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Q9WU28 (PFD5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prefoldin subunit 5
Alternative name(s):
C-Myc-binding protein Mm-1
EIG-1
Myc modulator 1
Gene names
Name:Pfdn5
Synonyms:Eig1, Mm1, Pfd5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC By similarity. HAMAP-Rule MF_00308

Subunit structure

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits By similarity.

Subcellular location

Nucleus By similarity HAMAP-Rule MF_00308.

Sequence similarities

Belongs to the prefoldin subunit alpha family.

Sequence caution

The sequence BAA92269.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 154153Prefoldin subunit 5 HAMAP-Rule MF_00308
PRO_0000153662

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue421N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WU28 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 0DA1EC744548CB14

FASTA15417,356
        10         20         30         40         50         60 
MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLNKSNEGK 

        70         80         90        100        110        120 
ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA 

       130        140        150 
LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA TVKA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of murine MM-1 and its expression."
Inazu T., Myint Z., Noguchi T.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Eig1 gene."
Oyamatsu T., Kotani S., Todokoro K.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF108357 mRNA. Translation: AAD28373.1.
AB011473 mRNA. Translation: BAA92269.1. Different initiation.
AK028206 mRNA. Translation: BAC25814.1.
AK145883 mRNA. Translation: BAE26723.1.
BC026920 mRNA. Translation: AAH26920.1.
CCDSCCDS37227.1.
RefSeqNP_081320.2. NM_027044.3.
UniGeneMm.158264.

3D structure databases

ProteinModelPortalQ9WU28.
SMRQ9WU28. Positions 10-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9WU28. 1 interaction.
MINTMINT-1581554.

PTM databases

PhosphoSiteQ9WU28.

2D gel databases

UCD-2DPAGEQ9WU28.

Proteomic databases

MaxQBQ9WU28.
PaxDbQ9WU28.
PRIDEQ9WU28.

Protocols and materials databases

DNASU56612.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000166658; ENSMUSP00000129178; ENSMUSG00000001289.
GeneID56612.
KEGGmmu:56612.
UCSCuc007xvh.1. mouse.

Organism-specific databases

CTD5204.
MGIMGI:1928753. Pfdn5.

Phylogenomic databases

eggNOGCOG1730.
GeneTreeENSGT00390000008783.
HOVERGENHBG004539.
InParanoidQ9WU28.
KOK04797.
OMAYYVKKTR.
OrthoDBEOG7B05FV.
TreeFamTF106509.

Gene expression databases

ArrayExpressQ9WU28.
BgeeQ9WU28.
CleanExMM_PFDN5.
GenevestigatorQ9WU28.

Family and domain databases

Gene3D1.10.287.370. 1 hit.
HAMAPMF_00308. PfdA.
InterProIPR011599. PFD_alpha.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamPF02996. Prefoldin. 1 hit.
[Graphical view]
SUPFAMSSF46579. SSF46579. 1 hit.
TIGRFAMsTIGR00293. TIGR00293. 1 hit.
ProtoNetSearch...

Other

NextBio313031.
PROQ9WU28.
SOURCESearch...

Entry information

Entry namePFD5_MOUSE
AccessionPrimary (citable) accession number: Q9WU28
Secondary accession number(s): Q3UKS8, Q9JMJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot