic DNA. Translation: AAD22476.1.
AL833771 Genomic DNA. Translation: CAM18035.1.
CH466519 Genomic DNA. Translation: EDL28292.1.
CCDSiCCDS16751.1.
RefSeqiNP_033860.2. NM_009730.3.
UniGeneiMm.119936.

Genome annotation databases

EnsembliENSMUST00000028781; ENSMUSP00000028781; ENSMUSG00000027312.
GeneIDi11990.
KEGGimmu:11990.
UCSCiuc008mkc.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Attractin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116897 mRNA. Translation: AAD20947.1. Frameshift.
AF119821 mRNA. Translation: AAD25372.1.
AH007542 Genomic DNA. Translation: AAD22476.1.
AL833771 Genomic DNA. Translation: CAM18035.1.
CH466519 Genomic DNA. Translation: EDL28292.1.
CCDSiCCDS16751.1.
RefSeqiNP_033860.2. NM_009730.3.
UniGeneiMm.119936.

3D structure databases

ProteinModelPortaliQ9WU60.
SMRiQ9WU60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028781.

PTM databases

iPTMnetiQ9WU60.
PhosphoSitePlusiQ9WU60.

Proteomic databases

MaxQBiQ9WU60.
PaxDbiQ9WU60.
PRIDEiQ9WU60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028781; ENSMUSP00000028781; ENSMUSG00000027312.
GeneIDi11990.
KEGGimmu:11990.
UCSCiuc008mkc.1. mouse.

Organism-specific databases

CTDi8455.
MGIiMGI:1341628. Atrn.

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOGENOMiHOG000231727.
HOVERGENiHBG004312.
InParanoidiQ9WU60.
OMAiDTGSSQC.
OrthoDBiEOG091G03A0.
TreeFamiTF321873.

Miscellaneous databases

PROiQ9WU60.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027312.
CleanExiMM_ATRN.
GenevisibleiQ9WU60. MM.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF01344. Kelch_1. 2 hits.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 3 hits.
SM00180. EGF_Lam. 2 hits.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50965. SSF50965. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATRN_MOUSE
AccessioniPrimary (citable) accession number: Q9WU60
Secondary accession number(s): A2AP43, Q9R263, Q9WU77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.