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Q9WU22 (PTN4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 4
EC=3.1.3.48
Alternative name(s):
Testis-enriched protein tyrosine phosphatase
Gene names
Name:Ptpn4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act at junctions between the membrane and the cytoskeleton By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm › cytoskeleton By similarity.

Tissue specificity

Highly expressed in testis. Specifically expressed in spermatocytes and spermatids within seminiferous tubules (at protein level). Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Cytoskeleton
Membrane
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnon-membrane spanning protein tyrosine phosphatase activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 926926Tyrosine-protein phosphatase non-receptor type 4
PRO_0000320075

Regions

Domain29 – 312284FERM
Domain517 – 58973PDZ
Domain655 – 911257Tyrosine-protein phosphatase
Region852 – 8587Substrate binding By similarity

Sites

Active site8521Phosphocysteine intermediate By similarity
Binding site8201Substrate By similarity
Binding site8961Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WU22 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: A344DAD4FF7E2AE2

FASTA926105,714
        10         20         30         40         50         60 
MTARFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFRVNKHDQ GQVLLDIVFK 

        70         80         90        100        110        120 
HLDLTERDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YNLNFRVKFF VSDPNKLQEE 

       130        140        150        160        170        180 
YTRYQYFLQI KQDILTGRLS CPCNTAALLA SFAVQSELGD YNQSENLAGY LSDYSFIPNQ 

       190        200        210        220        230        240 
PQDFEKEIAK LHQQHVGLSP AEAEFNYLNA ARTLELYGVE FHYARDQSNN EILIGVMSGG 

       250        260        270        280        290        300 
ILIYKNRVRM NTFLWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKTLWKA 

       310        320        330        340        350        360 
CVEHHTFFRL GRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSSS 

       370        380        390        400        410        420 
KPLARKLMDW EVVSRNSLSD DRLETQSLPS RSPPGTPNHR NSSFTQEATR VRPSSVGHLV 

       430        440        450        460        470        480 
DHVVHMSPSE DFVSQRSPSS TQANSIVLES SPSQETPEDG QPPALPPKQS KKNSWNQIHF 

       490        500        510        520        530        540 
SNSQQDLVTH TNESFDVPSS PEKSTPNGGI PHDNLVLIKM KPDENGRFGF NVKGGYDQKM 

       550        560        570        580        590        600 
PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC EKHSGELVLL 

       610        620        630        640        650        660 
VRPNAVYDVV EEKLESEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLAQFD 

       670        680        690        700        710        720 
QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVLLKG NEDYINANYI NMEIPSSSII 

       730        740        750        760        770        780 
NQYIACQGPL PHTCKDFWQM IWEQGSSMVV MLTTQVERGR VKCHQYWPEP SESSSYGCYQ 

       790        800        810        820        830        840 
ATCHSEEGNP AYIFRKMTLI NQEKNESRQL TQIQYTAWPD HGVPDDSSDF LDFVCHVRDQ 

       850        860        870        880        890        900 
RAGKEEPIIV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ 

       910        920 
YRFVCEAILK VYEEGFVKPL TTSSNK

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References

[1]"Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG."
Park K.-W., Lee E.-J., Lee S.-H., Lee J.-E., Choi E.-Y., Kim B.J., Hwang R., Park K.A., Baik J.-H.
Gene 257:45-55(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF106702 mRNA. Translation: AAD22773.1.
IPIIPI00123776.
RefSeqNP_064317.2. NM_019933.2.
UniGeneMm.458796.

3D structure databases

HSSPHSSP built from PDB template 2CS5 based on UniProtKB P29074.
ProteinModelPortalQ9WU22.
SMRQ9WU22. Positions 31-310, 513-913.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-126937.
STRING10090.ENSMUSP00000067614.

PTM databases

PhosphoSiteQ9WU22.

Proteomic databases

PaxDbQ9WU22.
PRIDEQ9WU22.

Protocols and materials databases

DNASU19258.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19258.
KEGGmmu:19258.
UCSCuc007ciz.1. mouse.

Organism-specific databases

CTD5775.
MGIMGI:1099792. Ptpn4.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000007048.
HOVERGENHBG008322.
InParanoidQ9WU22.
KOK01104.
OrthoDBEOG42RD6J.

Gene expression databases

CleanExMM_PTPN4.
GenevestigatorQ9WU22.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. FERM_3-hlx. 1 hit.
SSF50156. PDZ. 1 hit.
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio296108.
SOURCESearch...

Entry information

Entry namePTN4_MOUSE
AccessionPrimary (citable) accession number: Q9WU22
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 1, 1999
Last modified: May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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