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Q9WU42 (NCOR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor corepressor 2

Short name=N-CoR2
Alternative name(s):
Silencing mediator of retinoic acid and thyroid hormone receptor
Short name=SMRT
Short name=SMRTe
T3 receptor-associating factor
Short name=TRAC
Thyroid-, retinoic-acid-receptor-associated corepressor
Gene names
Name:Ncor2
Synonyms:Smrt
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2472 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1and isoform 5have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Ref.8

Subunit structure

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT)with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Ref.4 Ref.5 Ref.6 Ref.8 Ref.11

Subcellular location

Nucleus.

Tissue specificity

Ubiquitous. Also widely expressed in early embryos.

Domain

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).

The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

Sequence similarities

Belongs to the N-CoR nuclear receptor corepressors family.

Contains 2 SANT domains.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
   LigandDNA-binding
   Molecular functionRepressor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processType I pneumocyte differentiation

Inferred from mutant phenotype PubMed 22001906. Source: MGI

cell proliferation in forebrain

Inferred from mutant phenotype PubMed 17928865. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 17928865. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 19066220. Source: MGI

heart morphogenesis

Inferred from mutant phenotype PubMed 18347093. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 17928865. Source: MGI

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 19066220. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.1. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15681609. Source: MGI

telencephalon development

Inferred from mutant phenotype PubMed 17928865. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

white fat cell differentiation

Inferred from mutant phenotype PubMed 19066220. Source: MGI

   Cellular_componenthistone deacetylase complex

Inferred from direct assay PubMed 15832170. Source: MGI

nuclear body

Inferred from direct assay PubMed 11641275. Source: MGI

nuclear matrix

Inferred from sequence or structural similarity. Source: UniProtKB

nucleoplasm

Traceable author statement. Source: Reactome

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15681609. Source: MGI

chromatin binding

Inferred from direct assay PubMed 15832170PubMed 18347093PubMed 19066220. Source: MGI

protein binding

Inferred from physical interaction PubMed 16924111Ref.8. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay PubMed 17928865. Source: MGI

transcription corepressor activity

Inferred from direct assay Ref.8. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q9WU42-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q9WU42-2)

The sequence of this isoform differs from the canonical sequence as follows:
     36-254: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24722472Nuclear receptor corepressor 2
PRO_0000055623

Regions

Domain427 – 47852SANT 1
Domain606 – 65752SANT 2
Region254 – 31259Interaction with SIN3A/B By similarity
Region2086 – 20905Required for interaction with RARA in the absence of its ligand By similarity
Coiled coil165 – 20743 Potential
Coiled coil492 – 56069 Potential
Coiled coil658 – 68225 Potential
Motif2094 – 20985CORNR box of ID1
Motif2296 – 23005CORNR box of ID2
Compositional bias494 – 50714Poly-Gln
Compositional bias775 – 80430Pro-rich
Compositional bias989 – 99911Pro-rich
Compositional bias1351 – 13577Pro-rich
Compositional bias1615 – 16195Poly-Ala
Compositional bias2434 – 24374Poly-Pro

Amino acid modifications

Modified residue541Phosphoserine By similarity
Modified residue671Phosphoserine By similarity
Modified residue1491Phosphoserine By similarity
Modified residue1521Phosphoserine By similarity
Modified residue2151Phosphoserine By similarity
Modified residue5491Phosphothreonine By similarity
Modified residue5501Phosphoserine Ref.7
Modified residue7471Phosphoserine By similarity
Modified residue7501Phosphoserine By similarity
Modified residue8781N6-acetyllysine By similarity
Modified residue9381Phosphoserine By similarity
Modified residue9551Phosphoserine By similarity
Modified residue9581N6-acetyllysine By similarity
Modified residue11811N6-acetyllysine By similarity
Modified residue12091N6-acetyllysine By similarity
Modified residue12201Phosphoserine By similarity
Modified residue13501Phosphothreonine By similarity
Modified residue14491Phosphoserine By similarity
Modified residue17491Phosphoserine By similarity
Modified residue18191Phosphoserine By similarity
Modified residue19201N6-acetyllysine By similarity
Modified residue19631Phosphoserine By similarity
Modified residue19831N6-acetyllysine Ref.10
Modified residue20041Phosphoserine By similarity
Modified residue20121Phosphoserine By similarity
Modified residue20151Phosphoserine By similarity
Modified residue20161Phosphoserine By similarity
Modified residue20201Phosphothreonine By similarity
Modified residue21611Phosphoserine By similarity
Modified residue21811Phosphoserine Ref.9
Modified residue22151Phosphoserine Ref.7

Natural variations

Alternative sequence36 – 254219Missing in isoform Beta.
VSP_003414

Experimental info

Sequence conflict1761M → RL in AAD22972. Ref.2
Sequence conflict396 – 4027PPMLYDA → RHVVRR in AAD22972. Ref.2
Sequence conflict5551D → H in AAD20944. Ref.1
Sequence conflict7561T → M in AAD20944. Ref.1
Sequence conflict7851V → A in AAD22972. Ref.2
Sequence conflict806 – 84641PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20944. Ref.1
Sequence conflict806 – 84641PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20945. Ref.1
Sequence conflict8561E → K in AAD20945. Ref.1
Sequence conflict8591E → K in AAD20945. Ref.1
Sequence conflict8671E → K in AAD20945. Ref.1
Sequence conflict8951E → K in AAD20945. Ref.1
Sequence conflict9161S → F in AAD20944. Ref.1
Sequence conflict9751I → IQ in AAD20944. Ref.1
Sequence conflict1046 – 106318PKLPT…LPFPI → QSYRLSPHAGHRLPSH in AAD22972. Ref.2
Sequence conflict1073 – 10808PHAADPSA → TRADPL in AAD22972. Ref.2
Sequence conflict11331Missing in AAD22972. Ref.2
Sequence conflict11491Missing in AAD22972. Ref.2
Sequence conflict11571G → E in AAD22972. Ref.2
Sequence conflict1172 – 120130GSATS…SITHG → APPPVEASPRASQYPGCRRP QLQRLYHPR in AAD22972. Ref.2
Sequence conflict16961A → S in AAD22972. Ref.2
Sequence conflict1855 – 18573Missing in AAD22972. Ref.2
Sequence conflict19091P → A in AAD20944. Ref.1
Sequence conflict19091P → A in AAD20945. Ref.1
Sequence conflict19131A → G in AAD22972. Ref.2
Sequence conflict19231A → G in AAD20944. Ref.1
Sequence conflict19231A → G in AAD20945. Ref.1
Sequence conflict19561N → S in AAD22972. Ref.2
Sequence conflict19681A → G in AAD22972. Ref.2
Sequence conflict2195 – 21962TA → AV in AAD22972. Ref.2
Sequence conflict2213 – 22142SK → LE in AAD20944. Ref.1
Sequence conflict22241A → T in AAD20944. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 8068020DF0AAB9B7

FASTA2,472269,807
        10         20         30         40         50         60 
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARSHTDVGLL EYQHHPRDYT SHLSPGSIIQ 

        70         80         90        100        110        120 
PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI EFTESKRPRL ELLPDTLLRP 

       130        140        150        160        170        180 
SPLLATGQPS GSEDLTKDRS LAGKLEPVSP PSPPHADPEL ELAPSRLSKE ELIQNMDRVD 

       190        200        210        220        230        240 
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA 

       250        260        270        280        290        300 
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ 

       310        320        330        340        350        360 
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG 

       370        380        390        400        410        420 
LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM 

       430        440        450        460        470        480 
KVYKDRQVTN MWSEQERDTF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK 

       490        500        510        520        530        540 
SLVRRSYRRR GKSQQQQQQQ QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE 

       550        560        570        580        590        600 
LSKEKTDDTS GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL 

       610        620        630        640        650        660 
ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF NYKKRQNLDE 

       670        680        690        700        710        720 
ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE MEASGASANE EELAEEAEAS 

       730        740        750        760        770        780 
QASGNEVPRV GECSGPAAVN NSSDTESVPS PRSEATKDTG PKPTGTEALP AATQPPVPPP 

       790        800        810        820        830        840 
EEPAVAPAEP SPVPDASGPP SPEPSPSPAA PPATVDKDEQ EAPAAPAPQT EDAKEQKSEA 

       850        860        870        880        890        900 
EEIDVGKPEE PEASEEPPES VKSDHKEETE EEPEDKAKGT EAIETVSEAP LKVEEAGSKA 

       910        920        930        940        950        960 
AVTKGSSSGA TQDSDSSATC SADEVDEPEG GDKGRLLSPR PSLLTPAGDP RASTSPQKPL 

       970        980        990       1000       1010       1020 
DLKQLKQRAA AIPPIVTKVH EPPREDTVPP KPVPPVPPPT QHLQPEGDVS QQSGGSPRGK 

      1030       1040       1050       1060       1070       1080 
SRSPVPPAEK EAEKPAFFPA FPTEGPKLPT EPPRWSSGLP FPIPPREVIK TSPHAADPSA 

      1090       1100       1110       1120       1130       1140 
FSYTPPGHPL PLGLHDSARP VLPRPPISNP PPLISSAKHP GVLERQLGAI SQQGMSVQLR 

      1150       1160       1170       1180       1190       1200 
VPHSEHAKAP MGPLTMGLPL AVDPKKLGTA LGSATSGSIT KGLPSTRAAD GPSYRGSITH 

      1210       1220       1230       1240       1250       1260 
GTPADVLYKG TISRIVGEDS PSRLDRARED TLPKGHVIYE GKKGHVLSYE GGMSVSQCSK 

      1270       1280       1290       1300       1310       1320 
EDGRSSSGPP HETAAPKRTY DMMEGRVGRT VTSASIEGLM GRAIPEQHSP HLKEQHHIRG 

      1330       1340       1350       1360       1370       1380 
SITQGIPRSY VEAQEDYLRR EAKLLKREGT PPPPPPPRDL TETYKPRPLD PLGPLKLKPT 

      1390       1400       1410       1420       1430       1440 
HEGVVATVKE AGRSIHEIPR EELRRTPELP LAPRPLKEGS ITQGTPLKYD SGAPSTGTKK 

      1450       1460       1470       1480       1490       1500 
HDVRSIIGSP GRPFPALHPL DIMADARALE RACYEESLKS RSGTSSGAGG SITRGAPVVV 

      1510       1520       1530       1540       1550       1560 
PELGKPRQSP LTYEDHGAPF TSHLPRGSPV TTREPTPRLQ EGSLLSSKAS QDRKLTSTPR 

      1570       1580       1590       1600       1610       1620 
EIAKSPHSTV PEHHPHPISP YEHLLRGVTG VDLYRGHIPL AFDPTSIPRG IPLEAAAAAY 

      1630       1640       1650       1660       1670       1680 
YLPRHLAPSP TYPHLYPPYL IRGYPDTAAL ENRQTIINDY ITSQQMHHNA ASAMAQRADM 

      1690       1700       1710       1720       1730       1740 
LRGLSPRESS LALNYAAGPR GIIDLSQVPH LPVLVPPTPG TPATAIDRLA YLPTAPPPFS 

      1750       1760       1770       1780       1790       1800 
SRHSSSPLSP GGPTHLAKPT ATSSSERERE RERERDKSIL TSTTTVEHAP IWRPGTEQSS 

      1810       1820       1830       1840       1850       1860 
GAGGSSRPAS HTHQHSPISP RTQDALQQRP SVLHNTSMKG VVTSVEPGTP TVLRWARSTS 

      1870       1880       1890       1900       1910       1920 
TSSPVRPAAT FPPATHCPLG GTLEGVYPTL MEPVLLPKET SRVARPERPR VDAGHAFLTK 

      1930       1940       1950       1960       1970       1980 
PPAREPASSP SKSSEPRSLA PPSSSHTAIA RTPAKNLAPH HASPDPPAPT SASDLHREKT 

      1990       2000       2010       2020       2030       2040 
QSKPFSIQEL ELRSLGYHSG AGYSPDGVEP ISPVSSPSLT HDKGLSKPLE ELEKSHLEGE 

      2050       2060       2070       2080       2090       2100 
LRHKQPGPMK LSAEAAHLPH LRPLPESQPS SSPLLQTAPG IKGHQRVVTL AQHISEVITQ 

      2110       2120       2130       2140       2150       2160 
DYTRHHPQQL SGPLPAPLYS FPGASCPVLD LRRPPSDLYL PPPDHGTPAR GSPHSEGGKR 

      2170       2180       2190       2200       2210       2220 
SPEPSKTSVL GSSEDAIEPV SPPEGMTEPG HARSTAYPLL YRDGEQGEPR MGSKSPGNTS 

      2230       2240       2250       2260       2270       2280 
QPPAFFSKLT ESNSAMVKSK KQEINKKLNT HNRNEPEYNI GQPGTEIFNM PAITGAGLMT 

      2290       2300       2310       2320       2330       2340 
CRSQAVQEHA STNMGLEAII RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT 

      2350       2360       2370       2380       2390       2400 
ADGRSDHALT SPGGGGKAKV SGRPSSRKAK SPAPGLASGD RPPSVSSVHS EGDCNRRTPL 

      2410       2420       2430       2440       2450       2460 
TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH HAWDEEPKPL 

      2470 
LCSQYETLSD SE 

« Hide

Isoform Beta [UniParc].

Checksum: 7FA45277FC6300A1
Show »

FASTA2,253245,029

References

« Hide 'large scale' references
[1]"Unique forms of human and mouse nuclear receptor corepressor SMRT."
Ordentlich P., Downes M., Xie W., Genin A., Spinner N.B., Evans R.M.
Proc. Natl. Acad. Sci. U.S.A. 96:2639-2644(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
Tissue: Brain and Spleen.
[2]"SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor."
Park E.J., Schroen D.J., Yang M., Li H., Li L., Chen J.D.
Proc. Natl. Acad. Sci. U.S.A. 96:3519-3524(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Embryo.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH C1D.
[5]"Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression."
Kao H.-Y., Downes M., Ordentlich P., Evans R.M.
Genes Dev. 14:55-66(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HDAC7.
[6]"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W.
Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CBFA2T3.
[7]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-550 AND SER-2215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[8]"Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression."
Jacobs F.M., van Erp S., van der Linden A.J., von Oerthel L., Burbach J.P., Smidt M.P.
Development 136:531-540(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NR4A2.
[9]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1983, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[11]"Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms."
Huang C., Hatzi K., Melnick A.
Nat. Immunol. 14:380-388(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING, INTERACTION WITH BCL6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF113001 mRNA. Translation: AAD20944.1.
AF113002 mRNA. Translation: AAD20945.1.
AF125671 mRNA. Translation: AAD22972.1.
AC132118 Genomic DNA. No translation available.
AC139377 Genomic DNA. No translation available.
CCDSCCDS57382.1. [Q9WU42-2]
RefSeqNP_001240833.1. NM_001253904.1.
NP_001240834.1. NM_001253905.1. [Q9WU42-2]
UniGeneMm.278646.

3D structure databases

ProteinModelPortalQ9WU42.
SMRQ9WU42. Positions 167-207, 408-476, 611-681.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203350. 8 interactions.
IntActQ9WU42. 3 interactions.
MINTMINT-3154743.
STRING10090.ENSMUSP00000107033.

PTM databases

PhosphoSiteQ9WU42.

Proteomic databases

MaxQBQ9WU42.
PaxDbQ9WU42.
PRIDEQ9WU42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111394; ENSMUSP00000107025; ENSMUSG00000029478. [Q9WU42-2]
ENSMUST00000111398; ENSMUSP00000107029; ENSMUSG00000029478. [Q9WU42-1]
GeneID20602.
KEGGmmu:20602.
UCSCuc008zra.2. mouse. [Q9WU42-2]

Organism-specific databases

CTD9612.
MGIMGI:1337080. Ncor2.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00730000110846.
HOGENOMHOG000113746.
HOVERGENHBG052587.
KOK06065.

Enzyme and pathway databases

ReactomeREACT_188576. Developmental Biology.
REACT_200794. Mus musculus biological processes.

Gene expression databases

ArrayExpressQ9WU42.
BgeeQ9WU42.
CleanExMM_NCOR2.
GenevestigatorQ9WU42.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS51293. SANT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNCOR2. mouse.
NextBio298933.
PROQ9WU42.
SOURCESearch...

Entry information

Entry nameNCOR2_MOUSE
AccessionPrimary (citable) accession number: Q9WU42
Secondary accession number(s): E9Q9V0, Q9WU43, Q9WUC1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot