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Q9WU28

- PFD5_MOUSE

UniProt

Q9WU28 - PFD5_MOUSE

Protein

Prefoldin subunit 5

Gene

Pfdn5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC By similarity.By similarity

    GO - Biological processi

    1. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    2. negative regulation of transcription, DNA-templated Source: Ensembl
    3. protein folding Source: InterPro
    4. retina development in camera-type eye Source: MGI

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prefoldin subunit 5
    Alternative name(s):
    C-Myc-binding protein Mm-1
    EIG-1
    Myc modulator 1
    Gene namesi
    Name:Pfdn5
    Synonyms:Eig1, Mm1, Pfd5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1928753. Pfdn5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. prefoldin complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 154153Prefoldin subunit 5PRO_0000153662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei42 – 421N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9WU28.
    PaxDbiQ9WU28.
    PRIDEiQ9WU28.

    2D gel databases

    UCD-2DPAGEQ9WU28.

    PTM databases

    PhosphoSiteiQ9WU28.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WU28.
    BgeeiQ9WU28.
    CleanExiMM_PFDN5.
    GenevestigatoriQ9WU28.

    Interactioni

    Subunit structurei

    Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

    Protein-protein interaction databases

    IntActiQ9WU28. 1 interaction.
    MINTiMINT-1581554.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WU28.
    SMRiQ9WU28. Positions 10-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the prefoldin subunit alpha family.Curated

    Phylogenomic databases

    eggNOGiCOG1730.
    GeneTreeiENSGT00390000008783.
    HOVERGENiHBG004539.
    InParanoidiQ9WU28.
    KOiK04797.
    OMAiYYVKKTR.
    OrthoDBiEOG7B05FV.
    TreeFamiTF106509.

    Family and domain databases

    Gene3Di1.10.287.370. 1 hit.
    HAMAPiMF_00308. PfdA.
    InterProiIPR011599. PFD_alpha.
    IPR009053. Prefoldin.
    IPR004127. Prefoldin_subunit_alpha.
    [Graphical view]
    PfamiPF02996. Prefoldin. 1 hit.
    [Graphical view]
    SUPFAMiSSF46579. SSF46579. 1 hit.
    TIGRFAMsiTIGR00293. TIGR00293. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WU28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL    50
    NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK 100
    DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA 150
    TVKA 154
    Length:154
    Mass (Da):17,356
    Last modified:November 1, 1999 - v1
    Checksum:i0DA1EC744548CB14
    GO

    Sequence cautioni

    The sequence BAA92269.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF108357 mRNA. Translation: AAD28373.1.
    AB011473 mRNA. Translation: BAA92269.1. Different initiation.
    AK028206 mRNA. Translation: BAC25814.1.
    AK145883 mRNA. Translation: BAE26723.1.
    BC026920 mRNA. Translation: AAH26920.1.
    CCDSiCCDS37227.1.
    RefSeqiNP_081320.2. NM_027044.3.
    UniGeneiMm.158264.

    Genome annotation databases

    EnsembliENSMUST00000166658; ENSMUSP00000129178; ENSMUSG00000001289.
    GeneIDi56612.
    KEGGimmu:56612.
    UCSCiuc007xvh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF108357 mRNA. Translation: AAD28373.1 .
    AB011473 mRNA. Translation: BAA92269.1 . Different initiation.
    AK028206 mRNA. Translation: BAC25814.1 .
    AK145883 mRNA. Translation: BAE26723.1 .
    BC026920 mRNA. Translation: AAH26920.1 .
    CCDSi CCDS37227.1.
    RefSeqi NP_081320.2. NM_027044.3.
    UniGenei Mm.158264.

    3D structure databases

    ProteinModelPortali Q9WU28.
    SMRi Q9WU28. Positions 10-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WU28. 1 interaction.
    MINTi MINT-1581554.

    PTM databases

    PhosphoSitei Q9WU28.

    2D gel databases

    UCD-2DPAGE Q9WU28.

    Proteomic databases

    MaxQBi Q9WU28.
    PaxDbi Q9WU28.
    PRIDEi Q9WU28.

    Protocols and materials databases

    DNASUi 56612.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000166658 ; ENSMUSP00000129178 ; ENSMUSG00000001289 .
    GeneIDi 56612.
    KEGGi mmu:56612.
    UCSCi uc007xvh.1. mouse.

    Organism-specific databases

    CTDi 5204.
    MGIi MGI:1928753. Pfdn5.

    Phylogenomic databases

    eggNOGi COG1730.
    GeneTreei ENSGT00390000008783.
    HOVERGENi HBG004539.
    InParanoidi Q9WU28.
    KOi K04797.
    OMAi YYVKKTR.
    OrthoDBi EOG7B05FV.
    TreeFami TF106509.

    Miscellaneous databases

    NextBioi 313031.
    PROi Q9WU28.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WU28.
    Bgeei Q9WU28.
    CleanExi MM_PFDN5.
    Genevestigatori Q9WU28.

    Family and domain databases

    Gene3Di 1.10.287.370. 1 hit.
    HAMAPi MF_00308. PfdA.
    InterProi IPR011599. PFD_alpha.
    IPR009053. Prefoldin.
    IPR004127. Prefoldin_subunit_alpha.
    [Graphical view ]
    Pfami PF02996. Prefoldin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46579. SSF46579. 1 hit.
    TIGRFAMsi TIGR00293. TIGR00293. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of murine MM-1 and its expression."
      Inazu T., Myint Z., Noguchi T.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Eig1 gene."
      Oyamatsu T., Kotani S., Todokoro K.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiPFD5_MOUSE
    AccessioniPrimary (citable) accession number: Q9WU28
    Secondary accession number(s): Q3UKS8, Q9JMJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3