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Q9WU02

- V1BR_MOUSE

UniProt

Q9WU02 - V1BR_MOUSE

Protein

Vasopressin V1b receptor

Gene

Avpr1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

    GO - Molecular functioni

    1. vasopressin receptor activity Source: InterPro

    GO - Biological processi

    1. regulation of systemic arterial blood pressure by vasopressin Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V1b receptor
    Short name:
    V1bR
    Alternative name(s):
    AVPR V1b
    AVPR V3
    Antidiuretic hormone receptor 1b
    Vasopressin V3 receptor
    Gene namesi
    Name:Avpr1b
    Synonyms:V1br
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1347010. Avpr1b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Vasopressin V1b receptorPRO_0000070204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9WU02.

    PTM databases

    PhosphoSiteiQ9WU02.

    Expressioni

    Gene expression databases

    BgeeiQ9WU02.
    CleanExiMM_AVPR1B.
    GenevestigatoriQ9WU02.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WU02.
    SMRiQ9WU02. Positions 38-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini60 – 7112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 10815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 15121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 20229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 28057CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini301 – 31818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini339 – 42183CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17322Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30020Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei319 – 33820Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    GeneTreeiENSGT00660000095384.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiQ9WU02.
    KOiK04227.
    OMAiKVKTQAW.
    OrthoDBiEOG7Z69CP.
    PhylomeDBiQ9WU02.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000628. Vprs_rcpt_V1B.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00897. VASOPRSNV1BR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WU02-1 [UniParc]FASTAAdd to Basket

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    MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG    50
    GNLAVLLILG LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF 100
    QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPSQST 150
    YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI 200
    TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE RRGWPKSSSS 250
    AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW 300
    SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR 350
    ACCRGSKPRV HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP 400
    AGSLKDLEQV DGEATMETSI S 421
    Length:421
    Mass (Da):46,539
    Last modified:November 1, 1999 - v1
    Checksum:iE867DC0C700F596F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098867, AF098866 Genomic DNA. Translation: AAD27957.1.
    AB030449 Genomic DNA. Translation: BAA89205.1.
    CCDSiCCDS35703.1.
    RefSeqiNP_036054.1. NM_011924.2.
    UniGeneiMm.89986.

    Genome annotation databases

    EnsembliENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432.
    GeneIDi26361.
    KEGGimmu:26361.
    UCSCiuc007cnl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098867 , AF098866 Genomic DNA. Translation: AAD27957.1 .
    AB030449 Genomic DNA. Translation: BAA89205.1 .
    CCDSi CCDS35703.1.
    RefSeqi NP_036054.1. NM_011924.2.
    UniGenei Mm.89986.

    3D structure databases

    ProteinModelPortali Q9WU02.
    SMRi Q9WU02. Positions 38-335.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 367.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9WU02.

    Proteomic databases

    PRIDEi Q9WU02.

    Protocols and materials databases

    DNASUi 26361.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027690 ; ENSMUSP00000027690 ; ENSMUSG00000026432 .
    GeneIDi 26361.
    KEGGi mmu:26361.
    UCSCi uc007cnl.1. mouse.

    Organism-specific databases

    CTDi 553.
    MGIi MGI:1347010. Avpr1b.

    Phylogenomic databases

    eggNOGi NOG299951.
    GeneTreei ENSGT00660000095384.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi Q9WU02.
    KOi K04227.
    OMAi KVKTQAW.
    OrthoDBi EOG7Z69CP.
    PhylomeDBi Q9WU02.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 304219.
    PROi Q9WU02.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WU02.
    CleanExi MM_AVPR1B.
    Genevestigatori Q9WU02.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000628. Vprs_rcpt_V1B.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00897. VASOPRSNV1BR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor."
      Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E.
      J. Mol. Endocrinol. 22:251-260(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Structure and sequence of the mouse V1a and V1b vasopressin receptor genes."
      Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.
      Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.

    Entry informationi

    Entry nameiV1BR_MOUSE
    AccessioniPrimary (citable) accession number: Q9WU02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3