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Protein

Protein BEX3

Gene

Bex3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death.1 Publication

Miscellaneous

Binds transition metals.By similarity

GO - Molecular functioni

GO - Biological processi

  • extrinsic apoptotic signaling pathway via death domain receptors Source: MGI

Keywordsi

Biological processApoptosis
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-MMU-205025. NADE modulates death signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX3Curated
Alternative name(s):
Brain-expressed X-linked protein 3 homologBy similarity
Nerve growth factor receptor-associated protein 1
p75NTR-associated cell death executor
Gene namesi
Name:Bex3
Synonyms:Nade, Ngfrap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1338016. Bex3.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi94L → A: Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-97 and A-99. 1 Publication1
Mutagenesisi97L → A: Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-97 and A-99. 1 Publication1
Mutagenesisi99L → A: Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-94 and A-97. 1 Publication1
Mutagenesisi121C → A: Abolishes localization with replicating mitochondria. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297811 – 124Protein BEX3Add BLAST124

Post-translational modificationi

Ubiquitinated (Probable). Degraded by the proteasome.Curated

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9WTZ9.
PRIDEiQ9WTZ9.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000046432.
GenevisibleiQ9WTZ9. MM.

Interactioni

Subunit structurei

Self-associates (PubMed:11830582). Binds to the DEATH domain of p75NTR/NGFR (PubMed:11830582). Interacts with 14-3-3 epsilon (YWHAE) (PubMed:11278287). Interacts with DIABLO/SMAC (PubMed:15178455).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198339. 3 interactors.
MINTiMINT-128772.
STRINGi10090.ENSMUSP00000063039.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 124Interaction with 14-3-3 epsilonAdd BLAST44
Regioni81 – 106Interaction with p75NTR/NGFR1 PublicationAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi90 – 100Nuclear export signalAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 46Poly-AsnAdd BLAST12

Domaini

The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JCIT. Eukaryota.
ENOG41113TP. LUCA.
GeneTreeiENSGT00810000125492.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9WTZ9.
KOiK12465.
OMAiLIMANIH.
OrthoDBiEOG091G146U.
PhylomeDBiQ9WTZ9.
TreeFamiTF337909.

Family and domain databases

InterProiView protein in InterPro
IPR007623. BEX.
IPR021156. TF_A-like/BEX.
PfamiView protein in Pfam
PF04538. BEX. 1 hit.
PIRSFiPIRSF008633. BEX. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9WTZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANVHQENEE MEQPLQNGQE DRPVGGGEGH QPAANNNNNN HNHNHNHHRR
60 70 80 90 100
GQARRLAPNF RWAIPNRQMN DGLGGDGDDM EMFMEEMREI RRKLRELQLR
110 120
NCLRILMGEL SNHHDHHDEF CLMP
Length:124
Mass (Da):14,542
Last modified:November 1, 1999 - v1
Checksum:i3CCCD4F05E66F461
GO
Isoform 2 (identifier: Q9WTZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:114
Mass (Da):13,360
Checksum:i119D024E91E1F802
GO

Sequence cautioni

The sequence BAB23350 differs from that shown. Reason: Erroneous termination at position 125. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17N → D in BAB26986 (PubMed:16141072).Curated1
Sequence conflicti82M → I in BAB22697 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177441 – 10Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097440 mRNA. Translation: AAD24431.1.
AF187066 mRNA. Translation: AAF75131.1.
AK003294 mRNA. Translation: BAB22697.1.
AK004531 mRNA. Translation: BAB23350.1. Sequence problems.
AK010500 mRNA. Translation: BAB26986.1.
AL671493 Genomic DNA. Translation: CAM45862.1.
AL671493 Genomic DNA. Translation: CAM45863.1.
BC027815 mRNA. Translation: AAH27815.1.
CCDSiCCDS30419.1. [Q9WTZ9-1]
CCDS53194.1. [Q9WTZ9-2]
RefSeqiNP_001103703.1. NM_001110233.1. [Q9WTZ9-1]
NP_001103704.1. NM_001110234.1. [Q9WTZ9-2]
NP_033880.1. NM_009750.2. [Q9WTZ9-1]
UniGeneiMm.90787.

Genome annotation databases

EnsembliENSMUST00000053540; ENSMUSP00000063039; ENSMUSG00000046432. [Q9WTZ9-1]
ENSMUST00000113112; ENSMUSP00000108737; ENSMUSG00000046432. [Q9WTZ9-2]
ENSMUST00000113113; ENSMUSP00000108738; ENSMUSG00000046432. [Q9WTZ9-1]
ENSMUST00000178632; ENSMUSP00000136952; ENSMUSG00000046432. [Q9WTZ9-1]
GeneIDi12070.
KEGGimmu:12070.
UCSCiuc009uik.2. mouse. [Q9WTZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBEX3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTZ9
Secondary accession number(s): A3KGA0
, A3KGA1, Q9CWN9, Q9D0S2, Q9D1N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 1, 1999
Last modified: May 10, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families