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Protein

Protein BEX2

Gene

Bex2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX2
Alternative name(s):
Brain-expressed X-linked protein 2 homolog
Gene namesi
Name:Bex2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1338017. Bex2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Protein BEX2PRO_0000229778Add
BLAST

Proteomic databases

EPDiQ9WTZ8.
MaxQBiQ9WTZ8.
PaxDbiQ9WTZ8.
PRIDEiQ9WTZ8.

PTM databases

iPTMnetiQ9WTZ8.
PhosphoSiteiQ9WTZ8.

Expressioni

Tissue specificityi

Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level).1 Publication

Gene expression databases

BgeeiQ9WTZ8.
CleanExiMM_BEX2.
GenevisibleiQ9WTZ8. MM.

Interactioni

Subunit structurei

Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2 (By similarity). Interacts with OMP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-272029.
STRINGi10090.ENSMUSP00000043113.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9WTZ8.
OMAiEAGEYCV.
OrthoDBiEOG7XPZ7S.
PhylomeDBiQ9WTZ8.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVEQGVK NLNMENDHQE KEEKEEKPQD ASKRDPIVAL PFEAGDYYVP
60 70 80 90 100
RGGRRRFRVR QPIVHYRWDL MHRVGEPQGR MREENVQRFG DDVRQLMEKL
110 120
RERQLSHSLR AVSTDPPHHD HHDEFCLMP
Length:129
Mass (Da):15,452
Last modified:November 1, 1999 - v1
Checksum:i2CB3798C8BEC2E89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097439 mRNA. Translation: AAD24430.1.
AK132005 mRNA. Translation: BAE20934.1.
BC027529 mRNA. Translation: AAH27529.1.
CCDSiCCDS30413.1.
RefSeqiNP_033879.1. NM_009749.2.
UniGeneiMm.94160.

Genome annotation databases

EnsembliENSMUST00000049130; ENSMUSP00000043113; ENSMUSG00000042750.
GeneIDi12069.
KEGGimmu:12069.
UCSCiuc009uia.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097439 mRNA. Translation: AAD24430.1.
AK132005 mRNA. Translation: BAE20934.1.
BC027529 mRNA. Translation: AAH27529.1.
CCDSiCCDS30413.1.
RefSeqiNP_033879.1. NM_009749.2.
UniGeneiMm.94160.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-272029.
STRINGi10090.ENSMUSP00000043113.

PTM databases

iPTMnetiQ9WTZ8.
PhosphoSiteiQ9WTZ8.

Proteomic databases

EPDiQ9WTZ8.
MaxQBiQ9WTZ8.
PaxDbiQ9WTZ8.
PRIDEiQ9WTZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049130; ENSMUSP00000043113; ENSMUSG00000042750.
GeneIDi12069.
KEGGimmu:12069.
UCSCiuc009uia.2. mouse.

Organism-specific databases

CTDi84707.
MGIiMGI:1338017. Bex2.

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9WTZ8.
OMAiEAGEYCV.
OrthoDBiEOG7XPZ7S.
PhylomeDBiQ9WTZ8.
TreeFamiTF337909.

Miscellaneous databases

PROiQ9WTZ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTZ8.
CleanExiMM_BEX2.
GenevisibleiQ9WTZ8. MM.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome."
    Brown A.L., Kay G.F.
    Hum. Mol. Genet. 8:611-619(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Erratum
    Brown A.L., Kay G.F.
    Hum. Mol. Genet. 8:943-943(1999)
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Lung.
  5. "Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners."
    Behrens M., Margolis J.W., Margolis F.L.
    J. Neurochem. 86:1289-1296(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OMP.
  6. "The interaction of Bex and OMP reveals a dimer of OMP with a short half-life."
    Koo J.H., Gill S., Pannell L.K., Menco B.P.M., Margolis J.W., Margolis F.L.
    J. Neurochem. 90:102-116(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OMP.
  7. "Immunolocalization of Bex protein in the mouse brain and olfactory system."
    Koo J.H., Saraswati M., Margolis F.L.
    J. Comp. Neurol. 487:1-14(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiBEX2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.