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Q9WU02

- V1BR_MOUSE

UniProt

Q9WU02 - V1BR_MOUSE

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Protein

Vasopressin V1b receptor

Gene

Avpr1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

GO - Molecular functioni

  1. vasopressin receptor activity Source: InterPro

GO - Biological processi

  1. regulation of systemic arterial blood pressure by vasopressin Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1b receptor
Short name:
V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene namesi
Name:Avpr1b
Synonyms:V1br
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1347010. Avpr1b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Vasopressin V1b receptorPRO_0000070204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9WU02.

PTM databases

PhosphoSiteiQ9WU02.

Expressioni

Gene expression databases

BgeeiQ9WU02.
CleanExiMM_AVPR1B.
GenevestigatoriQ9WU02.

Structurei

3D structure databases

ProteinModelPortaliQ9WU02.
SMRiQ9WU02. Positions 38-375.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Topological domaini60 – 7112CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini94 – 10815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini131 – 15121CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini174 – 20229ExtracellularSequence AnalysisAdd
BLAST
Topological domaini224 – 28057CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini301 – 31818ExtracellularSequence AnalysisAdd
BLAST
Topological domaini339 – 42183CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5924Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei72 – 9322Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei152 – 17322Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei281 – 30020Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei319 – 33820Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ9WU02.
KOiK04227.
OMAiKVKTQAW.
OrthoDBiEOG7Z69CP.
PhylomeDBiQ9WU02.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WU02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG
60 70 80 90 100
GNLAVLLILG LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF
110 120 130 140 150
QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPSQST
160 170 180 190 200
YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI
210 220 230 240 250
TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE RRGWPKSSSS
260 270 280 290 300
AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW
310 320 330 340 350
SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR
360 370 380 390 400
ACCRGSKPRV HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP
410 420
AGSLKDLEQV DGEATMETSI S
Length:421
Mass (Da):46,539
Last modified:November 1, 1999 - v1
Checksum:iE867DC0C700F596F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098867, AF098866 Genomic DNA. Translation: AAD27957.1.
AB030449 Genomic DNA. Translation: BAA89205.1.
CCDSiCCDS35703.1.
RefSeqiNP_036054.1. NM_011924.2.
UniGeneiMm.89986.

Genome annotation databases

EnsembliENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432.
GeneIDi26361.
KEGGimmu:26361.
UCSCiuc007cnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098867 , AF098866 Genomic DNA. Translation: AAD27957.1 .
AB030449 Genomic DNA. Translation: BAA89205.1 .
CCDSi CCDS35703.1.
RefSeqi NP_036054.1. NM_011924.2.
UniGenei Mm.89986.

3D structure databases

ProteinModelPortali Q9WU02.
SMRi Q9WU02. Positions 38-375.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 367.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9WU02.

Proteomic databases

PRIDEi Q9WU02.

Protocols and materials databases

DNASUi 26361.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027690 ; ENSMUSP00000027690 ; ENSMUSG00000026432 .
GeneIDi 26361.
KEGGi mmu:26361.
UCSCi uc007cnl.1. mouse.

Organism-specific databases

CTDi 553.
MGIi MGI:1347010. Avpr1b.

Phylogenomic databases

eggNOGi NOG299951.
GeneTreei ENSGT00760000119156.
HOGENOMi HOG000237331.
HOVERGENi HBG105710.
InParanoidi Q9WU02.
KOi K04227.
OMAi KVKTQAW.
OrthoDBi EOG7Z69CP.
PhylomeDBi Q9WU02.
TreeFami TF106499.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 304219.
PROi Q9WU02.
SOURCEi Search...

Gene expression databases

Bgeei Q9WU02.
CleanExi MM_AVPR1B.
Genevestigatori Q9WU02.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor."
    Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E.
    J. Mol. Endocrinol. 22:251-260(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Structure and sequence of the mouse V1a and V1b vasopressin receptor genes."
    Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.
    Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.

Entry informationi

Entry nameiV1BR_MOUSE
AccessioniPrimary (citable) accession number: Q9WU02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3