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Q9WU22

- PTN4_MOUSE

UniProt

Q9WU22 - PTN4_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 4

Gene

Ptpn4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    May act at junctions between the membrane and the cytoskeleton.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei820 – 8201SubstrateBy similarity
    Active sitei852 – 8521Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei896 – 8961SubstrateBy similarity

    GO - Molecular functioni

    1. non-membrane spanning protein tyrosine phosphatase activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 4 (EC:3.1.3.48)
    Alternative name(s):
    Testis-enriched protein tyrosine phosphatase
    Gene namesi
    Name:Ptpn4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1099792. Ptpn4.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 926926Tyrosine-protein phosphatase non-receptor type 4PRO_0000320075Add
    BLAST

    Proteomic databases

    PaxDbiQ9WU22.
    PRIDEiQ9WU22.

    PTM databases

    PhosphoSiteiQ9WU22.

    Expressioni

    Tissue specificityi

    Highly expressed in testis. Specifically expressed in spermatocytes and spermatids within seminiferous tubules (at protein level).1 Publication

    Gene expression databases

    CleanExiMM_PTPN4.
    GenevestigatoriQ9WU22.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cd247P241613EBI-7249866,EBI-7803400

    Protein-protein interaction databases

    IntActiQ9WU22. 1 interaction.
    MINTiMINT-126937.
    STRINGi10090.ENSMUSP00000067614.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WU22.
    SMRiQ9WU22. Positions 31-310, 513-913.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 312284FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 58973PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini655 – 911257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni852 – 8587Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117342.
    HOGENOMiHOG000007048.
    HOVERGENiHBG008322.
    InParanoidiQ9WU22.
    KOiK18037.
    OMAiHTCTDFW.
    OrthoDBiEOG76HQ1B.
    TreeFamiTF315900.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WU22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTARFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFRVNKHDQ    50
    GQVLLDIVFK HLDLTERDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP 100
    YNLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLS CPCNTAALLA 150
    SFAVQSELGD YNQSENLAGY LSDYSFIPNQ PQDFEKEIAK LHQQHVGLSP 200
    AEAEFNYLNA ARTLELYGVE FHYARDQSNN EILIGVMSGG ILIYKNRVRM 250
    NTFLWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKTLWKA 300
    CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN 350
    KDRVFARSPS KPLARKLMDW EVVSRNSLSD DRLETQSLPS RSPPGTPNHR 400
    NSSFTQEATR VRPSSVGHLV DHVVHMSPSE DFVSQRSPSS TQANSIVLES 450
    SPSQETPEDG QPPALPPKQS KKNSWNQIHF SNSQQDLVTH TNESFDVPSS 500
    PEKSTPNGGI PHDNLVLIKM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG 550
    TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC EKHSGELVLL 600
    VRPNAVYDVV EEKLESEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL 650
    ITGTVLAQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVLLKG 700
    NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCKDFWQM TWEQGSSMVV 750
    MLTTQVERGR VKCHQYWPEP SESSSYGCYQ VTCHSEEGNP AYIFRKMTLF 800
    NQEKNESRQL TQIQYTAWPD HGVPDDSSDF LDFVCHVRDQ RAGKEEPIIV 850
    HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ 900
    YRFVCEAILK VYEEGFVKPL TTSSNK 926
    Length:926
    Mass (Da):105,832
    Last modified:September 18, 2013 - v2
    Checksum:i73E465D804C9C5FB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti311 – 3111D → G in AAD22773. (PubMed:11054567)Curated
    Sequence conflicti359 – 3591P → S in AAD22773. (PubMed:11054567)Curated
    Sequence conflicti741 – 7411T → I in AAD22773. (PubMed:11054567)Curated
    Sequence conflicti781 – 7811V → A in AAD22773. (PubMed:11054567)Curated
    Sequence conflicti800 – 8001F → I in AAD22773. (PubMed:11054567)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF106702 mRNA. Translation: AAD22773.1.
    AC123955 Genomic DNA. No translation available.
    AC124760 Genomic DNA. No translation available.
    CH466520 Genomic DNA. Translation: EDL39812.1.
    CCDSiCCDS15227.1.
    RefSeqiNP_064317.2. NM_019933.2.
    UniGeneiMm.458796.

    Genome annotation databases

    EnsembliENSMUST00000064091; ENSMUSP00000067614; ENSMUSG00000026384.
    GeneIDi19258.
    KEGGimmu:19258.
    UCSCiuc007ciz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF106702 mRNA. Translation: AAD22773.1 .
    AC123955 Genomic DNA. No translation available.
    AC124760 Genomic DNA. No translation available.
    CH466520 Genomic DNA. Translation: EDL39812.1 .
    CCDSi CCDS15227.1.
    RefSeqi NP_064317.2. NM_019933.2.
    UniGenei Mm.458796.

    3D structure databases

    ProteinModelPortali Q9WU22.
    SMRi Q9WU22. Positions 31-310, 513-913.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WU22. 1 interaction.
    MINTi MINT-126937.
    STRINGi 10090.ENSMUSP00000067614.

    PTM databases

    PhosphoSitei Q9WU22.

    Proteomic databases

    PaxDbi Q9WU22.
    PRIDEi Q9WU22.

    Protocols and materials databases

    DNASUi 19258.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064091 ; ENSMUSP00000067614 ; ENSMUSG00000026384 .
    GeneIDi 19258.
    KEGGi mmu:19258.
    UCSCi uc007ciz.1. mouse.

    Organism-specific databases

    CTDi 5775.
    MGIi MGI:1099792. Ptpn4.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117342.
    HOGENOMi HOG000007048.
    HOVERGENi HBG008322.
    InParanoidi Q9WU22.
    KOi K18037.
    OMAi HTCTDFW.
    OrthoDBi EOG76HQ1B.
    TreeFami TF315900.

    Miscellaneous databases

    NextBioi 296108.
    PROi Q9WU22.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PTPN4.
    Genevestigatori Q9WU22.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG."
      Park K.-W., Lee E.-J., Lee S.-H., Lee J.-E., Choi E.-Y., Kim B.J., Hwang R., Park K.A., Baik J.-H.
      Gene 257:45-55(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPTN4_MOUSE
    AccessioniPrimary (citable) accession number: Q9WU22
    Secondary accession number(s): G5E8E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3