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Q9WU19

- HAOX1_MOUSE

UniProt

Q9WU19 - HAOX1_MOUSE

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Protein

Hydroxyacid oxidase 1

Gene
Hao1, Gox1, Hao-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate By similarity.1 Publication

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMN.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261Substrate Reviewed prediction
Binding sitei108 – 1081FMN By similarity
Binding sitei130 – 1301FMN By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei158 – 1581FMN By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei236 – 2361FMN By similarity
Active sitei260 – 2601Proton acceptor By similarity
Binding sitei263 – 2631Substrate Reviewed prediction
Binding sitei315 – 3151FMN By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi291 – 31525FMN By similarityAdd
BLAST

GO - Molecular functioni

  1. (S)-2-hydroxy-acid oxidase activity Source: UniProtKB
  2. FMN binding Source: UniProtKB
  3. glycolate oxidase activity Source: UniProtKB
  4. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
  5. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
  6. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid alpha-oxidation Source: UniProtKB
  2. glycolate catabolic process Source: UniProtKB
  3. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00864; UER00830.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacid oxidase 1 (EC:1.1.3.15)
Short name:
HAOX1
Alternative name(s):
Glycolate oxidase
Short name:
GOX
Gene namesi
Name:Hao1
Synonyms:Gox1, Hao-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96011. Hao1.

Subcellular locationi

GO - Cellular componenti

  1. peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Hydroxyacid oxidase 1PRO_0000206319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841N6-succinyllysine1 Publication
Modified residuei194 – 1941Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WU19.
PaxDbiQ9WU19.
PRIDEiQ9WU19.

PTM databases

PhosphoSiteiQ9WU19.

Expressioni

Tissue specificityi

Liver.1 Publication

Gene expression databases

BgeeiQ9WU19.
CleanExiMM_HAO1.
GenevestigatoriQ9WU19.

Interactioni

Protein-protein interaction databases

IntActiQ9WU19. 2 interactions.
MINTiMINT-1848223.

Structurei

3D structure databases

ProteinModelPortaliQ9WU19.
SMRiQ9WU19. Positions 3-362.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 365365FMN hydroxy acid dehydrogenaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi368 – 3703Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
GeneTreeiENSGT00390000018717.
HOGENOMiHOG000217463.
HOVERGENiHBG051881.
InParanoidiQ9WU19.
KOiK11517.
OMAiSPTENFG.
OrthoDBiEOG7B5WW0.
PhylomeDBiQ9WU19.
TreeFamiTF313363.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WU19-1 [UniParc]FASTAAdd to Basket

« Hide

MLPRLVCISD YEQHVRSVLQ KSVYDYYRSG ANDQETLADN IQAFSRWKLY    50
PRMLRNVADI DLSTSVLGQR VSMPICVGAT AMQCMAHVDG ELATVRACQT 100
MGTGMMLSSW ATSSIEEVAE AGPEALRWMQ LYIYKDREIS RQIVKRAEKQ 150
GYKAIFVTVD TPYLGNRIDD VRNRFKLPPQ LRMKNFETND LAFSPKGNFG 200
DNSGLAEYVA QAIDPSLSWD DITWLRRLTS LPIVVKGILR GDDAKEAVKH 250
GVDGILVSNH GARQLDGVPA TIDVLPEIVE AVEGKVEVFL DGGVRKGTDV 300
LKALALGAKA VFVGRPIIWG LAFQGEKGVQ DVLEILKEEF RLAMALSGCQ 350
NVKVIDKTLV RKNPLAVSKI 370
Length:370
Mass (Da):41,001
Last modified:November 1, 1999 - v1
Checksum:i97339211AF9FC19C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104312 mRNA. Translation: AAD25332.1.
CCDSiCCDS16783.1.
RefSeqiNP_034533.1. NM_010403.2.
UniGeneiMm.26634.

Genome annotation databases

EnsembliENSMUST00000028704; ENSMUSP00000028704; ENSMUSG00000027261.
GeneIDi15112.
KEGGimmu:15112.
UCSCiuc008mns.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104312 mRNA. Translation: AAD25332.1 .
CCDSi CCDS16783.1.
RefSeqi NP_034533.1. NM_010403.2.
UniGenei Mm.26634.

3D structure databases

ProteinModelPortali Q9WU19.
SMRi Q9WU19. Positions 3-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WU19. 2 interactions.
MINTi MINT-1848223.

PTM databases

PhosphoSitei Q9WU19.

Proteomic databases

MaxQBi Q9WU19.
PaxDbi Q9WU19.
PRIDEi Q9WU19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028704 ; ENSMUSP00000028704 ; ENSMUSG00000027261 .
GeneIDi 15112.
KEGGi mmu:15112.
UCSCi uc008mns.1. mouse.

Organism-specific databases

CTDi 54363.
MGIi MGI:96011. Hao1.

Phylogenomic databases

eggNOGi COG1304.
GeneTreei ENSGT00390000018717.
HOGENOMi HOG000217463.
HOVERGENi HBG051881.
InParanoidi Q9WU19.
KOi K11517.
OMAi SPTENFG.
OrthoDBi EOG7B5WW0.
PhylomeDBi Q9WU19.
TreeFami TF313363.

Enzyme and pathway databases

UniPathwayi UPA00864 ; UER00830 .

Miscellaneous databases

ChiTaRSi HAO1. mouse.
NextBioi 287518.
PROi Q9WU19.
SOURCEi Search...

Gene expression databases

Bgeei Q9WU19.
CleanExi MM_HAO1.
Genevestigatori Q9WU19.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA."
    Kohler S.A., Menotti E., Kuhn L.C.
    J. Biol. Chem. 274:2401-2407(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHAOX1_MOUSE
AccessioniPrimary (citable) accession number: Q9WU19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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