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Protein

Vasopressin V1b receptor

Gene

Avpr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1b receptor
Short name:
V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene namesi
Name:Avpr1b
Synonyms:V1br
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1347010. Avpr1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 59Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 93Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini94 – 108ExtracellularSequence analysisAdd BLAST15
Transmembranei109 – 130Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini131 – 151CytoplasmicSequence analysisAdd BLAST21
Transmembranei152 – 173Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini174 – 202ExtracellularSequence analysisAdd BLAST29
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 280CytoplasmicSequence analysisAdd BLAST57
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini301 – 318ExtracellularSequence analysisAdd BLAST18
Transmembranei319 – 338Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini339 – 421CytoplasmicSequence analysisAdd BLAST83

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702041 – 421Vasopressin V1b receptorAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WU02.
PRIDEiQ9WU02.

PTM databases

PhosphoSitePlusiQ9WU02.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026432.
CleanExiMM_AVPR1B.
ExpressionAtlasiQ9WU02. baseline and differential.
GenevisibleiQ9WU02. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027690.

Structurei

3D structure databases

ProteinModelPortaliQ9WU02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ9WU02.
KOiK04227.
OMAiKVKTQAW.
OrthoDBiEOG091G0DB6.
PhylomeDBiQ9WU02.
TreeFamiTF106499.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WU02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG
60 70 80 90 100
GNLAVLLILG LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF
110 120 130 140 150
QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPSQST
160 170 180 190 200
YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI
210 220 230 240 250
TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE RRGWPKSSSS
260 270 280 290 300
AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW
310 320 330 340 350
SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR
360 370 380 390 400
ACCRGSKPRV HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP
410 420
AGSLKDLEQV DGEATMETSI S
Length:421
Mass (Da):46,539
Last modified:November 1, 1999 - v1
Checksum:iE867DC0C700F596F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098867, AF098866 Genomic DNA. Translation: AAD27957.1.
AB030449 Genomic DNA. Translation: BAA89205.1.
CCDSiCCDS35703.1.
RefSeqiNP_036054.1. NM_011924.2.
UniGeneiMm.89986.

Genome annotation databases

EnsembliENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432.
GeneIDi26361.
KEGGimmu:26361.
UCSCiuc007cnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098867, AF098866 Genomic DNA. Translation: AAD27957.1.
AB030449 Genomic DNA. Translation: BAA89205.1.
CCDSiCCDS35703.1.
RefSeqiNP_036054.1. NM_011924.2.
UniGeneiMm.89986.

3D structure databases

ProteinModelPortaliQ9WU02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027690.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9WU02.

Proteomic databases

PaxDbiQ9WU02.
PRIDEiQ9WU02.

Protocols and materials databases

DNASUi26361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432.
GeneIDi26361.
KEGGimmu:26361.
UCSCiuc007cnl.1. mouse.

Organism-specific databases

CTDi553.
MGIiMGI:1347010. Avpr1b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ9WU02.
KOiK04227.
OMAiKVKTQAW.
OrthoDBiEOG091G0DB6.
PhylomeDBiQ9WU02.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ9WU02.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026432.
CleanExiMM_AVPR1B.
ExpressionAtlasiQ9WU02. baseline and differential.
GenevisibleiQ9WU02. MM.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1BR_MOUSE
AccessioniPrimary (citable) accession number: Q9WU02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.