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Q9WU28

- PFD5_MOUSE

UniProt

Q9WU28 - PFD5_MOUSE

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Protein

Prefoldin subunit 5

Gene

Pfdn5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity).By similarity

GO - Biological processi

  1. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  2. negative regulation of transcription, DNA-templated Source: Ensembl
  3. protein folding Source: InterPro
  4. retina development in camera-type eye Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_245663. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 5
Alternative name(s):
C-Myc-binding protein Mm-1
EIG-1
Myc modulator 1
Gene namesi
Name:Pfdn5
Synonyms:Eig1, Mm1, Pfd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1928753. Pfdn5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. prefoldin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 154153Prefoldin subunit 5PRO_0000153662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei42 – 421N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9WU28.
PaxDbiQ9WU28.
PRIDEiQ9WU28.

2D gel databases

UCD-2DPAGEQ9WU28.

PTM databases

PhosphoSiteiQ9WU28.

Expressioni

Gene expression databases

BgeeiQ9WU28.
CleanExiMM_PFDN5.
ExpressionAtlasiQ9WU28. baseline and differential.
GenevestigatoriQ9WU28.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

Protein-protein interaction databases

IntActiQ9WU28. 1 interaction.
MINTiMINT-1581554.

Structurei

3D structure databases

ProteinModelPortaliQ9WU28.
SMRiQ9WU28. Positions 10-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiCOG1730.
GeneTreeiENSGT00390000008783.
HOVERGENiHBG004539.
InParanoidiQ9WU28.
KOiK04797.
OMAiYYVKKTR.
OrthoDBiEOG7B05FV.
TreeFamiTF106509.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
HAMAPiMF_00308. PfdA.
InterProiIPR011599. PFD_alpha.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
TIGRFAMsiTIGR00293. TIGR00293. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WU28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL
60 70 80 90 100
NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK
110 120 130 140 150
DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA

TVKA
Length:154
Mass (Da):17,356
Last modified:November 1, 1999 - v1
Checksum:i0DA1EC744548CB14
GO

Sequence cautioni

The sequence BAA92269.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108357 mRNA. Translation: AAD28373.1.
AB011473 mRNA. Translation: BAA92269.1. Different initiation.
AK028206 mRNA. Translation: BAC25814.1.
AK145883 mRNA. Translation: BAE26723.1.
BC026920 mRNA. Translation: AAH26920.1.
CCDSiCCDS37227.1.
RefSeqiNP_081320.2. NM_027044.3.
UniGeneiMm.158264.

Genome annotation databases

EnsembliENSMUST00000166658; ENSMUSP00000129178; ENSMUSG00000001289.
GeneIDi56612.
KEGGimmu:56612.
UCSCiuc007xvh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108357 mRNA. Translation: AAD28373.1 .
AB011473 mRNA. Translation: BAA92269.1 . Different initiation.
AK028206 mRNA. Translation: BAC25814.1 .
AK145883 mRNA. Translation: BAE26723.1 .
BC026920 mRNA. Translation: AAH26920.1 .
CCDSi CCDS37227.1.
RefSeqi NP_081320.2. NM_027044.3.
UniGenei Mm.158264.

3D structure databases

ProteinModelPortali Q9WU28.
SMRi Q9WU28. Positions 10-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WU28. 1 interaction.
MINTi MINT-1581554.

PTM databases

PhosphoSitei Q9WU28.

2D gel databases

UCD-2DPAGE Q9WU28.

Proteomic databases

MaxQBi Q9WU28.
PaxDbi Q9WU28.
PRIDEi Q9WU28.

Protocols and materials databases

DNASUi 56612.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000166658 ; ENSMUSP00000129178 ; ENSMUSG00000001289 .
GeneIDi 56612.
KEGGi mmu:56612.
UCSCi uc007xvh.1. mouse.

Organism-specific databases

CTDi 5204.
MGIi MGI:1928753. Pfdn5.

Phylogenomic databases

eggNOGi COG1730.
GeneTreei ENSGT00390000008783.
HOVERGENi HBG004539.
InParanoidi Q9WU28.
KOi K04797.
OMAi YYVKKTR.
OrthoDBi EOG7B05FV.
TreeFami TF106509.

Enzyme and pathway databases

Reactomei REACT_245663. Prefoldin mediated transfer of substrate to CCT/TriC.

Miscellaneous databases

NextBioi 313031.
PROi Q9WU28.
SOURCEi Search...

Gene expression databases

Bgeei Q9WU28.
CleanExi MM_PFDN5.
ExpressionAtlasi Q9WU28. baseline and differential.
Genevestigatori Q9WU28.

Family and domain databases

Gene3Di 1.10.287.370. 1 hit.
HAMAPi MF_00308. PfdA.
InterProi IPR011599. PFD_alpha.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view ]
Pfami PF02996. Prefoldin. 1 hit.
[Graphical view ]
SUPFAMi SSF46579. SSF46579. 1 hit.
TIGRFAMsi TIGR00293. TIGR00293. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of murine MM-1 and its expression."
    Inazu T., Myint Z., Noguchi T.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Eig1 gene."
    Oyamatsu T., Kotani S., Todokoro K.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPFD5_MOUSE
AccessioniPrimary (citable) accession number: Q9WU28
Secondary accession number(s): Q3UKS8, Q9JMJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3