Reviewed,
UniProtKB/Swiss-Prot Q9WU19 (HAOX1_MOUSE)
Last modified
June 16, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hydroxyacid oxidase 1 Short name=HAOX1 EC=1.1.3.15 Alternative name(s): Glycolate oxidase Short name=GOX | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 370 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids. |
| Catalytic activity | (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2. |
| Cofactor | FMN. |
| Pathway | |
| Subcellular location | |
| Tissue specificity | Liver. |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Peroxisome |
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | peroxisome Inferred from direct assay. Source: HGNC |
| Molecular function | (S)-2-hydroxy-acid oxidase activity Inferred from direct assay. Source: MGI FMN bindingInferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 370 | 370 | Hydroxyacid oxidase 1 | PRO_0000206319 | |||||
Regions | |||||||||
| Domain | 1 – 365 | 365 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 291 – 315 | 25 | FMN By similarity | ||||||
| Motif | 368 – 370 | 3 | Microbody targeting signal Potential | ||||||
Sites | |||||||||
| Active site | 260 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 26 | 1 | Substrate Potential | ||||||
| Binding site | 108 | 1 | FMN By similarity | ||||||
| Binding site | 130 | 1 | FMN By similarity | ||||||
| Binding site | 132 | 1 | Substrate By similarity | ||||||
| Binding site | 158 | 1 | FMN By similarity | ||||||
| Binding site | 167 | 1 | Substrate By similarity | ||||||
| Binding site | 236 | 1 | FMN By similarity | ||||||
| Binding site | 263 | 1 | Substrate Potential | ||||||
Sequences
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References
| [1] | "Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA." Kohler S.A., Menotti E., Kuhn L.C. J. Biol. Chem. 274:2401-2407(1999) [PubMed: 9891009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF104312 mRNA. Translation: AAD25332.1. | |
| IPI | IPI00123750. |
| RefSeq | NP_034533.1. |
| UniGene | Mm.26634 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AL8 based on UniProtKB P05414. |
| SMR | Q9WU19. Positions 4-361. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9WU19. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000027261. Mus musculus. [Contig view] |
| GeneID | 15112. |
| KEGG | mmu:15112. |
| NMPDR | fig|10090.3.peg.6979. |
Organism-specific databases | |
| MGI | MGI:96011. Hao1. |
Phylogenomic databases | |
| HOGENOM | Q9WU19. |
| HOVERGEN | Q9WU19. |
| OMA | Q9WU19. IDRSLSW. |
Enzyme and pathway databases | |
| BRENDA | 1.1.3.15. 244. |
Gene expression databases | |
| ArrayExpress | Q9WU19. |
| Bgee | Q9WU19. |
| CleanEx | MM_HAO1. |
| GermOnline | ENSMUSG00000027261. Mus musculus. |
Family and domain databases | |
| InterPro | IPR012133. a-Hydoxy_acid_DH_FMN. IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR017934. FMN-dep_OHA_DH. IPR008259. FMN_hydac_DH_AS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 287518. |
| SOURCE | Search... |
Entry information
| Entry name | HAOX1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9WU19 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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