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Q9WU00

- NRF1_MOUSE

UniProt

Q9WU00 - NRF1_MOUSE

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Protein
Nuclear respiratory factor 1
Gene
Nrf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi109 – 305197 By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. mitochondrion organization Source: MGI
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_205251. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear respiratory factor 1
Short name:
NRF-1
Alternative name(s):
Alpha palindromic-binding protein
Short name:
Alpha-pal
Gene namesi
Name:Nrf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1332235. Nrf1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Nuclear respiratory factor 1
PRO_0000100209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391Phosphoserine; by CK2 By similarity
Modified residuei44 – 441Phosphoserine; by CK2 By similarity
Modified residuei46 – 461Phosphoserine; by CK2 By similarity
Modified residuei47 – 471Phosphoserine; by CK2 By similarity
Modified residuei52 – 521Phosphoserine; by CK2 By similarity

Post-translational modificationi

Phosphorylation enhances DNA binding By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WU00.
PaxDbiQ9WU00.
PRIDEiQ9WU00.

PTM databases

PhosphoSiteiQ9WU00.

Expressioni

Tissue specificityi

Widely expressed in embryonic, fetal, and adult tissues.

Gene expression databases

ArrayExpressiQ9WU00.
BgeeiQ9WU00.
CleanExiMM_NRF1.
GenevestigatoriQ9WU00.

Interactioni

Subunit structurei

Homodimer. Binds DNA as a dimer. Interacts with PPRC1 By similarity.

Protein-protein interaction databases

BioGridi201845. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9WU00.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7878Dimerization By similarity
Add
BLAST
Regioni301 – 476176Required for transcriptional activation By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi88 – 11629Nuclear localization signal By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 6626Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi80 – 867Poly-Ala

Sequence similaritiesi

Belongs to the NRF1/Ewg family.

Phylogenomic databases

eggNOGiCOG0012.
GeneTreeiENSGT00390000006835.
HOGENOMiHOG000273898.
HOVERGENiHBG003062.
KOiK11831.
OMAiDDTDILN.
OrthoDBiEOG7N37CK.

Family and domain databases

InterProiIPR019526. Nrf1_activation-bd.
IPR019525. Nrf1_NLS/DNA-bd_dimer.
[Graphical view]
PfamiPF10492. Nrf1_activ_bdg. 1 hit.
PF10491. Nrf1_DNA-bind. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q9WU00-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED    50
TSYDDSDILN STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN 100
PSIRKRQQTR LLRKLRATLD EYTTRVGQQA IVLCISPSKP NPVFKVFGAA 150
PLENVVRKYK SMILEDLESA LAEHAPAPQE VNSELPPLTI DGIPVSVDKM 200
TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW ANVRSDVRTE 250
EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATTTHSIAHL 300
VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA 350
VADGEVEQNW ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA 400
TVTMALNSEA AAHAVATLAE ATLQGGGQIV LSGETAAAVG ALTGVQDANG 450
LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV TTRISDSAVT MDGQAVEVVT 500
LEQ 503
Length:503
Mass (Da):53,571
Last modified:July 27, 2011 - v2
Checksum:i6C3D6B8C83C3B227
GO
Isoform Short (identifier: Q9WU00-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-321: Missing.

Show »
Length:437
Mass (Da):46,157
Checksum:iD7B62154D8D015B2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei256 – 32166Missing in isoform Short.
VSP_003599Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921K → N in AAD21938. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098077 mRNA. Translation: AAD21938.1.
AK014494 mRNA. Translation: BAB29394.1.
AK029034 mRNA. Translation: BAC26256.1.
CH466533 Genomic DNA. Translation: EDL13755.1.
CH466533 Genomic DNA. Translation: EDL13757.1.
CCDSiCCDS19968.1. [Q9WU00-1]
RefSeqiNP_001157698.1. NM_001164226.1. [Q9WU00-1]
NP_035068.3. NM_010938.4. [Q9WU00-1]
UniGeneiMm.259258.

Genome annotation databases

EnsembliENSMUST00000115209; ENSMUSP00000110864; ENSMUSG00000058440. [Q9WU00-1]
ENSMUST00000115211; ENSMUSP00000110866; ENSMUSG00000058440. [Q9WU00-1]
ENSMUST00000115212; ENSMUSP00000110867; ENSMUSG00000058440. [Q9WU00-1]
ENSMUST00000167972; ENSMUSP00000130108; ENSMUSG00000058440. [Q9WU00-1]
GeneIDi18181.
KEGGimmu:18181.
UCSCiuc009bev.1. mouse. [Q9WU00-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098077 mRNA. Translation: AAD21938.1 .
AK014494 mRNA. Translation: BAB29394.1 .
AK029034 mRNA. Translation: BAC26256.1 .
CH466533 Genomic DNA. Translation: EDL13755.1 .
CH466533 Genomic DNA. Translation: EDL13757.1 .
CCDSi CCDS19968.1. [Q9WU00-1 ]
RefSeqi NP_001157698.1. NM_001164226.1. [Q9WU00-1 ]
NP_035068.3. NM_010938.4. [Q9WU00-1 ]
UniGenei Mm.259258.

3D structure databases

ProteinModelPortali Q9WU00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201845. 1 interaction.

PTM databases

PhosphoSitei Q9WU00.

Proteomic databases

MaxQBi Q9WU00.
PaxDbi Q9WU00.
PRIDEi Q9WU00.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115209 ; ENSMUSP00000110864 ; ENSMUSG00000058440 . [Q9WU00-1 ]
ENSMUST00000115211 ; ENSMUSP00000110866 ; ENSMUSG00000058440 . [Q9WU00-1 ]
ENSMUST00000115212 ; ENSMUSP00000110867 ; ENSMUSG00000058440 . [Q9WU00-1 ]
ENSMUST00000167972 ; ENSMUSP00000130108 ; ENSMUSG00000058440 . [Q9WU00-1 ]
GeneIDi 18181.
KEGGi mmu:18181.
UCSCi uc009bev.1. mouse. [Q9WU00-1 ]

Organism-specific databases

CTDi 4899.
MGIi MGI:1332235. Nrf1.

Phylogenomic databases

eggNOGi COG0012.
GeneTreei ENSGT00390000006835.
HOGENOMi HOG000273898.
HOVERGENi HBG003062.
KOi K11831.
OMAi DDTDILN.
OrthoDBi EOG7N37CK.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.
REACT_205251. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

NextBioi 293494.
PROi Q9WU00.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WU00.
Bgeei Q9WU00.
CleanExi MM_NRF1.
Genevestigatori Q9WU00.

Family and domain databases

InterProi IPR019526. Nrf1_activation-bd.
IPR019525. Nrf1_NLS/DNA-bd_dimer.
[Graphical view ]
Pfami PF10492. Nrf1_activ_bdg. 1 hit.
PF10491. Nrf1_DNA-bind. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Coding sequence, chromosomal localization, and expression pattern of Nrf1: the mouse homolog of Drosophila erect wing."
    Schaefer L., Engman H., Miller J.B.
    Mamm. Genome 11:104-110(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Skin.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNRF1_MOUSE
AccessioniPrimary (citable) accession number: Q9WU00
Secondary accession number(s): Q9CXE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi