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Protein

Nuclear receptor corepressor 2

Gene

Ncor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • histone deacetylase binding Source: MGI
  • ligand-dependent nuclear receptor binding Source: GO_Central
  • Notch binding Source: MGI
  • protein N-terminus binding Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: GO_Central

GO - Biological processi

  • cell proliferation in forebrain Source: MGI
  • forebrain development Source: MGI
  • glucose homeostasis Source: MGI
  • heart morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of production of miRNAs involved in gene silencing by miRNA Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of protein deacetylation Source: MGI
  • regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • telencephalon development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • Type I pneumocyte differentiation Source: MGI
  • white fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-381340. Transcriptional regulation of white adipocyte differentiation.
R-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-MMU-442533. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor corepressor 2
Short name:
N-CoR2
Alternative name(s):
Silencing mediator of retinoic acid and thyroid hormone receptor
Short name:
SMRT
Short name:
SMRTe
T3 receptor-associating factor
Short name:
TRAC
Thyroid-, retinoic-acid-receptor-associated corepressor
Gene namesi
Name:Ncor2
Synonyms:Smrt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1337080. Ncor2.

Subcellular locationi

GO - Cellular componenti

  • histone deacetylase complex Source: MGI
  • membrane Source: MGI
  • nuclear body Source: MGI
  • nuclear chromatin Source: MGI
  • nuclear matrix Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556231 – 2472Nuclear receptor corepressor 2Add BLAST2472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Asymmetric dimethylarginineCombined sources1
Modified residuei54PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei215PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei549PhosphothreonineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1
Modified residuei878N6-acetyllysineBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei945PhosphothreonineBy similarity1
Modified residuei955PhosphoserineBy similarity1
Modified residuei958N6-acetyllysineBy similarity1
Modified residuei1181N6-acetyllysineBy similarity1
Modified residuei1209N6-acetyllysineBy similarity1
Modified residuei1220PhosphoserineBy similarity1
Modified residuei1350PhosphothreonineCombined sources1
Modified residuei1449PhosphoserineBy similarity1
Modified residuei1509PhosphoserineBy similarity1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1624Asymmetric dimethylarginineBy similarity1
Modified residuei1746PhosphoserineBy similarity1
Modified residuei1749PhosphoserineCombined sources1
Modified residuei1819PhosphoserineBy similarity1
Modified residuei1854Omega-N-methylarginineCombined sources1
Modified residuei1920N6-acetyllysineBy similarity1
Modified residuei1963PhosphoserineBy similarity1
Modified residuei1983N6-acetyllysineCombined sources1
Modified residuei2004PhosphoserineCombined sources1
Modified residuei2012PhosphoserineCombined sources1
Modified residuei2015PhosphoserineCombined sources1
Modified residuei2016PhosphoserineCombined sources1
Modified residuei2018PhosphoserineCombined sources1
Modified residuei2020PhosphothreonineCombined sources1
Modified residuei2035PhosphoserineBy similarity1
Modified residuei2161PhosphoserineBy similarity1
Modified residuei2181PhosphoserineCombined sources1
Modified residuei2215PhosphoserineCombined sources1
Modified residuei2371PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9WU42.
PaxDbiQ9WU42.
PeptideAtlasiQ9WU42.
PRIDEiQ9WU42.

PTM databases

iPTMnetiQ9WU42.
PhosphoSitePlusiQ9WU42.

Expressioni

Tissue specificityi

Ubiquitous. Also widely expressed in early embryos.

Gene expression databases

BgeeiENSMUSG00000029478.
CleanExiMM_NCOR2.
ExpressionAtlasiQ9WU42. baseline and differential.
GenevisibleiQ9WU42. MM.

Interactioni

Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2.6 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203350. 9 interactors.
DIPiDIP-42595N.
IntActiQ9WU42. 3 interactors.
MINTiMINT-3154743.
STRINGi10090.ENSMUSP00000083250.

Structurei

3D structure databases

ProteinModelPortaliQ9WU42.
SMRiQ9WU42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 478SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini606 – 657SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 312Interaction with SIN3A/BBy similarityAdd BLAST59
Regioni2086 – 2090Required for interaction with RARA in the absence of its ligandBy similarity5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili165 – 207Sequence analysisAdd BLAST43
Coiled coili492 – 560Sequence analysisAdd BLAST69
Coiled coili658 – 682Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2094 – 2098CORNR box of ID15
Motifi2296 – 2300CORNR box of ID25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi494 – 507Poly-GlnAdd BLAST14
Compositional biasi775 – 804Pro-richAdd BLAST30
Compositional biasi989 – 999Pro-richAdd BLAST11
Compositional biasi1351 – 1357Pro-rich7
Compositional biasi1615 – 1619Poly-Ala5
Compositional biasi2434 – 2437Poly-Pro4

Domaini

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

Sequence similaritiesi

Contains 2 SANT domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1878. Eukaryota.
ENOG410YDXP. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000113746.
HOVERGENiHBG052587.
InParanoidiQ9WU42.
KOiK06065.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR031557. N-CoR_GPS2_interact.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF15784. GPS2_interact. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q9WU42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARSHTDVGLL EYQHHPRDYT
60 70 80 90 100
SHLSPGSIIQ PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI
110 120 130 140 150
EFTESKRPRL ELLPDTLLRP SPLLATGQPS GSEDLTKDRS LAGKLEPVSP
160 170 180 190 200
PSPPHADPEL ELAPSRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL
210 220 230 240 250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP
260 270 280 290 300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ
310 320 330 340 350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM
360 370 380 390 400
QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY
410 420 430 440 450
DADQQRIKFI NMNGLMDDPM KVYKDRQVTN MWSEQERDTF REKFMQHPKN
460 470 480 490 500
FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ
510 520 530 540 550
QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE LSKEKTDDTS
560 570 580 590 600
GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL
610 620 630 640 650
ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF
660 670 680 690 700
NYKKRQNLDE ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE
710 720 730 740 750
MEASGASANE EELAEEAEAS QASGNEVPRV GECSGPAAVN NSSDTESVPS
760 770 780 790 800
PRSEATKDTG PKPTGTEALP AATQPPVPPP EEPAVAPAEP SPVPDASGPP
810 820 830 840 850
SPEPSPSPAA PPATVDKDEQ EAPAAPAPQT EDAKEQKSEA EEIDVGKPEE
860 870 880 890 900
PEASEEPPES VKSDHKEETE EEPEDKAKGT EAIETVSEAP LKVEEAGSKA
910 920 930 940 950
AVTKGSSSGA TQDSDSSATC SADEVDEPEG GDKGRLLSPR PSLLTPAGDP
960 970 980 990 1000
RASTSPQKPL DLKQLKQRAA AIPPIVTKVH EPPREDTVPP KPVPPVPPPT
1010 1020 1030 1040 1050
QHLQPEGDVS QQSGGSPRGK SRSPVPPAEK EAEKPAFFPA FPTEGPKLPT
1060 1070 1080 1090 1100
EPPRWSSGLP FPIPPREVIK TSPHAADPSA FSYTPPGHPL PLGLHDSARP
1110 1120 1130 1140 1150
VLPRPPISNP PPLISSAKHP GVLERQLGAI SQQGMSVQLR VPHSEHAKAP
1160 1170 1180 1190 1200
MGPLTMGLPL AVDPKKLGTA LGSATSGSIT KGLPSTRAAD GPSYRGSITH
1210 1220 1230 1240 1250
GTPADVLYKG TISRIVGEDS PSRLDRARED TLPKGHVIYE GKKGHVLSYE
1260 1270 1280 1290 1300
GGMSVSQCSK EDGRSSSGPP HETAAPKRTY DMMEGRVGRT VTSASIEGLM
1310 1320 1330 1340 1350
GRAIPEQHSP HLKEQHHIRG SITQGIPRSY VEAQEDYLRR EAKLLKREGT
1360 1370 1380 1390 1400
PPPPPPPRDL TETYKPRPLD PLGPLKLKPT HEGVVATVKE AGRSIHEIPR
1410 1420 1430 1440 1450
EELRRTPELP LAPRPLKEGS ITQGTPLKYD SGAPSTGTKK HDVRSIIGSP
1460 1470 1480 1490 1500
GRPFPALHPL DIMADARALE RACYEESLKS RSGTSSGAGG SITRGAPVVV
1510 1520 1530 1540 1550
PELGKPRQSP LTYEDHGAPF TSHLPRGSPV TTREPTPRLQ EGSLLSSKAS
1560 1570 1580 1590 1600
QDRKLTSTPR EIAKSPHSTV PEHHPHPISP YEHLLRGVTG VDLYRGHIPL
1610 1620 1630 1640 1650
AFDPTSIPRG IPLEAAAAAY YLPRHLAPSP TYPHLYPPYL IRGYPDTAAL
1660 1670 1680 1690 1700
ENRQTIINDY ITSQQMHHNA ASAMAQRADM LRGLSPRESS LALNYAAGPR
1710 1720 1730 1740 1750
GIIDLSQVPH LPVLVPPTPG TPATAIDRLA YLPTAPPPFS SRHSSSPLSP
1760 1770 1780 1790 1800
GGPTHLAKPT ATSSSERERE RERERDKSIL TSTTTVEHAP IWRPGTEQSS
1810 1820 1830 1840 1850
GAGGSSRPAS HTHQHSPISP RTQDALQQRP SVLHNTSMKG VVTSVEPGTP
1860 1870 1880 1890 1900
TVLRWARSTS TSSPVRPAAT FPPATHCPLG GTLEGVYPTL MEPVLLPKET
1910 1920 1930 1940 1950
SRVARPERPR VDAGHAFLTK PPAREPASSP SKSSEPRSLA PPSSSHTAIA
1960 1970 1980 1990 2000
RTPAKNLAPH HASPDPPAPT SASDLHREKT QSKPFSIQEL ELRSLGYHSG
2010 2020 2030 2040 2050
AGYSPDGVEP ISPVSSPSLT HDKGLSKPLE ELEKSHLEGE LRHKQPGPMK
2060 2070 2080 2090 2100
LSAEAAHLPH LRPLPESQPS SSPLLQTAPG IKGHQRVVTL AQHISEVITQ
2110 2120 2130 2140 2150
DYTRHHPQQL SGPLPAPLYS FPGASCPVLD LRRPPSDLYL PPPDHGTPAR
2160 2170 2180 2190 2200
GSPHSEGGKR SPEPSKTSVL GSSEDAIEPV SPPEGMTEPG HARSTAYPLL
2210 2220 2230 2240 2250
YRDGEQGEPR MGSKSPGNTS QPPAFFSKLT ESNSAMVKSK KQEINKKLNT
2260 2270 2280 2290 2300
HNRNEPEYNI GQPGTEIFNM PAITGAGLMT CRSQAVQEHA STNMGLEAII
2310 2320 2330 2340 2350
RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT ADGRSDHALT
2360 2370 2380 2390 2400
SPGGGGKAKV SGRPSSRKAK SPAPGLASGD RPPSVSSVHS EGDCNRRTPL
2410 2420 2430 2440 2450
TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH
2460 2470
HAWDEEPKPL LCSQYETLSD SE
Length:2,472
Mass (Da):269,807
Last modified:July 27, 2011 - v3
Checksum:i8068020DF0AAB9B7
GO
Isoform Beta (identifier: Q9WU42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-254: Missing.

Show »
Length:2,253
Mass (Da):245,029
Checksum:i7FA45277FC6300A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176M → RL in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti396 – 402PPMLYDA → RHVVRR in AAD22972 (PubMed:10097068).Curated7
Sequence conflicti555D → H in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti756T → M in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti785V → A in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti806 – 846PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20944 (PubMed:10077563).CuratedAdd BLAST41
Sequence conflicti806 – 846PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20945 (PubMed:10077563).CuratedAdd BLAST41
Sequence conflicti856E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti859E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti867E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti895E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti916S → F in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti975I → IQ in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti1046 – 1063PKLPT…LPFPI → QSYRLSPHAGHRLPSH in AAD22972 (PubMed:10097068).CuratedAdd BLAST18
Sequence conflicti1073 – 1080PHAADPSA → TRADPL in AAD22972 (PubMed:10097068).Curated8
Sequence conflicti1133Missing in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1149Missing in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1157G → E in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1172 – 1201GSATS…SITHG → APPPVEASPRASQYPGCRRP QLQRLYHPR in AAD22972 (PubMed:10097068).CuratedAdd BLAST30
Sequence conflicti1696A → S in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1855 – 1857Missing in AAD22972 (PubMed:10097068).Curated3
Sequence conflicti1909P → A in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti1909P → A in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti1913A → G in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1923A → G in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti1923A → G in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti1956N → S in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1968A → G in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti2195 – 2196TA → AV in AAD22972 (PubMed:10097068).Curated2
Sequence conflicti2213 – 2214SK → LE in AAD20944 (PubMed:10077563).Curated2
Sequence conflicti2224A → T in AAD20944 (PubMed:10077563).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00341436 – 254Missing in isoform Beta. 1 PublicationAdd BLAST219

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113001 mRNA. Translation: AAD20944.1.
AF113002 mRNA. Translation: AAD20945.1.
AF125671 mRNA. Translation: AAD22972.1.
AC132118 Genomic DNA. No translation available.
AC139377 Genomic DNA. No translation available.
CCDSiCCDS57382.1. [Q9WU42-2]
RefSeqiNP_001240833.1. NM_001253904.1.
NP_001240834.1. NM_001253905.1. [Q9WU42-2]
XP_011239133.1. XM_011240831.2. [Q9WU42-1]
UniGeneiMm.278646.

Genome annotation databases

EnsembliENSMUST00000111394; ENSMUSP00000107025; ENSMUSG00000029478. [Q9WU42-2]
ENSMUST00000111398; ENSMUSP00000107029; ENSMUSG00000029478. [Q9WU42-1]
GeneIDi20602.
KEGGimmu:20602.
UCSCiuc008zra.2. mouse. [Q9WU42-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113001 mRNA. Translation: AAD20944.1.
AF113002 mRNA. Translation: AAD20945.1.
AF125671 mRNA. Translation: AAD22972.1.
AC132118 Genomic DNA. No translation available.
AC139377 Genomic DNA. No translation available.
CCDSiCCDS57382.1. [Q9WU42-2]
RefSeqiNP_001240833.1. NM_001253904.1.
NP_001240834.1. NM_001253905.1. [Q9WU42-2]
XP_011239133.1. XM_011240831.2. [Q9WU42-1]
UniGeneiMm.278646.

3D structure databases

ProteinModelPortaliQ9WU42.
SMRiQ9WU42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203350. 9 interactors.
DIPiDIP-42595N.
IntActiQ9WU42. 3 interactors.
MINTiMINT-3154743.
STRINGi10090.ENSMUSP00000083250.

PTM databases

iPTMnetiQ9WU42.
PhosphoSitePlusiQ9WU42.

Proteomic databases

EPDiQ9WU42.
PaxDbiQ9WU42.
PeptideAtlasiQ9WU42.
PRIDEiQ9WU42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111394; ENSMUSP00000107025; ENSMUSG00000029478. [Q9WU42-2]
ENSMUST00000111398; ENSMUSP00000107029; ENSMUSG00000029478. [Q9WU42-1]
GeneIDi20602.
KEGGimmu:20602.
UCSCiuc008zra.2. mouse. [Q9WU42-2]

Organism-specific databases

CTDi9612.
MGIiMGI:1337080. Ncor2.

Phylogenomic databases

eggNOGiKOG1878. Eukaryota.
ENOG410YDXP. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000113746.
HOVERGENiHBG052587.
InParanoidiQ9WU42.
KOiK06065.

Enzyme and pathway databases

ReactomeiR-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-381340. Transcriptional regulation of white adipocyte differentiation.
R-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-MMU-442533. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Miscellaneous databases

ChiTaRSiNcor2. mouse.
PROiQ9WU42.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029478.
CleanExiMM_NCOR2.
ExpressionAtlasiQ9WU42. baseline and differential.
GenevisibleiQ9WU42. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR031557. N-CoR_GPS2_interact.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF15784. GPS2_interact. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCOR2_MOUSE
AccessioniPrimary (citable) accession number: Q9WU42
Secondary accession number(s): E9Q9V0, Q9WU43, Q9WUC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.