Vasopressin V1b receptor - Mus musculus (Mouse)

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Q9WU02 (V1BR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Vasopressin V1b receptor
Short name=V1bR

Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor

Gene names

Name:	Avpr1b
Synonyms:	V1br

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of systemic arterial blood pressure by vasopressin Inferred from genetic interaction PubMed 12486173. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 421

421

Vasopressin V1b receptor

PRO_0000070204

Regions

Topological domain

1 – 35

Extracellular Potential

Transmembrane

36 – 59

Helical; Name=1; Potential

Topological domain

60 – 71

Cytoplasmic Potential

Transmembrane

72 – 93

Helical; Name=2; Potential

Topological domain

94 – 108

Extracellular Potential

Transmembrane

109 – 130

Helical; Name=3; Potential

Topological domain

131 – 151

Cytoplasmic Potential

Transmembrane

152 – 173

Helical; Name=4; Potential

Topological domain

174 – 202

Extracellular Potential

Transmembrane

203 – 223

Helical; Name=5; Potential

Topological domain

224 – 280

Cytoplasmic Potential

Transmembrane

281 – 300

Helical; Name=6; Potential

Topological domain

301 – 318

Extracellular Potential

Transmembrane

319 – 338

Helical; Name=7; Potential

Topological domain

339 – 421

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

107 ↔ 186

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9WU02 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: E867DC0C700F596F
Show »

FASTA

421

46,539

        10         20         30         40         50         60 
MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLILG 

        70         80         90        100        110        120 
LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA 

       130        140        150        160        170        180 
STYMLLAMTL DRYLAVCHPL RSLQQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG 

       190        200        210        220        230        240 
SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE 

       250        260        270        280        290        300 
RRGWPKSSSS AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW 

       310        320        330        340        350        360 
SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR ACCRGSKPRV 

       370        380        390        400        410        420 
HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP AGSLKDLEQV DGEATMETSI 


S

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References

[1]	"Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor." Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E. J. Mol. Endocrinol. 22:251-260(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"Structure and sequence of the mouse V1a and V1b vasopressin receptor genes." Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G. Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF098867, AF098866 Genomic DNA. Translation: AAD27957.1. AB030449 Genomic DNA. Translation: BAA89205.1.
IPI	IPI00230032.
RefSeq	NP_036054.1. NM_011924.2.
UniGene	Mm.89986.
3D structure databases
ProteinModelPortal	Q9WU02.
SMR	Q9WU02. Positions 38-375.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9WU02.
Proteomic databases
PRIDE	Q9WU02.
Protocols and materials databases
DNASU	26361.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432.
GeneID	26361.
KEGG	mmu:26361.
UCSC	uc007cnl.1. mouse.
Organism-specific databases
CTD	553.
MGI	MGI:1347010. Avpr1b.
Phylogenomic databases
eggNOG	NOG299951.
GeneTree	ENSGT00660000095384.
HOGENOM	HOG000237331.
HOVERGEN	HBG105710.
InParanoid	Q9WU02.
KO	K04227.
OMA	HLACCGG.
OrthoDB	EOG4640C2.
Gene expression databases
Bgee	Q9WU02.
CleanEx	MM_AVPR1B.
Genevestigator	Q9WU02.
GermOnline	ENSMUSG00000026432. Mus musculus.
Family and domain databases
InterPro	IPR015076. DUF1856. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001817. Vasoprsn_rcpt. IPR000628. Vprs_rcpt_V1B. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. PF08983. DUF1856. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR. PR00897. VASOPRSNV1BR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	304219.
SOURCE	Search...

Entry information

Entry name

V1BR_MOUSE

Accession

Primary (citable) accession number: Q9WU02

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents