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Protein

Advillin

Gene

Avil

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ca2+-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in ciliogenesis.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

  • actin filament capping Source: UniProtKB-KW
  • cilium morphogenesis Source: UniProtKB
  • cytoskeleton organization Source: InterPro
  • nervous system development Source: RGD
  • positive regulation of neuron projection development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding, Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Advillin
Alternative name(s):
Peripheral nervous system villin-like protein
Short name:
Pervin
Gene namesi
Name:Avil
Synonyms:Advil
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620301. Avil.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • cell projection Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • neuron projection Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829AdvillinPRO_0000407313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881PhosphotyrosineBy similarity
Modified residuei767 – 7671PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WU06.
PRIDEiQ9WU06.

Expressioni

Tissue specificityi

Expressed in dorsal root ganglion (DRG) neurons and superior cervical ganglia (SCG).1 Publication

Interactioni

Subunit structurei

Associates (via C-terminus) with actin. Interacts with F-actin. Interacts with SCARF1; the interaction occurs in embryonic dorsal root ganglions at 18 dpc and induces neurite-like outgrowth (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067218.

Structurei

3D structure databases

ProteinModelPortaliQ9WU06.
SMRiQ9WU06. Positions 17-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 10882Gelsolin-like 1Add
BLAST
Repeati147 – 22478Gelsolin-like 2Add
BLAST
Repeati274 – 34875Gelsolin-like 3Add
BLAST
Repeati415 – 49581Gelsolin-like 4Add
BLAST
Repeati533 – 60169Gelsolin-like 5Add
BLAST
Repeati640 – 71374Gelsolin-like 6Add
BLAST
Domaini762 – 82968HPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 740737CoreBy similarityAdd
BLAST
Regioni112 – 1198Polyphosphoinositide bindingBy similarity
Regioni138 – 1469Polyphosphoinositide bindingBy similarity
Regioni741 – 82989HeadpieceBy similarityAdd
BLAST

Domaini

The C-terminal domain is necessary for the induction of long fine actin-containing filopodia-like structures in fibroblast and neurite-like outgrowth.

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 6 gelsolin-like repeats.Curated
Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
HOVERGENiHBG004183.
InParanoidiQ9WU06.
PhylomeDBiQ9WU06.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR030014. Advillin.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF33. PTHR11977:SF33. 1 hit.
PfamiPF00626. Gelsolin. 6 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
SSF82754. SSF82754. 2 hits.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WU06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MXXXSLSSAF RTVTNDPGII TWRIEKMELV LVPLSAHGNF YEGDCYIILS
60 70 80 90 100
TRRVGSLLSQ NIHFWIGKDS SQDEQSCAAI YTTQLDDYLG GSPVQHREVQ
110 120 130 140 150
YHESDTFRGY FKRGIIYKKG GVASGMKHVE TFSYDVKRLL HVKGKRNIRA
160 170 180 190 200
TEVEMSWDSF NQGDVFLLDL GMVIIQWNGP ESNSGERLXX XXXXKAMLLA
210 220 230 240 250
KDIRDREGGG RAEIGVIEGD KEAASPELMT VLQNTLGRRS IIKPAVPSEV
260 270 280 290 300
TDQQQKSTIM LYHVSDTTGQ LSVTEVATRP LVQELLNHDD CYILDQSGTK
310 320 330 340 350
IYVWKGKGAT KVEKQAAMSK ALDFIKMKGY PSSTNVETVN DGAESAMFKQ
360 370 380 390 400
LFQKWSVKDQ TTGLGKTFSI GKIAKIFQDK FDVTLLHTKP EVAAQERMVD
410 420 430 440 450
DGNGKVEVWR IENLELVPVE YQWHGFFYGG DCYLVLYTYD VNGKPCYILY
460 470 480 490 500
IWQGRHASQD ELAASAYQAV EVDQQFGGAP VQVRVSMGKE PRHFMAIFKG
510 520 530 540 550
KLVIYERGTS RKGNVEPDPP VRLFQIHGND KSNTKAVEVS ASASSLNSND
560 570 580 590 600
VFLLWTQAEH YLWYPKGSSG DERAMAKELA ELLCDGDADT VAEGQEPPEF
610 620 630 640 650
WDLLGGKAPY ANDKRLQQET LDIQVRLFEC SNKTGRFLVT EVTDFTQDDL
660 670 680 690 700
SPGDVMLLDT WDQVFLWIGA EANATEKEGA LSTAQEYLVT HPSGRDPDTP
710 720 730 740 750
ILIIKQGFEP PTFTGWFLAW DPHIWSEGKS YEQLKNELGD ATAIVRITTD
760 770 780 790 800
MKNATLSLNS SESGPKYYPV EVLLKSQDQE LPEDVDPTKK ENYLSXERDF
810 820
VSVFGITRGQ FVSLPGWKQL QLKKEAGLF
Length:829
Mass (Da):93,038
Last modified:November 1, 1999 - v1
Checksum:iF7EE171E138BD3AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099929 mRNA. Translation: AAD22523.1.
UniGeneiRn.20161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099929 mRNA. Translation: AAD22523.1.
UniGeneiRn.20161.

3D structure databases

ProteinModelPortaliQ9WU06.
SMRiQ9WU06. Positions 17-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067218.

Proteomic databases

PaxDbiQ9WU06.
PRIDEiQ9WU06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620301. Avil.

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
HOVERGENiHBG004183.
InParanoidiQ9WU06.
PhylomeDBiQ9WU06.

Miscellaneous databases

PROiQ9WU06.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR030014. Advillin.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF33. PTHR11977:SF33. 1 hit.
PfamiPF00626. Gelsolin. 6 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
SSF82754. SSF82754. 2 hits.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVIL_RAT
AccessioniPrimary (citable) accession number: Q9WU06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.