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Q9WU02 (V1BR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin V1b receptor

Short name=V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene names
Name:Avpr1b
Synonyms:V1br
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Vasopressin V1b receptor
PRO_0000070204

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5924Helical; Name=1; Potential
Topological domain60 – 7112Cytoplasmic Potential
Transmembrane72 – 9322Helical; Name=2; Potential
Topological domain94 – 10815Extracellular Potential
Transmembrane109 – 13022Helical; Name=3; Potential
Topological domain131 – 15121Cytoplasmic Potential
Transmembrane152 – 17322Helical; Name=4; Potential
Topological domain174 – 20229Extracellular Potential
Transmembrane203 – 22321Helical; Name=5; Potential
Topological domain224 – 28057Cytoplasmic Potential
Transmembrane281 – 30020Helical; Name=6; Potential
Topological domain301 – 31818Extracellular Potential
Transmembrane319 – 33820Helical; Name=7; Potential
Topological domain339 – 42183Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond107 ↔ 186 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WU02 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: E867DC0C700F596F

FASTA42146,539
        10         20         30         40         50         60 
MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLILG 

        70         80         90        100        110        120 
LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA 

       130        140        150        160        170        180 
STYMLLAMTL DRYLAVCHPL RSLQQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG 

       190        200        210        220        230        240 
SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE 

       250        260        270        280        290        300 
RRGWPKSSSS AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW 

       310        320        330        340        350        360 
SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR ACCRGSKPRV 

       370        380        390        400        410        420 
HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP AGSLKDLEQV DGEATMETSI 


S 

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References

[1]"Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor."
Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E.
J. Mol. Endocrinol. 22:251-260(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"Structure and sequence of the mouse V1a and V1b vasopressin receptor genes."
Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.
Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF098867, AF098866 Genomic DNA. Translation: AAD27957.1.
AB030449 Genomic DNA. Translation: BAA89205.1.
CCDSCCDS35703.1.
RefSeqNP_036054.1. NM_011924.2.
UniGeneMm.89986.

3D structure databases

ProteinModelPortalQ9WU02.
SMRQ9WU02. Positions 38-335.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY367.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9WU02.

Proteomic databases

PRIDEQ9WU02.

Protocols and materials databases

DNASU26361.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432.
GeneID26361.
KEGGmmu:26361.
UCSCuc007cnl.1. mouse.

Organism-specific databases

CTD553.
MGIMGI:1347010. Avpr1b.

Phylogenomic databases

eggNOGNOG299951.
GeneTreeENSGT00660000095384.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidQ9WU02.
KOK04227.
OMAKVKTQAW.
OrthoDBEOG7Z69CP.
PhylomeDBQ9WU02.
TreeFamTF106499.

Gene expression databases

BgeeQ9WU02.
CleanExMM_AVPR1B.
GenevestigatorQ9WU02.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304219.
PROQ9WU02.
SOURCESearch...

Entry information

Entry nameV1BR_MOUSE
AccessionPrimary (citable) accession number: Q9WU02
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries