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Q9WU42

- NCOR2_MOUSE

UniProt

Q9WU42 - NCOR2_MOUSE

Protein

Nuclear receptor corepressor 2

Gene

Ncor2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: MGI
    5. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation in forebrain Source: MGI
    2. forebrain development Source: MGI
    3. glucose homeostasis Source: MGI
    4. heart morphogenesis Source: MGI
    5. in utero embryonic development Source: MGI
    6. negative regulation of fat cell differentiation Source: MGI
    7. negative regulation of transcription, DNA-templated Source: MGI
    8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    9. telencephalon development Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW
    11. Type I pneumocyte differentiation Source: MGI
    12. white fat cell differentiation Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor corepressor 2
    Short name:
    N-CoR2
    Alternative name(s):
    Silencing mediator of retinoic acid and thyroid hormone receptor
    Short name:
    SMRT
    Short name:
    SMRTe
    T3 receptor-associating factor
    Short name:
    TRAC
    Thyroid-, retinoic-acid-receptor-associated corepressor
    Gene namesi
    Name:Ncor2
    Synonyms:Smrt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1337080. Ncor2.

    Subcellular locationi

    GO - Cellular componenti

    1. histone deacetylase complex Source: MGI
    2. nuclear body Source: MGI
    3. nuclear matrix Source: UniProtKB
    4. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24722472Nuclear receptor corepressor 2PRO_0000055623Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541PhosphoserineBy similarity
    Modified residuei67 – 671PhosphoserineBy similarity
    Modified residuei149 – 1491PhosphoserineBy similarity
    Modified residuei152 – 1521PhosphoserineBy similarity
    Modified residuei215 – 2151PhosphoserineBy similarity
    Modified residuei549 – 5491PhosphothreonineBy similarity
    Modified residuei550 – 5501Phosphoserine1 Publication
    Modified residuei747 – 7471PhosphoserineBy similarity
    Modified residuei750 – 7501PhosphoserineBy similarity
    Modified residuei878 – 8781N6-acetyllysineBy similarity
    Modified residuei938 – 9381PhosphoserineBy similarity
    Modified residuei955 – 9551PhosphoserineBy similarity
    Modified residuei958 – 9581N6-acetyllysineBy similarity
    Modified residuei1181 – 11811N6-acetyllysineBy similarity
    Modified residuei1209 – 12091N6-acetyllysineBy similarity
    Modified residuei1220 – 12201PhosphoserineBy similarity
    Modified residuei1350 – 13501PhosphothreonineBy similarity
    Modified residuei1449 – 14491PhosphoserineBy similarity
    Modified residuei1749 – 17491PhosphoserineBy similarity
    Modified residuei1819 – 18191PhosphoserineBy similarity
    Modified residuei1920 – 19201N6-acetyllysineBy similarity
    Modified residuei1963 – 19631PhosphoserineBy similarity
    Modified residuei1983 – 19831N6-acetyllysine1 Publication
    Modified residuei2004 – 20041PhosphoserineBy similarity
    Modified residuei2012 – 20121PhosphoserineBy similarity
    Modified residuei2015 – 20151PhosphoserineBy similarity
    Modified residuei2016 – 20161PhosphoserineBy similarity
    Modified residuei2020 – 20201PhosphothreonineBy similarity
    Modified residuei2161 – 21611PhosphoserineBy similarity
    Modified residuei2181 – 21811Phosphoserine1 Publication
    Modified residuei2215 – 22151Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9WU42.
    PaxDbiQ9WU42.
    PRIDEiQ9WU42.

    PTM databases

    PhosphoSiteiQ9WU42.

    Expressioni

    Tissue specificityi

    Ubiquitous. Also widely expressed in early embryos.

    Gene expression databases

    ArrayExpressiQ9WU42.
    BgeeiQ9WU42.
    CleanExiMM_NCOR2.
    GenevestigatoriQ9WU42.

    Interactioni

    Subunit structurei

    Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA.5 Publications

    Protein-protein interaction databases

    BioGridi203350. 8 interactions.
    IntActiQ9WU42. 3 interactions.
    MINTiMINT-3154743.
    STRINGi10090.ENSMUSP00000107033.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WU42.
    SMRiQ9WU42. Positions 167-207, 408-476, 611-681.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini427 – 47852SANT 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini606 – 65752SANT 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 31259Interaction with SIN3A/BBy similarityAdd
    BLAST
    Regioni2086 – 20905Required for interaction with RARA in the absence of its ligandBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili165 – 20743Sequence AnalysisAdd
    BLAST
    Coiled coili492 – 56069Sequence AnalysisAdd
    BLAST
    Coiled coili658 – 68225Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi2094 – 20985CORNR box of ID1
    Motifi2296 – 23005CORNR box of ID2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi494 – 50714Poly-GlnAdd
    BLAST
    Compositional biasi775 – 80430Pro-richAdd
    BLAST
    Compositional biasi989 – 99911Pro-richAdd
    BLAST
    Compositional biasi1351 – 13577Pro-rich
    Compositional biasi1615 – 16195Poly-Ala
    Compositional biasi2434 – 24374Poly-Pro

    Domaini

    The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
    The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

    Sequence similaritiesi

    Contains 2 SANT domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00730000110846.
    HOGENOMiHOG000113746.
    HOVERGENiHBG052587.
    KOiK06065.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    [Graphical view]
    PfamiPF00249. Myb_DNA-binding. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51293. SANT. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: Q9WU42-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARSHTDVGLL EYQHHPRDYT     50
    SHLSPGSIIQ PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI 100
    EFTESKRPRL ELLPDTLLRP SPLLATGQPS GSEDLTKDRS LAGKLEPVSP 150
    PSPPHADPEL ELAPSRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL 200
    EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP 250
    QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ 300
    RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM 350
    QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY 400
    DADQQRIKFI NMNGLMDDPM KVYKDRQVTN MWSEQERDTF REKFMQHPKN 450
    FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ 500
    QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE LSKEKTDDTS 550
    GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL 600
    ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF 650
    NYKKRQNLDE ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE 700
    MEASGASANE EELAEEAEAS QASGNEVPRV GECSGPAAVN NSSDTESVPS 750
    PRSEATKDTG PKPTGTEALP AATQPPVPPP EEPAVAPAEP SPVPDASGPP 800
    SPEPSPSPAA PPATVDKDEQ EAPAAPAPQT EDAKEQKSEA EEIDVGKPEE 850
    PEASEEPPES VKSDHKEETE EEPEDKAKGT EAIETVSEAP LKVEEAGSKA 900
    AVTKGSSSGA TQDSDSSATC SADEVDEPEG GDKGRLLSPR PSLLTPAGDP 950
    RASTSPQKPL DLKQLKQRAA AIPPIVTKVH EPPREDTVPP KPVPPVPPPT 1000
    QHLQPEGDVS QQSGGSPRGK SRSPVPPAEK EAEKPAFFPA FPTEGPKLPT 1050
    EPPRWSSGLP FPIPPREVIK TSPHAADPSA FSYTPPGHPL PLGLHDSARP 1100
    VLPRPPISNP PPLISSAKHP GVLERQLGAI SQQGMSVQLR VPHSEHAKAP 1150
    MGPLTMGLPL AVDPKKLGTA LGSATSGSIT KGLPSTRAAD GPSYRGSITH 1200
    GTPADVLYKG TISRIVGEDS PSRLDRARED TLPKGHVIYE GKKGHVLSYE 1250
    GGMSVSQCSK EDGRSSSGPP HETAAPKRTY DMMEGRVGRT VTSASIEGLM 1300
    GRAIPEQHSP HLKEQHHIRG SITQGIPRSY VEAQEDYLRR EAKLLKREGT 1350
    PPPPPPPRDL TETYKPRPLD PLGPLKLKPT HEGVVATVKE AGRSIHEIPR 1400
    EELRRTPELP LAPRPLKEGS ITQGTPLKYD SGAPSTGTKK HDVRSIIGSP 1450
    GRPFPALHPL DIMADARALE RACYEESLKS RSGTSSGAGG SITRGAPVVV 1500
    PELGKPRQSP LTYEDHGAPF TSHLPRGSPV TTREPTPRLQ EGSLLSSKAS 1550
    QDRKLTSTPR EIAKSPHSTV PEHHPHPISP YEHLLRGVTG VDLYRGHIPL 1600
    AFDPTSIPRG IPLEAAAAAY YLPRHLAPSP TYPHLYPPYL IRGYPDTAAL 1650
    ENRQTIINDY ITSQQMHHNA ASAMAQRADM LRGLSPRESS LALNYAAGPR 1700
    GIIDLSQVPH LPVLVPPTPG TPATAIDRLA YLPTAPPPFS SRHSSSPLSP 1750
    GGPTHLAKPT ATSSSERERE RERERDKSIL TSTTTVEHAP IWRPGTEQSS 1800
    GAGGSSRPAS HTHQHSPISP RTQDALQQRP SVLHNTSMKG VVTSVEPGTP 1850
    TVLRWARSTS TSSPVRPAAT FPPATHCPLG GTLEGVYPTL MEPVLLPKET 1900
    SRVARPERPR VDAGHAFLTK PPAREPASSP SKSSEPRSLA PPSSSHTAIA 1950
    RTPAKNLAPH HASPDPPAPT SASDLHREKT QSKPFSIQEL ELRSLGYHSG 2000
    AGYSPDGVEP ISPVSSPSLT HDKGLSKPLE ELEKSHLEGE LRHKQPGPMK 2050
    LSAEAAHLPH LRPLPESQPS SSPLLQTAPG IKGHQRVVTL AQHISEVITQ 2100
    DYTRHHPQQL SGPLPAPLYS FPGASCPVLD LRRPPSDLYL PPPDHGTPAR 2150
    GSPHSEGGKR SPEPSKTSVL GSSEDAIEPV SPPEGMTEPG HARSTAYPLL 2200
    YRDGEQGEPR MGSKSPGNTS QPPAFFSKLT ESNSAMVKSK KQEINKKLNT 2250
    HNRNEPEYNI GQPGTEIFNM PAITGAGLMT CRSQAVQEHA STNMGLEAII 2300
    RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT ADGRSDHALT 2350
    SPGGGGKAKV SGRPSSRKAK SPAPGLASGD RPPSVSSVHS EGDCNRRTPL 2400
    TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH 2450
    HAWDEEPKPL LCSQYETLSD SE 2472
    Length:2,472
    Mass (Da):269,807
    Last modified:July 27, 2011 - v3
    Checksum:i8068020DF0AAB9B7
    GO
    Isoform Beta (identifier: Q9WU42-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-254: Missing.

    Show »
    Length:2,253
    Mass (Da):245,029
    Checksum:i7FA45277FC6300A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761M → RL in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti396 – 4027PPMLYDA → RHVVRR in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti555 – 5551D → H in AAD20944. (PubMed:10077563)Curated
    Sequence conflicti756 – 7561T → M in AAD20944. (PubMed:10077563)Curated
    Sequence conflicti785 – 7851V → A in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti806 – 84641PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20944. (PubMed:10077563)CuratedAdd
    BLAST
    Sequence conflicti806 – 84641PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20945. (PubMed:10077563)CuratedAdd
    BLAST
    Sequence conflicti856 – 8561E → K in AAD20945. (PubMed:10077563)Curated
    Sequence conflicti859 – 8591E → K in AAD20945. (PubMed:10077563)Curated
    Sequence conflicti867 – 8671E → K in AAD20945. (PubMed:10077563)Curated
    Sequence conflicti895 – 8951E → K in AAD20945. (PubMed:10077563)Curated
    Sequence conflicti916 – 9161S → F in AAD20944. (PubMed:10077563)Curated
    Sequence conflicti975 – 9751I → IQ in AAD20944. (PubMed:10077563)Curated
    Sequence conflicti1046 – 106318PKLPT…LPFPI → QSYRLSPHAGHRLPSH in AAD22972. (PubMed:10097068)CuratedAdd
    BLAST
    Sequence conflicti1073 – 10808PHAADPSA → TRADPL in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1133 – 11331Missing in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1149 – 11491Missing in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1157 – 11571G → E in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1172 – 120130GSATS…SITHG → APPPVEASPRASQYPGCRRP QLQRLYHPR in AAD22972. (PubMed:10097068)CuratedAdd
    BLAST
    Sequence conflicti1696 – 16961A → S in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1855 – 18573Missing in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1909 – 19091P → A in AAD20944. (PubMed:10077563)Curated
    Sequence conflicti1909 – 19091P → A in AAD20945. (PubMed:10077563)Curated
    Sequence conflicti1913 – 19131A → G in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1923 – 19231A → G in AAD20944. (PubMed:10077563)Curated
    Sequence conflicti1923 – 19231A → G in AAD20945. (PubMed:10077563)Curated
    Sequence conflicti1956 – 19561N → S in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti1968 – 19681A → G in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti2195 – 21962TA → AV in AAD22972. (PubMed:10097068)Curated
    Sequence conflicti2213 – 22142SK → LE in AAD20944. (PubMed:10077563)Curated
    Sequence conflicti2224 – 22241A → T in AAD20944. (PubMed:10077563)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei36 – 254219Missing in isoform Beta. 1 PublicationVSP_003414Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113001 mRNA. Translation: AAD20944.1.
    AF113002 mRNA. Translation: AAD20945.1.
    AF125671 mRNA. Translation: AAD22972.1.
    AC132118 Genomic DNA. No translation available.
    AC139377 Genomic DNA. No translation available.
    CCDSiCCDS57382.1. [Q9WU42-2]
    RefSeqiNP_001240833.1. NM_001253904.1.
    NP_001240834.1. NM_001253905.1. [Q9WU42-2]
    UniGeneiMm.278646.

    Genome annotation databases

    EnsembliENSMUST00000111394; ENSMUSP00000107025; ENSMUSG00000029478. [Q9WU42-2]
    ENSMUST00000111398; ENSMUSP00000107029; ENSMUSG00000029478. [Q9WU42-1]
    GeneIDi20602.
    KEGGimmu:20602.
    UCSCiuc008zra.2. mouse. [Q9WU42-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113001 mRNA. Translation: AAD20944.1 .
    AF113002 mRNA. Translation: AAD20945.1 .
    AF125671 mRNA. Translation: AAD22972.1 .
    AC132118 Genomic DNA. No translation available.
    AC139377 Genomic DNA. No translation available.
    CCDSi CCDS57382.1. [Q9WU42-2 ]
    RefSeqi NP_001240833.1. NM_001253904.1.
    NP_001240834.1. NM_001253905.1. [Q9WU42-2 ]
    UniGenei Mm.278646.

    3D structure databases

    ProteinModelPortali Q9WU42.
    SMRi Q9WU42. Positions 167-207, 408-476, 611-681.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203350. 8 interactions.
    IntActi Q9WU42. 3 interactions.
    MINTi MINT-3154743.
    STRINGi 10090.ENSMUSP00000107033.

    PTM databases

    PhosphoSitei Q9WU42.

    Proteomic databases

    MaxQBi Q9WU42.
    PaxDbi Q9WU42.
    PRIDEi Q9WU42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111394 ; ENSMUSP00000107025 ; ENSMUSG00000029478 . [Q9WU42-2 ]
    ENSMUST00000111398 ; ENSMUSP00000107029 ; ENSMUSG00000029478 . [Q9WU42-1 ]
    GeneIDi 20602.
    KEGGi mmu:20602.
    UCSCi uc008zra.2. mouse. [Q9WU42-2 ]

    Organism-specific databases

    CTDi 9612.
    MGIi MGI:1337080. Ncor2.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00730000110846.
    HOGENOMi HOG000113746.
    HOVERGENi HBG052587.
    KOi K06065.

    Enzyme and pathway databases

    Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    ChiTaRSi NCOR2. mouse.
    NextBioi 298933.
    PROi Q9WU42.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WU42.
    Bgeei Q9WU42.
    CleanExi MM_NCOR2.
    Genevestigatori Q9WU42.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    [Graphical view ]
    Pfami PF00249. Myb_DNA-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51293. SANT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Unique forms of human and mouse nuclear receptor corepressor SMRT."
      Ordentlich P., Downes M., Xie W., Genin A., Spinner N.B., Evans R.M.
      Proc. Natl. Acad. Sci. U.S.A. 96:2639-2644(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
      Tissue: Brain and Spleen.
    2. "SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor."
      Park E.J., Schroen D.J., Yang M., Li H., Li L., Chen J.D.
      Proc. Natl. Acad. Sci. U.S.A. 96:3519-3524(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
      Tissue: Embryo.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
      Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
      Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH C1D.
    5. "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression."
      Kao H.-Y., Downes M., Ordentlich P., Evans R.M.
      Genes Dev. 14:55-66(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HDAC7.
    6. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
      Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W.
      Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CBFA2T3.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-550 AND SER-2215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression."
      Jacobs F.M., van Erp S., van der Linden A.J., von Oerthel L., Burbach J.P., Smidt M.P.
      Development 136:531-540(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NR4A2.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1983, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    11. "Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms."
      Huang C., Hatzi K., Melnick A.
      Nat. Immunol. 14:380-388(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, INTERACTION WITH BCL6.

    Entry informationi

    Entry nameiNCOR2_MOUSE
    AccessioniPrimary (citable) accession number: Q9WU42
    Secondary accession number(s): E9Q9V0, Q9WU43, Q9WUC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3