Q9WU10 (Q9WU10_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protocadherin EMBL AAD20459.1

Gene names

Name:	Fat1 RGD 621254
Synonyms:	Fat RGD 621254 EMBL AAD20459.1, Fath RGD 621254

Organism

Rattus norvegicus (Rat) EMBL AAD20459.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	4589 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS020894
Cellular component	Membrane
Domain	EGF-like domain RuleBase RU000459 SAAS SAAS018097 Repeat SAAS SAAS020894 Transmembrane SAAS SAAS020894
Ligand	Calcium RuleBase RU000484 SAAS SAAS020894
PTM	Disulfide bond SAAS SAAS018097
Gene Ontology (GO)
Biological_process	cell migration Inferred from sequence or structural similarity. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	cell leading edge Inferred from direct assay PubMed 16682528PubMed 19131340. Source: UniProtKB cell-cell junction Inferred from direct assay PubMed 16682528PubMed 19131340. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay PubMed 16682528. Source: UniProtKB perinuclear region of cytoplasm Inferred from direct assay PubMed 19131340. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9WU10 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8CD0561B1DC58677	FASTA	4,589	505,997
	10 20 30 40 50 60 MGRHLALLLL LLFFLQHFGD GDGSQRLEPT PSLQFTHVQY NVTVHENSAA KTYVGHPRKM 70 80 90 100 110 120 GIYILDPSWE IRYKIISGDN ENLFKAEEYV LGDFCFLRIR TKGGNTAILN REVRDHYTLV 130 140 150 160 170 180 IKAVEKVTDA EARAKVRVQV LDTNDLRPLF SPTSYSVSLP ENTAIRTSIA RVSATDADIG 190 200 210 220 230 240 TNGEFYYSFK DRTDMFAIHP TSGVVVLTGR LDVLETQRYE LEILAVDRGM KLYGSSGVSS 250 260 270 280 290 300 LAKLTVHVEQ ANECAPGITA VTLSPSELDK DPTYAIITVE DCDQGANGEI ASLSIVAGDL 310 320 330 340 350 360 LQQFKTVRSF PGSKAFKVKA VGGVDWDSHP YGYNLTVQAK DKGTPPQFSP VKVIHVISPQ 370 380 390 400 410 420 FRAGPVKFEM DVYRAEISEF APPHTPVVLV KAIPSYSHLR YVFKSTPGKP KFGLNHNTGL 430 440 450 460 470 480 ISILEPIKRQ HTSHFELEVT TSDRRASTKV VVKVVGTNSN PPEFTQTSYK ASFDENAPVG 490 500 510 520 530 540 TPVMRVSAVD PDEGENGYVT YSIANLNHVP FVIDHFTGAV STSENLDYEL MPRVYTLRIR 550 560 570 580 590 600 ASDWGLPYRR EVEVLATITL NNLNDNTPLF EKTNCEGTIP RDLGVGEQIT TVSAIDADEL 610 620 630 640 650 660 QLVRYQIEAG NELDLFGLNP SSGVLSLKHS LMDGLGAKVS FHSLRITATD GENFATPLYI 670 680 690 700 710 720 NLTVAASRKP VNLRCEETGV AKMLAEKLLQ ANKLHHQGDA EDIFFDSHSV NAHAPQFRGS 730 740 750 760 770 780 LPTGIEVKED LPVGASILFM NATDLDSGFN GKLVYAISGG NDDSCFTVDM ETGMLKVLSP 790 800 810 820 830 840 LDREVTDKYT LNITVYDLGI PQRAAWRLLD VTVLDANDNA PEFLQESYFV EVSEDKEINS 850 860 870 880 890 900 EIIQVEATDK DLGPSGHVTY AILTDTEKFA IDRVTGVVKI IQPLDREVQR VHYLKIEARD 910 920 930 940 950 960 QATEEPWLSS TVLLKVSLDD VNDNPPRFIP PSYSVKVRED LPEGTIIMWL EAHDPDVGQS 970 980 990 1000 1010 1020 SQVRYSLLDH GEGHFDVDKL SGAVRIVQQL DFEKKQLYNL TVRAKDKGKP ASLSSTGYVE 1030 1040 1050 1060 1070 1080 VEVVDVNENL HAPVFSSFVE KGTVKEDVPM GSSVMTVSAH DEDTGRDGEI RYSIRDGSGV 1090 1100 1110 1120 1130 1140 GVFRIDEETG VIETSDRLDR ESTSHYWLTV YATDQGVVPL SSFIEVYIEV EDVNDNAPQT 1150 1160 1170 1180 1190 1200 SEPVYYPEIM ENSPKDVSVV QIEAFDPDSS SSDKLTYRIT SGNPQGFFSI HPKTGLITTT 1210 1220 1230 1240 1250 1260 SRKLDREQQD EHILEVTVTD NGVPPRSTIA RVIVKILDEN DNRPQFLQKF YKIRLPEREK 1270 1280 1290 1300 1310 1320 ADGDRSAKRE PLYRVIAADK DEGPNAELSY SIEEGNEHGR FSIEPKTGVV SSKKFSAAGE 1330 1340 1350 1360 1370 1380 YDILSIKAID NGRPQKSSTT RLHIEWISKP KPSLEPISFE ESVFSFTVME SDPVAHMIGV 1390 1400 1410 1420 1430 1440 ISVEPPGMPL WFDIIGGNYD SHFDVDKGTG TIIVAKPLDA EQKSSYNLTV EATDGTSTIL 1450 1460 1470 1480 1490 1500 TQVLIKVIDT NDHRPQFSTS KYEVSVPEDT EPETEILQIS AVDRDEKNKL IYTLQSSIDP 1510 1520 1530 1540 1550 1560 ASLKKFRLDP ATGALYTSEK LDHEAIHQHV LTVMVRDQDV PVKRNFARII VNVSDMNDHS 1570 1580 1590 1600 1610 1620 PWFTSSSYEG RVYESAAVGS VVLQVTALDR DKGRNAEVLY SIESGNIGNS FTIDPILGSI 1630 1640 1650 1660 1670 1680 KTARELDRSH QVDYDLMVKA TDKGEPPMSE MTSVRISVTV ADNASPKFTS KEYSAEISEA 1690 1700 1710 1720 1730 1740 IRIGSFVGMV SAHSQSSVMY EVKDGNIGDA FNINPHSGSI VTQRALDFET LPIYTLTVQG 1750 1760 1770 1780 1790 1800 TNMAGLSTNT TVVVHIQDEN DNPPAFTRAE YSGFISESAS VNSVVLTDKN VPLVIRATDA 1810 1820 1830 1840 1850 1860 DRESNALLVY QIVEPSVHNY FAIDPTTGAI HTVLSLDYEE TRVFHFTVQV HDMGTPRLFA 1870 1880 1890 1900 1910 1920 EYAANVTVHV IDINDCPPVF SKSLYEASLL LPTYKGVNVI TVNATDADSR AFSQLIYSIT 1930 1940 1950 1960 1970 1980 KGNIGEKFSM DHKTGTIAIQ NTTQLRSRYE LTVRASDGRF TSVASVRINV KESRESPLKF 1990 2000 2010 2020 2030 2040 TQDAYSAVVK ENSTEAKTLA VITAIGNPIN EPLFYRILNP DRRFKISHTS GVLSTTGIPF 2050 2060 2070 2080 2090 2100 DREQQETFVV VVEVTKEREP SAVAHVVVKV TVEDQNDNAP VFVNLPYYAV VKVDAEVGHV 2110 2120 2130 2140 2150 2160 IRHVTAIDRD SGRNGDVHYY LKEHHDHFEI GPSGDISLKK QFEHDTLNKE YLVTVVAKDG 2170 2180 2190 2200 2210 2220 GNPAFSAEVL VPITVMNKAM PVFEKAFYSA EIPENVQTHS PVVHVQANSP EGLKVFYSIT 2230 2240 2250 2260 2270 2280 DGDPFSQFTI NFNTGVINVI APLDFESHPA YKLSIRATDS LTGAHAEVFV DIVVEDINDN 2290 2300 2310 2320 2330 2340 PPVFVQQSYS TTLSEASVIG APILQVRATD SDSEPNRGIS YQLIGNHSKS HDHFHIDSHT 2350 2360 2370 2380 2390 2400 GLISLVRALD YEQFQQHKLL VRAVDGGMPP LSSDVVVTVD VTDLNDNPPL FEQQVYEARI 2410 2420 2430 2440 2450 2460 SEHAAHGHFV MCVKACDADR SDLDRLEYSI LSGNDHKSFV IDGETGIITL SNPRRHTLKP 2470 2480 2490 2500 2510 2520 FYSLNVSVSD GVFRSSARVN VTVMGGNLHS PVFHQNEYEV ELAENAPLHT LVVQVKATDR 2530 2540 2550 2560 2570 2580 DSGIYGHLTY HLVNDFAKDR FYVNDGGQVF TLERLDREAP AEKVISVRLM AKDAGGKVAF 2590 2600 2610 2620 2630 2640 CTVNVILTDD NDNAPQFRST KYEVNVGSSA AKGTSVVKVF ASDADEGSNA DVTYAIEADS 2650 2660 2670 2680 2690 2700 ESVEENLEIN QLTGLITTKE SLIGLENEFF TFFVRAVDNG SPPKESVVPV YVKILPPEVQ 2710 2720 2730 2740 2750 2760 LPRFSEPFYT YSISEDMPIG TEIDLIRVEH SGTVLYTLVK GNTPESNRDE FFVIDRQSGR 2770 2780 2790 2800 2810 2820 LKLEKSLDHE TTKWYQFSIL ARCTLDDYEV VASIDVSIQV KDANDNSPVL ESNPYEAFIV 2830 2840 2850 2860 2870 2880 ENLPAGSRVI QVRASDLDSG VNGQVMYSLD QSQDADIIES FAINMETGWI TTLKELDHEE 2890 2900 2910 2920 2930 2940 RASYQIKVVA SDHGEKVQLS STAIVDVTVT DVNDSPPRFT AEIYKGTVSE DDPPGGVIAI 2950 2960 2970 2980 2990 3000 LSTTDADSEE INRQVSYFIT GGDALGQFAV ENMQNDWRVY VKKPLDREQK DSYLLTVTAT 3010 3020 3030 3040 3050 3060 DGTFSSKARV EVKVLDANDN SPVCERTAYS DAIPEDALPG KLVMQVSATD ADIRSNAEIT 3070 3080 3090 3100 3110 3120 YTLFGSGAEK FKLNPDTGEL RTLALLDREE QAVYHLLVKA TDGGGRSCQA TIVLTLEDVN 3130 3140 3150 3160 3170 3180 DNTPEFTADP YAITVFENTE PGTPLTRVQA TDADAGLNRK ISYSLLDSAD GQFSINEQSG 3190 3200 3210 3220 3230 3240 ILQLEKHLDR ELQAVYTLTL KAADQGLPRK LTATGTVVVS VLDINDNPPV FEYREYGATV 3250 3260 3270 3280 3290 3300 SEDIVIGTEV LQVYAASRDI EANAEITYAI ISGNEHGKFS IDSKTGAIFI IENLDYESSH 3310 3320 3330 3340 3350 3360 GYYLTVEATD GGTPSLSDVA TVNINITDIN DNSPVFSQDS YTTVVSEDAA LEQPVITIMA 3370 3380 3390 3400 3410 3420 DDADGPSNSH ILYSIIEGNQ GSPFTIDPVR GEIKVTKPLD RETISGYTLT VQAADNGNPP 3430 3440 3450 3460 3470 3480 RVNTTTVNID VSDVNDNAPL FSRDNYSVII QENKPVGFSV LKLVVTDKDS SHNGPPFSFA 3490 3500 3510 3520 3530 3540 IVSGNDDNMF EVNQHGVLLT AATVKRKVKD HYLLHVKVAD NGKPQLSSLT HIDIRVIEES 3550 3560 3570 3580 3590 3600 IHPPAILPLE IFITASGEEY SGGVIGKIHA TDQDVYDTLT YSLDPHMDGL FSVSSTGGKL 3610 3620 3630 3640 3650 3660 IAHRKLDIGQ YLLNVSVTDG KFTTVADITV HIQQVTQEML NHTIAIRFAN LTPEEFVGDY 3670 3680 3690 3700 3710 3720 WRNFQRALRN ILGIRKNDIQ IVSLQPSEPH SHLDVLLFVE KSGGTQISTK QLLHKINSSV 3730 3740 3750 3760 3770 3780 TDIEEIIGVR ILDVFQKLCA GLDCPWKFCD EKVSVDENIM STHSTARLSF VTPRHHRTAV 3790 3800 3810 3820 3830 3840 CLCKDGTCPP VHQGCEDNPC PAGSECVADP REEKYSCVCP GGGFAKCPGS SSITFTGSSF 3850 3860 3870 3880 3890 3900 VKYRLMENEN RLEMKLTMRL RTYSSHAVVM YARGTDYSIL EIHTGRLQYK FDCGSGPGIV 3910 3920 3930 3940 3950 3960 SVQSIQVNDG QWHAVSLEVE GNYAKLVLDE VHTASGTAPG ALKTLNLDNY VIFGGHLRQQ 3970 3980 3990 4000 4010 4020 GTKHGRNTQV ANGFRGCMDS IYLNGQELPL NNKPRAYAHI EEWVDLAHGC LLTATEDCSS 4030 4040 4050 4060 4070 4080 NPCQNGGVCN PSPTGGYYCK CSALHAGTYC EVSVNPCSSN PCLYGGTCMV DNGGFVCQCR 4090 4100 4110 4120 4130 4140 GLYTGQRCQL SPYCKDEPCK NGGTCFDSLD GAVCQCDSGF RGERCQSDID ECAGNPCRNG 4150 4160 4170 4180 4190 4200 ALCENTHGSY HCNCSQEYRG KHCEDATPNH YVSTPWNIGL AEGIGIIVFI AGIFLLVVVF 4210 4220 4230 4240 4250 4260 VLCRKMISRK KKHQAEPEDK RLGPTTAFLQ RPYFDSKPSK NIYSDIPPQV PVRPISYTPS 4270 4280 4290 4300 4310 4320 IPSDSRNNLD RNSFEGSAIP EHPEFSTFNP ESMHGHRKAV AVCSVAPNLP PPPPSNSPSD 4330 4340 4350 4360 4370 4380 SDSIQKPSWD FDYDAKVVDL DPCLSKKPLE EKPSQPYSAR ESLSEVQSLS SFQSESCDDN 4390 4400 4410 4420 4430 4440 GYHWDTSDWM PSVPLPDIQE FPNYEVIDEH TPLYSADPNA IDTDYYPGGY DIESDFPPPP 4450 4460 4470 4480 4490 4500 EDFPAPDELP PLPPEFSDQF ESIHPPRDMP AAGSLGSSSR NRQRFNLNQY LPNFYPVDMS 4510 4520 4530 4540 4550 4560 EPQKQGAGEN STCREPYTPY PPGYQRNFEA PTIENMPMSV YTSTASCSDV SACCEVESEV 4570 4580 MMSDYESGDD GHFEEVTIPP LDSQQHTEV

References

[1]	"Expression of the rat homologue of the Drosophila fat tumour suppressor gene." Ponassi M., Jacques T.S., Ciani L., ffrench Constant C. Mech. Dev. 80:207-212(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAD20459.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF100960 mRNA. Translation: AAD20459.1.
IPI	IPI00203286.
RefSeq	NP_114007.1. NM_031819.2.
UniGene	Rn.8633.
3D structure databases
HSSP	HSSP built from PDB template 1EGF based on UniProtKB P01132.
ProteinModelPortal	Q9WU10.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9WU10. 1 interaction.
STRING	10116.ENSRNOP00000061869.
PTM databases
PhosphoSite	Q9WU10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	83720.
KEGG	rno:83720.
Organism-specific databases
CTD	2195.
RGD	621254. Fat1.
Phylogenomic databases
HOGENOM	HOG000046499.
HOVERGEN	HBG005641.
InParanoid	Q9WU10.
KO	K16506.
Gene expression databases
Genevestigator	Q9WU10.
Family and domain databases
Gene3D	2.60.120.200. 2 hits. 2.60.40.60. 33 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR001791. Laminin_G. [Graphical view]
Pfam	PF00028. Cadherin. 28 hits. PF00008. EGF. 2 hits. PF07645. EGF_CA. 1 hit. PF02210. Laminin_G_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 33 hits. SM00181. EGF. 3 hits. SM00179. EGF_CA. 1 hit. SM00282. LamG. 1 hit. [Graphical view]
SUPFAM	SSF49313. Cadherin. 33 hits. SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00232. CADHERIN_1. 17 hits. PS50268. CADHERIN_2. 33 hits. PS00022. EGF_1. 4 hits. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 5 hits. PS01187. EGF_CA. 1 hit. PS50025. LAM_G_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	616293.

Entry information

Entry name

Q9WU10_RAT

Accession

Primary (citable) accession number: Q9WU10

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)