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Protein

Protein BEX2

Gene

Bex2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX2
Alternative name(s):
Brain-expressed X-linked protein 2 homolog
Gene namesi
Name:Bex2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1338017. Bex2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297781 – 129Protein BEX2Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ9WTZ8.
PaxDbiQ9WTZ8.
PRIDEiQ9WTZ8.

PTM databases

iPTMnetiQ9WTZ8.
PhosphoSitePlusiQ9WTZ8.

Expressioni

Tissue specificityi

Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000042750.
CleanExiMM_BEX2.
GenevisibleiQ9WTZ8. MM.

Interactioni

Subunit structurei

Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2 (By similarity). Interacts with OMP.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
OmpQ642882EBI-6991468,EBI-6991436

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WTZ8. 1 interactor.
MINTiMINT-272029.
STRINGi10090.ENSMUSP00000043113.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9WTZ8.
OMAiRWDIMHR.
OrthoDBiEOG091G0ZN3.
PhylomeDBiQ9WTZ8.
TreeFamiTF337909.

Family and domain databases

InterProiView protein in InterPro
IPR007623. BEX.
IPR021156. TF_A-like/BEX.
PfamiView protein in Pfam
PF04538. BEX. 1 hit.
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVEQGVK NLNMENDHQE KEEKEEKPQD ASKRDPIVAL PFEAGDYYVP
60 70 80 90 100
RGGRRRFRVR QPIVHYRWDL MHRVGEPQGR MREENVQRFG DDVRQLMEKL
110 120
RERQLSHSLR AVSTDPPHHD HHDEFCLMP
Length:129
Mass (Da):15,452
Last modified:November 1, 1999 - v1
Checksum:i2CB3798C8BEC2E89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097439 mRNA. Translation: AAD24430.1.
AK132005 mRNA. Translation: BAE20934.1.
BC027529 mRNA. Translation: AAH27529.1.
CCDSiCCDS30413.1.
RefSeqiNP_033879.1. NM_009749.2.
UniGeneiMm.94160.

Genome annotation databases

EnsembliENSMUST00000049130; ENSMUSP00000043113; ENSMUSG00000042750.
GeneIDi12069.
KEGGimmu:12069.
UCSCiuc009uia.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiBEX2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families