ID   V1BR_MOUSE              Reviewed;         421 AA.
AC   Q9WU02;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   24-JAN-2024, entry version 161.
DE   RecName: Full=Vasopressin V1b receptor;
DE            Short=V1bR;
DE   AltName: Full=AVPR V1b;
DE   AltName: Full=AVPR V3;
DE   AltName: Full=Antidiuretic hormone receptor 1b;
DE   AltName: Full=Vasopressin V3 receptor;
GN   Name=Avpr1b; Synonyms=V1br;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/Sv;
RX   PubMed=10343284; DOI=10.1677/jme.0.0220251;
RA   Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E.;
RT   "Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary
RT   vasopressin receptor.";
RL   J. Mol. Endocrinol. 22:251-260(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ;
RX   PubMed=10669045; DOI=10.1254/jjp.81.388;
RA   Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.;
RT   "Structure and sequence of the mouse V1a and V1b vasopressin receptor
RT   genes.";
RL   Jpn. J. Pharmacol. 81:388-392(1999).
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate a phosphatidyl-
CC       inositol-calcium second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF098867; AAD27957.1; -; Genomic_DNA.
DR   EMBL; AF098866; AAD27957.1; JOINED; Genomic_DNA.
DR   EMBL; AB030449; BAA89205.1; -; Genomic_DNA.
DR   CCDS; CCDS35703.1; -.
DR   RefSeq; NP_036054.1; NM_011924.2.
DR   AlphaFoldDB; Q9WU02; -.
DR   SMR; Q9WU02; -.
DR   BioGRID; 204921; 1.
DR   STRING; 10090.ENSMUSP00000027690; -.
DR   GlyCosmos; Q9WU02; 1 site, No reported glycans.
DR   GlyGen; Q9WU02; 1 site.
DR   PhosphoSitePlus; Q9WU02; -.
DR   PaxDb; 10090-ENSMUSP00000027690; -.
DR   ProteomicsDB; 300100; -.
DR   Antibodypedia; 20687; 426 antibodies from 36 providers.
DR   DNASU; 26361; -.
DR   Ensembl; ENSMUST00000027690.7; ENSMUSP00000027690.7; ENSMUSG00000026432.8.
DR   GeneID; 26361; -.
DR   KEGG; mmu:26361; -.
DR   UCSC; uc007cnl.1; mouse.
DR   AGR; MGI:1347010; -.
DR   CTD; 553; -.
DR   MGI; MGI:1347010; Avpr1b.
DR   VEuPathDB; HostDB:ENSMUSG00000026432; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244882; -.
DR   HOGENOM; CLU_009579_15_3_1; -.
DR   InParanoid; Q9WU02; -.
DR   OMA; FNSHLWP; -.
DR   OrthoDB; 2879183at2759; -.
DR   PhylomeDB; Q9WU02; -.
DR   TreeFam; TF106499; -.
DR   Reactome; R-MMU-388479; Vasopressin-like receptors.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   BioGRID-ORCS; 26361; 4 hits in 81 CRISPR screens.
DR   PRO; PR:Q9WU02; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q9WU02; Protein.
DR   Bgee; ENSMUSG00000026432; Expressed in embryonic post-anal tail and 24 other cell types or tissues.
DR   ExpressionAtlas; Q9WU02; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0005000; F:vasopressin receptor activity; ISO:MGI.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR   GO; GO:0090238; P:positive regulation of arachidonic acid secretion; ISO:MGI.
DR   GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; ISO:MGI.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR   GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISO:MGI.
DR   GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IGI:MGI.
DR   GO; GO:0046718; P:viral entry into host cell; ISO:MGI.
DR   CDD; cd15386; 7tmA_V1bR; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR015076; V1R_C.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR000628; Vprs_rcpt_V1B.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF18; VASOPRESSIN V1B RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF08983; V1R_C; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00897; VASOPRSNV1BR.
DR   SMART; SM01164; DUF1856; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9WU02; MM.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..421
FT                   /note="Vasopressin V1b receptor"
FT                   /id="PRO_0000070204"
FT   TOPO_DOM        1..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..93
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..108
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..151
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..280
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..300
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        301..318
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..338
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        339..421
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          399..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        21
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        107..186
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   421 AA;  46539 MW;  E867DC0C700F596F CRC64;
     MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLILG
     LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA
     STYMLLAMTL DRYLAVCHPL RSLQQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG
     SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE
     RRGWPKSSSS AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW
     SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR ACCRGSKPRV
     HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP AGSLKDLEQV DGEATMETSI
     S
//